Clinical trials: Partial Epilepsy, open to volunteers
Epilepsy, Dravet Syndrome
A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome
Dravet Syndrome (DS) is a severe neurodevelopmental disease, which is predominantly caused by mutations of SCN1A, the gene coding for Nav1.1 voltage-gated sodium channels.
- Conditions
- Epilepsy, Dravet Syndrome, Drug Resistant Epilepsy, Healthy Controls
- Trial name
- DRAPETONINE (NCT07013331)
- Testing
- [18F]MPPF PET-MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Epilepsy, Temporal Lobe
Enhanced MRI Imaging in Healthy Participants and Participants With Epilepsy
Temporal lobe epilepsy (TLE) is a common type of epilepsy and one of the most likely to not be controlled by medication. For patients who do not respond to medication, surgery can result in a cure of seizures.
- Trial name
- NCT06483061
- Testing
- Ferumoxytol
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Epilepsy, Drug-resistant Focal Epilepsy
Impact of Epilepsy on the Brainstem Adenosine Pathway and Its Relation With Arousal and Respiratory Reactivity
Despite the continuous development of new antiseizure medications over the past 25 years, 30% of patients with epilepsy suffer from drug-resistant seizures and are at risk of epilepsy-related complications, like cognitive…
- Conditions
- Epilepsy, Drug-resistant Focal Epilepsy, Healthy Controls
- Trial name
- BRAVE (NCT07249034)
- Testing
- 1 Hypercapnic challenge while participant is awake, PET/MRI acquisition
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Epilepsy, Epilepsy Intractable
Localizing Epileptic Networks Using MRI and iEEG
Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes.
- Conditions
- Epilepsy, Epilepsy Intractable, Epilepsy, Temporal Lobe
- Trial name
- NCT04649008
- Testing
- 3T Magnetic Resonance Imaging, Intracranial electroencephalography recordings, 7T Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Epilepsy, Temporal Lobe, Drug Resistant Epilepsy
Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With Epilepsy
The goal of this observational study is to understand heart rhythm changes in adults with epilepsy. It will also explore whether computer programs can use heart recordings to detect or predict seizures.
- Trial name
- EpHR-DP (NCT07835594)
- Testing
- Textile-based wearable electrocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Epilepsy
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
Objectives: The overall study objective is to compare the sensitivities and specificities of morphometric analysis techniques using structural MRI images based on pre- and postsurgical localization of epileptic foci in patients…
- Trial name
- NCT02107989
- Testing
- MRI, MEG
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Temporal Lobe Epilepsy (TLE)
MRI Volumetry and Diffusion Tensor Imaging in Temporal Lobe Epilepsy
This works aims at evaluating the diagnostic performance of combined MRI Volumetry, Diffusion tensor imaging and Conventional MRI in lateralizing the epileptogenic focus in patients with temporal lobe epilepsy and correlate these…
- Trial name
- NCT07384351
- Testing
- MRI
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Assiut University
Epilepsy, Temporal Lobe, Cognitive Decline
Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients
Anterior temporal epilepsy is the most frequent form of focal epilepsy (more than 50% of focal epilepsies). The epilepsy is drug-resistant when epileptic seizures persist despite antiepileptic treatment (25% of cases).
- Trial name
- CARTA (NCT05339438)
- Testing
- functional MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Epilepsies, Partial, Epilepsy, Tonic-Clonic
A Clinical Study on the Efficacy and Safety of Zonisamide as a First Add-On Treatment in Epileptic Seizures
This study primarily aims to assess the efficacy and safety of zonisamide when used as an adjunctive therapy for focal epilepsy. The main questions it aims to answer are: 1.
- Trial name
- NCT06967012
- Testing
- Oral Zonisamide Therapy
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Epilepsy, Temporal Lobe
Innovative MRI to Localize the Epileptic Zone
The goal of EPI-CATCHER is to outline the clinical potential of multiparametric quantitative MRI (mqMRI) and of GABA-edited magnetic resonance spectroscopy (GABA-MRS), combined with machine learning tools, as imaging biomarkers…
- Trial name
- EPI-CATCHER (NCT06057233)
- Testing
- mqMRI and GABA-MRS
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble