Clinical trials: Pathophysiology
Heavy Drinking, Metabolic Syndrome
Aerobic Exercise Addition to Cognitive Behavioural Treatment in Impotence Metabolic-syndrome Drinkers
Cognitive Behavioural Treatment is used as treatment for Heavy Drinking, Impotence, and Metabolic Syndrome. The efficacy of adding aerobic training to this treatment is not tested till now.
- Conditions
- Heavy Drinking, Metabolic Syndrome, Impotence
- Trial name
- NCT07277673
- Testing
- aerobci physical training and cognitive behavioural treatment, Cognitive behavioural treatment
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Vitamin D Deficiency, Pre-Eclampsia
Vitamin D in Pregnancy
Danish pregnant women are recommended ad daily vitamin D supplement of 10 µg. Despite the fact that 9 out of 10 women take vitamin D supplements, more than 40% of pregnant women are vitamin D deficient, putting them at an…
- Conditions
- Vitamin D Deficiency, Pre-Eclampsia, Fetal Growth Retardation, Gestational Diabetes
- Trial name
- GRAVITD (NCT04291313)
- Testing
- Vitamin D3 (90µg), Vitamin D3 (10µg)
- Where
- 2 sites in Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sepsis, Acute Kidney Injury Due to Sepsis
Presepsin:Gelsolin Ratio in Sepsis-related Organ Dysfunction
In the present study, 126 patients were enrolled (23 control, 38 non-septic and 65 septic patients). Blood samples were collected from septic patients at the intensive care unit (ICU) at three time points (T1-3): T1: within 12h…
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Septic Shock, Acute Respiratory Distress Syndrome
- Trial name
- NCT05060679
- Testing
- Supportive therapy at the ICU, Sepsis therapy, Sepsis-related organ dysfunction therapy
- Where
- Hungary
- Volunteers
- 126 people
- Sponsor
- University of Pecs
Dementia, Cognitive Impairment, Mild
Cognitive Stimulation Therapy for Dementia: A Two-Armed Pragmatic Trial
Cognitive Stimulation Therapy (CST) is an evidence-based non-pharmacological group therapy shown to benefit people with mild to moderate dementia.
- Conditions
- Dementia, Cognitive Impairment, Mild, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT05860127
- Testing
- Referral for Cognitive Stimulation Therapy, No change to Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 133 people
- Sponsor
- University of Massachusetts, Amherst
Multiple Myeloma, Plasma Cell Neoplasm
Lenalidomide and Low-Dose Dexamethasone in Patients With Previously Treated Multiple Myeloma and Kidney Dysfunction
Patients with previously treated multiple myeloma and kidney dysfunction will be treated with lenalidomide and low-dose dexamethasone.
- Trial name
- PrE1003 (NCT00790842)
- Testing
- Lenalidomide, Dexamethasone, Anticoagulants
- Where
- 16 sites in United States
- Volunteers
- 63 people
- Sponsor
- PrECOG, LLC.
Mild Cognitive Impairment
Metformin in Alzheimer's Dementia Prevention
MAP will be a multi-center phase 2/3 1:1 randomized controlled trial (RCT) of long-acting metformin (reduced mass Glucophage XR) vs.
- Trial name
- MAP (NCT04098666)
- Testing
- extended release metformin
- Where
- 22 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cognitive Impairment, Perceived Stress
Robot-Assisted Meditation for Older Adults With Cognitive Concerns
While traditional app-based mindfulness meditation programs relying solely on audio guidance have shown potential benefits for older adults, the programs often face challenges such as low engagement.
- Trial name
- NCT07435220
- Testing
- Robot-Guided Meditation, Audio-Only Robot
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment
Cognitive Detection of Preclinical AD: Validation Using Biomarkers
The current study aims to validate several novel cognitive tasks expected to be sensitive to brain impairment in specific anatomic regions affected in preclinical Alzheimer's disease(pAD).
- Trial name
- NCT02616679
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
MASH - Metabolic Dysfunction-Associated Steatohepatitis, T2DM (Type 2 Diabetes Mellitus)
A Study of Chiglitazar in Patients With Metabolic Dysfunction-associated Steatohepatitis and Type 2 Diabetes Mellitus
This trial aims to evaluate the efficacy and safety of chiglitazar as a combination therapy for patients with MASH and T2DM.
- Trial name
- CHIG-MASH (NCT07303803)
- Testing
- Chiglitazar, vitamin E, Polyene Phosphatidyl choline
- Where
- 17 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Alzheimer's Disease, Mild Cognitive Impairment
Effectiveness of an Electronic Training Program for Orienting and Interpreting [18F]Flutemetamol Positron Emission Tomography (PET) Images
To Evaluate the Effectiveness of an Electronic Training Program for Orienting and Interpreting [18F]flutemetamol Positron Emission Tomography (PET) Images.
- Trial name
- NCT01672827
- Testing
- [18F]Flutemetamol
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Hearing Loss, Sensorineural, Dementia of Alzheimer Type
Characterizing Variability in Hearing Aid Outcomes in Among Older Adults With Alzheimer's Dementia
This current translational project, funded by NIH, aims to better understand the impact of various signal modification strategies for older adults with Alzheimer's dementia and its potential precursor, known as amnestic mild…
- Conditions
- Hearing Loss, Sensorineural, Dementia of Alzheimer Type, Amnestic Mild Cognitive Impairment
- Trial name
- NCT04240561
- Testing
- High level of signal manipulation, Low level of signal manipulation
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Acute Heart Failure
Loop Diuretic Therapy in Acutely Decompensated Heart Failure
DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF.
- Trial name
- DIUR-AHF (NCT02638142)
- Testing
- Continuous Furosemide Infusion, Intermittent Furosemide Infusion
- Where
- 4 sites in Italy
- Volunteers
- 370 people
- Sponsor
- University of Siena
Erectile Dysfunction
Evaluating of the Efficacy and Safety of Vardenafil in Subjects With Erectile Dysfunction
Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance.
- Trial name
- NCT00662441
- Testing
- Levitra (Vardenafil, BAY38-9456)
- Volunteers
- 102 people
- Sponsor
- Bayer
STEMI - ST Elevation Myocardial Infarction, Left Ventricular Systolic Dysfunction
The Effect of Early Administration of Dapagliflozin in STEMI Patients With LV Systolic Dysfunction
300 STIMI patients with LV systolic dysfunction will be divided into two equal groups (Group I (Study arm, n=150); will receive dapagliflozin plus conventional therapy and group (II) Control arm (n=150); will receive conventional…
- Trial name
- NCT05045274
- Testing
- Dapagliflozin 10Mg Tab
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Spinal Cord Injury, Neurogenic Bladder (NB)
Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD
The main objective of the proposed research study is to determine in men and women with spinal cord injury/disease and neurogenic bladder whether the dose of coupled gentamicin \& Lactobacillus rhamnosus GG affects the…
- Conditions
- Spinal Cord Injury, Neurogenic Bladder (NB), Neurogenic Lower Urinary Tract Dysfunction, Multiple Sclerosis
- Trial name
- NCT07643974
- Testing
- Gentamicin, Lactobacillus Rhamnosus GG
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Medstar Health Research Institute
Postoperative; Dysfunction Following Cardiac Surgery
Cerebral Energy State in Cardiac Surgery
Impaired cerebral function remains an important complication of cardiopulmonary bypass (CPB) during cardiac surgery. The aim of the present study is to investigate whether the lactate to pyruvate (LP) ratio obtained by…
- Trial name
- NCT02846818
- Testing
- Microdialysis
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Progressive Supranuclear Palsy, Cognitive Impairment
Neuropsychological Evaluation for Early Diagnosis of PSP
The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.
- Trial name
- NCT03478124
- Testing
- Cognitive evaluation
- Volunteers
- 112 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Dry Eye Syndromes
Lipiflow Treatment Alone vs. Lipiflow + Dextenza Treatment for Dry Eye Disease
To evaluate the benefit of treatment with a physician administered intracanalicular dexamethasone insert in evaporative dry eye disease (DED) patients with meibomian gland disfunction (MGD) and underlying inflammation undergoing…
- Trial name
- NCT04413279
- Testing
- LipiFlow Thermal Pulsation, Dexamethasone Intracanalicular Insert, 0.4mg with LipiFlow Thermal Pulsation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eye Surgeons of Indiana
Biochemical Dysfunction
Concordance of Capillary Blood Biological Samples With Conventional Venousbiological Blood Samples.
The main objectives are to evaluate the concordance between the results of natremia, kalaemia and blood sugar levels obtained 1) by capillary puncture, analysed on a delocalized resuscitation machine GEM 4000 (Werfen) and 2) by…
- Trial name
- CAPIVEIN (NCT03890146)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Uremic Pruritus
CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
This is a multicenter, international study to evaluate the safety and efficacy of intravenous (IV) CR845 at a dose of 0.5 mcg/kg administered after each dialysis session.
- Trial name
- KALM-2 (NCT03636269)
- Testing
- CR845 0.5 mcg/kg
- Where
- 92 sites in United States, Australia and 9 more
- Volunteers
- 473 people
- Sponsor
- Cara Therapeutics, Inc.
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