Clinical trials: Patency Rate
Pain
Investigation of Rate + Extent of Excretion of Radioactivity in Urine +Faeces After Oral Administration of [14C]AZD2066
The aim of this study is to get information about absorption, distribution, metabolism and excretion as well as the tolerability and safety of AZD2066 in healthy male volunteers.
- Trial name
- NCT00829088
- Testing
- AZD2066
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Attention Deficit Hyperactivity Disorder, INSOMNIA
Study of the Effect of Individualizing Daytrana Wear-times on Sleep in Children With ADHD
Methylphenidate may improve sleep in children with ADHD. By leaving Daytrana (methylphenidate) patch for a longer time then 9 hours, many children report short sleep latencies and better quality of sleep.
- Trial name
- Daytsleep (NCT00989950)
- Testing
- Daytrana
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Cox Health Systems
Graft Rejection
Efficacy and Safety of Everolimus in Recipients of Heart Transplants to Prevent Acute and Chronic Rejection
This trial was to examine the impact of everolimus and reduced dose of cyclosporine on efficacy and safety compared to mycophenolate mofetil and a standard dose of cyclosporine in heart transplant recipients.
- Trial name
- NCT00300274
- Testing
- everolimus, mycophenolate mofetil, cyclosporine
- Where
- 64 sites in United States, Argentina and 13 more
- Volunteers
- 721 people
- Sponsor
- Novartis Pharmaceuticals
Esophageal Cancer, Non Small Cell Lung Cancer
A Multiple Tumor Species, Open and Multi-center Clinical Study of Alpaloritovorelli Antibodies (QL-1706) Combined with Pulsed Low Dose Rate External Irradiation (PLDR) for Disease Progression After Previous Anti-tumor Therapy
For the recurrent and metastatic tumors after first-line treatment (such as lung cancer, esophageal cancer and cervical cancer), the risk of conventional fractionated secondary radiotherapy is high because the tumor is close to…
- Conditions
- Esophageal Cancer, Non Small Cell Lung Cancer, Cervical Cancer
- Trial name
- NCT06760676
- Testing
- Pulsed low dose rate radiotherapy (PLDR), Alpaloritovorelli antibodies
- Volunteers
- 90 people
- Sponsor
- Anhui Provincial Hospital
Acute Kidney Injury, Continuous Renal Replacement Therapy
Continuous Veno-venous Hemodialysis and Continuous Veno-venous Hemodiafiltration on Urea Reduction Rate in Intensive Care Patient
In patients requiring renal replacement therapy (RRT) in the intensive care unit (ICU), continuous techniques are predominantly using due to better hemodynamic tolerance.
- Conditions
- Acute Kidney Injury, Continuous Renal Replacement Therapy, Intensive Care Unit
- Trial name
- CompEER (NCT06369064)
- Testing
- CVVHD Dialysis parameters, CVVHDF Dialysis parameters
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Streptococcus Pneumoniae Vaccines
Study to Evaluate the Response Rate to the Licensed Pneumovax 23™ in Elderly Population.
Streptococcus pneumoniae are bacteria which normally live in the upper respiratory tract of humans. However, these bacteria can also cause severe infectious diseases such as pneumonia, septicemia and meningitis.
- Trial name
- NCT00307008
- Testing
- Pneumovax 23™
- Where
- 5 sites in Sweden
- Volunteers
- 1,198 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Breast Cancer
A Study of Avastin (Bevacizumab) Plus Herceptin (Trastuzumab) in Patients With Primary Inflammatory HER2-Positive Breast Cancer.
This single arm study will assess the efficacy and safety of preoperative treatment with Avastin combined with Herceptin-based chemotherapy in patients with primary inflammatory HER2-positive breast cancer.
- Trial name
- NCT00717405
- Testing
- Standard chemotherapy, bevacizumab [Avastin], trastuzumab [Herceptin]
- Where
- 28 sites in France
- Volunteers
- 52 people
- Sponsor
- Hoffmann-La Roche
High-risk Locally Advanced Colorectal Cancer, Neoadjuvant Chemotherapy
FOLFOXIRI for Neoadjuvant Treatment of High-risk Locally Advanced Colorectal Cancer
The main cause of recurrence after surgical treatment of colorectal cancer is distant metastasis. Neoadjuvant chemotherapy has potential benefits of improving the effectiveness of chemotherapy.
- Conditions
- High-risk Locally Advanced Colorectal Cancer, Neoadjuvant Chemotherapy, FOLFOXIRI Regimen
- Trial name
- NCT05018182
- Testing
- Oxaliplatin, Irinotecan, Folinic Acid
- Where
- China
- Volunteers
- 69 people
- Sponsor
- West China Hospital
Prostate Cancer
A Study of Talazoparib in Men With DNA Repair Defects and Metastatic Castration-Resistant Prostate Cancer
The purpose of this international, phase 2, open-label, response rate study of talazoparib is to assess the efficacy and safety of talazoparib in men with DNA repair defects metastatic castration-resistant prostate cancer (CRPC)…
- Trial name
- NCT03148795
- Testing
- Talazoparib
- Where
- 120 sites in United States, Australia and 12 more
- Volunteers
- 128 people
- Sponsor
- Pfizer
Tobacco Smoking
Heart Rate Variability Biofeedback for Smoking Cessation Treatment
The purpose of the study is to conduct an open trial examining the feasibility and acceptability of an adapted heart rate variability biofeedback and smoking cessation treatment that was using a primarily virtual remote…
- Trial name
- HRVB-SCT (NCT05224050)
- Testing
- Cognitive-Behavioral Smoking Cessation, Heart Rate Variability Biofeedback, Nicotine patch
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Healthy, Bioavailability
Comparative Bioavailability Study of an Immediate Release and Controlled Release Oral Formulations of Huperzine A
The purpose of this study is to develop oral controlled release formulation of Huperzine A that will provide optimal pharmacokinetic profile of the drug enhancing safety and compliance, as possible cure to neurodegenerative…
- Trial name
- NCT01136551
- Testing
- Huperzine A
- Where
- Israel
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Infertility
Predictors of Pregnancy Rate in Assisted Reproductive Technology According to Actual Guidelines
Goals: To explore the association of probability of pregnancy with certain prognostic factors in patients undergoing assisted reproductive technology in Russian population according to international and national guidelines.
- Trial name
- IRIS (NCT04249297)
- Testing
- Duphaston® (Dydrogesteron)
- Where
- 52 sites in Kazakhstan, Russia
- Volunteers
- 1,150 people
- Sponsor
- Abbott
IgA Nephropathy
Rituximab in Progressive Immunoglobulin A (IgA) Nephropathy
This study was about IgA nephropathy, a form of kidney disease characterized by the presence of blood and protein in the urine. This study was done to determine if the medication rituximab could reduce protein in the patient's…
- Trial name
- NCT00498368
- Testing
- Intravenous Rituximab, ACE/ARB, Omega-3 Fatty Acid Fish Oil Supplement
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Cancer
RaSOLVE: 125I Radioactive Seed Marking Effects on Pathological Complete Response Rate and Prognosis Post-Neoadjuvant Therapy in Early/Advanced Breast Cancer
This study is an open-label, controlled, multicenter phase III clinical trial designed to evaluate whether the use of iodine-125 radioactive seed markers can improve treatment response for patients with early or locally advanced…
- Trial name
- NCT07269691
- Testing
- Iodine-125 Radioactive Seed Marking, Standard Neoadjuvant Therapy
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Pengfei Qiu
Abdominal Hernia
Open Mesh Versus Suture Repair in Treatment of Abdominal Wall Hernias
The purpose of this study is to: 1. compare the long term results of mesh versus suture repair in treatment of abdominal wall defects; 2.
- Trial name
- HSS-AHS (NCT01018524)
- Testing
- abdominal wall reconstruction
- Where
- Hungary
- Volunteers
- 2 people
- Sponsor
- Hungarian Surgical Society
Objective Response Rate, Progression-free Survival
Real-world Study for Patients With Advanced Hepatobiliary Tumors
The investigators design a large sample size study in the real-world to explore whether targeted therapy and immunotherapy can improve the survival, quality of life and drug safety of patients with advanced hepatobiliary tumors…
- Conditions
- Objective Response Rate, Progression-free Survival, Overall Survival, Disease Control Rate
- Trial name
- NCT03892577
- Testing
- Precision oncology including targeted therapy and immunotherapy
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Peking Union Medical College Hospital
Hemophilia A
Study to Evaluate the Efficacy and Safety of PF-07055480 / Giroctocogene Fitelparvovec Gene Therapy in Moderately Severe to Severe Hemophilia A Adults
C3731003 is a pivotal Phase 3 study to evaluate the clinical efficacy and safety of a single IV infusion of PF-07055480 / giroctocogene fitelparvovec (Recombinant AAV2/6 Human Factor VIII Gene Therapy) in adult male participants…
- Trial name
- AFFINE (NCT04370054)
- Testing
- PF-07055480 (giroctocogene fitelparovec): Recombinant AAV2/6 Human Factor VIII Gene Therapy
- Where
- 45 sites in United States, Australia and 14 more
- Volunteers
- 77 people
- Sponsor
- Pfizer
Contraception
LCS16 vs. COC User Satisfaction and Tolerability Study
To evaluate user satisfaction in young nulliparous and parous women (18-29 years of age [inclusive]), using LCS16 compared to a COC over a period of 12 months.
- Trial name
- NCT03074045
- Testing
- Levonorgestrel (Kyleena, BAY86-5028), Ethinyl estradiol and drospirenone (Yarina, BAY86-5131)
- Where
- 9 sites in Russia
- Volunteers
- 145 people
- Sponsor
- Bayer
Muscle Strain
Rate of Leg Curl to Leg Press During Isokinetic Testing
The functional condition of the leg muscles is not only relevant to performance in sports, but is also of great importance in health, prevention and rehabilitation, where not only the general strength level is decisive but also…
- Trial name
- NCT03966690
- Testing
- Isokinetic leg extension/-flexion on a legpress device, Isokinetic leg extension/-flexion on a legcurl device
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Gastric Cancer
A Study of Capecitabine [Xeloda] in Combination With Trastuzumab [Herceptin] and Oxaliplatine in Patients With Resectable Gastric Cancer
This study will evaluate the disease free survival rate of a combination of capecitabine [Xeloda] and oxaliplatin (XELOX) with trastuzumab [Herceptin] in patients with resectable gastric cancer.
- Trial name
- NCT01130337
- Testing
- Capecitabine [Xeloda], Oxaliplatin, Trastuzumab [Herceptin]
- Where
- 30 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Hoffmann-La Roche