Clinical trials: Pathophysiology
Alzheimer's Type Dementia
A Study Versus E2020 10mg Followed by an Open-label Extension Phase to Explore the Safety of E2020 SR 23 mg in Japanese Subjects With Severe Alzheimer's Type Dementia
The purpose of this study is to compare 23 mg donepezil sustained release (SR) to the currently marketed formulation of 10 mg donepezil immediate release (IR) in patients with severe Alzheimer's disease.
- Trial name
- NCT01276353
- Testing
- E2020
- Where
- 11 sites in Japan
- Volunteers
- 45 people
- Sponsor
- Eisai Inc.
Mild Cognitive Impairment
Applying a Person-Centered Approach to Enhance Cognitive Training in Senior Living Community Residents With Mild Cognitive Impairment
Computerized cognitive interventions (CCIs) have been increasingly widely implemented among older adults with mild cognitive impairment (MCI).
- Trial name
- CogT-PACT (NCT03292705)
- Testing
- PEP, CCI
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Microalbuminuria
Low Dose Versus Aggressive Inhibition of the Renin-Angiotensin-Aldosterone (RAS) to Treat Microalbuminuria
The objective of the study is to assess the effect of standard versus aggressive inhibition of the renin-angiotensin system (RAS)in type 2 diabetic patients with microalbuminuria (MA) on; a)progression of microalbuminuria…
- Trial name
- END-IT (NCT00907374)
- Testing
- benazepril
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Charles Drew University of Medicine and Science
Atrophy of Vagina, Menopause
The Vaginal Health Trial
This is a new application from the Menopause Strategies: Finding Lasting Answers for Symptoms and Health (MsFLASH) Clinical Trials network.
- Conditions
- Atrophy of Vagina, Menopause, Dyspareunia (Female)
- Trial name
- NCT02516202
- Testing
- Vagifem, Replens
- Where
- 2 sites in United States
- Volunteers
- 302 people
- Sponsor
- Fred Hutchinson Cancer Center
HIV Infection, Mitochondrial Dysfunction
Switching From Efavirenz to Atazanavir/ Ritonavir in HIV-infected Subjects With Good Virologic Suppression
The purposes of this study are to evaluate if switching an antiretroviral medication from efavirenz (EFV) to atazanavir/ ritonavir (ARV/r) will, in a 96-week period, change: 1.
- Trial name
- NCT01194856
- Testing
- Atazanavir/ritonavir, Efavirenz
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- The Cleveland Clinic
Advanced Refractory Left Ventricular Heart Failure
HeartMate 3 CE Mark Study Long Term Follow-up
The purpose of this clinical investigation is to report the long term survival and incidence of adverse events in the patients who were implanted with HM3 in the CE Mark Study and continue to be ongoing with the HeartMate 3 LVAS…
- Trial name
- HM3 CE LTFU (NCT03022461)
- Testing
- Long term follow-up
- Where
- 8 sites in Australia, Austria and 4 more
- Volunteers
- 25 people
- Sponsor
- Abbott Medical Devices
Smoking Cessation
Cognition and Smoking Relapse (HCS)
This study tests whether withdrawal-related cognitive deficits increase smoking relapse among HIV-infected (HIV+) vs. HIV-uninfected smokers (HIV-).
- Trial name
- HCS (NCT03169101)
- Testing
- Nicotine patch, Behavioral counseling
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- University of Pennsylvania
Peripheral Arterial Disease
Clinical Utility of Endothelial Dysfunction in PAD
This study will seek to determine whether non-invasive measures of endothelial function have utility as surrogate markers of cardiovascular risk in patients with peripheral arterial disease undergoing vascular surgery.
- Trial name
- NCT00491751
- Testing
- atorvastatin, ascorbic acid
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Boston University
Eustachian Tube Dysfunction
Eustachian Tube Dysfunction Assessment
The purpose of the study is to understand the exact mechanism of the activity of paratubal muscles in opening eustachian tube in patients with the functional eustachian tube and those with the eustachian tube dysfunction problem.
- Trial name
- ETDA (NCT02667301)
- Testing
- EMG recording, Tympanic Cavity Air Exchange Test, Tympanometer test
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stratejik Yenilikci Girisimler Ltd.
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention in High-Fidelity Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- LABYR (NCT04253587)
- Testing
- LabyrinthVR, Coherence, Tablet
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Traumatic Brain Injury, Cognitive Impairment
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
Difficulties with intellectual functioning, particularly memory functions, are common and source of long-term disability after Traumatic Brain Injury (TBI).
- Trial name
- RIVET (NCT01670526)
- Testing
- Rivastigmine Transdermal Patch
- Where
- 8 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Erectile Dysfunction
Radial Shockwave Therapy for Erectile Dysfunction
Objective: To evaluate the efficacy and safety of radial shock waves for the treatment of erectile dysfunction [ED]. Patients and methods: Randomized, double-blind clinical trial.
- Trial name
- NCT03596047
- Testing
- Radial wave therapy
- Where
- Colombia
- Volunteers
- 80 people
- Sponsor
- Boston Medical Group
Heart Failure, Heart Diseases
Effects of Passive Heat Therapy on Oxygen Consumption and Cardiovascular Fitness in Adults
The purpose of this study is to determine if enhanced endothelial arterial distensibility observed with heat therapy translates into improved cardiorespiratory fitness.
- Conditions
- Heart Failure, Heart Diseases, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- NCT04026126
- Testing
- Heat Therapy Treatment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Lung Cancer, Sexual Dysfunction
Characteristics of Sexual Dysfunction in Patients With Lung Cancer
The general objective of this observational study is identify and describe the type, frequency, and severity of sexual dysfunction in patients with lung cancer and generate strategies for clinical management and oncological…
- Trial name
- LUDICAS (NCT06018376)
- Testing
- Systemic oncological treatment
- Where
- 29 sites in Argentina, Colombia and 3 more
- Volunteers
- 553 people
- Sponsor
- Fundación GECP
Advanced Refractory Left Ventricular Heart Failure
HeartMate 3™ CE Mark Clinical Investigation Plan
The purpose of this clinical investigation is to evaluate the performance and safety of the HeartMate 3 Left Ventricular Assist System (HM3 LVAS) To support obtaining CE Mark for the HM3 LVAS in Europe, a multi-center clinical…
- Trial name
- HM3 CE Mark (NCT02170363)
- Testing
- Left Ventricular Assist System (LVAS)
- Where
- 10 sites in Australia, Austria and 4 more
- Volunteers
- 50 people
- Sponsor
- Abbott Medical Devices
Parkinson's
Cognitive Dysfunction In Parkinson's
We hypothesize that reductions in gamma activity are a key mechanism underlying cognitive dysfunction in PD and that interventions to increase gamma activity will improve cognition.
- Trial name
- KL2 (NCT02468804)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sexual Dysfunction, Physiological
Efficacy of VR101 as a Personal Lubricant
This Clinical Investigation (CI03) is designed to validate the efficacy of the VR101 lubricating Intravaginal Ring (IVR) as a personal lubricant device.
- Trial name
- NCT04288752
- Testing
- VR101 Lubricating Intravaginal Ring
- Where
- 2 sites in United States
- Volunteers
- 176 people
- Sponsor
- J3 Bioscience, Inc.
Amputation Stumps, Neuroma
Pathophysiology of Post Amputation Pain
The purpose of this study is to see how Post Amputation Pain (PAP) affects the body and brain by using sensory testing (such as pinprick testing), taking pictures of your brain (using a functional magnetic resonance imaging…
- Trial name
- PPAP (NCT01632709)
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Delirium
Recommendations and Alerting for Delirium Alleviation in Real-Time (RADAR)
This is a pilot randomized controlled trial that will test whether a multicomponent decision support system will improve the postoperative environment for neurocognitive and clinical recovery in older, high-risk surgical…
- Trial name
- NCT04007523
- Testing
- Family Support System, HELP Support System
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Chronic Pain, Cognitive Impairment
Chronic Pain Self-management for Older Adults With Cognitive Impairment: A Randomized Pilot Trial
The goal of this randomized pilot trial is to test a chronic pain self-management program customized for people living with both chronic pain and cognitive impairment.
- Trial name
- STEPS-CI (NCT06182423)
- Testing
- STEPS-CI (Support, Training, and Education for Pain Self-management- Cognitively Inclusive version)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Michigan
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