Clinical trials: Pathophysiology
Hypertension, High Blood Pressure
Pre-clinical Cardiac Dysfunction Among Asymptomatic Hypertensive Patients
This project will evaluate the clinical and cost effectiveness of a novel, multidisciplinary approach to identify and treat pre-clinical cardiac dysfunction (PCCD) in asymptomatic hypertensive patients identified in a single…
- Conditions
- Hypertension, High Blood Pressure, Ventricular Hypertrophy, Diastolic Dysfunction
- Trial name
- NCT00689819
- Testing
- Exercise, Weight Loss, Low Sodium Diet
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Diabetes Mellitus, Type 2, Erectile Dysfunction
Exploratory CSII Trial on Erectile Dysfunction in T2DM Patients
Erectile dysfunction (ED) is a common form of organic sexual dysfunction in males with diabetes, with estimated incidence rates between 35 and 75%.
- Trial name
- ECSIITED (NCT01468519)
- Testing
- Insulin
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Jothydev's Diabetes and Research Centre
Dementia, Mild Cognitive Impairment
Case-Finding for Neurocognitive Disorders in Pavia
Dementia is a global public health challenge with a heavy caregiving burden, impacting families, communities, and healthcare systems. It is a priority in healthcare planning, with focus on early diagnosis and ongoing support.
- Trial name
- C-FiND Pavia (NCT06983119)
- Testing
- Case-finding for Neurocognitive Disorders
- Where
- Italy
- Volunteers
- 490 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Verticality Perception, Self-motion Perception
Altered Vestibular Perception and Transcranial Magnetic Stimulation
The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences motion sensation.
- Trial name
- NCT02184130
- Testing
- transcranial magnetic stimulation and motion stimuli
- Where
- Switzerland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Endothelial Dysfunction
Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx
The glycocalyx is a dynamic and complex biochemical structure composed of proteoglycans, glycoproteins, and soluble proteins. The glycocalyx interacts with various proteins such as albumin and orosomucoid to form a thick surface…
- Trial name
- NCT05068336
- Testing
- desflurane anesthesia, sevoflurane anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kocaeli Derince Education and Research Hospital
Metabolic Dysfunction-Associated Steatotic Liver Disease
Effects of Short-term Perioperative Daidzein Intervention on Liver Histopathology in Patients With MASLD
This clinical trial aims to learn whether daidzein can improve liver tissue changes in adults with metabolic dysfunction-associated steatotic liver disease, also called MASLD.
- Trial name
- DAIMAS (NCT07623044)
- Testing
- Daidzein
- Volunteers
- 44 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Sleep Apnea
Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study B
In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood.
- Trial name
- NCT01738009
- Testing
- Induction of flow limitation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Anesthesia Morbidity, Cesarean Section Complications
Effect of General Anesthesia on Early Postoperative Cognitive Function in Cesarean Section
Cognitive dysfunction is the impairment of the mental process of perception, memory and information processing. The preoperative cognitive state is important, as mild cognitive impairment may be worsened following a cesarean…
- Trial name
- NCT03818009
- Testing
- Assessment document
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Beni-Suef University
Temporomandibular Disorder
INVESTIGATION AND COMPARISON OF THE EFFECTS OF POSTURE EXERCISES ON DYSFUNCTION, POSTURE AND BALANCE IN INDIVIDUALS WITH POSTERIOR EDENTULOUS AND FULL-TOOTHED TEMPOROMANDIBULAR DISORDER
The aim of this study is to investigate the relationship between neck posture and balance in patients with posterior edentulous and full-toothed temporomandibular disorder and to compare the effectiveness of the physiotherapy…
- Trial name
- NCT05704998
- Testing
- Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Dokuz Eylul University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery
Postoperative neurocognitive impairments often occur in elderly patients undergoing anesthesia and non-cardiac surgery, including postoperative delirium (POD) and postoperative cognitive dysfunction (POCD).
- Trial name
- NCT04341844
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Fudan University
Pain and Cognitive Dysfunction Management in Hip Surgery
Prospective Comparative Study Between Ultrasound-guided Quadratus Lumborum Block Versus Fascia Iliaca Compartment Block for Postoperative Pain and Cognitive Dysfunction Management in Patient Undergoing Hip Surgery
Hip fractures are more common in older people due to osteoporosis. It is estimated that around six million patients worldwide will suffer hip fractures annually by 2050 as the population ages [1].
- Trial name
- NCT06407544
- Testing
- peripheral nerve block, PCA device as rescue medication with IV morphine 1mg if VAS more than 4
- Volunteers
- 60 people
- Sponsor
- Sohag University
Healthy Volunteers
Early Environmental and Maternal Determinants of Airway Inflammation in Wheezing Disorders in Infants
This study collects data on microbiological, genetic and environmental factors, as well as lung function parameters (e.g. spirometry, body plethysmography, lung-MRI) to assess the complex interaction of predisposing risk factors…
- Trial name
- NCT04286464
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cognitive Impairment
PAMNEU - Memory in Neurology
Memory in Neurology project (PAMNEU) aims to map the distribution and severity of cognitive impairment in patients of outpatient neurologic offices across the geographical area of the Czech Republic.
- Trial name
- NCT06154564
- Where
- Czechia
- Volunteers
- 600 people
- Sponsor
- Charles University, Czech Republic
CADASIL
Safety and Efficacy of Edaravone Dexborneol Sublingual Tablets for Blood-Brain Barrier Dysfunction in CADASIL
This study is a single-center, prospective, single-arm, self-controlled clinical trial designed to assess the safety and efficacy of edaravone dexborneol sublingual tablets for blood-brain barrier (BBB) dysfunction in patients…
- Trial name
- NCT07692399
- Testing
- Edaravone Dexborneol Sublingual Tablets
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Premature Ejaculation
The Impact and Benefit of Physical Activity on Premature Ejaculation
The purpose of this study is to investigate the relationship between physical activity and PE, and determine whether moderate physical activity might delay ejaculation time or be an alternative treatment for PE.
- Trial name
- PE (NCT02844998)
- Testing
- physical activity, dapoxetine 30 mg on demand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Premature Ejaculation
IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT), Patient Reported Outcomes and Safety in Men With Premature Ejaculation (PE)
A Phase 2b, 8-week, double-blind, placebo-controlled, parallel group study to evaluate the effect of 3 different dose levels of IX-01 on IELT and patient-reported outcome in men with lifelong PE.
- Trial name
- NCT03055806
- Testing
- IX-01 400 mg, IX-01 800 mg, IX-01 1200 mg
- Where
- 29 sites in United States
- Volunteers
- 239 people
- Sponsor
- Ixchelsis Limited
Ischemic Stroke, Cognitive Decline
Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke
Aim of this randomized controlled study is to test if intensive polyintervention therapy including life style modifications targeting at reduction of modifiable risk factors of stroke can reduce the risk of post-stroke cognitive…
- Conditions
- Ischemic Stroke, Cognitive Decline, Dementia
- Trial name
- ASPIS (NCT01109836)
- Testing
- Motivation and lifestyle intervention
- Where
- 5 sites in Austria
- Volunteers
- 202 people
- Sponsor
- Danube University Krems
Executive Dysfunction
Improving Self-regulation & School Readiness in Preschoolers
This project will develop and evaluate the initial effectiveness of an intervention training executive functioning, metacognition, and self-regulation in preschoolers attending certain high poverty Cincinnati preschools.
- Trial name
- NCT02225236
- Testing
- Classroom Intervention
- Where
- United States
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Migraine Headache, Cognitive Impairment
Treximet in Acute Migraine Headache: Assessing Cognitive Function
Migraine headache occurs frequently in women more than men and is associated with symptoms not only of significant pain but also of symptoms typically including of photophobia, phonophobia, nausea and vomiting.
- Trial name
- NCT00837044
- Testing
- Treximet, Migraine rescue medication of choice
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Neurological Research Center
Trunk Extensor Muscle Endurance
Correlation Between Trunk Muscles Endurance and Dynamic Balance in Sacroiliac Joint Dysfunction
This cross-sectional observational study aims to investigate the correlation between trunk muscle endurance and dynamic balance in patients with sacroiliac joint dysfunction (SIJD).
- Trial name
- NCT07894432
- Testing
- Patients with Sacroiliac Joint Dysfunction
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Deraya University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.