Clinical trials: Pathogenesis
Clostridium Difficile
To Determine the Feasibility of a Fidaxomicin Study in Neonates and to Assess C. Difficile (Clostridium Difficile) Involvement in the Pathogenesis
The objective of this multi-center, prospective observational study is to determine the feasibility of a potential interventional study with fidaxomicin.
- Trial name
- DAISY (NCT01533844)
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 1 people
- Sponsor
- Astellas Pharma Europe B.V.
Colorectal Adenoma and Carcinoma
Investigation of the Role of the Microbiome in the Pathogenesis of Colorectal Adenoma and Carcinoma
The purpose of this study is the investigation of new host-microbiome interactions promoting adenoma formation and adenocarcinoma progression.
- Trial name
- NCT02947607
- Testing
- Colon biopsies
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 799 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Open GI Surgery
Surgical Site Infections and the Microbiome: Understanding the Pathogenesis of Surgical Site Infections
This is a prospective, observational study of patients undergoing open GI surgery. At the time of operation, samples will be collected from the incision site and GI tract.
- Trial name
- NCT06300892
- Testing
- No intervention
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Minnesota
Sarcoidosis
Janus Kinase Inhibition in Sarcoidosis
The purpose of this study is to investigate the role of the oral JAK1 inhibitor, abrocitinib 200 mg once daily, for the treatment of patients with moderate to severe cutaneous sarcoidosis.
- Trial name
- NCT05696795
- Testing
- Abrocitinib 200 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Lung Disease, Pneumothorax
Study of the Disease Process of Lymphangioleiomyomatosis
Pulmonary lymphangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor.
- Conditions
- Lung Disease, Pneumothorax, Tuberous Sclerosis, Lymphangioleiomyomatosis
- Trial name
- NCT00001465
- Testing
- Toshibia Aquilion One CT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
NK Cell Mediated Immunity, Endometriosis
Clinical Study of NK Cells in the Treatment of Severe Endometriosis
Dysfunction of natural koller cells (NK cells) is an important factor in the development of endometriosis. NK cell therapy was applied to treat severe endometriosis, which is an exploration of the pathogenesis of this refractory…
- Trial name
- NCT03948828
- Testing
- Autologous NK cell therapy, GnRHa combained with reverse addition therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenzhen People's Hospital
Migraine, Headache
The Role of CGRPand Nociceptin in Migraine
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was…
- Trial name
- NCT00155129
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Lung Diseases, Hypertension, Pulmonary
Genetic and Environmental Characteristics of Primary Pulmonary Hypertension
The goal of this study is to identify the modifying genes and environmental features that regulate the clinical expression of mutations in bone morphogenetic protein receptor 2 (BMPR2); to develop the understanding of how BMPR2…
- Trial name
- NCT00091546
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Vanderbilt University
Idiopathic Anaphylaxis, Drug Anaphylaxis
Cause of Unexplained Anaphylaxis
This study will explore the possible cause of unexplained, or idiopathic, anaphylaxis. Anaphylaxis is a rapid, life-threatening, severe reaction that occurs suddenly after contact with an allergy-causing substance, usually a…
- Conditions
- Idiopathic Anaphylaxis, Drug Anaphylaxis, Venom Anaphylaxis, Food Anaphylaxis
- Trial name
- NCT00719719
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dermatomyositis, Polymyositis
Adult and Juvenile Myositis
This study will evaluate subjects with adult- and childhood-onset myositis to learn more about their cause and the immune system changes and medical problems associated with them.
- Conditions
- Dermatomyositis, Polymyositis, Inclusion Body Myositis
- Trial name
- NCT00017914
- Where
- 4 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Ischaemic Stroke
Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis
Negligence or contempt of the etiology and pathogenesis of minor ischaemic stroke in the early diagnosis and effective treatment leads to more than 40-50% of patient with recurrent episodes, and 10% patient died.
- Trial name
- NCT01665729
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Li Haiyan
Asthma, Obesity
Role of Cysteinyl Leukotrienes in the Pathogenesis of Asthma in Obesity
The purpose of this study is to examine whether there are higher levels of cysteinyl leukotrienes in obese subjects than in non-obese subjects.
- Trial name
- NCT01158573
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Michigan
HIV-infection/Aids, NAFLD
NAFLD in HIV-infected Patients
The prevalence of NAFLD (nonalcoholic fatty liver disease) in HIV-infected patients is higher than that in general population, but the causes of morbidity and pathogenesis have not been fully explored.
- Trial name
- NAFLDIH (NCT04215926)
- Testing
- No intervention; cross-sectional study
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Public Health Clinical Center
Hypoxia, Autophagy
Hypoxia-induced Autophagy in the Pathogenesis of MAP
To investigate the role of HIF 1α and LC3B in the pathogenesis of MAP, to evaluate the role of MMP-9 in the antenatal prediction of MAP, and to compare the expression of HIF1α, LC3B, and level MMP-9 between patients of placenta…
- Conditions
- Hypoxia, Autophagy, Placenta, Morbidly Adherent Placenta
- Trial name
- NCT05817448
- Testing
- HIF 1α and LC3B expression and MMP-9 level
- Volunteers
- 80 people
- Sponsor
- Assiut University
Adrenal Tumors, Adrenocortical Carcinoma
Adrenal Tumors - Pathogenesis and Therapy
The pathogenesis of adrenal tumors is still not fully elucidated and the treatment options for malignant tumors are poor. The current study investigates different aspects of the pathogenesis of adrenal tumors and evaluates…
- Conditions
- Adrenal Tumors, Adrenocortical Carcinoma, Cushing Syndrome, Conn Syndrome
- Trial name
- NCT00669266
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Wuerzburg
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Neutrophils
Mechanism of Delayed Neutrophil Apoptosis in Acute Lung Injury
Literature basis Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by respiratory distress and progressive hypoxemia, which is caused by diffuse alveolar and pulmonary interstitial edema caused by…
- Conditions
- Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Neutrophils, Apoptosis, Immunosuppression
- Trial name
- NCT04607434
- Testing
- Ocotillol Type Ginsenoside Derivatives
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Hospital of Jilin University
Hemostatic Disorders
Hemostatic Complications in Hematopoietic Stem Cell Transplantation
Hemostatic disorders are common and potentially fatal complications in patients undergoing hematopoietic stem-cell transplantation (HSCT). Limited data exist on early diagnosis and prevention of these complications.
- Trial name
- HCIHSCT (NCT02281240)
- Testing
- thrombopoietin, interleukin-11, heparin,
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Soochow University
NAFLD
Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)
The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.
- Trial name
- NCT04634643
- Testing
- Usual diet and physical activity
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Yale University
Sjogren's Syndrome, Salivary Gland
The Pathogenesis and Natural History of Sjogren's Disease
Background: -Sjogren s Disease (formerly: Sjogrens Syndrome, Sj(SqrRoot)(Delta)gren s syndrome) is a disease that affects about 1-4 million Americans. It is more common in women.
- Conditions
- Sjogren's Syndrome, Salivary Gland, Pathogenesis
- Trial name
- NCT01425892
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Preeclampsia, Preeclampsia Complications
Role of Progesterone Membrane Receptors in the Pathogenesis of Preeclampsia
Preeclampsia is a pregnancy-specific hypertensive disorder and remains a leading cause of maternal and perinatal morbidity and mortality worldwide.
- Trial name
- NCT07745036
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Samsun University