Clinical trials: Pathophysiology
Sexual Pain Disorders, Postmenopausal Symptoms
Sexual Penetration Pain in Postmenopausal Women: A Topical Botanical Drug Treatment
This study will evaluate the use of topical 5 or 10% sinecatechins, a botanical drug derived from green tea for the alleviation of sexual pain in the area around the vaginal opening (the vulvar vestibule), that is a main source…
- Conditions
- Sexual Pain Disorders, Postmenopausal Symptoms, Vulvovaginal Atrophy, Female Sexual Dysfunction
- Trial name
- NCT03682601
- Testing
- 5% sinecatechins ointment, 10% sinecatechins ointment
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GTO Pharmaceutical, LLC
Mild Cognitive Impairment, Alzheimer Dementia
Brain Fitness APP for Cognitive Enhancement
Memory and cognitive declines are associated with normal brain aging but are also precursors to dementia, in particular the so called the pandemic of the century, Alzheimer's disease.
- Trial name
- NCT03587012
- Testing
- Brain fitness app, Brain fitness app with tACS
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Depression, Mild Cognitive Impairment
Combination Treatment Study for Memory Impairment and Depression
Patients presenting with depression (DEP) and cognitive impairment (CI), represent a unique, understudied population that is difficult to diagnose, treat and estimate prognosis.
- Trial name
- DEP-CI (NCT01658228)
- Testing
- Donepezil, Citalopram, Venlafaxine
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- New York State Psychiatric Institute
Cardiotoxicity, Heart Failure
ML Score Prediction of Cardiotoxicity in Cancer Patients Receiving Anthracycline Chemotherapy or HER2-Targeted Therapies
Cancer treatments have improved substantially over the past decades, but some effective therapies such as anthracyclines and HER2-targeted agents are associated with severe cardiovascular adverse effects, including heart failure.
- Conditions
- Cardiotoxicity, Heart Failure, Neoplasms, Breast Neoplasms
- Trial name
- ML-CardioTox (NCT07191730)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Sexual Dysfunction, Endothelial Dysfunction
Effects of Diet-induced Weight Loss in Obese Men
This study aims to compare the efficacy of a partial meal replacement diet with a conventional diet, for inducing weight loss and improving metabolic and inflammatory profile, endothelial function, erectile function, sexual…
- Conditions
- Sexual Dysfunction, Endothelial Dysfunction, Quality of Life, Inflammation
- Trial name
- NCT01554865
- Testing
- Optifast, Conventional diet counseling
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Transfer Dysphagia, Oropharyngeal Dysphagia
Onabotulinum Toxin A (Botox) in the Treatment of Pharyngo-esophageal Dysphagia
Dysphagia in patients with stroke, multiple sclerosis, parkinsonism or dystonia can occur due to relative hypertonia of the cricopharyngeus muscle. In the resting state, muscle is contracted and relaxes only during deglutition.
- Conditions
- Transfer Dysphagia, Oropharyngeal Dysphagia, Cricopharyngeus Muscle Dysfunction
- Trial name
- NCT04695600
- Testing
- Botulinum Toxin Type A Injection [Botox]
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Chronic Granulomatous Disease
Generation of Powerful Biological Tools for Understanding the Pathophysiology of Chronic Granulomatous Disease.
Chronic granulomatous disease (CGD) is a rare genetic disease of innate immune due to the malfunction of phagocytic cells unable to destroy pathogens during infection.
- Trial name
- FIBRO CGD (NCT02926963)
- Testing
- samples collection : hair and skin biopsy
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Grenoble
Mild Cognitive Impairment, Healthy Aging
Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition
Impaired working memory (WM) plays a crucial role in normal aging, in mild cognitive impairment (MCI) and cognitive decline associated with dementia, such as Alzheimer's disease (AD).
- Trial name
- NiBS-iCog (NCT04986787)
- Testing
- tACS, TMS, TIS
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Cardiovascular Pathology
New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function
Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the…
- Trial name
- LAX (NCT01275963)
- Where
- Germany
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Mild Cognitive Impairment, Aging
Supporting Aging Through Green Exercise (SAGE)
Aerobic exercise is an evidence-based approach to mitigate cognitive decline in older adults with mild cognitive impairment (MCI).
- Trial name
- SAGE (NCT05036304)
- Testing
- Aerobic Exercise Indoors, Aerobic Exercise Outdoors
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Oxidative Stress Induction, Endothelial Dysfunction
Role of Traditional Cigarettes, Electronic and IQOS Cigarettes on Oxidative Stress.
Electronic cigarettes (E-cigarettes) and new heat-not-burn tobacco products such as IQOS®, an electronic device that heats a cigarette-like stick without combustion, are a modern and technological surrogate of traditional tobacco…
- Conditions
- Oxidative Stress Induction, Endothelial Dysfunction, Platelet Activation
- Trial name
- NCT03301129
- Testing
- Smoke
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Pituitary Tumor
Postoperative Cognitive Dysfunction in Patients Undergoing Pituitary Removal Surgery
As postoperative cognitive dysfunction rates are high especially in elder patients, cognitive dysfunction is not diagnosed and treated effectively.
- Trial name
- NCT03719781
- Testing
- standardized minimental testing
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Kocaeli University
HDL, Health, Subjective
HDL Function Dietary Supplement Safety and QOL
Nutritional supplements are routinely purchased by consumers with suboptimal HDL to support their health, lifestyle and overall quality of life. Many such products receive minimal evaluation prior to marketing.
- Trial name
- NCT04097119
- Testing
- Dietary supplementation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Premature Ejaculation
Silicone Band Versus Prilocaine Spray for Lifelong Premature Ejaculation
This pilot study compared two approaches for men with lifelong premature ejaculation, a condition in which ejaculation occurs sooner than desired from the first sexual experiences and is difficult to delay.
- Trial name
- NCT07820865
- Testing
- Frenular Silicone Band, Prilocaine 10% Spray
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Mild Cognitive Impairment (MCI)
Non-pharmacological Interventions for People With Mild Cognitive Impairment in the Community
Mild cognitive impairment (MCI) may increase the risk of dementia. This study will evaluate an 8-week community-family mutual support intervention for adults aged 60 years or older with MCI.
- Trial name
- CNPI-MCI (NCT07703267)
- Testing
- Community-Family Mutual Support Intervention, Routine Community Care
- Volunteers
- 70 people
- Sponsor
- Anhui Medical University
Acute Coronary Syndrome, Cognitive Impairment
Effect of CI on Prognosis in the Elderly Patients With ACS
This study aims to investigate the incidence and characteristics of cognitive Impairment(CI) in the elderly patients with acute coronary syndrome (ACS), and to determine whether CI are predictive of the prognosis of major adverse…
- Conditions
- Acute Coronary Syndrome, Cognitive Impairment, Elderly
- Trial name
- CIACS (NCT04278911)
- Testing
- MMSE and MoCA
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Friendship Hospital
Insomnia, Cognitive Disorder
Study on Cognitive Impairment of Insomnia Based on MRI
Insomnia is a common sleep disorder. In recent years, the incidence of insomnia is increasing worldwide. Studies point out that insomnia plays an important role in the pathogenesis of cognitive impairment.
- Conditions
- Insomnia, Cognitive Disorder, MRI
- Trial name
- NCT05659511
- Testing
- MRI
- Where
- China
- Volunteers
- 684 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Endothelial Dysfunction
A Phase 2, Pharmacokinetic (PK) Study of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial Dysfunction
This Phase 2, randomized, open-label, 2-treatment, 2-sequence, 2-period crossover, pharmacokinetic (PK) study will compare plasma concentrations of BH4 in subjects with endothelial dysfunction following 14 days of treatment by…
- Trial name
- NCT00532844
- Testing
- Sapropterin Dihydrochloride, Sapropterin Dihydrochloride and Vitamin C
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- BioMarin Pharmaceutical
Brain Ischemia
Iron, Alpha-Synuclein, and Lymphocyte-activation Gene-3 in Ischemic Stroke
This observational study aims to detect levels of iron, alpha-synuclein, and soluble lymphocyte activation gene 3 in acute ischemic stroke patients.
- Trial name
- NCT05748587
- Testing
- Serum Iron, RBCs Alpha-synuclein, Serum Soluble lymphocyte activation gene
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Aswan University Hospital
Decline, Cognitive
Intermittent Cooling During Baseball Games on Hitting and Defense Performance
This study adopted a practical approach in intermittent cooling on forehead and neck during an intra-squad baseball game. Exit velocity of batted balls was used as an indicator for hitting performance and a baseball-specific…
- Trial name
- NCT05068804
- Testing
- Cooling, control
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
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