Clinical trials: Parotid Neoplasms
Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm
Customized 3D Printed Oral Stents During Head and Neck Radiotherapy
This clinical trial studies the effect of customized 3 dimensional (3D) printed oral tents on patients with head and neck cancer who are receiving radiotherapy.
- Conditions
- Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm, Maxillary Sinus Carcinoma, Nasal Cavity Carcinoma
- Trial name
- NCT04870762
- Testing
- Best Practice, Medical Device Usage and Evaluation
- Where
- 7 sites in United States
- Volunteers
- 88 people
- Sponsor
- M.D. Anderson Cancer Center
Head and Neck Cancer
Phase II Study of Whole or Partial Parotid Sparing Intensity Modulated Radiotherapy in Patients With Head and Neck Cancers
Phase II and III studies have demonstrated IMRT to be safe and standard practice for head and neck cancers treated with radiotherapy.
- Trial name
- NCT02068313
- Testing
- Toxicity and outcome measures of IMRT
- Where
- 2 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Head and Neck Cancer, Parotid Gland Cancer
Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer
To determine a safe and effective doses of two biologic drugs, erlotinib and bevacizumab when used with chemotherapy and radiation therapy in advanced head and neck cancer
- Conditions
- Head and Neck Cancer, Parotid Gland Cancer, Thyroid Gland Cancer, Melanoma
- Trial name
- NCT00405405
- Testing
- Cisplatin, Docetaxel, Bevacizumab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Benign Tumor of Parotid Gland, Endoscope-assisted Surgery
The Effect of Endoscopy-assisted Transoral Parotid Gland Tumor Excision Compared With Traditional Operation
Endoscopic-assisted surgery has become a popular technique in salivary gland surgery, particularly for parotid gland tumors. However, this technique has not yet been routinely applied to transoral parotid tumor resection.
- Conditions
- Benign Tumor of Parotid Gland, Endoscope-assisted Surgery, Gland Preservation, Minimally Invasive Surgery
- Trial name
- NCT07028437
- Testing
- Endoscopic-assisted transoral approach for parotid tumor resection, Blair S-shaped incision for parotid tumor
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Parotid Cancer
Investigating the Role of Adjuvant Proton Beam Therapy in Patients With Parotid Carcinoma
Proton Beam Therapy (PBT) is an advanced radiotherapy technique. There are two National Health Service (NHS) PBT treatment centres in the UK, one in Manchester and one in London.
- Trial name
- PRONTO (NCT06421649)
- Testing
- Proton Beam Therapy
- Volunteers
- 97 people
- Sponsor
- The Christie NHS Foundation Trust
Parotid Tumors, Postoperative Complications
Retrospective Clinical Outcome of Parotid Tumor Surgery
The aim of this study was to determine the histopathological results of parotid tumors and postoperative complications after partial superficial or total parotidectomy with facial nerve dissection and superficial…
- Trial name
- NCT01983176
- Where
- Taiwan
- Volunteers
- 767 people
- Sponsor
- National Taiwan University Hospital
Parotid Gland Neoplasm
Pattern and Surgical Treatment of Parotid Gland Neoplasms
in these study we analyze pattern of parotid gland neoplasms according to histopathological types, most common type clinical presentation and type of surgical treatment(superficial parotidectomy or total parotidectomy radical…
- Trial name
- NCT05505318
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Parotid Neoplasms
Application of 3D MR Neurogram for Intraparotid Facial Nerves Evaluation
Parotid neoplasm consists of a wide range of benign and malignant lesions, and parotidectomy has been the mainstay for management of these neoplasms.
- Trial name
- NCT05296109
- Testing
- Magnetic Resonance Imaging on 3T scanner (Magnetom Prisma, SIemens) with dedicated neurogram sequences (Constructive interference in steady state - CISS; Dual Echo Steady State - DESS)
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Parotid Tumor, Parotid Neoplasms
Trident Landmark as a Safe and Easy Method for Facial Nerve Trunk Identification During Superficial Parotidectomy
The parotid has a close relationship with the extra temporal course of the facial nerve. The study aimed to evaluate the accuracy and safety of trident landmark during superficial parotidectomy in the identification of the facial…
- Conditions
- Parotid Tumor, Parotid Neoplasms, Surgery, Head and Neck Disorder
- Trial name
- NCT04803032
- Testing
- Superficial parotidectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Adenocarcinoma, Adenocystic Carcinoma
The Registry of Oncology Outcomes Associated With Testing and Treatment
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation.
- Conditions
- Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer
- Trial name
- ROOT (NCT04028479)
- Testing
- Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Taproot Health
Parotid Neoplasm, Parotid Cancer
Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology for Parotid Gland Neoplasms
Parotid gland tumors are mostly treated surgically, but the extent of parotidectomy is decided upon preoperative work-up information.
- Trial name
- NCT03849482
- Testing
- Multiparametric Magnetic Resonance Imaging, Fine Needle Aspiration Cytology, Clinical Evaluation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Davide Di Santo
Head and Neck Cancer
Cross-Sectional Study of Oral Health in Patients After Parotid-Sparing Radiation Therapy for Head and Neck Cancer
The investigators are conducting research about oral health and saliva to find out more about the impact of radiation therapy on the oral health of patients.
- Trial name
- NCT01663246
- Testing
- Saliva Sample
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Swallowing Dysfunction
SW-IMRT Versus ST-IMRT in the Treatment of Head and Neck Cancer
To clinically validate whether SW-IMRT actually reduce the occurrence of swallowing dysfunction as compared to ST-IMRT.
- Trial name
- NCT04597177
- Testing
- ST-IMRT SW-IMRT
- Where
- Egypt
- Volunteers
- 146 people
- Sponsor
- National Cancer Institute, Egypt
Parotid Neoplasm, Bupivacaine
Clinical Tolerance of an Intraparotid Injection of Bupivacaine, Combined With Dexamethasone, After Parotidectomy for Benign Tumor
There has been a paradigm shift toward less invasive surgical techniques for parotidectomies, primarily to mitigate post-surgical complications.
- Conditions
- Parotid Neoplasm, Bupivacaine, Dexamethasone
- Trial name
- PAROCAINE (NCT07812259)
- Testing
- Intraparotid injection of bupivacaine/ dexamethasone
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Parotid Neoplasms
Feasibility Study of MRI Imaging on Parotid Gland Stimulation
The aim of this study is to determine the feasibility of demonstrating the following physiologically-descriptive quantities ('metrics'): the volume of plasma/volume of tissue (νp), Apparent Diffusion Coefficient (ADC), the volume…
- Trial name
- SPIT (NCT02294838)
- Testing
- MRI, Citric acid, Gadovist
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Parotid Tumor
The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome
The aim of the study was to explore whether human acellular dermal matrix (ADM) implantation could prevent infraauricular depressed deformities and Frey's syndrome following total parotidectomy.
- Trial name
- NCT01414790
- Testing
- ADM
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Parotid Tumor
FArial NErf MRI in the Preoperative Assessment of PArotide Tumors
1. st visit: Inclusion, 3Tesla injected parotid MRI performed as part of routine care for characterization, to which two specific high resolution sequences will be added.
- Trial name
- NEFAPA (NCT04613349)
- Testing
- MRI
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Squamous Cell Head and Neck Cancer, Radiation Induced Xerostomia
Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction
Background: Radiation can cause the parotid salivary glands to make less saliva (dry mouth). This can cause problems like infections and tooth decay. Researchers hope a new drug can help people with dry mouth caused by radiation.
- Conditions
- Squamous Cell Head and Neck Cancer, Radiation Induced Xerostomia, Salivary Hypofunction
- Trial name
- NCT02446249
- Testing
- AAV2hAQP1
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- MeiraGTx, LLC
Head and Neck Cancer
Parotid-gland Stem-cell Sparing Intensity-modulated Radiotherapy
Rationale: Radiation-induced parotid gland dysfunction, often leading to xerostomia is the most-frequently occurring side-effect with a major impact on patient-reported quality of life after radiotherapy for head and neck cancer…
- Trial name
- SCS-IMRT (NCT01955239)
- Testing
- Intensity-modulated Radiotherapy
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- University Medical Center Groningen