Clinical trials: Patient Blood Management
Surgery
Safety and Effectiveness of a Patient Blood Management (PBM) Program in Surgical Patients
This study will evaluate clinical outcome after the step-wise implementation of a Patient Blood Management (PBM) Program in surgical patients at 4 hospitals.
- Trial name
- PBM (NCT01820949)
- Where
- 4 sites in Germany
- Volunteers
- 110,000 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Schizophrenia
A Study of Paliperidone Blood Concentrations in Patients With Schizophrenia After Administration of Paliperidone Palmitate
The purpose of this study is to evaluate the concentration of paliperidone in the blood after intramuscular injection in upper arm (deltoid muscle) or in the buttock (gluteal muscle) in patients with schizophrenia.
- Trial name
- NCT01110317
- Testing
- paliperidone palmitate 100 mg
- Volunteers
- 49 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Hematologic Diseases, Hematologic Malignancies
Dose-ranging Study of a Single Administration of T-cell Add-back Depleted of Host Alloreactive Cells in Patients Undergoing a Peripheral Blood Stem Cell Transplant From a Related, Haploidentical Donor
The purpose of this study is to determine the maximum tolerated dose and evaluate the safety of the administration of donor lymphocytes depleted of alloreactive T-cells following a stem cell transplant from a related…
- Trial name
- NCT00993486
- Testing
- Donor lymphocyte preparation depleted of functional host alloreactive T-cells (ATIR)
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Kiadis Pharma
Coronary Heart Disease, Dyslipidemia
Cardiovascular Risk Factor Management in HIV Infection
There is growing evidence that antiretroviral therapy (ART) increases the risk of coronary heart disease (CHD) through metabolic side effects, such as dyslipidemia, insulin resistance, and type II diabetes.
- Conditions
- Coronary Heart Disease, Dyslipidemia, Diabetes Mellitus, Non-Insulin-Dependent, HIV Infection
- Trial name
- NCT00264394
- Testing
- Updated CHD risk profiles, Guidelines
- Where
- 7 sites in Switzerland
- Volunteers
- 4,097 people
- Sponsor
- University Hospital, Basel, Switzerland
Type 2 Diabetes Mellitus (T2DM)
The Effect of Individualized Nursing Interventions on Glycemic Variability and Self-Management in Type 2 Diabetes
Type 2 diabetes is a chronic disease with an increasing prevalence worldwide and in our country. In managing type 2 diabetes, the primary goal in the nursing process is to ensure blood glucose stability.
- Trial name
- NCT06973395
- Testing
- Nursing interventions, education, and follow-up will be provided to Type 2 diabetes patients for blood glucose variability.
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ataturk University
Aortic Dissection, Lung Infection
Population Pharmacokinetics of Lassila Tazobactam in Patients After Aortic Dissection
The individualized drug use research on optimizing piperacillin tazobactam for CRRT of hospital-acquired pulmonary infection after cardiopulmonary bypass is still in the initial stage at home and abroad, lacking systematic…
- Trial name
- NCT05349305
- Testing
- continuous renal replacement therapy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Shandong University
HIV Infections
The Safety and Effectiveness of Adefovir Dipivoxil Plus Indinavir Combined With Zidovudine or Lamivudine or Stavudine in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs
To evaluate the safety and tolerance of adefovir dipivoxil and indinavir administered orally in combination with zidovudine, lamivudine, or stavudine in HIV-infected patients with CD4 cell counts >= 100 cells/mm3 and an HIV-1 RNA…
- Trial name
- NCT00002379
- Testing
- Indinavir sulfate, Levocarnitine, Adefovir dipivoxil
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 100 people
- Sponsor
- Gilead Sciences
Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia
Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant
RATIONALE: Infection prophylaxis and management may help prevent cytomegalovirus (CMV) infection caused by a stem cell transplant.
- Conditions
- Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
- Trial name
- NCT01199562
- Testing
- infection prophylaxis and management, laboratory biomarker analysis, flow cytometry
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- City of Hope Medical Center
Leukemia, Lymphoma
Antiviral Therapy Plus Either Peripheral Stem Cell or Umbilical Cord Blood Transplantation in Treating Patients Who Are HIV Positive and Have Hematologic Cancer
RATIONALE: Antiviral agents are drugs that act against viruses and may be an effective treatment for HIV. Peripheral stem cell transplantation or umbilical cord blood transplantation may be able to replace immune cells that were…
- Trial name
- NCT00003435
- Testing
- anti-thymocyte globulin, melphalan, antiviral therapy
- Where
- United States
- Sponsor
- Duke University
Transfusion
Intraoperative Transfusion Practice in Children
The purpose of this study is to examine factors, impact and outcome on perioperative blood transfusion for pediatric patients.
- Trial name
- NCT04282382
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Maternal Behavior, Mobile Health
A Prospective Randomized Controlled Trial of Mobile Medical Used for Management of Pregnant Women
A multicenter, randomized controlled trial was conducted to investigate whether health education and life style management through WeChat group chat was: 1. more effective in improving pregnancy outcomes in normal pregnant women.
- Conditions
- Maternal Behavior, Mobile Health, Pregnancy Outcome, GDM
- Trial name
- NCT03748576
- Testing
- telemedicine: management through WeChat group chat
- Where
- China
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Type 1 Diabetes
The Effects of Regular Home Use Vs Diabetic Team- Supported Use of the Medtronic CareLink Therapy Management System.
Randomized, two arms, controlled, open study comprised of two consecutive segments. At the first segment that will last during the first 4 months of the study, patients will be randomized to the Care link treated group or non…
- Trial name
- CareLink (NCT00814476)
- Testing
- Medtronic CareLink therapy management system, regular home use and Medtronic CareLink Therapy Management
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Rabin Medical Center
Immune Thrombocytopenia
DEX Combined With RTX, CSA and IVIG in the Management of Newly Diagnosed ITP Patients
The project was undertaken by Qilu Hospital, Shandong University in China. In order to report the efficacy and safety of dexamethasone combined with rituximab, cyclosporin and intravenous immunoglobulin in the management of newly…
- Trial name
- NCT02834468
- Testing
- DEX Combined With RTX, CSA and IVIG
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shandong University
Myocardial Infarction, Hypertension
Reducing Blood Pressure in Patients With High Cardiovascular Risk
BP-REACH is a study of a team-based (pharmacist and health coach) program for lowering blood pressure for people with a prior stroke or heart attack in the Los Angeles Department of Health Services healthcare system.
- Conditions
- Myocardial Infarction, Hypertension, Stroke
- Trial name
- BP-REACH (NCT05937685)
- Testing
- BP REACH Intervention
- Where
- 4 sites in United States
- Volunteers
- 546 people
- Sponsor
- University of Southern California
Hypoprothrombinemia
Randomized Controlled Feasibility Trial of the Fearon Algorithm to Improve Management of Unstable Warfarin
Patients on warfarin but with unstable international normalized ratio (INR) will be recruited to a randomized trial comparing dosing based on an algorithm (Fearon algorithm, named after the mathematician Michael Fearon), which…
- Trial name
- NCT02267408
- Testing
- Warfarin adjustment using the Fearon algorithm, Warfarin adjustment using standard dosing
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- McMaster University
Haemophilia
Combining Registry Data in Haemophilia: TARGET H
This is an investigator-initiated, multinational, retrospective, non-interventional pilot study conducted in five haemophilia treatment centres from different geographical regions that maintain a local (Algeria, Malaysia) or…
- Trial name
- TARGET-H (NCT03264014)
- Volunteers
- 100 people
- Sponsor
- University of Pretoria
Anemia
A Study to Observe the Causes and Treatment of Anemia in Critically Ill Children
The purpose of this study is to determine the incidence of anemia and blood transfusions and management of these in critically ill children
- Trial name
- NCT00211055
- Volunteers
- 1,201 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
HIV Infections
A Study of BMY-27857 in Patients With AIDS or AIDS Related Complex
To evaluate the safety, minimum effective dose (MED), pharmacokinetics and efficacy of orally administered 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) in patients with AIDS or AIDS related complex (ARC).
- Trial name
- NCT00000988
- Testing
- Stavudine
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Blood Transfusion Complication
To Establish a Blood Transfusion Prediction Model for Liver Transplantation Patients Based on PBM
Based on the principle of patient blood management, this study aims to reduce the risk of blood transfusion in allogeneic liver transplantation patients, to ensure the safety of blood transfusion, and to provide new methods and…
- Trial name
- NCT03814772
- Testing
- Liver transplant
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Cytomegalovirus Retinitis, HIV Infections
Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis
To compare cidofovir with a commonly used treatment regimen, ganciclovir given by mouth (oral) and through an eye device (intraocular) , in order to determine the safety and effectiveness of cidofovir in preventing vision loss in…
- Trial name
- NCT00000894
- Testing
- Cidofovir, Probenecid, Ganciclovir
- Where
- 12 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)