Clinical trials: Pathophysiology
Mild Cognitive Impairment, Subjective Cognitive Decline
Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog
The purpose of this study is to establish a longitudinal cohort of older adults with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI): 1) at heightened risk for dementia, and 2) from…
- Trial name
- NCT06542458
- Testing
- Assessments, Neuroimaging volumetric measures, Biofluid samples
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Meibomian Gland Dysfunction, MGD-Meibomian Gland Dysfunction
Study to Evaluate the Safety and Efficacy of Minocycline Ointment in Subjects With Inflamed Meibomian Gland Dysfunction
To evaluate the efficacy and safety of two strengths of HY02 Ointment versus Vehicle administered twice daily for twelve weeks in subjects with a diagnosis of Inflamed Meibomian Gland Dysfunction.
- Trial name
- NCT03888378
- Testing
- 0.3% Topical Minocycline Ointment, 1% Topical Minocycline Ointment, Topical Vehicle Ointment
- Where
- 20 sites in United States
- Volunteers
- 270 people
- Sponsor
- Hovione Scientia Limited
Heart Failure, Mild Cognitive Impairment
Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure
This research project is relevant to public health because both heart failure (HF) and mild cognitive impairment (e.g., trouble remembering and concentrating beyond normal aging) are highly prevalent among older adults in the…
- Trial name
- NCT05601817
- Testing
- Vita, Com, Vita+Com
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Indiana University
Alzheimer's Disease - MCI
Noninvasive Brain Stimulation for pAD
Episodic memory refers to the conscious recalling of a personal experience and includes information of an event and the context in which the event took place.
- Trial name
- pADmemory (NCT05468268)
- Testing
- 20 Hz rTMS
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Trento
Chronic Renal Insufficiency
An Ascending Dose Study to Assess Safety, Tolerability, PK/PD of LHW090 in Healthy Volunteers and in Subjects With Renal Dysfunction
The purpose of the study is to provide pertinent information to enable decisions regarding the developability of LHW090 for use in patients with chronic renal insufficiency, including a comparison of the potential risk-benefit…
- Trial name
- NCT01846468
- Testing
- LHW090
- Where
- 2 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Lower Urinary Tract Disorder
Pelvic Floor Muscle Activity, Respiratory Functions, Respiratory Muscle Strength, and Functional Capacity in Children With Lower Urinary Tract Dysfunction
The functional disorders of the lower urinary tract in children involve overactive bladder with thickening of the bladder muscle, resulting in a decrease in functional bladder volume and an increase in intra-bladder pressure.
- Trial name
- NCT06652178
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Alzheimer Disease, Mild Cognitive Impairment
LEADing Dementia End-of-Life Planning Conversations
Advance care planning is important for all adults, but perhaps even more so for the 5.7 million persons with Alzheimer's disease or related dementia (ADRD), due to the progressive and protracted cognitive deterioration associated…
- Trial name
- LEAD (NCT05909189)
- Testing
- LEADing Dementia End-of-Life Planning Conversations
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Utah
Melatonin, Cognitive Dysfunction
Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia
This study aims to evaluate the possible effect of melatonin on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing transurethral resection of the prostate (TURP) under spinal anesthesia
- Conditions
- Melatonin, Cognitive Dysfunction, Postoperative Complications, Prostate Hyperplasia
- Trial name
- NCT03966950
- Testing
- melatonin
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Ascites
Comparison of Crystalloid and Colloid I.V Fluid Therapy in Prevention of Paracentesis Induced Circulatory Dysfunction (PICD) and Renal Dysfunction in Patients With Decompensated Liver Cirrhosis in Egypt: a Randomized Piolet Study
2.2 Aim(s) of the Research (50 words max): To Compare between crystalloid and colloid I.V fluid therapy in the prevention of paracentesis induced circulatory dysfunction (PICD) and renal dysfunction in patients with decompensated…
- Trial name
- NCT05220891
- Testing
- Paracentesis
- Volunteers
- 60 people
- Sponsor
- Shady Ashraf Kassem
Preterm Birth
Evaluating Patterned Oral Somatosensory Entrainment Stimulation Using the NTrainer on Oral Feeding Performance
This is a research study to determine if an experimental device called the NTrainer can improve oral feeding skills more quickly and more effectively than traditional methods in infants who are at high risk of feeding dysfunction…
- Trial name
- NCT01069718
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- KC BioMediX, Inc
Anemia, Sickle Cell
Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease - Pilot Intervention Study
Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited blood disease that can cause intense pain episodes and may lead to organ failure.
- Trial name
- NCT00850018
- Testing
- Monthly blood transfusion regimen, Usual care
- Where
- 14 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Obesity
Executive Function in Obese
This study was planned to examine the effect of executive function problems on physical performance and general well-being in obese individuals.
- Trial name
- NCT06578091
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kutahya Health Sciences University
Gastrointestinal Dysfunction
Determination of the Safety and Efficacy of Two Probiotic Strains
The goal of this study is to determine the safety and efficacy of two probiotic strains in adults with mild to moderate gastrointestinal discomfort.
- Trial name
- CODECS (NCT06466174)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Allergic Conjunctivitis, Dry Eye Disease (DED)
Clinical and Biological Evaluation of NAAGA Versus Azelastine Eye Drops in Allergic Subjects With Tear Film Dysfunction
This randomized, single-blind study aims to compare the efficacy and safety of N-acetyl-aspartyl-glutamate (NAAGA) and azelastine hydrochloride eye drops in patients with allergic conjunctivitis associated with tear film…
- Trial name
- NCT06800274
- Testing
- NAAGA (N-acetyl-aspartyl-glutamate) 49 mg/mL, azelastine hydrochloride 0.05%
- Where
- Italy
- Volunteers
- 134 people
- Sponsor
- Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona
Upper Extremity Dysfunction, Dementia
Upper Limb Reeducation Across Life Span
Program Ready2E.A.T. was developed to be tested in the upper limb reeducation on population at risk, such as: Children with dysfunction Cognitive impaired elderly Dementia people
- Conditions
- Upper Extremity Dysfunction, Dementia, Cerebral Palsy, Cognitive Decline
- Trial name
- ULReed (NCT03997591)
- Testing
- Ready2E.A.T. PROGRAM
- Where
- Portugal
- Volunteers
- 15 people
- Sponsor
- Instituto Politécnico de Leiria
Heart Failure, Left Bundle-Branch Block
Optimised MultiSite Pacing Vector Study
The objective of this clinical investigation is to evaluate the clinical benefits of an MultiSite pacing (MSP) with patient specific left ventricular vector optimization in patients receiving cardiac resynchronization therapy…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Systolic Dysfunction
- Trial name
- NCT03938090
- Testing
- Optimised MultiSite Pacing, Standard biventricular pacing
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Right-sided Colon Cancer
RISE Ileocecal Valve Functional Reconstruction
The traditional surgical treatment for right-sided colon cancer involves the removal of an important structure, the ileocecal valve, which includes the ileocecal valve.
- Trial name
- NCT07167420
- Testing
- RISE (Revolute Insert Side-End ileocecal valve reconstruction)
- Volunteers
- 188 people
- Sponsor
- Army Medical University, China
Apathy, Mild Cognitive Impairment
Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment
Apathy, a profound loss of initiative and motivation, is often seen in older Veterans with memory problems. Apathy leads to serious health problems, increases dependency, and caregiver burden.
- Conditions
- Apathy, Mild Cognitive Impairment, Transcranial Magnetic Stimulation, Loneliness
- Trial name
- TAMCI (NCT03590327)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Taurine, Cognitive Decline
Taurine Supplementation on Cognitive Function in Patients With Diabetes
Diabetes has become important risk factors for threatening human life and health. Studies have shown that chronic hyperglycemia lead to microvascular brain injury. The more common types of dementia are Alzheimer's disease (AD).
- Conditions
- Taurine, Cognitive Decline, Diabetes Mellitus
- Trial name
- NCT03410173
- Testing
- Taurine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Military Medical University
Acute Kidney Injury
Application of CLCVP Technique in Early Intervention of CSA-AKI
The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT05855954
- Testing
- controlled low central venous pressure technique (CLCVP)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
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