Clinical trials: Pathological Fractures
Acetabular Fracture, Heterotopic Ossification
Heterotopic Ossification Prophylaxis
One complication that can occur after surgery on the acetabulum is the development of bone in abnormal places such as muscle and soft tissues.
- Trial name
- NCT04867278
- Testing
- External Beam Radiation (XRT), Debridement
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Maryland, Baltimore
Rib Fracture, Postoperative Pain
SPSIP vs ESP Block for Analgesia After Rib Fracture Surgery
This randomized clinical trial aims to evaluate and compare the analgesic efficacy of the Serratus Posterior Superior Intercostal Plane (SPSIP) block and the Erector Spinae Plane (ESP) block in patients undergoing surgical…
- Conditions
- Rib Fracture, Postoperative Pain, Thoracic Trauma
- Trial name
- NCT07553208
- Testing
- Erector Spinae Plane Block (ESP), Serratus Posterior Superior Intercostal Plane (SPSIP)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Antalya City Hospital
Distal Radius Fractures, Poor Bone Quality
The Influence of Local Bone Status on Complications After Surgical Treatment of Distal Radius Fractures
The purpose of this study is to evaluate if poor bone quality increases the risk of specific types of treatment complications in patients with distal radius fractures treated with open reduction and Locking Compression…
- Conditions
- Distal Radius Fractures, Poor Bone Quality, Treatment Complications
- Trial name
- NCT01144208
- Where
- 11 sites in United States, Austria and 4 more
- Volunteers
- 244 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Tendon Injuries, Fracture
Question Prompt List for Orthopaedic Conditions
The purpose of this study is to investigate whether providing patients with a question prompt list (QPL) prior to their orthopaedic surgery clinic appointment improves their perceived involvement in care (PICs) score compared to…
- Conditions
- Tendon Injuries, Fracture, Arthritis, Sprains
- Trial name
- NCT03912168
- Testing
- Question Prompt List, 3 questions list
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Stanford University
Tibia Fracture
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures
The proposed study is a two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial. 1,000 patients with tibia fractures treated with intramedullary (IM) nail will be randomized into two treatment arms.
- Trial name
- NCT05000281
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Emergency Service, Hospital, Child/Adolescent Problem
A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture
MSK-I is the most common cause for ED visits for children with pain, with a child's risk of sustaining a fracture ranging from 27-42% by the age of 16 years.
- Conditions
- Emergency Service, Hospital, Child/Adolescent Problem, Acute Pain, Fentanyl
- Trial name
- CAST (NCT02985177)
- Testing
- INF2.0 + IBU, INF1.0 + IBU
- Where
- 3 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Rib Fracture Multiple, Trauma Chest
Lidocaine Infusions for Rib Fractures
Patients with traumatic rib fractures not receiving regional anesthesia through a epidural or nerve block catheter will be recruited for the study.
- Conditions
- Rib Fracture Multiple, Trauma Chest, Pain, Acute
- Trial name
- Lidocare (NCT03571919)
- Testing
- Lidocaine infusion, Saline infusion
- Where
- United States
- Sponsor
- Stanford University
Osteoarthritis, Hip, Femur Head Necrosis
Clinical Outcomes of Primary Cementless Total Hip Arthroplasty Using the Collarless Actis Stem
This study looks at how well a hip replacement using the collarless Actis stem works over five years. Total hip replacement is a common operation for people whose hip joint has been damaged by arthritis, by loss of blood supply…
- Conditions
- Osteoarthritis, Hip, Femur Head Necrosis, Femoral Neck Fractures, Arthritis Rheumatoid
- Trial name
- NCT07828080
- Testing
- Collarless Actis femoral stem
- Where
- South Korea
- Volunteers
- 210 people
- Sponsor
- Seoul National University Bundang Hospital
Osteoarthritis, Hip, Rheumatoid Arthritis
Avenir Müller Hip Stem Post Market Surveillance Study
This study is a Post Market Clinical Follow up study to fulfil the post market surveillance obligations according to Medical Device Directive and European Medical Device Vigilance System (MEDDEV) 2.12-2.
- Conditions
- Osteoarthritis, Hip, Rheumatoid Arthritis, Fracture of Hip, Dislocated Hip
- Trial name
- NCT04079127
- Testing
- Patients who met the inclusion/exclusion criteria to receive the Avenir Müller stem.
- Volunteers
- 150 people
- Sponsor
- Zimmer Biomet
Weight Loss
The Effect of Severe Weight Loss and Protein Intake on Bone
The purpose of this study is to learn whether the amount of dietary protein can influence bone health during the weight loss after weight loss surgery.
- Trial name
- NCT00472680
- Testing
- Caloric restriction, high protein, Caloric restriction; normal protein, Nutrition Education
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rutgers University
Muscle Wasting (Atrophy) After Hip Fracture Surgery
Study of Efficacy and Safety of Bimagrumab in Patients After Hip Fracture Surgery
The purpose of this study was to assess if bimagrumab is safe and effective in patients with muscle wasting (atrophy) after hip fracture surgery.
- Trial name
- NCT02152761
- Testing
- bimagrumab
- Where
- 53 sites in United States, Argentina and 17 more
- Volunteers
- 251 people
- Sponsor
- Novartis Pharmaceuticals
Hip Fractures
Regional Anesthesia by PENG-Block in Emergency Department
The study is a single-centre, open-label randomized comparative trial. Adult patients admitted to the emergency department for a hip fracture will be enrolled.
- Trial name
- ED-PENGBLOCK (NCT05673486)
- Testing
- PENG Block, Multimodal analgesia
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Hip Fractures, Pain, Postoperative
Effects of Pericapsular Nerve Group Block Applied in Patients Undergoing Hip Fracture Surgery.
In this study, it was aimed to compare the multimodal analgesia application or the pericapsular nerve group (PENG) block methods in patients undergoing hip surgery.
- Trial name
- NCT06183541
- Testing
- Pericapsular Nerve Group (PENG) Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Umraniye Education and Research Hospital
Postoperative Pain, Wrist Fracture
Comparing Efficacity of Analgesia Between Ultrasound-guided Nerve Block and Local Infiltration After Wrist Fracture Surgery
Distal radial fracture reparations by volar plating are often managed under regional anaesthesia, but are associated with severe pain when the block ends.
- Trial name
- BNINF (NCT02693288)
- Testing
- Local infiltration anesthesia
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Necrosis of Femoral Head, Knee Osteoarthritis
Probiotics Attenuate Postoperative Cognition Decline
The aim of this study was to evaluate whether perioperative probiotics can reduce the incidence of postoperative cognitive dysfunction and postoperative delirium.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Neck of Femur, Lumbar Disc Herniation
- Trial name
- NCT04017403
- Testing
- Bifidobacterium triple live capsule
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- RenJi Hospital
Osteonecrosis, Femoral Neck Fracture
A Comparison of Two Different Surgical Techniques in Hip Resurfacing Arthroplasty
The purpose of the study is to compare two different surgical techniques in hip resurfacing arthroplasty (RHA), comparing bloodflow and metabolism in the femoral head, as well as implant migration, periprosthetic bone mineral…
- Conditions
- Osteonecrosis, Femoral Neck Fracture, Implant Failure
- Trial name
- NCT00913679
- Testing
- Surgical approach (ReCap Hip Resurfacing System)
- Where
- Denmark
- Volunteers
- 49 people
- Sponsor
- University of Aarhus
Femoral Neck Fractures
Practice Survey on Femoral Neck Fractures and the Incidence of Type of Anesthesia on Patient Outcome
Inclusion of all patients with femoral neck fracture presenting in Saint-Luc Bouge Hospital between October 1th 2014 and September 30th 2015.
- Trial name
- NCT02198820
- Testing
- General Anesthesia, Loco Regional Anesthesia
- Where
- Belgium
- Sponsor
- Astes
Pain, Fracture, Sprain
Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain
Assess whether transbuccal fentanyl provides more rapid relief of orthopedic pain, than does the comparator Percocet
- Trial name
- FAIRTOP (NCT00685295)
- Testing
- Fentanyl, Lansoprazole, Oxycodone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Bone Sarcoma, Femur Fracture
Dalteparin in Preventing DVT in Participants With Cancer
This trial studies how well dalteparin works in preventing deep vein thrombosis (DVT) (blood clots) in participants with cancer. Dalteparin is a blood thinner that can treat blood clots and may prevent them from forming.
- Conditions
- Bone Sarcoma, Femur Fracture, Lymphoma, Metastatic Neoplasm
- Trial name
- NCT00525057
- Testing
- Dalteparin
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- M.D. Anderson Cancer Center
Fractured Neck of Femur, Postoperative Pain
Postoperative Analgesia for Fractured Neck of Femur With Periarticular Infiltration of Local Anaesthetic
The purpose of this study is to determine that periarticular levobupivacaine infiltration after surgical fixation of fractured neck of femur will improve the early postoperative pain sensation.
- Trial name
- NCT02057601
- Testing
- Levobupivacaine infiltration group
- Where
- Ireland
- Volunteers
- 37 people
- Sponsor
- Cork University Hospital