Clinical trials: Pathological Processes, open to volunteers
Septic Shock
Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock
The best strategy for managing fever in patients with septic shock remains unknown. In a pilot study, the investigators showed that fever control at normothermia allowed a better control of shock and evolution of organ failures.
- Trial name
- NCT04494074
- Testing
- External Cooling
- Where
- 33 sites in France
- Volunteers
- 820 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Older Adults
Frailty, Geriatric Syndromes and Care Pathways of Older Adults Living With HIV in West Africa
With currently available antiretroviral therapy, people living with HIV (PLWHIV) are living longer. This exposure to HIV and combination antiretroviral therapy may accelerate the aging of this population, thus increasing the…
- Trial name
- NCT07355413
- Where
- 6 sites in Burkina Faso, Côte d’Ivoire and 1 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Non-Small Cell Lung Cancer, Advanced/Metastatic
Dual-Target CAR-NK Cells Targeting MSLN, EGFR, or HER2 in Advanced NSCLC
This is a two-part, biomarker-guided Phase 1/2 study evaluating the safety, feasibility, and preliminary anti-tumor activity of off-the-shelf dual-target CAR-NK cells in participants with advanced or metastatic NSCLC whose tumors…
- Trial name
- DUO-NK-NSCLC (NCT07641023)
- Testing
- Dual-target CAR-NK cells, Lymphodepleting chemotherapy, Supportive care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Biotech
Postoperative Pain, Shoulder Arthroscopic Surgeries
Interscalene Block Versus Infraspinatus-Teres Minor Interfascial Plane Block for Shoulder Arthroscopy
This prospective randomized controlled study aims to compare the effects of interscalene block, infraspinatus-teres minor interfascial plane block, and a control group on postoperative analgesia and diaphragmatic function in…
- Conditions
- Postoperative Pain, Shoulder Arthroscopic Surgeries, Diaphragmatic Dysfunction
- Trial name
- NCT07670780
- Testing
- Ultrasound-Guided Interscalene Block, Ultrasound-Guided Infraspinatus-Teres Minor Interfascial Plane Block
- Volunteers
- 120 people
- Sponsor
- TC Erciyes University
Emergence Delirium, Perioperative Neurocognitive Disorder
Quantitative Neurofeedback Techniques for Treating Perioperative Cognitive Disorders in Elderly Patients
The goal of this clinical trial is to learn if quantitative measurement of brain and neurofeedback intervention techniques works to prevent perioperative neurocognitive deficits in elderly oncology patients who are to undergo…
- Trial name
- NCT06752148
- Testing
- neurofeedback intervention training game
- Volunteers
- 390 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Diabetes, End Stage Renal Disease
Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial
This is a prospective, multi-center, two-arm, randomized trial to quantify the performance of the EchoMark®/EchoSure® System for AVF diagnostic ultrasound when used under a protocol of biweekly use for assessing fistula…
- Trial name
- MAFASA (NCT06190717)
- Testing
- EchoMark/EchoSure, Standard of Care
- Where
- 23 sites in United States
- Volunteers
- 304 people
- Sponsor
- Sonavex, Inc.
Solid Tumor, Advanced Cancer
Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors
This is an open label, multi-center, multiple dose Phase 1 study to evaluate the safety, tolerability, MTD PK, and PD of TJ033721 (givastomig) in subjects with advanced or metastatic solid tumors.
- Conditions
- Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer
- Trial name
- NCT04900818
- Testing
- TJ033721 (givastomig), TJ033721 (givastomig) , nivolumab, chemotherapy, TJ033721 (givastomig), chemotherapy
- Where
- 21 sites in United States, China
- Volunteers
- 330 people
- Sponsor
- I-Mab Biopharma US Limited
Chronic Inflammatory Demyelinating Polyneuropathy
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This is a Phase 2b study to evaluate the efficacy and safety of Imeroprubart in adults with CIDP.
- Trial name
- NCT07032662
- Testing
- Imeroprubart
- Where
- 142 sites in United States, Argentina and 28 more
- Volunteers
- 162 people
- Sponsor
- Immunovant Sciences GmbH
Chronic Myeloid Leukemia (CML)
Study of CD38 and CD56 in Chronic Myeloid Leukemia
Chronic myeloid leukemia is a myelo-proliferative neoplasm characterized by abnormal proliferation of myeloid cells. There is an accumulation of mature granulocytes in the blood and bone marrow.
- Trial name
- NCT07740603
- Testing
- cd 38 and cd 56
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Liver Transplant
Fluid Management Strategies on Blood Loss in Liver Transplantation
During liver transplantation, due to the complexity of the operation and abnormal coagulation function, there may be a large amount of bleeding and corresponding blood transfusion.
- Trial name
- NCT06215404
- Testing
- Liberal group, restrictive group
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Acute Myocardial Infarction Type 1, Myocardial Injury
TROPOnin FRAGMentation in Myocardial Injury Study
Troponin T (TnT) is a part of the troponin protein complex that principally exists in cardiac and skeletal muscle cells and is widely used as diagnostic biomarker for myocardial injury and, thus, myocardial infarction (MI).
- Trial name
- Tropo-Fragm (NCT04465591)
- Testing
- troponin T fragmentation test
- Where
- 2 sites in Finland, Switzerland
- Volunteers
- 1,500 people
- Sponsor
- University of Turku
Pulmonary Disease, Chronic Obstructive
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
Depemokimab is being developed as a treatment for individuals with moderate to severe COPD. The aim of this study is to assess the efficacy and safety of depemokimab compared as an add-on medicine in participants with…
- Trial name
- ENDURA-2 (NCT06961214)
- Testing
- Depemokimab
- Where
- 193 sites in United States, Argentina and 14 more
- Volunteers
- 961 people
- Sponsor
- GlaxoSmithKline
Sepsis, Septic Shock
Cortisol Levels and Mortality in Septic Shock ICU Patients
This prospective observational study aims to evaluate the prognostic value of cortisol levels and their dynamic changes in critically ill patients with sepsis and septic shock admitted to the intensive care unit.
- Trial name
- NCT07582926
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people
- Sponsor
- Ankara Etlik City Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Time Course of Respiratory Oscillometry Parameters During Nasal High-Flow Therapy in Stable Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) can affect the small airways and alter respiratory mechanics. Nasal high-flow therapy delivers warmed and humidified gas through nasal cannulas and may change airway resistance.
- Trial name
- NHFlOscillo (NCT07750613)
- Testing
- Heated Humidified Nasal High-Flow Therapy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- ADIR Association
Hypertension, Primary Aldosteronism
Genetic Predisposition to High Blood Pressure
Primary aldosteronism (PA) is a known but underdiagnosed cause of high blood pressure. It is estimated that more than 10% of all people with high blood pressure (HT) suffer from PA, which is often caused by aldosterone-producing…
- Conditions
- Hypertension, Primary Aldosteronism, Genetic Predisposition to Disease
- Trial name
- NCT07181213
- Testing
- Adrenalectomy
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Linkoeping University
Cerebral Infarction, Chinese Herbal Medicine
Th Tl Xb Prescription on Reprogramming of Lipid Metabolism and Endothelial Injury for Cerebral Infarction Patients
This study is a prospective, open-label, randomized control trial. It is planning to include 160 cerebral infarction patients which will be randomized in a 1﹕1 fashion to receive Chinese herbal medicines combined basic medicine…
- Conditions
- Cerebral Infarction, Chinese Herbal Medicine, Clinical Trial, Lipid Metabolism Disorder
- Trial name
- NCT06549582
- Testing
- Taohong Tongluo Xiaoban Prescription, Fundamental medical treatment
- Volunteers
- 160 people
- Sponsor
- Yan Zhu
Pain, Chronic, Pain, Chronic Post-Surgical
iCanCope With Post-Operative Pain (iCanCope PostOp)
There are few applications available in the community to help teenagers manage pain after surgery. The focus of this study is to better understand the pain experience of children after having surgery and to design a Smartphone…
- Trial name
- NCT05382962
- Testing
- iCanCope Post Op Application
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Multimodal Analgesia, Tramadol
Tramadol Versus Morphine for Postoperative Pain Relief Following Laparoscopic Abdominal Surgery
Tramadol is commonly used postoperatively due to its ease of administration, but it carries several risks, including interindividual variability, drug interactions, neuropsychiatric risks in elderly patients, and long-term…
- Conditions
- Multimodal Analgesia, Tramadol, Enhanced Recovery After Surgery, Opioid and Postoperative Pain
- Trial name
- TRAMORNOT (NCT07914335)
- Testing
- Anesthesia induction, Anesthesia maintenance, Multimodal analgesia
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Colorectal Cancer
T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)
The goal of this two-arm clinical trial is to compare additional surgery with active surveillance in patients with high-risk pT1 colorectal cancer after local excision.
- Trial name
- T1LDA (NCT07900620)
- Testing
- Additional surgery
- Where
- 14 sites in Finland
- Volunteers
- 500 people
- Sponsor
- Tampere University Hospital
Bone Growth Abnormal, Inflammation
Effects of Increased Greek Yogurt Consumption in Youth and Young Adult Athletes
Physical activity and dairy consumption during growth and development are each known to improve peak bone mass in young adults. Peak bone mass, the maximum amount of bone a person will have in their lifetime, is typically reached…
- Trial name
- NCT05922462
- Testing
- Greek yogurt, Whey protein
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brock University
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