Clinical trials: Parodontitis
Periapical Lesion, Periapical Periodontitis
Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment
This study compares two commonly used intracanal medicaments-Triple Antibiotic Paste and Calcium Hydroxide-in patients with infected single-rooted teeth.
- Trial name
- NCT07239739
- Testing
- Triple Antibiotic Paste, Calcium Hydroxide (Ca(OH)2)
- Volunteers
- 62 people
- Sponsor
- Faiz ur rahman
Periodontitis
Conservative Surgery with Modified Widman Flap Vs Papilla Preservation Technique for the Treatment of Residual Pockets
The primary aim of the study is to evaluate the efficacy of conservative surgery with or without papilla preservation technique in the treatment of deep residual pockets ≥ 6 mm in stage III-IV periodontitis patients after cause…
- Trial name
- MWF vs PPT (NCT06661928)
- Testing
- Papilla preservation flap, Widman flap procedure
- Volunteers
- 80 people
- Sponsor
- University of Turin, Italy
Temporomandibular Disorders (TMD), Acute Apical Periodontitis of Pulpal Origin
The Role of Root Canal Treatment in Alleviating Endodontic Pain-Induced Asymmetry and Restoring Muscle Balance
The study hypothesizes that masticatory laterality caused by acute apical periodontitis pain result in muscle asymmetry. Furthermore, it posits that successful root canal treatment, by restoring normal bilateral chewing function…
- Trial name
- NCT06853028
- Testing
- ultrasound measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Cukurova University
Periodontitis
Local Injection of Periodontal Pocket Method for the Treatment of Gingivitis
Preliminary clinical studies have confirmed that injection of freshly prepared HA35 can reduce symptoms and signs of gingivitis or periodontitis. This clinical study is a prospective repeated experiments.
- Trial name
- NCT05812300
- Testing
- Freshly manufactured 35 kDa hyaluronan fragment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Dove Medical Press Ltd
Symptomatic Irreversible Pulpitis, Apical Periodontitis
Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator
Patients with painful molars will be randomly assigned to 2 different groups: GentleWave and EndoActivator. The root canals will be completed using identical protocols except in the mode of delivery and activation of irrigation…
- Trial name
- NCT04552132
- Testing
- Multisonic vs Sonic activation of irrigants
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Parodontitis, Obesity
Inflammatory Status of Visceral Adipose Tissue in Obese Patients Related to Periodontitis Severity
The research aims to compare the inflammatory status of visceral adipose tissue from obese patients depending on the presence and severity of periodontitis, in order to establish a potential causal link between the severity of…
- Conditions
- Parodontitis, Obesity, Metabolism Disorders
- Trial name
- BACTERIOB (NCT02853734)
- Testing
- SEVERE PERIODONTITIS, NO PERIODONTITIS
- Where
- Reunion
- Volunteers
- 122 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Gingivitis, Periodontitis
Oral Health Care in Stroke Patients in Tertiary Care Hospital
To investigate oral care provision in stroke care settings in Pakistan. Stroke can have adverse effects on oral care and health. Little is known about current oral care practices in stroke care settings.
- Conditions
- Gingivitis, Periodontitis, Dental Hygiene
- Trial name
- NCT05114681
- Testing
- Assessment of Oral care as per patient personal choice
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Periodontitis, Gingivitis
Endoplasmic Reticulum Stress Response in Periodontal Disease
Periodontal disease causes inflammation and damage to the tissues that support the teeth. This study looks at whether stress inside gum cells contributes to this damage.
- Trial name
- NCT07751419
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Inonu University
Chronic Periodontitis
Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison with collagen membrane for management of periodontal intrabony defects.
- Trial name
- NCT02248103
- Testing
- Periosteal pedicle graft, Bioresorbable collagen membrane
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endodontic-Periodontal Lesions, Apical Periodontitis
The MTA Effect on Healing and Biomarkers in Endo-Perio Lesions
This project is a randomized controlled clinical study investigating the effect of Mineral Trioxide Aggregate (MTA) used as an apical plug in root canal obturation on periodontal healing and inflammatory biomarkers in teeth with…
- Conditions
- Endodontic-Periodontal Lesions, Apical Periodontitis, Periapical Disease
- Trial name
- NCT07653997
- Testing
- Root Canal Treatment with MTA Apical Plug, Root Canal Treatment with Resin-Based Sealer (AH Plus), Periodontal Therapy (Scaling and Root Planing)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Peridontal Disease, Aging
Taurine in Periodontitis and Aging
Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth.
- Trial name
- NCT06635369
- Testing
- Periodontal Indices
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Diabete Type 2, Apical Periodontitis
Effect of Primary Non-surgical Endodontic Therapy on Glycaemic Control in Type 2 Diabetic Patients With Asymptomatic Apical Periodontitis
To evaluate the effect of primary non-surgical endodontic therapy on glycaemic control in type 2 diabetic patients with asymptomatic apical periodontitis.After fulfilling the eligibility criteria, patients will be informed about…
- Trial name
- NCT05170880
- Testing
- Primary endodontic treatment
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Cardiovascular Diseases
Periodontal and Cardiovascular Diseases Project
The purpose of this study is to investigate whether basic periodontal therapy aim to reduce subgingival levels of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, has an impact on the vascular function of…
- Trial name
- NCT02716259
- Testing
- Scaling and root planing, Supragingival prophylaxis
- Where
- 2 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Universidad Complutense de Madrid
Preterm Birth, Low Birthweight Neonate
Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial
The ground-breaking Prevention of Prematurity and Xylitol (PPaX) cluster randomized controlled clinical trial was conducted in Lilongwe, Malawi and enrolled approximately 10,069 pregnant individuals seeking to evaluate the impact…
- Conditions
- Preterm Birth, Low Birthweight Neonate, Periodontitis, Gingivitis
- Trial name
- XaPPP (NCT07424846)
- Testing
- Xylitol Chewing gum, Sorbitol chewing gum
- Where
- Malawi
- Volunteers
- 6,000 people
- Sponsor
- University of Washington
Periodontitis, Oxidative Stress
Gingival TrxR1 Expression in Periodontal Health and Periodontitis
This study aims to investigate the role of the thioredoxin system in the development and progression of periodontitis. Researchers will examine the levels of specific antioxidant markers, such as thioredoxin reductase 1 (TrxR1)…
- Trial name
- NCT07598942
- Testing
- Gingival Tissue Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Chronic Periodontitis
Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin
Periodontitis is an inflammatory/infectious disease of high prevalence in the population and which has been linked to several chronic inflammatory systemic diseases.
- Trial name
- NCT02641210
- Testing
- Periodontal Treatment, Albendazole
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Federal University of Maranhao
Periodontal Diseases, Gingival Diseases
Asprosin and Total Antioxidant/Oxidant Status in Diabetes and Periodontal Disease
The goal of this observational study is to learn about how different periodontal health status affects the levels of asprosin (a hormone) and total oxidant/antioxidant status in the gingival crevicular fluid and blood serum of…
- Conditions
- Periodontal Diseases, Gingival Diseases, Type 2 Diabetes
- Trial name
- NCT07691060
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Periodontitis
Effect of Essential Oils as Adjutants on the Treatment of Subjects With Periodontitis: Assessment of Metabolic Variables as Effect Modifiers
Periodontitis, an infectious disease that affects the tooth-supporting tissues and shows a wide range of clinical, microbiological, and immunological manifestations, is associated with and probably caused by dynamic interaction…
- Trial name
- NCT04692246
- Testing
- Plant-based oral rinse
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
Type 2 Diabetes Mellitus MeSH:D003924, Periodontitis MeSH:D010518
Non-surgical Periodontal Therapy and Kidney Outcomes in Type 2 Diabetes Mellitus
Brief Summary (Lay Description) This research study is being conducted to understand whether treating gum disease (periodontitis) can help improve kidney health in patients who have type-2 diabetes mellitus (T2DM).
- Conditions
- Type 2 Diabetes Mellitus MeSH:D003924, Periodontitis MeSH:D010518, Diabetic Nephropathies MeSH:D003928
- Trial name
- KIDPER (NCT07256613)
- Testing
- scaling and root planning
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Dow University of Health Sciences
Hyperlipidemia, Periodontal Disease
Is There a Relationship Between Hyperlipidemia and Periodontitis?
The aim of present study is to investigate any relationship between hyperlipidemia and periodontal disease regarding the periodontal parameters and plasma lipid parameters, along with age, gender, brushing habit, body mass index…
- Trial name
- NCT02826720
- Testing
- No intervention was applied
- Volunteers
- 160 people
- Sponsor
- Marmara University
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