Clinical trials: Patient Comprehension
Pathologically Confirmed Differentiated Thyroid Carcinoma, All Patients Are in the Initial Treatment Phase
The Effect of a Psychosomatic Symptom Intervention Program on the Primary Treatment of Differentiated Thyroid Cancer
The psychosomatic symptoms of patients with differentiated thyroid cancer (DTC) during the initial treatment phase need to be improved.
- Conditions
- Pathologically Confirmed Differentiated Thyroid Carcinoma, All Patients Are in the Initial Treatment Phase, Normal Cognitive and Communicative Abilities, Capable of Reading and Understanding Questionnaires in Chinese, Ability to Use a Smartphone
- Trial name
- NCT06422702
- Testing
- Psychosomatic Symptoms Intervention, Extended supportive care
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Harbin Medical University
COVID-19
Minimal Invasive Autopsies to Investigate Changes in Deceased COVID-19 Patients
Rationale In a very short time corona virus disease 2019 (COVID-19) has become a pandemic with high morbidity and mortality. The main cause of death is respiratory failure including acute respiratory distress syndrome, however…
- Trial name
- MIA-COVID-19 (NCT04366882)
- Testing
- CT-scan with minimal invasive autopsy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Jessa Hospital
Cardiology, Pediatric Cardiac Surgery
PULSE - Patient Understanding and Learning Through Structured Education - Effectiveness and Implementation of Patient Education Videos in a New Pediatric Cardiology Clinic
This study is looking at whether short educational videos shown during pediatric cardiology visits can help families better understand their child's condition while also making clinic visits run more efficiently.
- Conditions
- Cardiology, Pediatric Cardiac Surgery, Education, Patient Education
- Trial name
- PULSE (NCT07594041)
- Testing
- Room-based educational video: Murmur, Chest Pain, Room-based educational video: Syncope, Palpitations, Room-based educational video: Sports Clearance, Kawasaki, General
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Driscoll Children's Hospital
Osteoarthritis, Arthritis, Degenerative
Understanding the Differences in the Management of Patients With Arthritis of the Knee or Hip
The purpose of this study is to examine cultural and clinical context factors in African-American and white veterans with knee or hip osteoarthritis with a focus on how these factors may be potentially modifiable determinants of…
- Conditions
- Osteoarthritis, Arthritis, Degenerative, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT00105677
- Where
- United States
- Volunteers
- 980 people
- Sponsor
- US Department of Veterans Affairs
Heart Failure With Reduced Ejection Fraction
Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score
The purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics.
- Trial name
- NCT07490067
- Testing
- Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Communication
Simulation Training in Undergraduate Nursing Education as a Means to Improve Awareness of Team Member Roles
Based on investigator's hypothesis, that incorporating the SBAR worksheet into the training of undergraduate Nursing students will increase their capacity to work in an interdisciplinary team, the investigators will assess…
- Trial name
- SBAR (NCT02289001)
- Testing
- Education on SBAR worksheet
- Volunteers
- 93 people
- Sponsor
- Universitat de Girona
Ovarian Cancer
The Effectiveness of an Online Support Group in Enhancing Recovery Identity and Health-Related Quality of Life
Background Ovarian cancer poses challenges for middle-aged and older patients, impacting physical and self-conceptual aspects. A research gap exists on the impact of online support groups (SPs) on identity synthesis and…
- Trial name
- NCT06145295
- Testing
- mobile online support group (experiment group), offline support group (control group)
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Obsessive-Compulsive Disorder
Translational Approach to the Understanding and Treatment of Obsessive-Compulsive Disorder (OCD). Can D-Cycloserine Enhance and Stabilize the Treatment-response in Relapsed and Non-responding OCD-patients?
In this randomized controlled trial (RCT) the investigators experimentally test if patients with Obsessive-Compulsive Disorder (OCD) who have received treatment with exposure and response prevention (ERP), but either relapsed or…
- Trial name
- NCT02656342
- Testing
- D-Cycloserine
- Where
- 14 sites in Norway
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Health Education
Dentists' Understanding of Diagnostic Test Results and Treatment Efficacy.
There is little evidence on how best to present diagnostic and treatment effect information to dentists and whether this makes any difference to their understanding of the information given and clinical management.
- Trial name
- RCDENT2017 (NCT03051295)
- Testing
- Dental health information form
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Invasive Aspergillosis, Mucormycosis
A Study to Understand How the Use of Paxlovid Affected the Healthcare Use in People With Pre-existing Conditions.
This is a non-interventional medical chart review study aiming to examine the effectiveness, safety, and treatment patterns of isavuconazole in 5 European countries (France, Germany, Italy, Spain, and United Kingdom).
- Trial name
- PRISMA (NCT04550936)
- Testing
- Isavuconazole
- Where
- 15 sites in France, Germany and 3 more
- Volunteers
- 307 people
- Sponsor
- Pfizer
Hematologic Neoplasms
Understanding What Matters Most to Patients: Establishing the Validity of a Best-Worst Scaling Survey
This study will evaluate the validity of using a survey to quantify patient preferences at the point-of-care and the potential effectiveness of the survey to improve goal-concordant care.
- Trial name
- NCT05061095
- Testing
- Assessment Surveys, Qualitative Interviews
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Opioid-use Disorder, Adherence, Medication
Social Networks and Methadone Maintenance Treatment Retention and Antiretroviral Therapy Retention in Tanzania
Investigators will adapt the Brief Social Behaviour and Network Therapy (B-SBNT) intervention developed to facilitate recovery among people receiving medication-assisted treatment for opioid use disorder in the United Kingdom.
- Conditions
- Opioid-use Disorder, Adherence, Medication, HIV Infections
- Trial name
- NCT04479475
- Testing
- Supportive care through community support persons
- Where
- Tanzania
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cancer
Visual Communication: Digital Tool to Improve the Understanding of Treatment Options for Patients With Cancer and Increase Satisfaction of the Overall Experience for Patients, Caregivers, and Providers
This is a study in patients with newly diagnosed cancer to prospectively evaluate the feasibility of integration of a visual communication tool for patients/caregivers/providers by determining whether such a tool can increase…
- Trial name
- NCT06927050
- Testing
- Visual Communication Tool
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- NYU Langone Health
Critical Illness, Respiratory Failure
International Observational Study on Airway Management in Critically Ill Patients
Endotracheal intubation (ETI) is a potentially life-threatening procedure for critically ill patients and major severe complications such as severe hypoxia, cardiovascular collapse and cardiac arrest are common.
- Conditions
- Critical Illness, Respiratory Failure, Hemodynamic Instability, Coma
- Trial name
- INTUBE (NCT03616054)
- Where
- Italy
- Volunteers
- 3,600 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Neurological Diseases or Conditions, Psychiatric Diseases
Understanding the Role of Monoaminergic Neurotransmitters in Cognitive Functions Using Fast-cyclic Voltammetry in Patients With Neurological and Psychiatric Diseases Eligible for Neurosurgical Treatment (COGAMINE)
This study aims at dynamically mapping local variations in the concentrations of monoaminergic neurotransmitters (for e.g. dopamine, serotonin and noradrenaline) in the human brain using fast-scan cyclic voltammetric recordings…
- Conditions
- Neurological Diseases or Conditions, Psychiatric Diseases, Candidates for Deep Brain Stimulation, Candidates for Invasive S-EEG
- Trial name
- COGAMINE (NCT06853977)
- Testing
- Cognitive tasks
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier St Anne
Weaning Failure
Improving Our Understanding of Respiratory Muscle Training to Facilitate Weaning From Mechanical Ventilation in the ICU
Mechanical ventilation is a life-saving treatment frequently applied in intensive care unit (ICU). Nonetheless, by putting at rest the respiratory muscles, it can lead to respiratory muscle weakness and atrophy, which are…
- Trial name
- TrainToWean (NCT04658498)
- Testing
- Procedure: Usual Care (UC), Procedure: UC + HI-IMT
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- KU Leuven
Pneumonia, Ventilator-Associated
Can we Better Understand the Development of VAP and Eventually Predict and Prevent it?
Pathogens of ventilator-associated pneumonia (VAP) come from colonizers of the trachea. The hypothesis of the investigators is that during the first days of intubation, independently of the use of antibiotics, there is a change…
- Trial name
- NCT01875692
- Where
- Switzerland
- Volunteers
- 286 people
- Sponsor
- University Hospital, Geneva
Hematology, Diffused Large B Cell Lymphoma
A Multicenter Observational Study to Understand the Clinical Characteristics, Treatment Patterns and Access to Novel Therapies of Patients With Diffuse Large B-Cell Lymphoma in the MEA Region
Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy, with over 80,500 estimated new cases diagnosed in the United States in 20231.
- Trial name
- DOMAIN (NCT07065344)
- Where
- 21 sites in Egypt, Iraq and 8 more
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Fibromyalgia
A DCE to Understand Patients' Preferences for Alternative Models of Care
A pilot survey for a Discrete Choice Experience to understand the strength of patient's preferences for alternative models of care for fibromyalgia.
- Trial name
- NCT05053464
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Chronic Lymphocytic Leukemia
Study to Understand Clinical Characteristics, Treatment Pathway in Chronic Lymphocytic Leukemia
A Multicenter Retrospective Study to understand the clinical characteristics, treatment pathway and resource utilization for patients with chronic lymphocytic leukemia A retrospective, multi-centre, observational study to…
- Trial name
- CREEK (NCT04964908)
- Where
- 52 sites in Argentina, Brazil and 15 more
- Volunteers
- 1,088 people
- Sponsor
- AstraZeneca