Clinical trials: Pathologic Complete Response
Nephrotic Syndrome
Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome
A multicenter, randomized, study will be performed to evaluate the efficacy of low dose steroid combined with mycophenolic acid (MyforticR) versus high dose steroid in inducing remission in adults with minimal change nephrotic…
- Trial name
- MSN (NCT01197040)
- Testing
- Prednisone, acid mycophenolic (Myfortic)
- Where
- France
- Volunteers
- 117 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blood And Marrow Transplantation, Leukemia
Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies
The goal of this clinical research study is to learn if it is safe and feasible to transplant changed cord blood for patients with leukemia or lymphoma. Researchers also want to learn if this can help to control the disease.
- Conditions
- Blood And Marrow Transplantation, Leukemia, Lymphoma, Transplantation Infection
- Trial name
- NCT01471067
- Testing
- Melphalan, Fludarabine, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Myeloid Leukemia
Sulindac for Patients With AML
This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational drug to learn whether the drug is effective in treating a specific cancer.
- Trial name
- NCT01843179
- Testing
- Cytarabine, Sulindac
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Triple Negative Breast Cancer
Trial of Afatinib With Paclitaxel for Neoadjuvant Therapy of TNBC and Research of Biomarkers of Afatinib
[Background]: Triple-negative breast cancer (TNBC) is defined by a lack of expression of both estrogen and progesterone receptor as well as human epidermal growth factor receptor 2 (HER-2).
- Trial name
- NCT02511847
- Testing
- Afatinib
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Early-Stage Breast Cancer
Trial to Evaluate Genomic Expression Profiles to Direct Preoperative Chemotherapy in Early Stage Breast Cancer
This multi-center randomized Phase II study assigned HER2-negative early-stage breast cancer patients to receive preoperative systemic chemotherapy in either a "genomic-guided" arm or a "non-guided arm." The "genomic-guided"…
- Trial name
- NCT00636441
- Testing
- Doxorubicin/Cyclophosphamide (AC) or Docetaxel/Cyclophosphamide (TC)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Duke University
Breast Neoplasms
Comparative Analysis of the Efficacies in Neoadjuvant Chemotherapy of Breast Cancer
The purpose of this study is to compare the short-term and long-term efficacies and the safeties of pirarubicin plus docetaxel(AT group) and pirarubicin plus cyclophosphamide followed by docetaxel(AC-T group) in neoadjuvant…
- Trial name
- NCT02613026
- Testing
- Pirarubicin, Docetaxel, Cyclophosphamide
- Where
- 5 sites in China
- Volunteers
- 104 people
- Sponsor
- 307 Hospital of PLA
Upper Respiratory Infections
Evaluation of Accuracy and Ease of Use of the FilmArray™ Respiratory Panel (RP EZ) in a CLIA-Waived Clinical Setting
The purpose of this study is to assess the accuracy and ease-of-use of a simplified FilmArray Respiratory Panel test (FilmArray RP EZ) when performed according to the manufacturer's instructions by personnel in laboratories…
- Trial name
- NCT02232711
- Where
- 4 sites in United States
- Volunteers
- 1,082 people
- Sponsor
- BioFire Diagnostics, LLC
Mastitis, Staphylococcus Aureus
Staphylococcus Aureus Carrier Status in Breastfeeding Mothers and Infants and the Risk of Lactation Mastitis
Lactation (breastfeeding) mastitis is an acute infection of the milk ducts of the breastfeeding woman. Staphylococcus aureus (S. aureus) is the infectious germ most commonly associated with lactation mastitis.
- Conditions
- Mastitis, Staphylococcus Aureus, Staphylococcal Infections
- Trial name
- NCT00620984
- Where
- United States
- Volunteers
- 557 people
- Sponsor
- State University of New York - Upstate Medical University
Breast Cancer
Dose-dense (Biweekly) Carboplatin Plus Paclitaxel With or Without Trastuzumab as Neoadjuvant Treatment for Breast Cancer
The purpose of this study is to determine the efficacy and safety of dose-dense(biweekly) carboplatin and paclitaxel ± trastuzumab as neoadjuvant treatment in early breast cancer.
- Trial name
- NCT02059876
- Testing
- carboplatin and paclitaxel and or without trastuzumab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Provincial People's Hospital
Assess the Variation of Apparent Diffusion Coefficient
Contribution of MRI in the Evaluation of Apparent Diffusion Coefficient and Prediction of Response to Neoadjuvant Chemotherapy in Breast Cancer
The main objective of the study is to assess the sensitivity and the specificity of the variation of apparent diffusion coefficient for prediction, after a course of neoadjuvant chemotherapy or after modification of the treatment…
- Trial name
- ADC (NCT01956513)
- Testing
- MRI (Magnetic resonance imaging)
- Sponsor
- Centre Jean Perrin
Multiple Myeloma
VELCADE-Thalidomide-Dexamethasone (VTD) vs Thalidomide-Dexamethasone (TD) Incorporated Into Double Autotransplantation for Untreated Multiple Myeloma (MM)
Thalidomide-Dexamethasone (TD) is a standard induction therapy for Multiple Myeloma (MM). The present study is designed to compare TD with VELCADE-Thalidomide-Dexamethasone (VTD) as induction therapy in preparation for, and as…
- Trial name
- NCT01134484
- Testing
- Velcade, Thalidomide, Dexamethasone
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- Michele Cavo
Gastroesophageal Reflux Disease
Comparison of the Classical Healing Concept With the Complete Remission Concept After Treatment With Pantoprazole in Adult Patients With Erosive GERD (Gastroesophageal Reflux Disease) (BY1023/M3-342)
The aim of this study is to evaluate the complete remission rates, endoscopic relapses, study discontinuation rates, and quality of life parameters in patients with erosive GERD.
- Trial name
- NCT00325676
- Testing
- Pantoprazole
- Where
- 45 sites in Brazil, Germany and 2 more
- Volunteers
- 639 people
- Sponsor
- Takeda
Recurrent Genital Herpes (RGH)
RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir
This trial will assess whether RGH patients who have two recurrent episodes within a three month period would benefit from suppressive treatment and whether patients prefer episodic therapy or suppressive therapy for the…
- Trial name
- NCT00219310
- Testing
- Famciclovir
- Where
- United States
- Sponsor
- Novartis
Locally Advanced Malignant Neoplasm
Metformin Plus Neoadjuvant Chemotherapy in Breast Cancer
Background Obesity and overweight are well known risk factors for breast cancer and also are associated with higher recurrence and mortality rates.
- Trial name
- NCT01566799
- Testing
- Metformin
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
HER-2 Positive Breast Cancer
Characteristics of Disseminated Her2+ Breast Cancer Patients Treated With Trastuzumab That Have Reached Complete, Partial Remission or Stabilization of Disease During More Than 3 Years
Main objective: To analyze the clinical and biological characteristics of patients with disseminated breast cancer HER2 + treated with trastuzumab that have achieved a complete remission, partial or stable disease for a period…
- Trial name
- LongHer (NCT01433926)
- Where
- 39 sites in Spain
- Volunteers
- 114 people
- Sponsor
- Asociación para el Progreso de la Oncología en Málaga
Breast Cancer
Weekly Paclitaxel Plus Carboplatin in Preoperative Treatment of Breast Cancer
The purpose of this study is to evaluate the pathological complete response (pCR) rate in breast cancer patients treated with weekly paclitaxel plus carboplatin preoperative regimen.
- Trial name
- NCT01203267
- Testing
- Paclitaxel, Carboplatin
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Non-Small Cell Lung Cancer
Study of Alimta® (Pemetrexed) Plus VELCADE® (Bortezomib) or Alimta Alone or VELCADE Alone in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Prior Therapy
The purpose of this study is to establish the objective response rate (complete response + partial response), following treatment with Alimta plus VELCADE, Alimta alone, or VELCADE alone in patients with locally advanced or…
- Trial name
- NCT00343720
- Testing
- VELCADE, Alimta
- Where
- Belgium
- Sponsor
- Millennium Pharmaceuticals, Inc.
Multiple Myeloma
Autologous Transplantation for Multiple Myeloma
The present study was designed in an attempt to prospectively evaluate in a randomized fashion whether further cytotoxic dose intensification, as delivered with two sequential autologous stem-cell transplantations, improved the…
- Trial name
- NCT00378222
- Testing
- Autologous Stem Cell Transplantation
- Volunteers
- 324 people
- Sponsor
- University of Bologna