Clinical trials: Pathological Fractures
Postoperative Cognitive Dysfunction, Hip Fractures
The Comparison of Cognition, Depression and Anxiety, and Quality of Life After Hip Fracture Surgery Under General or Regional Anesthesia
Postoperative cognitive dysfunction is a relatively common in elderly patients after hip surgery, but exact mechanism of its onset is still unclear as well as contributing factors.
- Conditions
- Postoperative Cognitive Dysfunction, Hip Fractures, Depression, Anxiety, Quality of Life
- Trial name
- NCT04518839
- Volunteers
- 140 people
- Sponsor
- University of Zagreb
Hip Fractures
Ultrasound Assessment of Gastric Contents in Fasted Elderly Patients With Hip Fracture
Evaluation of gastric contents in fasted elderly patients with hip fracture. The gastric contents will be examined by using ultrasonography in fasted elderly patients scheduled for hip fracture surgery.
- Trial name
- NCT03242733
- Testing
- Ultrasound assessment of gastric contents
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- SMG-SNU Boramae Medical Center
Postoperative Pain, Postoperative Cognitive Dysfunction
S-ketamine Prevents Postoperative Pain and Cognitive Dysfunction After Tibial Fracture
Purpose: To explore effects of S-ketamine on postoperative pain and cognitive dysfunction after tibial fracture and orthopedic surgery.
- Trial name
- NCT04643132
- Testing
- Normal saline, S-ketamine (low-dose), S-ketamine (high-dose)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University General Hospital
Hip Fracture, Delirium
Incidence of Delirium in Hip Fracture Patients Randomized to Regular Hypnotics vs Placebo
To examine the influence of regular hypnotic therapy on the incidence of delirium after hip fracture surgery
- Trial name
- NCT00286936
- Testing
- Zolpidem
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Hvidovre University Hospital
Smoking, Smoking Cessation
Feasibility of a Virtual Smoking Cessation Program
The goal of this pilot study of a clinical trial is to learn about the acceptability and feasibility of a virtual smoking cessation program in both the perioperative and fracture clinic settings.
- Conditions
- Smoking, Smoking Cessation, Smoking Reduction, Perioperative/Postoperative Complications
- Trial name
- NCT05594199
- Testing
- Virtual Smoking Cessation Program
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University Health Network, Toronto
Pathological Fracture of Hip, Bone Metastases
Evaluation of the Performance of Y-STRUT® Medical Device to Strengthen Pre-fractural Tumour-induced Lesions at the Level of the Proximal Femur
HIPPON 100 is a national, multicentre, prospective, retrospective, descriptive and non-interventional study, in patients having a Y-STRUT® medical device implanted to prevent a high risk of impending pathological fracture.
- Trial name
- NCT03579212
- Testing
- Y-STRUT® (Hyprevention, Pessac, France)
- Where
- 4 sites in France
- Volunteers
- 16 people
- Sponsor
- Hyprevention
Thorax; Fracture, Rib Fracture
Naproxen and Lidocaine Gel Combination for Rib Fracture
This study evaluates whether adding a topical gel containing naproxen and lidocaine to routine intravenous analgesic treatment improves pain relief in adults with isolated traumatic rib fractures presenting to the emergency…
- Conditions
- Thorax; Fracture, Rib Fracture, Pain Management
- Trial name
- NCT07706036
- Testing
- A gel combination containing 10% naproxen and 5% lidocaine, Dexketoprofen trometamol 50 mg IV
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Ankara City Hospital Bilkent
Radius Fractures, Edema
Acute Effects of Interferential Current on Edema, Pain and Muscle Strength in Patients With Distal Radius Fracture
Interferential current is a form of electrotherapy that is obtained by placing two different plates that produce medium frequency waveform current, resulting in a low frequency interferential waveform in deeper tissues.
- Conditions
- Radius Fractures, Edema, Pain
- Trial name
- NCT03438864
- Testing
- Electrotherapy, interferential current, Control
- Volunteers
- 105 people
- Sponsor
- Ege University
Lactate Blood Increase, Trauma Blunt
Lactate Monitoring in Traumatic Long Bone Fractures Requiring Emergent Surgical Intervention
Serum lactate has been utilized as a standard in guiding management of orthopedic injuries. Elevated preoperative lactate has been associated with a higher likelihood of postoperative complications.
- Conditions
- Lactate Blood Increase, Trauma Blunt, Trauma, Secondary, Injury Traumatic
- Trial name
- NCT05611398
- Testing
- Orthopedic Surgery
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Arrowhead Regional Medical Center
Wrist Fractures, Pain
Proprioceptive Training Following a Wrist Fracture
The goal of this randomized clinical trial is to compare how a program of proprioceptive exercises for the wrist could influence in pain, functionality and quality of life in people that have suffered a wrist fracture.
- Trial name
- NCT06132646
- Testing
- Proprioceptive exercises
- Volunteers
- 28 people
- Sponsor
- University of Malaga
Colles' Fracture
A Trial Comparing Circumferential Casting Versus Splinting in Displaced Colles' Fractures
Displaced fractures of the distal radius requiring closed reduction (otherwise known as Colles fractures) are common in the emergency department.
- Trial name
- NCT00704743
- Testing
- Cylindrical cast, Modified sugar tong cast, Volar dorsal splint
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
Acute Pain, Multiple Trauma
Ketamine Patient-Controlled Analgesia for Acute Pain
This study will compare ketamine and hydromorphone as alternative patient-controlled interventions for trauma-related pain. Patients receiving ketamine PCA are expected to require less total and breakthrough opioid and to have…
- Conditions
- Acute Pain, Multiple Trauma, Fractures
- Trial name
- NCT02062879
- Testing
- Ketamine, Hydromorphone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Hemorrhage, Fracture Femur
Comparative Use of Tranexamic Acid Intravenous and Topical Application in Intertrochanteric Fractures With PFNA
An intertrochanteric (ITF) trochanteric fracture of the femur is an exclusively extra capsular fracture in which the fracture line extends from the greater trochanter to the lesser trochanter.
- Trial name
- NCT04696224
- Testing
- Tranexamic acid, Saline solution
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Osteoporosis, Osteoporotic Fractures
Multifaceted Intervention Using Telehealth to Reduce the Risk of Falls and Fractures in Older Men
Men sustain over one-third of osteoporosis-related fractures worldwide. The burden of osteoporotic fractures in older men is substantial, and men suffer significantly worse fracture-related outcomes than women.
- Conditions
- Osteoporosis, Osteoporotic Fractures, Osteoporosis, Age-Related, Muscle Loss
- Trial name
- MisterFIt (NCT05927623)
- Testing
- Multifaceted Virtual Fracture Prevention Program, Attention Control
- Where
- 5 sites in Canada
- Volunteers
- 45 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Postoperative Delirium
Study of Postoperative Delirium in Elderly People After Orthopedic Surgery
The purpose of this study is to investigate the possible relationship of microRNA and postoperative delirium.
- Trial name
- NCT02817386
- Testing
- interview
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Ankle Fracture
Ankle Fracture Tourniquet Utilization
Lower extremity tourniquet utilization remains a controversial practice during the operative fixation of rotational ankle fractures and is often left to surgeon discretion.
- Trial name
- NCT06863688
- Testing
- Tourniquet, No Tourniquet
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Alex Demers
Pain, Acute
Evaluation of Pericapsular Nerve Group Block on Positioning Pain for Spinal Anesthesia in Hip Fracture Patients
The purpose of this study is to evaluate of analgesic effects of pericapsullar nerve group block which is performed preoperatively to assist positioning patients for performance of spinal anesthesia.
- Trial name
- NCT04871061
- Testing
- PENG Block, Conventional opioid analgesia (Fentanyl)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cigli Regional Training Hospital
Hallux Valgus and Bunion (Disorder), Morton Neuroma
Feasibility of Specific Anesthesia of the Forefoot Preserving the Sensitivity of the Heel for Foot Surgery
Foot surgery is a painful surgery that is usually scheduled in outpatients. A good management of analgesia is the crucial point.
- Conditions
- Hallux Valgus and Bunion (Disorder), Morton Neuroma, Metatarsal Fracture, Ingrown Nail
- Trial name
- DISTIB (NCT03504462)
- Testing
- Specific block of medial and lateral plantar nerves
- Where
- France
- Volunteers
- 27 people
- Sponsor
- CMC Ambroise Paré
Delirium
A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Hip Fracture Repair Surgery
The purpose of this study is to evaluate the efficacy and safety of perioperative use of dexmedetomidine in the prevention of postoperative delirium in subjects undergoing surgery for fractured hip with general anesthesia.
- Trial name
- NCT00460473
- Testing
- Dexmedetomidine
- Where
- 30 sites in United States
- Volunteers
- 52 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Aging
Atropine Weight and Risk of Postoperative Confusion in the Elderly
The identification of a high atropine load of treatment received during hospitalization as a predictor of postoperative confusion could have various benefits: Pharmacoepidemiological: identify factors associated with…
- Trial name
- ATROPAGE (NCT03390751)
- Testing
- Data collection
- Where
- France
- Volunteers
- 161 people
- Sponsor
- University Hospital, Toulouse