Clinical trials: Patient Non-Compliance
Patient Noncompliance
Customized Adherence Enhancement Plus Long-acting Injectable Antipsychotic
Psychotropic medications are a cornerstone of treatment for individuals with schizophrenia and schizoaffective disorder, however rates of full or partial non-adherence can exceed 60%.
- Trial name
- CAE-L (NCT01152697)
- Testing
- haloperidol decanoate, haloperidol, Customized Adherence Enhancement
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Child Behavior, Attention Deficit and Disruptive Behavior Disorders
Tantrum Tamers 2.0: The Role of Emotion
This study aims to better understand how to best help parents of young children with problem behavior. Problem behaviors vary between and within children, but can include inattention/hyperactivity, tantrums, and/or noncompliance.
- Conditions
- Child Behavior, Attention Deficit and Disruptive Behavior Disorders, Problem Behavior
- Trial name
- NCT03597789
- Testing
- Helping the Noncompliant Child (HNC)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Medication Adherence
Establishing Novel Antiretroviral Imaging for Hair to Elucidate Non-Adherence (ENLIGHTEN)
This is a pilot study to assess the feasibility, acceptability and appropriateness of delivery of the investigational "MedViewer" intervention in adult patients living with HIV who have been prescribed antiretroviral (ARV)…
- Trial name
- ENLIGHTEN (NCT04232540)
- Testing
- MedViewer report
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of North Carolina, Chapel Hill
Bipolar Disorder, Schizophrenia
Event Marker Ingested To Trigger Event Recorder 3.0 Psychiatry Study
Feasibility study of using a digital health feedback system (DHFS) to monitor medication-taking and physiologic and behavioral parameters in patients with bipolar disorder or schizophrenia.
- Trial name
- EMITTER3PSY (NCT01804257)
- Testing
- Digital Health Feedback System
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Proteus Digital Health, Inc.
Maxillary Sinusitis
Non-Interventional Open Label Prospective Comparative Observational Study Of Evaluation Of Compliance In The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Of Acute Bacterial Maxillary Sinusitis
The purpose of this study is to compare compliance between patients with Acute Bacterial Sinusitis (ABS) treated with Azithromycin SR 2.0 g single dose orally and those treated with Amoxiclav - 1000 mg twice daily 10 days for the…
- Trial name
- EASY (NCT01032174)
- Testing
- Azithromycin SR, Amoxiclav 1000 mg
- Volunteers
- 123 people
- Sponsor
- Pfizer
Epilepsy
Valproate Sustained Release Minitablets (Orfiril(R) Long) Once Daily in the Evening
Valproate is the first line therapy in primary generalized seizures. The applied drug contains sodium valproate in sustained release minitablets.
- Trial name
- NCT00870688
- Testing
- sodium valproate
- Volunteers
- 82 people
- Sponsor
- Desitin Arzneimittel GmbH
Schizophrenia
Patient-Centered Medication Adherence Intervention for Schizophrenia
Efficacious antipsychotic medication treatments for schizophrenia are available; however , antipsychotic regimens frequently do not achieve their potential because of poor medication adherence.
- Trial name
- AMAIS (NCT00144027)
- Testing
- Antipsychotic medication adherence intervention
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- US Department of Veterans Affairs
Venous Ulcer
Comparison of the Effectiveness of Two Medical Compression Bandage Application Techniques by Measuring Interface Pressures Depending on Whether or Not the Heel is Included in Patients With Open Venous Ulcers
The importance of wearing medical compression to heal the venous ulcer has already been shown. However, no studies have been carried out on variations in medical compression tape and their impact on interface pressures which…
- Trial name
- COMPARACHILLE (NCT04046120)
- Testing
- Heel-free bandage
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Nantes University Hospital
Hepatitis C, Chronic, Hepatitis C
Compliance of HCV Genotype 1 Infected Patients Receiving PegIntron/Rebetol and a Patient Assistance Program (Study P04671)
Enrolled patients will be recruited to two parallel groups during therapy for Hepatitis C. Patients in the first one will receive a patient assistance program, and patients in the second group will not.
- Trial name
- NCT00728494
- Testing
- PegIntron (peginterferon alfa-2b; SCH 54031), Rebetol (ribavirin; SCH 18908), Patient Assistance Program
- Volunteers
- 99 people
- Sponsor
- Merck Sharp & Dohme LLC
Adherence, Medication
Alterations in the Vaginal Microenvironment Using a Non-pharmacological Intervention
Breast cancer patients commonly take medications to reduce the risk of recurrence, including aromatase inhibitors (AIs). AIs can cause significant side effects that reduce patient adherence.
- Trial name
- NCT03739983
- Testing
- Vaginal Renewal Program
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Wisconsin, Madison
Bipolar Disorder
Customized Medication Adherence Enhancement for Adults With Bipolar Disorder
This study is a modular intervention that is intended to improve treatment adherence among individuals with bipolar disorder on atypical antipsychotic therapy who have been identified as having treatment adherence problems.
- Trial name
- UH CAE (NCT00830310)
- Testing
- Psychoeducation module, Substance use module, Improved communication/rapport with provider module
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University Hospitals Cleveland Medical Center
HIV Infections, Adolescent Development
Tailored Motivational Interviewing Implementation-Effectiveness Trial in Multidisciplinary Adolescent HIV Care Settings
The goal of this study is to test a multi-faceted Tailored Motivational Interviewing Implementation intervention (TMI), based on the Dynamic Adaptation Process (DAP) to scale up an Evidence-based Practice (EBP) in…
- Conditions
- HIV Infections, Adolescent Development, Care Eliciting Behavior, Patient Non-Compliance
- Trial name
- TMI (NCT03681912)
- Testing
- Competency: 12-Item Motivational Interviewing (MI) Coach Rating Scale (CRS), Randomized Guided Development of COPs with an internal facilitator after one year of implementation., CoP development without internal facilitation.
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Florida State University
Psychotic Disorders, Schizophrenia
A Concierge Model of CAE Plus LAI in Individuals With Schizophrenia at Risk for Treatment Non-adherence and Homelessness
This is a prospective study using a concierge model of customized adherence enhancement and long-acting injectable antipsychotic (CAL-Concierge) in 30 individuals with schizophrenia or schizoaffective disorder at risk for…
- Conditions
- Psychotic Disorders, Schizophrenia, Schizoaffective Disorder, Medication Adherence
- Trial name
- CAL-C (NCT02085447)
- Testing
- CAE-L
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Hepatitis C, Chronic
An Observational Study of Pegasys (Peginterferon Alfa-2a) Plus Copegus (Ribavirin) in Participants With Chronic Hepatitis C (CHC), Genotype 2, 3, 1 or 4, Undergoing Opioid Maintenance Therapy
This prospective, multi-center, observational study will evaluate the efficacy and safety of Pegasys (peginterferon alfa-2a) plus Copegus (ribavirin) in participants with previously untreated chronic hepatitis C, genotype 2, 3, 1…
- Trial name
- PEGHOPE (NCT01416610)
- Where
- 10 sites in Austria
- Volunteers
- 88 people
- Sponsor
- Hoffmann-La Roche
Hyperlipidemia
Compliance With Treatment For Patients With Hyperlipidemia
It is a prospective observational study. Patients will be high risk patients (for developing cardiovascular events) that are treated with a statin.
- Trial name
- COLL (NCT00828945)
- Testing
- Lipid Self Test
- Where
- 17 sites in Sweden
- Volunteers
- 259 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Medication Non-adherence
Mind Your Heart Study
This study investigated the feasibility and acceptability of a phone-delivered mindfulness intervention to improve medication adherence among outpatients with heart failure.
- Trial name
- NCT03571581
- Testing
- Mindfulness Training (MT)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The Miriam Hospital
Community-Acquired Pneumonia
Non-Interventional Open Label Prospective Observational Comparative Study On Evaluation Of Compliance Of The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Mild To Moderate Community Acquired Pneumonia
To compare compliance between patients with CAP treated with Azithromycin SR 2.0 g single dose orally and those treated with Amoxiclav - 1000 mg twice daily 10 days for the empiric treatment of CAP in outpatient clinic practice.
- Trial name
- PROSTO (NCT01032694)
- Testing
- Azithromycin SR, Amoxiclav
- Volunteers
- 30 people
- Sponsor
- Pfizer
Compliance Behavior
Beta Glucosylceramide for Treatment of NASH
Oral administration of betaglucosylceramide was shown effective in reducing inflammation in animal models and was found safe in humans.
- Trial name
- NCT02126306
- Testing
- Beta Glucosylceramide
- Volunteers
- 23 people
- Sponsor
- Hadassah Medical Organization
Alcohol Dependence, Alcohol Use Disorder
Extended-release Naltrexone and Care Management for Alcohol Dependent Frequent Emergency Department Users
Our primary aim is to assess the feasibility of initiating treatment in the ED with extended-release naltrexone (XR-NTX) plus care management (CM) vs.
- Trial name
- NCT02445339
- Testing
- XR-NTX+CM (Extended-Release Naltrexone plus Care Management)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Hyperlipidemia, Diabetes
Tele-Pharmacy Intervention to Improve Treatment Adherence
The purpose of this cluster randomized controlled trial is to evaluate whether a novel tele-pharmacist-based intervention for patients with hyperlipidemia, hypertension, and diabetes improves medication adherence, disease…
- Conditions
- Hyperlipidemia, Diabetes, Hypertension
- Trial name
- STIC2IT (NCT02512276)
- Testing
- Telepharmacist intervention
- Where
- United States
- Volunteers
- 4,078 people
- Sponsor
- Brigham and Women's Hospital