Clinical trials: Pathophysiology
Vulvar Atrophy, Vulvovaginal Signs and Symptoms
Changes in the Impact of Genitourinary Syndrome of Menopause With a Novel Nonhormonal Vulvovaginal Gel Assessed by PROMs.
The goal of this clinical trial is to improve the management of Genitourinary syndrome of menopause (GSM) to preliminary assess safety and effectivity of a novel hormone-free mucosa composition (XCMIM20m) applied topically to the…
- Conditions
- Vulvar Atrophy, Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause, Quality of Life
- Trial name
- STOPGSMP (NCT06962345)
- Testing
- Hormone-free vulvovaginal gel with the tested composition XCMIM20m
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Mucosa Innovations, S.L.
Stroke, Stroke Sequelae
Mindfulness Based Stress Reduction and Post-Stroke Cognition
The investigators don't fully understand how, regardless of the size or location in the brain, minor strokes can result in significant problems with focus, attention, and multi-tasking that prevent individuals from returning to…
- Conditions
- Stroke, Stroke Sequelae, Depression, Cognitive Impairment
- Trial name
- NCT04302493
- Testing
- Mindfulness Based Stress Reduction (MBSR), Stroke Support Group (SSG)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Sphincter of Oddi Dysfunction
Virtual Reality in SOD
Patients with classic type-3 Sphincter of Oddi dysfunction have chronic debilitating pain not amenable to pharmacologic or endoscopic therapy.
- Trial name
- NCT03999333
- Testing
- Virtual Reality (Oculus Go)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Cedars-Sinai Medical Center
Parkinson's Disease, Mild Cognitive Impairment
A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease
This randomized, controlled trial (RCT) evaluates the benefits of memory and problem solving training compared to supportive therapy in individuals with Parkinson's Disease with Mild Cognitive Impairment (MCI) and their support…
- Trial name
- NCT01646333
- Testing
- Memory and Problem-Solving Intervention, Supportive Therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Virginia Commonwealth University
Endometriosis
A Study to Evaluate the Safety and Effectiveness of Asoprisnil in the Treatment of Women With Endometriosis.
The objective of this study is to determine the safety and efficacy of 3 asoprisnil doses (0.5 mg, 1.5 mg, and 5.0 mg) for 12 weeks in women with endometriosis.
- Trial name
- NCT00160433
- Testing
- Asoprisnil
- Volunteers
- 131 people
- Sponsor
- Abbott
Erectile Dysfunction
Psychotherapy and Pharmacotherapy in the Treatment of Erectile Dysfunction: A Pilot Study
The study involved the administration of pharmacotherapy and cognitive behavior psychotherapy to individuals suffering from erectile dysfunction. The study was randomized controlled trial with two arms involving a control group.
- Trial name
- NCT04179747
- Testing
- Cognitive Behavioral Psychotherapy, Sildenafil Citrate 50Mg Tab
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- International Islamic University, Islamabad
Older Patients, Cognitive Impairment
Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery
Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery (DNR) and postoperative neurocognitive disorder (POCD).
- Conditions
- Older Patients, Cognitive Impairment, Repetitive Transcranial Magnetic Stimulation, Delayed Neurocognitive Recovery
- Trial name
- NCT06482749
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- 3 sites in China
- Volunteers
- 568 people
- Sponsor
- Peking University First Hospital
Major Depressive Disorder, Apathy
Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
The goal of this randomized controlled trial is to evaluate the potential of a customized digital cognitive training intervention to target aspects of brain function in apathy of late-life depression and reduce symptoms of apathy…
- Trial name
- NCT05877885
- Testing
- Targeted Cognitive Training Intervention, General Cognitive Training Intervention
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- AdventHealth
Post-Stroke Cognitive Impairment (PSCI), Ischemic Stroke
Evaluation of Clinical Efficacy and Mechanism of Hand Jing-Well Acupoint Transcutaneous Electrical Stimulation in Improving Post-Stroke Cognitive Impairment
This study evaluates a non-invasive electrical stimulation therapy applied to specific acupoints on the fingers (called Jing-Well points) to improve thinking and memory problems after stroke.
- Conditions
- Post-Stroke Cognitive Impairment (PSCI), Ischemic Stroke, Cognitive Dysfunction, Cognitive Disorder, Hemorrhagic Strokes
- Trial name
- NCT07736885
- Testing
- Transcutaneous Electrical Stimulation at Jing-Well Acupoints
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Breast Cancer, Cognitive Change
Computerized Cognitive Training in Breast Cancer Survivors
For millions of cancer survivors, cognitive impairment is a prevalent, severe, and persistent problem that is associated with other symptoms (depressive symptoms, anxiety and fatigue), poorer work ability, and poorer quality of…
- Conditions
- Breast Cancer, Cognitive Change, Cognitive Impairment, Quality of Life
- Trial name
- NCT05570604
- Testing
- Sweep Seeker, Bird Safari, Jewel Diver
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Ohio State University
Diabetes Mellitus and Heart Failure
A Dose Finding Study to Assess the Effect of LIK066 Compared to Placebo or Empagliflozin in Patients With Type 2 Diabetes Mellitus and Heart Failure
This was a dose-finding study to evaluate the efficacy, safety and tolerability of 3 different doses of LIK066 compared to placebo or empagliflozin in T2DM patients with heart failure
- Trial name
- NCT03152552
- Testing
- LIK066, Empagliflozin
- Where
- 106 sites in United States, Argentina and 22 more
- Volunteers
- 125 people
- Sponsor
- Novartis Pharmaceuticals
PARKINSON DISEASE (Disorder)
Virtual tES Device Treatment for Parkinson's Disease Motor Symptoms
This study tests a new, non-invasive brain stimulation device called Sphere V3.0 to help improve movement problems in people with Parkinson's disease.
- Trial name
- NCT07182058
- Testing
- Transcranial Electrical Stimulation Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- U: The Mind Company
Blood Coagulation Disorders
Study of Megakaryocytes From Patients With Abnormal Platelet Vesicles
Congenital bleeding disorders characterized by abnormal platelet granules include Gray Platelet syndrome (GPS; defective alpha-granules), Hermansky-Pudlak syndrome (HPS; defective delta-granules), and combined alpha delta-storage…
- Trial name
- NCT00086476
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
End Stage Renal Disease, Cardiovascular Disease
Pomegranate and Hemodialysis Pilot Trial
In this study, the investigators will administer pomegranate juice or fruit extract as a targeted antioxidant therapy to hemodialysis patients.
- Conditions
- End Stage Renal Disease, Cardiovascular Disease, Inflammation
- Trial name
- POM Pilot (NCT01562340)
- Testing
- Pomegranate juice, Pomegranate fruit extract
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
Transcranial Direct Current Stimulation
Noninvasive Transcranial Direct Current Stimulation to Improve Executive Functions in Stroke Patients. MODUL-EXE Clinical Trial.
This study will examine the possible effects of tDCS (Transcranial Direct Current Stimulation) treatment to the left DLPFC on executive functions in patients with an acute stroke affecting the frontal lobe or the basal ganglia.
- Trial name
- MODUL-EXE (NCT05628818)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Mild Cognitive Impairment
Multidisciplinary Intervention for Mild Cognitive Impairment
The purpose of this investigation is to conduct a series of case studies on the impact of a novel functional medicine approach to improving cognitive skills, brain structure, and daily functioning for participants with Mild…
- Trial name
- (MCI) (NCT02943187)
- Testing
- Cognitive training, Nutrition
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Gibson Institute of Cognitive Research
Metabolic Dysfunction-assocated Steatohepatitis/ Nonalcoholic Fatty Liver Disease
Study of TVB-2640 in Subjects With Nonalcoholic Steatohepatitis (NASH)
This is a Phase 2, multi-center, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy on TVB-2640 in subjects with non-alcoholic steatohepatitis (NASH).
- Trial name
- NCT04906421
- Testing
- TVB-2640
- Where
- 117 sites in United States, Canada and 2 more
- Volunteers
- 168 people
- Sponsor
- Sagimet Biosciences Inc.
Erectile Dysfunction
A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation
The primary purpose of the study is to demonstrate that dapoxetine can prolong intravaginal ejaculatory latency time (IELT) compared with placebo in men with premature ejaculation (PE).
- Trial name
- NCT00210704
- Testing
- Dapoxetine
- Volunteers
- 1,067 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Stroke, Executive Dysfunction
Effectiveness of Computer-based Cognitive Training for Executive Functions After Stroke
Objective: To determine the efficacy of computer-based cognitive training(CBCT) in patients with stroke in the community settings.
- Conditions
- Stroke, Executive Dysfunction, Cognitive Impairment, Randomized Controlled Trial
- Trial name
- NCT04944004
- Testing
- CogniPlus, Training As Usual (TAU)
- Volunteers
- 100 people
- Sponsor
- TWGHs Wong Tai Sin Hospital
Irritable Bowel Syndrome, Gastrointestinal Diseases
Evaluation of Efficacy of Skål Pro Powder on Symptoms of Irritable Bowel Syndrome
The objective of this randomized, double-blind, placebo-controlled study is to evaluate the effectiveness of Skal Pro in alleviating symptoms, enhancing stool consistency, improving quality of life, and addressing psychological…
- Conditions
- Irritable Bowel Syndrome, Gastrointestinal Diseases, Colonic Diseases, Functional, Intestinal Disease
- Trial name
- NCT06271538
- Testing
- Skal Pro
- Where
- Malaysia
- Volunteers
- 57 people
- Sponsor
- EP Plus Group Sdn Bhd
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