Clinical trials: Particle Therapy
Neuroendocrine Tumors Unresectable, Neuroendocrine Tumor Metastatic
Targeted Alpha-Particle Therapy for Advanced Somatostatin Receptor Type 2 (SSTR2) Positive Tumors
This study is Phase I/IIa First-in-Human Study of [212Pb]VMT-α-NET Targeted Alpha-Particle Therapy for Advanced SSTR2 Positive Tumors
- Conditions
- Neuroendocrine Tumors Unresectable, Neuroendocrine Tumor Metastatic, Gastroenteropancreatic Neuroendocrine Tumor, Bronchial Neuroendocrine Tumor
- Trial name
- NCT05636618
- Testing
- [203Pb]VMT-α-NET, [212Pb]VMT-α-NET
- Where
- 20 sites in United States
- Volunteers
- 300 people
- Sponsor
- Perspective Therapeutics
Healthy Volunteers, Norovirus
Long-Term Immunogenicity of the Norovirus GI.1/GII.4 Bivalent Virus-like Particle (VLP) Vaccine (NoV Vaccine) in Adults
The purpose of this study is to evaluate descriptively the long-term immunogenicity of at least 1 NoV vaccine administration.
- Trial name
- NCT03039790
- Testing
- NoV Vaccine
- Where
- 11 sites in United States, Belgium
- Volunteers
- 528 people, healthy volunteers welcome
- Sponsor
- Takeda
Head and Neck Cancer
Sarcopenia in Head and Neck Cancer Patients Treated with Curative Hadrontherapy
The study focuses on the impact of sarcopenia on acute and late toxicities in head and neck tumor affected patients treated with particle therapy.
- Trial name
- NCT06207708
- Testing
- questionnaires QLQ-FA12, Mini Nutritional Assessment Short Form, Nutritional Risk Screening, diet questionnaire of frequency, ,body mass index measurement, blood biomarkers
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Embolization, Hemorrhoids
SRAE With Embospheres for Hemorrhoids.
In this study , safety and efficacy of superior rectal artery embolization with embospheres will be researched prospectively.
- Trial name
- NCT03740321
- Testing
- Embolization with tri-acryl gelatin (Embosphere) particles
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Eskisehir Osmangazi University
Chronic Kidney Disease
Micro-Particle Curcumin for the Treatment of Chronic Kidney Disease
An investigator initiated pilot trial: two arm, double blind, placebo controlled, randomized, parallel group of approximately 750 patients with chronic kidney disease, and who have evidence of overt proteinuria, will be treated…
- Trial name
- MPAC-CKD (NCT02369549)
- Testing
- Micro-particle Curcumin
- Where
- 4 sites in Canada
- Volunteers
- 518 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteosarcoma
Therapy Trial to Determine the Safety and Efficacy of Heavy Ion Radiotherapy in Patients With Osteosarcoma
The primary objectives of this trial are the determination of feasibility and toxicity of Heavy Ion Radiotherapy (C12) in patients with non-resectable osteosarcoma.
- Trial name
- NCT01005043
- Testing
- heavy ion radiotherapy (C12)
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy
The ACCEPT (A(denoid) c(ystic) c(arcinoma), E(rbitux, and) p(article) t(herapy))-trial is a prospective, monocentric phase I/II feasibility trial evaluating toxicity and efficacy in the combined treatment of intensity-modulated…
- Trial name
- ACCEPT (NCT01192087)
- Testing
- Cetuximab
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Heidelberg University
Healthy
Bioequivalence Study of Dr. Reddy's Divalproex Sodium Capsules (Sprinkle), 125 mg Under Fasting Conditions
An open label, balanced, randomized, two-treatment, two-period, two-sequence, single dose, crossover, bioequivalence study of Divalproex Sodium coated particles in capsules 125 mg with Depakote® Sprinkle125 mg capsules in…
- Trial name
- NCT01055938
- Testing
- Divalproex Sodium
- Where
- India
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Ulcerative Colitis (UC)
Predictive Efficacy of Fecal Calprotectin Assay by Magnetic Particle Chemiluminescence for Mucosal Healing in Moderate-to-Severe Ulcerative Colitis Patients Undergoing Initial Biologic Therapy（PRECAL）
This is a national prospective, multicenter, observational study. A total of 200 eligible patients will be enrolled from 10 hospitals across the country.
- Trial name
- PRECAL (NCT07721441)
- Testing
- fecal calprotectin test
- Where
- 10 sites in China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital
Breast Cancer, Head and Neck Cancer
Radiation Therapy (HB-001) by Alpha-particle Sources for Recurrent Malignant Solid Tumors in Japan
An intratumoral alpha particle based approach for cancer treatment using diffusion alpha-emitting radiation therapy (DaRT)
- Trial name
- NCT04906070
- Testing
- HB-001
- Where
- 4 sites in Japan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hekabio
Healthy Volunteers
Efficacy and Immunogenicity of Norovirus GI.1/GII.4 Bivalent Virus-like Particle Vaccine in Adults
The purpose of this study is to evaluate the efficacy of the Norovirus (NoV) GI.1/GII.4 bivalent virus-like particle vaccine against moderate or severe acute gastroenteritis (AGE) due to genotype-specific (GI.1 and GII.4) NoV…
- Trial name
- NCT02669121
- Testing
- NoV GI.1/GII.4 Bivalent VLP Vaccine
- Where
- United States
- Volunteers
- 4,748 people, healthy volunteers welcome
- Sponsor
- Takeda
Rapid Detection, Pseudomonas Aeruginosa Infection
Rapid Detection of Pseudomonas Aeruginosa in Bronchoalveolar Lavage Fluid Using Label-free Single-particle Imaging Technology and Assessment of Post-treatment Efficacy in Patients With Pseudomonas Aeruginosa Infection
The aim of this study is to observe specimens of bronchoalveolar lavage fluid from patients using a reflection enhanced dark-field scattering microscopy.
- Trial name
- NCT06986512
- Testing
- bronchoscopy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Asthma
Targeted Small Airways Therapy in Persistent Asthma
The mainstay of asthma treatment is with inhaled steroids (commonly called a 'preventer') to keep the symptoms of asthma under control.
- Trial name
- ANDA3 (NCT01894048)
- Testing
- Qvar® (beclometasone dipropionate HFA)
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Dundee
Ventricular Tachycardia, Ventricular Arrhythmias
CARA-VT: a Dosimetric in Silico Study
Ventricular tachycardia (VT) is a potentially deadly condition, common in patients with structural heart disease or dilated cardiomyopathy.
- Trial name
- CARA-VT (NCT07590908)
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Stage III Periodontitis
Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management
To better understand and treat your gum disease, dentists now use a system that stages its severity and grades its speed, rather than using old labels.
- Trial name
- NCT07316023
- Testing
- Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded nanoparticles, Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded macroparticles, Non- surgical periodontal therapy only
- Where
- Egypt
- Volunteers
- 27 people
- Sponsor
- Nada Mahmoud Soliman
Asthma
Effects of QVAR in Smokers With Asthma
We hypothesize that extra-fine particle treatment with HFA-QVAR will be superior in improving small airways dysfunction, especially in ex-smokers and smokers with asthma.
- Trial name
- OLiVIA (NCT01741285)
- Testing
- Beclomethasone (QVAR), Beclomethasone (Clenil), Fluticasone
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- University Medical Center Groningen
Carcinoma, Squamous Cell of Head and Neck
State of the Art Photon Therapy Versus Particle Therapy for Recurrent Head & Neck Tumors; a Planning Study
Given that the cost of proton therapy is considerably higher than that of conventional radiotherapy with photons, it is necessary to establish whether these higher costs are worthwhile in light of the expected advantages2,3,4.
- Trial name
- ROCOCO (NCT02242916)
- Testing
- Photon therapy versus proton therapy, Photon therapy versus C-ion therapy
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht Radiation Oncology
Advanced Hepatocellular Carcinoma (HCC)
Trans-catheter Arterial Embolization Combined With p53 Gene Therapy for Treatment of Advanced Hepatocellular Carcinoma
An open-labeled, randomized, active-controlled phase II study to investigate clinical efficacy and immunoreaction using trans-catheter arterial embolization (TAE) combined with p53 gene therapy in treatment of advanced…
- Trial name
- NCT02509169
- Testing
- TAE plus P53 gene, TAE
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenzhen SiBiono GeneTech Co.,Ltd
Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
A Phase 1/2 Study of High-dose Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure
The purpose of this trial is to characterize the safety profile and preliminary activity of high-dose MYDICAR® in persons with advanced heart failure when added to their maximal and optimized therapy.
- Conditions
- Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy, Heart Failure, Cardiomyopathies
- Trial name
- NCT02346422
- Testing
- MYDICAR Phase 1, MYDICAR Phase 2
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- Celladon Corporation
Particle Therapy
Monitoring of Patients Treated With Particle Therapy Using Positron-Emission-Tomography (PET): The MIRANDA Study
The purpose of this clinical study is to investigate the clinical feasibility and effectiveness of off-line Positron-Emission-Tomography (PET) quality assurance for promoting the accuracy of proton and carbon ion beam therapy.
- Trial name
- MIRANDA (NCT01528670)
- Where
- Germany
- Sponsor
- University Hospital Heidelberg