Clinical trials: Pathophysiology
Heart Failure, Cardiomyopathies
Towards Understanding the Phenotype of Cardiovascular Disease in CKD - TRUE-Type-CKD Study
Premature cardiovascular disease (CVD) is the leading cause of death in patients with kidney disease (CKD). Excessive cardiac mortality is thought to be secondary to non-atherosclerotic processes, with left ventricular (LV)…
- Conditions
- Heart Failure, Cardiomyopathies, Chronic Kidney Diseases, Hypertrophy, Left Ventricular
- Trial name
- TRUE-TypeCKD (NCT03749551)
- Testing
- cardiac magnetic resonance (CMR) post haemodialysis
- Where
- Germany
- Volunteers
- 276 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Smoking, Orofacial Dysfunction
Effect of Passive Smoking on Orofacial Dysfunction Among a Group of Egyptian Children: A Cohort Study
This study aims to investigate the orofacial dysfunction in children who are subjected to passive smoking and to correlate its results to their saliva cotinine levels
- Trial name
- ACU222 (NCT05678153)
- Testing
- Nordic Orofacial Test-Screen (NOT-S)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ahram Canadian University
Mild Cognitive Impairment
Effects of Memory Boot Camp on Brain Function in Adults With Symptoms of Mild Cognitive Impairment (MCI)
This is a prospective controlled clinical trial to determine the effects of a 12-week Memory Boot Camp (MBC) program on cognitive function in older adults with symptoms of Mild Cognitive Impairment.
- Trial name
- NCT04426162
- Testing
- Multi-domain Intervention
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Neurocore
Blepharitis, Meibomian Gland Dysfunction
Antimicrobial and Clinical Efficacy of Cliradex® as Compared With I-Lid'n Lash® Hygiene in Treating Blepharitis
Previous studies have shown the clinical and antimicrobial efficacy of eyelid hygiene with tea tree oil (TTO) in resolving chronic blepharitis.
- Trial name
- NCT03422146
- Testing
- Tea Tree Oil (TTO), I-Lid'n Lash® Hygiene
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Temporomandibular Joint Disorders, Bruxism
Botox for Treatment of TMJ Disorder With Bruxism
Hypothesis: Myofascial temporomandibular joint disorder and related symptoms are associated with mandibular condyle and temporal fossa overloading secondary to temporalis and masseter muscle hyperactivity and spasm This study…
- Conditions
- Temporomandibular Joint Disorders, Bruxism, Temporomandibular Joint Dysfunction Syndrome, Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint
- Trial name
- TMJ (NCT02202070)
- Testing
- onabotulinumtoxinA
- Where
- United States
- Sponsor
- Washington University School of Medicine
Erectile Dysfunction
Evaluation of the Coloplast Titan® IPP for Maintaining Penile Length While Treating Erectile Dysfunction (ED)
This study is designed to assess the effectiveness of the Coloplast Titan® Inflatable Penile Prosthesis (IPP) at maintaining or increasing penile length after implantation of the device.
- Trial name
- NCT00731666
- Testing
- Inflatable Penile Prosthesis
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Coloplast A/S
Lung Transplant Failure and Rejection
Long Term Follow up of the LTOG Cohort
The purpose of the study is to follow participants who enrolled in the Lung Transplant Outcomes Group. Clinical data, functional assessments, and surveys will be collected to determine long term graft function and functional…
- Trial name
- LTOG (NCT04787822)
- Where
- 10 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- University of Pennsylvania
Autoimmune Diseases, Cardiovascular Disorders
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions
This multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions.
- Conditions
- Autoimmune Diseases, Cardiovascular Disorders, Diabetes Complications, Integumentary Disease
- Trial name
- NCT04684602
- Testing
- PrimePro™/ PrimeMSK™
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Thomas Advanced Medical LLC
Sexual Dysfunction
Efficiency of Tadalafil for Management of Female Sexual Dysfunction
comparative study between tadalafil versus placebo effect for the management of circumsized female
- Trial name
- NCT05266651
- Testing
- Tadalafil 5mg
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Kasr El Aini Hospital
Cognitive Decline
Evaluation of Cognitive State Using Neurosteer EEG System
This is an observational study. Patients who fulfill all inclusion criteria and none of the exclusion criteria will be enrolled in the study, be neurologically evaluated and will go through EEG recordings while listening to an…
- Trial name
- NCT04386902
- Testing
- Neurosteer Aurora system
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Neurosteer Ltd.
Cognitive Decline
MASCoD - Multidimensional Assessment of Subjective Cognitive Decline
Subjective cognitive decline-SCD is a subclinical cognitive impairment subjectively experienced without being detectable from a diagnostic and neuropsychological perspective.
- Trial name
- NCT05815329
- Testing
- cognitive training
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Cognitive Decline
Cognitive Function in Elderly Marathon Runners
There is substantial research on the effects of physical exercise on cognitive functions. However, less attention has been paid on the requirements of training intensity and length to enhance cognitive abilities in the elderly.
- Trial name
- APSOEM (NCT01045031)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Mild Cognitive Impairment, Alzheimer's Disease
Construction of Diagnosis System for Early AD Based on Multi-Modality MRI Technology
One purpose of this study is to construct the diagnosis system for early Alzheimer's disease(AD), which is also called amnestic mild cognitive impairment (aMCI), and then further construct the predictable classifier from aMCI to…
- Trial name
- NCT02353845
- Where
- China
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- XuanwuH 2
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
SARS-CoV2 Infection, Proximal Tubule Dysfunction
Analysis of SARS-CoV2 Urine Viral Particles and Association With Proximal Tubular Dysfunction
The primary goal is to detect Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV2) urine viral particles in patients in intensive care units, hospitalized for coronavirus Coronavirus Disease-19 (COVID-19) infection, and…
- Trial name
- CovUrinePTD (NCT04937712)
- Testing
- RT-PCR SARS-COV2 in urine
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Central Hospital, Nancy, France
Alzheimer Disease, Mild Cognitive Impairment
The COMFORTage Project at Ace Alzheimer Center Barcelona
The COMFORTage study at Ace Alzheimer Center Barcelona is investigating whether a personalized cognitive and functional stimulation program can help slow cognitive decline in individuals diagnosed with mild cognitive impairment…
- Trial name
- COMFORTage (NCT07031167)
- Testing
- Cognitive and functional stimulation using digital platforms
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació ACE Institut Català de Neurociències Aplicades
Mild Cognitive Impairment
Shanghai Mild Cognitive Impairment Cohort Study
This study was planned 1) to identify individuals with Mild Cognitive Impairment (MCI) who convert to Alzheimer's Disease (AD), and 2) to explore factors associated with the conversion.
- Trial name
- NCT01552265
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Pulmonary Disease, Pulmonary Hypertension
Natural History Study of Biomarkers in Pulmonary Arterial Hypertension
Background: High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a rare disorder. Some people have disease-associated PAH and some have PAH from an unknown cause.
- Trial name
- NCT01730092
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Urinary Retention
Treatment for Acute Postoperative Voiding Dysfunction
If patients are unable to have their foley catheter removed because their bladder is not emptying well, they may be eligible for study participation.
- Trial name
- PTNS (NCT01189136)
- Testing
- PTNS Active Treatment
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Relapsing-Remitting Multiple Sclerosis
Assessment of Attentional and Executive Disorders in Multiple Sclerosis Using Techniques of Virtual Reality
Since many years cognitive disorders are a main topic of clinical research in Multiple Sclerosis (MS) as there could be observed early on in the disease and could induce with time in patients significant socio-professional…
- Trial name
- SEPREV (NCT01805336)
- Testing
- Assessment of attentional functions by traditional tests, Assessment of attentional functions by virtual reality tests, Assessment of executive functions by traditional tests
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
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