Clinical trials: Pathophysiology
Prostate Cancer, Sleep Disturbance
Sleep Hygiene Education, ReadiWatchTM Actigraphy, and Telehealth Cognitive Behavioral Training for Insomnia Effect, on Symptom Relief for Men With Prostate Cancer Receiving Androgen Deprivation Therapy
Many treatments for prostate cancer can cause significant fatigue and/or problems with memory and concentration. Many treatments for prostate cancer also result in disturbed sleep.
- Conditions
- Prostate Cancer, Sleep Disturbance, Fatigue, Cognitive Impairment
- Trial name
- SHERE-Relief 2 (NCT05582759)
- Testing
- teleCBT-I + SH/ReadiWatchTM, SH/ReadiWatchTM
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Kansas Medical Center
Sepsis-Induced Myocardial Dysfunction
Investigating the Clinical Benefits and Underlying Mechanisms of Danhong Injection in Modulating Mitochondrial Homeostasis Against Sepsis-Associated Myocardial Dysfunction
This study aims to evaluate the clinical efficacy of Danhong injection in patients with septic myocardial injury through a prospective randomized controlled trial.
- Trial name
- NCT07375862
- Testing
- Danhong injection, Saline
- Volunteers
- 140 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Mild Cognitive Impairment, Healthy Controls
Cross-Cultural Use of Performance-Based Functional Assessment in Alzheimer's Disease
This study plans to assess the effectiveness of performance-based functional assessments (PBFAs) and cognitive assessments in diagnosing Alzheimer's disease in Hispanic/Latino populations.
- Trial name
- NCT03081546
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus
Vascular Dysfunction in Diabetes: Genes and Hormones
The investigators are very excited that the National Institutes of Health are sponsoring us to investigate why patients with diabetes are more likely to develop high blood pressure, atherosclerosis (hardening of the arteries)…
- Trial name
- NCT01511042
- Testing
- Para-aminohippuric Acid, Angiotensin II, Norepinephrine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Dyspareunia (Female)
Rigid Hymenal Ring as a Cause for Insertional Dyspareunia
Given the frequently observed rigid hymenal ring as a cause of insertional dyspareunia as well as the resolution of pain (including posterior vestibulodynia) following its targeted therapy, the study aims to describe its…
- Trial name
- NCT07913386
- Testing
- Hymenectomy
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Erectile Dysfunction, Periodontitis
Periodontal Disease as a Risk Indicator for Erectile Dysfunction - A Cross-sectional Study on 100 Patients
Background Increased levels of C reactive protein (CRP) can be found not only within individuals with periodontal diseases and those with atherosclerotic alterations but also have been proved in men with erectile dysfunction…
- Conditions
- Erectile Dysfunction, Periodontitis, hsCRP
- Trial name
- NCT01852240
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity, Diastolic Dysfunction
Changes in Intramyocardial Fat Assessed by Cardiac CT Before and After Bariatric Surgery and Their Relationship With Cardiac Diastolic Function
The goal of this observational study is to learn if weight loss surgery can lower fat inside the heart muscle and improve how the heart relaxes in adults with obesity.
- Conditions
- Obesity, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- NCT07565610
- Volunteers
- 150 people
- Sponsor
- Itshak Amsalem
Sensory Impairments, Cognitive Impairment
Development of an Ensemble Learning-based, Multi-dimensional Sensory Impairment Score to Predict Cognitive Impairment in an Elderly Cohort of Southern Italy
There is now strong scientific literature showing a relationship between sensory loss and cognitive performance and between sensory loss and incident dementia.
- Conditions
- Sensory Impairments, Cognitive Impairment, Artificial Intelligence
- Trial name
- DEMETRA (NCT06783010)
- Volunteers
- 30 people
- Sponsor
- Azienda Sanitaria Locale Bari
Thoracic Anesthesia, Geriatric Anesthesia
The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients
One lung ventilation (OLV) is commonly used in thoracic surgery. Although the lack of ventilation of the lung in the surgical area (independent lung) during OLV redirects pulmonary blood flow to the dependent lung, shunt…
- Conditions
- Thoracic Anesthesia, Geriatric Anesthesia, One Lung Ventillation (OLV), POCD - Postoperative Cognitive Dysfunction
- Trial name
- NCT07339124
- Testing
- Cognitive Remediation, Pain Medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Cognitive Dysfunction, Schizophrenia
TC-5619 as Augmentation Therapy to Improve Cognition in Outpatients With Cognitive Dysfunction in Schizophrenia
Schizophrenia affects approximately 1% of the population worldwide, and in about 80% of cases, it is a lifelong, disabling illness.
- Trial name
- NCT01003379
- Testing
- TC-5619
- Where
- 16 sites in United States, India
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Targacept Inc.
Tinnitus, Epilepsy, Temporal Lobe
Pathophysiology, Psycho-emotional and Cognitive Functioning Associated With Tinnitus
the investigators have recently shown that patients with drug-resistant temporal lobe epilepsy who have undergone brain surgery targeting the medial temporal lobe structures were more likely to develop tinnitus postoperatively.
- Trial name
- AudiCog (NCT04717388)
- Testing
- acoustics tests, Questionaries,, MRI
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mild Cognitive Impairment (MCI)
Aging Stereotypes and Prodromal Alzheimer's Disease
Because of the lengthening of life expectancy, more and more people are concerned with the effects of aging on their mental faculties (e.g., memory decline) and with the possibility of getting Alzheimer's Disease (AD) or other…
- Trial name
- AGING (NCT03138018)
- Testing
- Diagnosis of MCI versus No MCI (SCI or healthy patient)
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Physical Inactivity, Cognitive Decline
Developing and Assessing an Innovative Exergaming Technology for Older Adults Living in Long-term Care Homes
Residents living in long-term care (LTC) homes spend up to 75% of their day in sedentary, socially withdrawn situations which increases their risk for depression, dementia, decreased functional status and increased care costs.
- Conditions
- Physical Inactivity, Cognitive Decline, Aging, Social Isolation
- Trial name
- MouvMat (NCT05130203)
- Testing
- MouvMat Exergaming, Standard Recreational Programming
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Microvascular Coronary Artery Disease, Heart Failure With Reduced Ejection Fraction
CMR Assessment of Cardiac Microvascular Dysfunction in Patients With HFpEF
Heart failure with preserved ejection fraction (HFpEF) causes hospitalizations, premature mortality and high health care costs. This is also due to poor understanding of HFpEF pathogenesis and, thus, lack of specific therapies.
- Trial name
- MAPPED (NCT06316661)
- Testing
- stress perfusion cardiac magnetic resonance, cardiopulmonary exercise test
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Supratentorial Craniotomy Dysfunction
Effect of Lidocaine in Antiarrhythmic Dosage on Postoperative Cognitive Dysfunction in Supratentorial Craniotomy Dysfunction in Supratentorial Craniotomy
The purpose of this study is to investigate the effect of lidocaine in antiarrhythmic dosage on postoperative cognitive dysfunction in supratentorial craniotomy.
- Trial name
- NCT00975910
- Testing
- lidocaine, saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Capital Medical University
Heart Failure
A Pharmacogenomic Study of Candesartan in Heart Failure
The purpose of this study is to evaluate the impact of genetic variations on the response to candesartan in patients with heart failure who are already treated with an ACE inhibitor.
- Trial name
- NCT00400582
- Testing
- Candesartan up to 32 mg daily
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Montreal Heart Institute
Alzheimer Type Dementia, Alzheimer's Disease (AD)
Impact of Ketoflex 12/3 Diet on Early-to-Mid Stage Alzheimer's Progression
This study investigates the effects of the Ketoflex 12/3 diet on the clinical progression of early-to-mid stage Alzheimer's disease.
- Trial name
- NCT06898424
- Testing
- Ketoflex 12/3 Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Lutfu Hanoglu, MD
Proteinuria, Kidney Dysfunction
Azilsartan in Patients With Diabetic Kidney Disease and Hypertension
Hypertension is the most common complication in patients with diabetes nephropathy. Strengthening blood pressure and blood sugar control is the basic treatment for patients with diabetes nephropathy.
- Conditions
- Proteinuria, Kidney Dysfunction, Blood Pressure, Diabetic Kidney Disease
- Trial name
- NCT05753696
- Testing
- Azilsartan, Losartan
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rectal Cancer Patients
Validation of the French Version of the Low Anterior Resection Syndrome (LARS) Among Rectal Cancer Patients
Oncological rectal cancer outcomes have improved considerably because of optimal surgery by total mesorectal excision in conjunction with multidisciplinary team management by selective multimodal therapy (ie, neo-adjuvant…
- Trial name
- LARS (NCT03569488)
- Testing
- FT-LARS questionnaire
- Where
- 8 sites in France
- Volunteers
- 1,100 people
- Sponsor
- University Hospital, Caen
Rectal Cancer
Intraoperative Monitoring of the Pelvic Autonomic Nerves
One of the major problems of rectal cancer surgery is pelvic autonomic nerve damage, which is the main cause of urogenital dysfunction influencing postoperative quality of life.
- Trial name
- NEUROS (NCT01585727)
- Testing
- TME, Neuromonitoring
- Where
- Germany
- Volunteers
- 188 people
- Sponsor
- Johannes Gutenberg University Mainz
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