Clinical trials: Pathological Processes, open to volunteers
AIDS Pneumonia, Septic Shock
Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock
Observing the Real-World Application Effectiveness of Cytokine Immune Adsorption Technology in AIDS Patients with Severe Pneumonia or septic shock.
- Trial name
- NCT06145828
- Testing
- Cytokine Adsorption
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou 8th People's Hospital
Caregiver Participation, Emergency Department Presentation
Supporting Caregivers Following Mental Health Emergency Department Visits
The investigators plan to conduct a pilot hybrid effectiveness-implementation type 1 randomized controlled trial comparing 3 arms of varying follow-up intervention.
- Conditions
- Caregiver Participation, Emergency Department Presentation, Safety Plan
- Trial name
- SCFMHEDV (NCT07411300)
- Testing
- Telephone Calls, Automatic MyChart Messages
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Intra Cerebral Hemorrhage, Stroke
Ultra-Early, Minimally inVAsive intraCerebral Haemorrhage evacUATion Versus Standard trEatment
A randomized controlled trial of ultra-early, minimally invasive, hematoma evacuation versus standard care within 8 hours of intracerebral hemorrhage.
- Trial name
- EVACUATE (NCT04434807)
- Testing
- Minimally invasive hematoma evacuation
- Where
- 13 sites in Australia
- Volunteers
- 240 people
- Sponsor
- University of Melbourne
Liver Transplant; Complications, Cirrhosis, Liver
Prehabilitation and Posttransplant Training Program in Liver Transplantation
PreLiveR-T consists of a prospective randomized clinical trial conducted in an adult population that is a candidate for liver transplantation (LT) at the Hospital La Fe Valencia (Spain).
- Conditions
- Liver Transplant; Complications, Cirrhosis, Liver, Hepatic Carcinoma
- Trial name
- PreLiveR-T (NCT04246970)
- Testing
- Prehabilitation, Prehabilitation and posttransplant training program
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Maria dels Angels Cebria i Iranzo, PT, PhD
Enterovirus, Clinical Syndrome
Neonatal Enterovirus Infections in Italy: Virological Characterization, Genomic and Clinical-epidemiological Insights on Echovirus 11
The Enterovirus genus, belonging to the Picornaviridae family, consists of positively polarized single-stranded RNA viruses classified into the species Enterovirus (EV, comprising Coxsackievirus, Echovirus and Poliovirus) A-J and…
- Conditions
- Enterovirus, Clinical Syndrome, Respiratory Complications, Gastrointestinal
- Trial name
- Entero-Neo (NCT07356583)
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Pain, Postoperative
Bupivacaine Hydrochloride for Pain Control in Cutaneous Surgery
The purpose of this study is to determine if the addition of bupivacaine HCl injections will improve pain control after skin surgery. This is a randomized clinical trial.
- Trial name
- NCT04260854
- Testing
- Bupivacaine Hydrochloride, Saline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Acute Disseminated Encephalomyelitis
ADAM'S Prognostic Markers
Acute Disseminated Encephalomyelitis (ADEM) is an immune-mediated demyelinating disorder of the central nervous system that predominantly affects children.
- Trial name
- NCT07188194
- Volunteers
- 32 people
- Sponsor
- Assiut University
Post-Op Complication, Spine Surgery
Irrisept Solution for Instrumented Spine Surgery
Various spine surgeons perform wound irrigation using saline mixed with vancomycin, relying on mechanical debridement of non-viable tissue, physical disruption of biofilm, and bacteriostatic effect against gram positive flora.
- Conditions
- Post-Op Complication, Spine Surgery, Site Infection, Surgical Site Infection
- Trial name
- NCT06439953
- Testing
- Chlorhexidine gluconate solution, Vancomycin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rhode Island Hospital
Sepsis, Trauma Injury
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis
Adverse outcomes in surgical sepsis patients are secondary to dysregulated emergency myelopoiesis, and expansion of myeloid-derived suppressor cells.
- Trial name
- NCT05110937
- Testing
- Blood sampling
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Florida
Atrial Fibrillation (AF)
Comparative Evaluation of Optrell and Octaray Mapping Catheters for Conduction Block Confirmation and Voltage Assessment During Atrial Ablation
This prospective, single-center observational study aims to compare the clinical performance, workflow efficiency, and electrophysiological metrics of two commercially available, high-density multielectrode mapping catheters…
- Trial name
- NCT07563257
- Testing
- Atrial Fibrillation Radiofrequency Ablation Only
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Maxime Zabern
Chronic Pain, Wound Dehiscence
Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure
This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy.
- Conditions
- Chronic Pain, Wound Dehiscence, Surgical Site Infection (SSI), Incisional Hernia
- Trial name
- PolySuture (NCT07280975)
- Testing
- Polyglactin 910 (Vicryl) Suture, Polypropylene (Prolene) Suture
- Where
- Pakistan
- Volunteers
- 156 people
- Sponsor
- Lady Reading Hospital, Pakistan
COPD, Chronic Obstructive Pulmonary Disease
Home-based Pulmonary Rehabilitation for COPD Patients
Objectives The objective of this project is to motivate patients with COPD to incorporate the habit of doing daily mindful physical activity by using the proposed home-based pulmonary rehabilitation program that integrates video…
- Trial name
- NCT04820257
- Testing
- Home based exercise
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Severe Sepsis, Severe Sepsis Without Septic Shock
Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol
This protocol will collect real-world data retrospectively from the electronic health record (EHR) as data obtained from the delivery of routine medical care to develop a machine learning (ML)-based Clinical Decision Support…
- Trial name
- NCT05304728
- Where
- 10 sites in United States
- Volunteers
- 40,000 people
- Sponsor
- Beckman Coulter, Inc.
Brugada Syndrome (BrS), Ventricular Arrhythmia
Prospective Multicentre Observational Registry of Peri-procedural Anaesthesia, Sedation and Related Medication Exposure in Patients With Brugada Syndrome
The goal of this observational study is to evaluate the perioperative risk of malignant ventricular arrhythmias in adult patients diagnosed with Brugada Syndrome undergoing anaesthetic procedures.
- Conditions
- Brugada Syndrome (BrS), Ventricular Arrhythmia, Anesthesia, Sedation
- Trial name
- PROSP_BRUGANAE (NCT07655102)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Lung Cancer (Diagnosis), Acupressure
Acupressure for Cough in Lung Cancer Survivors
The goal of this randomized controlled trial is to examine the effect of an acupressure intervention in alleviating cough and reducing co-occurring symptoms (dyspnea, cough, and fatigue) in patients with lung cancer.
- Conditions
- Lung Cancer (Diagnosis), Acupressure, Coughing, Symptom Cluster
- Trial name
- NCT07315672
- Testing
- acupressure, Education
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 80 people
- Sponsor
- The University of Hong Kong
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
COPD
PEP Buddy in Pulmonary Rehabilitation
In this study, the investigators will test Veterans with COPD in Pulmonary Rehabilitation. Between two groups, the investigators will give one group a device that assists with breathing and symptoms and the other receives a…
- Trial name
- PEPR (NCT07404826)
- Testing
- PEP Buddy
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Periodontitis, Adult, Prediabetes / Type 2 Diabetes
HbA1c Screening in Dental Care and Primary Care Referral in Patients With Advanced Periodontitis
This study will evaluate whether HbA1c screening can be performed in dental care to detect elevated blood glucose in patients with advanced periodontitis and support referral to primary care.
- Trial name
- DENT-PC (NCT07688278)
- Testing
- Point-of-care HbA1c screening, Conditional standardized primary care referral
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Skane
Chronic Pancreatitis Pancreatic Exocrine Insufficiency Blood Glucose
A Study on the Changes of Glucose Metabolism and Exocrine Function in Patients With Chronic Pancreatitis
This study aims to investigate the impact of pancreatic exocrine insufficiency on the glucose profile and pancreatic and gastrointestinal endocrine hormones in patients with chronic pancreatitis through pancreatic enzyme…
- Trial name
- NCT07314489
- Testing
- Creon（Pancreatin Enteric-coated Capsules）
- Where
- 2 sites in China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Isthmocele, Cesarean Scar Defect
Clinical Impact of Uterine Repair During Cesarean Section With Barbed Suture on the Incidence of Isthmocele
Pregnant women, irrespective of their pregnancy risk, who undergo a cesarean section for any reason will be randomized to one of two suturing techniques: conventional suture or barbed suture for uterine repair after the cesarean…
- Conditions
- Isthmocele, Cesarean Scar Defect, Pelvic Pain, Spotting
- Trial name
- CESARIS (NCT06691750)
- Testing
- Barbed suture, Conventional smooth suture
- Where
- Spain
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
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