Clinical trials: Pathogenesis
Smokers, Human Bronchial Epithelial Cells
Smoker Extracellular Vesicles Influence on Human Bronchial Epithelial Cells
Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease(COPD),asthma and lung cancer.
- Conditions
- Smokers, Human Bronchial Epithelial Cells, Lung Pathogenesis, Biomarkers
- Trial name
- Aerotox-1 (NCT03608293)
- Testing
- Broncho Alveolar Lavages (BAL)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Disorder of Endocrine Ovary, Hypersecretion; Cortisol
Pathogenesis of Functional Hypothalamic Amenorrhea
This is a randomized pilot study of the use of cognitive behavior therapy versus observation to treat functional hypothalamic amenorrhea, often termed stress-induced anovulation.
- Conditions
- Disorder of Endocrine Ovary, Hypersecretion; Cortisol, Metabolic Disturbance, Stress, Psychological
- Trial name
- NCT01674426
- Testing
- Cognitive behavior therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Pittsburgh
Atopic Dermatitis, Staphylococcus Aureus
Staphylococcal Toxins in Atopic Dermatitis and Eczema Herpeticum
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Clinical studies have demonstrated a link between staphylococcal skin colonization and the pathogenesis of AD, but the implication of bacterial…
- Conditions
- Atopic Dermatitis, Staphylococcus Aureus, Bacterial Toxins, Immune Response
- Trial name
- STADEH (NCT04274348)
- Testing
- Skin biopsies and blood samples
- Where
- 2 sites in France
- Volunteers
- 41 people
- Sponsor
- Poitiers University Hospital
Inflammatory Bowel Diseases
Role of the Chemical Environment in the Pathogenesis of Inflammatory Bowel Disease
Inflammatory Bowel Diseases (IBD) including Crohn's disease and ulcerative colitis are multifactorial diseases leading to chronic inflammation of intestinal mucosa. Their etiology is still unknown.
- Trial name
- CHIMICI (NCT03376230)
- Testing
- Collect of blood, urines, and intestinal biopsies
- Where
- France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Lille
Primary Immune Thrombocytopenia (ITP)
Study of Immune Thrombocytopenia Pathogenesis:
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet count responsible for bleedings. The disease is mostly mediated by antiplatelet antibodies produced by specific B cells.
- Trial name
- PTI PARI (NCT02042560)
- Testing
- Blood samples, Spleen samples
- Where
- 3 sites in France
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pathogenesis, Cardiovascular Diseases
Pathogenic Mechanisms of Cancer and Cardiovascular Diseases
Subjects with cardiovascular diseases (CVD) have higher incidence of cancers compared to general population. The investigators hypothesized that shared molecular mechanism play a pivotal role in the pathogenesis of CVD including…
- Conditions
- Pathogenesis, Cardiovascular Diseases, Cancer
- Trial name
- NCT03051191
- Testing
- micro RNA
- Where
- 2 sites in Japan
- Volunteers
- 66 people
- Sponsor
- Sakakibara Heart Institute
Focal Dermal Hypoplasia (FDH), Goltz Syndrome
Study of Selected X-linked Disorders: Goltz Syndrome
Focal dermal hypoplasia, or Goltz syndrome, results from genetic changes, or mutations in the PORCN gene located on the X chromosome.
- Trial name
- NCT00691223
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Baylor College of Medicine
Osteoarthritis
Prevention of Post-Traumatic Osteoarthritis (OA)
Joint injury and trauma dramatically increase the risk of developing osteoarthritis (OA). The purpose of this study is to determine what factors lead to decreased pain, improved joint function, and repair of the joint surface in…
- Trial name
- NCT00054821
- Testing
- Ankle distraction permitting motion, Ankle distraction without motion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ned Amendola
Peripheral Artery Disease, Carotid Artery Stenosis
Study on PAD and CAS Based on Omics and Imaging
This study aims to investigate the pathogenesis of Peripheral Artery Disease (PAD) and Carotid Artery Stenosis (CAS) using a comprehensive multi-omics and multi-modal imaging approach.
- Conditions
- Peripheral Artery Disease, Carotid Artery Stenosis, Artery Stenosis
- Trial name
- NCT06917547
- Volunteers
- 100 people
- Sponsor
- Yijie Ning
Non Alcoholic Fatty Liver Disease
The Role of Obstructive Sleep Apnea in Children With Fatty Liver Disease
The purpose of this study is to examine whether CPAP therapy can reduce or eliminate hepatic fat accumulation in obese children and adolescents.
- Trial name
- NCT02134522
- Testing
- Continuous positive airway pressure (CPAP).
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Yale University
Kwashiorkor
Aromatic Amino Acid Metabolism in the Pathogenesis of Kwashiorkor
This research may explain whether a shortage of three special compounds called aromatic amino acids is responsible for the severe illness and high death rate of children with the kwashiorkor type of malnutrition and whether…
- Trial name
- NCT00429351
- Where
- Jamaica
- Volunteers
- 82 people
- Sponsor
- Baylor College of Medicine
Rett Syndrome
Independent Studies of Dextromethorphan and of Donepezil Hydrochloride for Rett Syndrome
Rett syndrome (RTT) is a disorder in which the nervous system does not develop properly. RTT generally affects girls, but there are some boys who have been diagnosed with RTT.
- Trial name
- NCT00069550
- Testing
- dextromethorphan, donepezil hydrochloride
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obstructive Sleep Apnea, Obstructive Sleep Apnea (OSA)
Identification of Biomarkers of Obstructive Sleep Apnea.
Obstructive sleep apnea (OSA) is a common sleep disorder associated with intermittent hypoxia, systemic inflammation, oxidative stress, and an increased risk of cardiovascular and metabolic diseases.
- Conditions
- Obstructive Sleep Apnea, Obstructive Sleep Apnea (OSA), Obstructive Sleep Apnea (OSAS), Obstructive Sleep Apnea (SAOS)
- Trial name
- NCT07723144
- Testing
- Positive Airway Pressure (PAP) Therapy
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Hypophosphatemia, Familial, Hyperparathyroidism
Effectiveness of Paricalcitol in Reducing Parathyroid Hormone (PTH) Levels in X-linked Hypophosphatemic Rickets
The purpose of this study is to determine the effectiveness of paricalcitol, a form of synthetic vitamin D, in lowering parathyroid hormone (PTH) levels and reducing disease symptoms in children and adults with X-linked…
- Trial name
- NCT00417612
- Testing
- Paricalcitol
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Yale University
Lung Cancer, Microbiome
Study of the Correlation of Tumor Tissue Microbiome to the Pathogenesis of Lung Cancer
Lung cancer is the malignant tumor with the highest incidence, accounting for the first cause of tumor death. At present, smoking, occupational and environmental exposure, air pollution and genetic factors are considered to be…
- Trial name
- STARS (NCT04260295)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huashan Hospital
HIV
The Use of Leukapheresis to Support HIV Pathogenesis Studies
Despite the dramatic improvements that have resulted from combination antiretroviral treatment, long-term efficacy, toxicity, cost, and the requirements for life-long adherence remain as formidable challenges.
- Trial name
- NCT01161199
- Testing
- Leukapheresis
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Understand Pathogenicity of SSc-specific Antibodies in SSc and the Effect of Antibody Blockade in Vitro
AUTOANTIBODIES AND SYSTEMIC SCLEROSIS
Established in vitro assays, combined with state-of-the-art multi-omics approaches and innovative in vitro experimental models, will gain insights into the mechanistic bases underlying Systemic Sclerosis (SS) pathogenesis and…
- Trial name
- AUTO (NCT06502678)
- Testing
- Fcr blocker of autoantibodies
- Volunteers
- 6 people
- Sponsor
- IRCCS Ospedale San Raffaele
Cancer Cachexia
A Pilot Study of Eicosapentaenoic Acid (EPA) in Patients With Cancer Cachexia
The data collected through this pilot study will allow us to increase our understanding of cancer cachexia and the effect of Eicosapentaenoic Acid (EPA) on cancer cachexia.
- Trial name
- NCT00815685
- Testing
- Eicosapentaenoic Acid
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Healthy
Nitric Oxide, LPS and the Pathogenesis of Asthma Phase II
The purpose of the study is to determine the role of nitric oxide (NO) in asthma and to characterize the symptoms associated with inhaled endotoxin (lipopolysaccharide [LPS]) in normal subjects.
- Trial name
- NCT00643058
- Testing
- LPS endotoxin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- John Sundy
Hepatic Steatosis, Fatty Liver
Hepatic De Novo Lipogenesis (DNL)in the Pathogenesis of Hepatic Steatosis in Obese Youth
Nonalcoholic Fatty Liver Disease (NAFLD) is becoming the most common cause of liver disease in pediatrics, but little is known about its pathophysiology in children.
- Trial name
- DNL (NCT01725035)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University