Clinical trials: Pathophysiology
Aortic Valve Stenosis, Diastolic Dysfunction
Danish National Randomized Study on Early Aortic Valve Replacement in Patients With Asymptomatic Severe Aortic Stenosis
The purpose of this study is to examine the impact of early surgery in patients with asymptomatic severe aortic valve stenosis with signs of subclinical LV dysfunction despite preserved LVEF, with a watchfull waiting approach.
- Trial name
- DANAVR (NCT03972644)
- Testing
- Aortic valve replacement
- Where
- Denmark
- Volunteers
- 1,700 people
- Sponsor
- Odense University Hospital
Posterior Tibial Tendon Dysfunction
Effect of Percutaneous Needle Electrolysis (PNE) on Tendinopathy
The aim of this study is to test the efficacy of percutaneous electrolysis in posterior tibial tendinopathies. The posterior tibial tendon injury is one of the most frequent pathologies in the lower extremities, and therefore a…
- Trial name
- PNE (NCT05370092)
- Testing
- Percutaneous needle electrolysis, Therapeutic exercise, Manual therapy
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Universidad Rey Juan Carlos
Malnutrition, Environmental Enteropathy
Intervention and Mechanisms of Alanyl-Glutamine for Inflammation, Nutrition, and Enteropathy
Several host factors underlie the pathogenesis of the reciprocal cycle of childhood diarrhea and undernutrition in developing countries.
- Conditions
- Malnutrition, Environmental Enteropathy, Diarrhea
- Trial name
- IMAGINE (NCT01832636)
- Testing
- Alanyl-Glutamine
- Where
- Brazil
- Volunteers
- 112 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Executive Dysfunction, Pain
Feasibility and Efficacy of rTMS in Healthy Persons
Transcranial magnetic stimulation (TMS) is a neuromodulation device that is FDA-approved for use in treating depression and obsessive compulsive disorder.
- Conditions
- Executive Dysfunction, Pain, Mood
- Trial name
- TPD (NCT04074811)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wayne State University
Sacroiliac Dysfunction
Study of Bone Growth in the Sacroiliac Joint After Minimally Invasive Surgery With Titanium Implants
SALLY studies sacroiliac joint fusion with the iFuse-3D implant.
- Trial name
- SALLY (NCT03122899)
- Testing
- SIJ fusion with iFuse-3D
- Where
- 11 sites in United States
- Volunteers
- 51 people
- Sponsor
- SI-BONE, Inc.
Cognitive Ability, General, High Blood Pressure
Assessing the Impact of Calcium Channel Blockers on COGnitive Function in the Very Elderly (AI-COG)
Older adults are at increased risk of high blood pressure and cognitive decline. High blood pressure itself also increases risk of cognitive decline.
- Trial name
- NCT01868165
- Where
- 7 sites in United Kingdom
- Volunteers
- 337 people
- Sponsor
- Imperial College London
Alzheimer Disease, Mild Cognitive Impairment
Brain Energy for Amyloid Transformation in Alzheimer's Disease Study
The Brain Energy for Amyloid Transformation in AD (Alzheimer's disease) or BEAT-AD study will compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment.
- Trial name
- BEAT-AD (NCT03472664)
- Testing
- low carbohydrate/high fat diet, low fat/high carbohydrate diet
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Wake Forest University Health Sciences
Pelvic Floor Dysfunction, Perineal Laceration
Perineal Protection Device for Reducing Perineal Trauma During Vaginal Delivery in First-time Mothers: a Multicenter Randomized Controlled Trial
The goal of this clinical trial is to determine whether using a soft perineal protection device (BabySlide®) in addition to standard manual perineal support during vaginal delivery can reduce the risk of perineal trauma in…
- Conditions
- Pelvic Floor Dysfunction, Perineal Laceration, Wound Dehiscence, Anal Incontinence
- Trial name
- PeriPROTECT (NCT07862660)
- Testing
- Perineal protection device, BabySlide, Standard manual perineal support
- Where
- Sweden
- Volunteers
- 4,226 people
- Sponsor
- Region Skane
Functional Disturbance Following Cardiac Surgery
Respiratory Physiotherapy After Cardiac Surgery
Although incentive spirometry is commonly used to avoid pulmonary complications in cardiac surgery patients, the breath-stacking technique has been proposed as an alternative to increase pulmonary volumes in the post-operative…
- Trial name
- NCT01513642
- Testing
- Breath Stacking
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Mild Cognitive Impairment in Middle-aged Adults
Deafness and Cognition in Middle-aged Adults
A mild cognitive impairment was observed in 50% of cochlear implant candidates aged 65 years and over, compared to 5-19% in general population. No studies analysed cognition in patients younger than 65 years.
- Trial name
- SURDICOG (NCT05149742)
- Testing
- Cognitive and audiometry evaluation
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberous Sclerosis Complex, Aspirin
Aspirin as an add-on Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex
There had been much evidence in aspirin controlling tumorous conditions conducted by basic researches, especially through mammilian target of rapamycin (mTOR) pathway.
- Conditions
- Tuberous Sclerosis Complex, Aspirin, Epilepsy, Cognitive Decline
- Trial name
- NCT03356769
- Testing
- Aspirin, AED
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Peking Union Medical College Hospital
Neuropathic Pain
The Prevalence of Neuropathic Pain Pathophysiology Associated With Ankle Fracture
This application addresses the Peer Reviewed Medical Research Program Investigator-Initiated Research Award FY21 W81XWH-22-CPMRP-IIRA area of Chronic Pain Management Research Program- The investigators will utilize subjects who…
- Trial name
- AFNP (NCT06420141)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Indiana University
Postoperative Gastrointestinal Dysfunction (POGD)
the Effect of Transcutaneous Electrical Acupoint Stimulation on Postoperative Gastrointestinal Dysfunction After Urological Laparoscopic Surgery
The purpose of this clinical trial is to understand the effect of percutaneous acupoint electrical stimulation on postoperative gastrointestinal dysfunction.
- Trial name
- NCT07133620
- Testing
- Transcutaneous electrical acupoint stimulation
- Where
- China
- Volunteers
- 112 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Sexuality, Sexual Dysfunction
Sexual Health in Patients With Hematologic Malignancies
Sexual wellbeing is an integral component of psychosocial and physical wellbeing. Cancer-related symptoms, treatment side-effects and psychosocial distress have significant impact on sexual well-being and sexual health.
- Conditions
- Sexuality, Sexual Dysfunction, Psychological, Quality of Life
- Trial name
- NCT05222282
- Testing
- Sexual Health
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sickle Cell Anemia
The Influence of micro-and Macro Vascular Dysfunction on Clinical Severity in Adults With Sickle Cell Anemia (SS) and Sickle Cell Hemoglobin C Disease (SC)
The primary aim of this study is to determine the implication of micro and macro vascular function on the clinical severity of SCD (SS, SC, Sß°) adults.
- Trial name
- VASCUDREPA (NCT07277023)
- Testing
- The influence of micro-and macro vascular dysfunction on clinical severity in adults with sickle cell anemia (SS) and sickle cell hemoglobin C disease (SC)
- Where
- Guadeloupe
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Distress, Emotional, Emotional Dysfunction
Brief Interventions for Coping with Distress
This study is being done to compare the effectiveness of three different skills trainings to cope with distress. These three trainings are: 1) an attention skills training, 2) an attention and reflective thought skills training…
- Conditions
- Distress, Emotional, Emotional Dysfunction, Anxiety, Depression
- Trial name
- NCT05779761
- Testing
- Online, Self-Directed Attention Skills Training with Coaching Support, Online, Self-Directed Attention & Reflective Thought Skills Training with Coaching Support, Online, Self-Directed Health & Wellness Education Training with Coaching Support
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Teachers College, Columbia University
Breast Cancer, Heart Failure
Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction
Trastuzumab is an important treatment for HER 2 positive breast cancer. But trastuzumab can cause injury to the heart, and this is one of the main reasons it cannot be administered as planned.
- Trial name
- SCHOLAR-2 (NCT04680442)
- Testing
- Trastuzumab, Pertuzumab, Trastuzumab emtansine
- Where
- 8 sites in Brazil, Canada and 1 more
- Volunteers
- 130 people
- Sponsor
- Population Health Research Institute
Hypogonadism
The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism
The study is designed to answer the following questions: 1) What is the effect of testosteron replacement treatment on the endothelial dysfunction. 2/ What is the effect of testosteron replacement on the bone mineral metabolism.
- Trial name
- NCT02111473
- Testing
- Testosterone
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Gulhane School of Medicine
Smell Dysfunction, Olfactory Disorder
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss.
- Conditions
- Smell Dysfunction, Olfactory Disorder, Long COVID
- Trial name
- NCT05855369
- Testing
- Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Medical University of South Carolina
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), HIV Infections
Lifestyle, Dietary Patterns, and Cardiometabolic Risk in Metabolic Dysfunction-Associated Steatotic Liver Disease Among People Living With HIV
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, is an increasingly recognized comorbidity in people living with human immunodeficiency virus (HIV).
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), HIV Infections, Non-Alcoholic Fatty Liver Disease, Liver Cirrhosis
- Trial name
- NCT07861594
- Volunteers
- 250 people
- Sponsor
- Assiut University
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