Clinical trials: Parturients
Labor Onset and Length Abnormalities
Misoprostol Versus Oxytocin for Induction of Labour in Parturients With Spontaneous Rupture of Fetal Membranes at Term
Intravenous oxytocin titration has a prime position as a choice agent for induction of labour following term PROM as it has been shown to be efficacious for such purpose.
- Trial name
- NCT06343480
- Testing
- Labour Induction
- Where
- 2 sites in Nigeria
- Volunteers
- 120 people
- Sponsor
- Federal Teaching Hospital Abakaliki
Cardiac Arrythmias
Carbetocin on Myocardial Repolarization Dynamics in Obstetrics Study
Relationship between carbetocin dose on transmural dispersion of repolarization (TDR).
- Trial name
- CaRDIO (NCT03716076)
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Effects of; Anesthesia, in Labor and Delivery, Pregnancy
Effects of Analgesic Techniques on Duration of Spontaneously Laboring Patients
The purpose of this study is to determine if there is a difference in the duration of the first stage of labor in nulliparous women in spontaneous labor with whom analgesia is maintained with a combined spinal epidural (CSE)…
- Conditions
- Effects of; Anesthesia, in Labor and Delivery, Pregnancy, Prolonged First Stage of Labor
- Trial name
- NCT01982838
- Testing
- Epidural de novo, CSE
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Anesthesia
Magnesium for Shivering in Epidural Lidocaine Deliveries
Magnesium has been shown to decrease the shivering experienced from neuraxial anesthesia. This study aims to investigate whether magnesium decreases the shivering experienced in parturients undergoing labor epidural anesthesia…
- Trial name
- Mag-SHIELD (NCT03439358)
- Testing
- Magnesium Sulfate, Normal Saline
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hypotension
Reduction in Spinal-induced Hypotension With Ondansetron in Parturients Undergoing Caesarean Section
Subarachnoid block is the preferred method of anaesthesia for caesarean section, but is associated with hypotension and bradycardia, which may be deleterious to both parturient and baby.
- Trial name
- NCT02913768
- Testing
- Ondansetron, Normal saline
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Assiut University
Parturients
Epidural Sonoanatomy Between Parturient and Non-Pregnant
The failure in indwelling epidural catheter for a parturient might cause an anesthetic difficulty. Furthermore, no one can predict the accuracy of needle placement prior to skin puncture with any of landmark-based technique.
- Trial name
- NCT00811707
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Parturients, Childbirth
Comparison Of The Analgesia Obtained By Infiltration For The Joinings Of Episiotomies (Liropep)
Lateral episiotomy is a current care practiced with childbirth room. One of the problems encountered with this surgical act is the residual pain on perineal scar level.
- Trial name
- LiRoPep (NCT00727935)
- Testing
- Lidocaïne, Ropivacaïne
- Where
- France
- Volunteers
- 165 people
- Sponsor
- University Hospital, Angers
Labor Onset and Length Abnormalities
Breath Metabolomics in the Laboring Parturient
This is primarily a feasibility study to determine whether quantitative measurement of volatile organic compounds (VOCs) in the breath of parturients undergoing labor is possible.
- Trial name
- NCT04564196
- Testing
- Breath Sample
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Stanford University
Obstetric Complication, Lung Injury, Acute
Lung Ultrasound to Detect Pulmonary Complications in Critically Ill Parturients
This study aims at describing the frequency, timing and type of pulmonary complications detected with lung ultrasound in critically-ill parturients in admitted to a high-dependency unit in Freetown, Sierra Leone.
- Conditions
- Obstetric Complication, Lung Injury, Acute, Pulmonary Disease, Acute Respiratory Distress Syndrome
- Trial name
- LUSIP (NCT03828630)
- Where
- Sierra Leone
- Volunteers
- 168 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pregnancy
Three-Dimensional Ultrasound (3D US) in Parturients
The purpose of this study is to compare accuracy of a new three-dimensional ultrasound (3D US) technique with the traditional palpation method for identification of the needle insertion site on patients' skin before epidural…
- Trial name
- NCT01523249
- Testing
- Lumbar 3D ultrasound scanning and palpation (Ultrasonix )
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Complications; Cesarean Section, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Phenylephrine Dose and Mode of Administration for Spinal Anesthesia Induced Hypotension
Three different regimens of phenylephrine are being evaluated to see if one is superior over the other in the maintenance of cardiac output while keeping normotension and/or treating hypotension experienced when receiving spinal…
- Trial name
- NCT02101047
- Testing
- Phenylephrine
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Postoperative Pain, Cesarean Delivery
Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial
The goal of this clinical trial is to compare intrathecal bupivacaine with or without morphine for postoperative analgesia in patients undergoing elective cesarean section.
- Conditions
- Postoperative Pain, Cesarean Delivery, Analgesia, Obstetrical
- Trial name
- NCT07094802
- Testing
- Intrathecal morphine with bupivacaine, Hyperbaric Bupivicaine
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Analgesia, Obstetrical
Intrapartum Epidural Catheter Displacement: Dressing Methods
Failure of labor epidural is a well-recognized situation in obstetric anesthesia practice. Incidence of epidural failure was shown to be 12% in a retrospective analysis of 19,259 deliveries.
- Trial name
- NCT03574441
- Testing
- Tegaderm dressing + catheter support pad, Tegaderm dressing + Steri-strip dressing, Tegaderm dressing only
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Augusta University
Pregnancy Preterm, Neonatal Hypoglycemia
Continuous Glucose Monitoring of Late Preterm Birth After Corticosteroids
Women undergoing late preterm birth are at high risk of delivering a newborn with neonatal hypoglycemia. The investigators plan to monitor interstitial glucose levels prior to delivery in these women in order to develop a better…
- Conditions
- Pregnancy Preterm, Neonatal Hypoglycemia, Prematurity
- Trial name
- NCT03738293
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
Pain
Breakthrough Pain Computer Integrated Patient Controlled Epidural Analgesia
The computer-integrated patient controlled epidural analgesia (CIPCEA) system can automatically adjust the background infusion rate during combined spinal-epidural (CSE) analgesia based on the parturient's need as labour…
- Trial name
- BTP (NCT02313571)
- Where
- Singapore
- Volunteers
- 350 people
- Sponsor
- KK Women's and Children's Hospital
Labour Analgesia
Role of the Single-shot Spinal Analgesia to Control Labour Pain
Labor pain is the most severe pain most women will endure in their lifetimes. The most complete and effective method of pain relief during childbirth is neuraxial labor analgesia which provides adequate analgesia without maternal…
- Trial name
- NCT02800694
- Testing
- "bupivacainediluted with 1 ml of normal saline" and "25 μg fentanyl "
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Minia University
Pregnancy, Respiratory Aspiration of Gastric Content
Intra- and Interrater Reliability of Quantitative Ultrasound Assessment of Gastric Content in Term Parturients Before Elective Caesarean Delivery
The presence of solid food or fluid residue in the stomach is always a major concern when patients require medical procedures under sedation or general anesthesia, due to the high risk of pulmonary aspiration of the stomach…
- Trial name
- NCT05946447
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Total Dose of Bupivacaine Administered During Labor
Dexmedetomidine as an Adjuvant During Dural Puncture Epidural
The study aimed to determine the effects of using varied doses of DEX on the concentration of bupivacaine injected for epidural labor analgesia, and to assess the benefits of the dural puncture epidural.
- Trial name
- NCT07506044
- Testing
- Epidural Catheter with bupivacaine, Epidural with dural puncture, Dexmedetomidine 0.4 added
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Menoufia University
Obesity, Morbid
Ultrasound Guided Versus Land-mark Method for Spinal Anesthesia in Super Obesity Parturients
This study will investigate whether an ultrasound-assisted technique is better than a classical land-mark technique to facilitate spinal anesthesia in the sitting position in super obese pregnant women with BMI ≥ 50 who will…
- Trial name
- NCT06410820
- Testing
- Procedure/Surgery: Ultrasound method group, Landmark method group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Prenatal Depression, Ketamine
Low-dose S-Ketamine and Postpartum Depression in Parturients With Prenatal Depression
Prenatal depression is an important risk factor of postpartum depression. Low-dose ketamine has been used for depression treatment. As a stereoisomer of ketamine, s-ketamine has similar effects to ketamine in anti-depression.
- Conditions
- Prenatal Depression, Ketamine, Postpartum Depression
- Trial name
- NCT03927378
- Testing
- S-ketamine
- Where
- 7 sites in China
- Volunteers
- 364 people
- Sponsor
- Peking University First Hospital