Clinical trials: Patient-Reported Outcomes
Lupus Erythematosus, Systemic, Pulmonary Disease
Pulmonary Disease Among Patients With Systemic Lupus Erythematosus
Pulmonary diseases are common among patients with Systemic Lupus Erythematosus (SLE) and associated with a significantly increased morbidity, mortality, and lower self-reported health related quality of life.
- Trial name
- NCT06087523
- Testing
- Multidisciplinary discussion
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Odense University Hospital
Aortic Valve Stenosis, Limited Access Aortic Valve Replacement
Patient Reported Health-Related Quality of Life After Limited Access and Conventional Aortic Valve Replacement
The LIAR-Trial is a single-center, single blind randomized controlled clinical trial comparing patients undergoing isolated AVR via J-shaped upper hemi-sternotomy (UHS) and conventional AVR through a full median sternotomy (FMS).
- Conditions
- Aortic Valve Stenosis, Limited Access Aortic Valve Replacement, Quality of Life
- Trial name
- LIAR (NCT04012060)
- Testing
- Limited access aortic valve replacement., Conventional aortic valve replacement
- Where
- Netherlands
- Volunteers
- 161 people
- Sponsor
- St. Antonius Hospital
Musculoskeletal Pain, Neuropathic Pain
Association of High PainDETECT Scores With Pain Region and Diagnosis in Patients Attending a Musculoskeletal and Sports Medicine Clinic
This observational study aims to evaluate the relationship between PainDETECT questionnaire scores, pain regions, and clinical diagnoses in patients presenting to a musculoskeletal and sports medicine clinic.
- Trial name
- PD-MSK (NCT07356115)
- Testing
- No Interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Uskudar University
Class II Malocclusion, Division 1
Pain, Discomfort, and Acceptance During Using Electrical Stimulation to Accelerate Orthodontic Teeth Movement
Forty patients with class II division 1 malocclusion who will require extraction of the upper first premolars as a part of the orthodontic treatment plan will be invited to participate in the study.
- Trial name
- NCT05920525
- Testing
- Electrical stimulation, Traditional retraction of the front upper teeth
- Where
- Syria
- Volunteers
- 40 people
- Sponsor
- Damascus University
Chronic Obstructive Pulmonary Disease (COPD)
Study to Evaluate Long-term Effectiveness and Safety, Patient Characteristics and Subjective Patient-reported Outcomes of Dupilumab in Patients With Chronic Obstructive Pulmonary Disease (COPD) Under Real-world Conditions
Study to evaluate the change of health-related quality of life, patient characteristics, efficacy and safety in Chronic Obstructive Pulmonary Disease (COPD) patients with Dupilumab therapy in a real-world setting over 24 months.
- Trial name
- ANEMO (NCT07052396)
- Testing
- Dupilumab
- Where
- 18 sites in Germany
- Volunteers
- 350 people
- Sponsor
- Sanofi
COVID-19
An Outpatient Study Investigating Non-prescription Treatments for COVID-19
This is a platform study to investigate the effectiveness of a variety of non-prescription approaches for the treatment of non-hospitalized adults recently tested positive for COVID-19.
- Trial name
- PROFACT-01 (NCT04621149)
- Testing
- chlorine dioxide, zinc acetate, Famotidine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Profact, Inc.
Migraine
Study to Assess Effectiveness of Oral Atogepant in Adult Participants For Prevention of Migraine in the United Kingdom
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound.
- Trial name
- PRACTICE (NCT07690215)
- Volunteers
- 200 people
- Sponsor
- AbbVie
Temporomandibular Joint Ankylosis
Comparison of Three Osteotomy Techniques in Temporomandibular Joint Ankylosis Surgery
Temporomandibular joint (TMJ) ankylosis is a condition in which the jaw joint becomes partially or completely fused, resulting in restricted mouth opening and difficulties with chewing, speaking, and daily activities.
- Trial name
- TMJ-OST (NCT07883889)
- Testing
- Piezoelectric Surgical Device, Ultrasonic Bone Scalpel, Conventional Reciprocating Saw
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Ankara University
Cardiac Implantable Electronic Devices, Quality of Life
Assessment of Validity and Reliability of the Turkish Version of the Quality of Life and Related Events Assessment Scale for Pacemaker Patients
Cardiac implantable electronic devices are widely utilized to lower the rates of morbidity and mortality from ventricular tachycardia and ventricular fibrillation, as well as the incidence of sudden cardiac death.
- Trial name
- NCT06775223
- Testing
- Cardiac implantable electronic devices
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Erol Olcok Corum Training and Research Hospital
Heart Defects, Congenital
Patient-Reported Outcomes in Adults With Congenital Heart Disease
The purpose of this study is to examine the differences in perceived health, psychosocial functioning, behavioral outcomes and quality of life of adults with congenital heart disease who are living in different areas of the…
- Trial name
- APPROACH-IS (NCT02150603)
- Where
- 24 sites in United States, Argentina and 13 more
- Volunteers
- 4,000 people
- Sponsor
- Philip Moons
Transthyretin Amyloidosis
Patient-Reported Outcome Measures in Wild-Type and Variant Cardiac Transthyretin Amyloidosis
Specific, standardized, comprehensive, universally accepted Patient-Reported Outcome Measures (PROMs) are currently lacking for variant and wild-type cardiac amyloid transthyretin amyloidosis (v-ATTR/wt-ATTR).
- Trial name
- ITALY (NCT04563286)
- Testing
- questionnaire on life quality
- Where
- 5 sites in Italy
- Volunteers
- 250 people
- Sponsor
- University of Messina
Breast Cancer, Breast Surgery
Measuring Patient Satisfaction and Quality of Life Following Body Image Altering Surgery
The goal of this study is to develop a questionnaire to measure patient satisfaction with their breast surgery. This questionnaire will help surgeons better understand how patients feel about their surgical results.
- Conditions
- Breast Cancer, Breast Surgery, Breast Reconstruction, Breast Reduction
- Trial name
- NCT00605670
- Testing
- questionnaires
- Where
- 5 sites in United States, Canada
- Volunteers
- 722 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hemophilia
Patient Reported Outcomes Burdens and Experiences - Phase 2
The Patient Reported Outcomes, Burdens, and Experiences (PROBE) Study aims to develop a new global tool to enhance the direct patient-voice in health care decision-making.
- Trial name
- PROBE (NCT02439710)
- Testing
- Quality of life measure (survey)
- Where
- Canada
- Volunteers
- 656 people
- Sponsor
- McMaster University
Bladder Cancer
Enhancing Patient Comfort and Reducing Anxiety During Flexible Cystoscopy and Bladder Instillation in Bladder Cancer Patients: A Randomized Controlled Trial and Observational Study
The goal of this clinical trial is to learn if certain comfort-enhancing interventions can reduce pain and anxiety during flexible cystoscopy and bladder instillation in patients with bladder cancer.
- Trial name
- Flexi-comfort (NCT07204301)
- Testing
- Optimized Timing of Intravesical Lidocaine Gel, Calming Music During Procedure, Visual Distraction with Screen Content
- Where
- Canada
- Volunteers
- 378 people
- Sponsor
- Western University, Canada
Spinal Pathologies, Pain
Patient Reported Outcome Measurements Registration in Spinal Pathologies and Neuromodulation
Longitudinal prospective observational data collection with questionnaires and categorical diagnostic and therapeutic registration and follow-up in spinal pathologies and neuromodulation
- Conditions
- Spinal Pathologies, Pain, Cervical Pain, Lumbar Pain Syndrome
- Trial name
- PROMSPINE (NCT07552519)
- Where
- Belgium
- Volunteers
- 5,000 people
- Sponsor
- Jessa Hospital
Post-ERCP Acute Pancreatitis
PAN-PROMISE to Detect Post-ERCP Pancreatitis Symptoms
The aim of this study is to use a validated patient-reported outcome measure to evaluate how many patients have symptoms of pancreatitis after ERCP and how it correlates with their quality of life and productivity.
- Trial name
- PAN-PROMISE (NCT05310409)
- Where
- 2 sites in United States
- Volunteers
- 700 people
- Sponsor
- University of Pennsylvania
Complete Edentulism, Satisfaction, Patient
"Acrylic Vs. Metal Palatal Coverage in Complete Dentures: Patient-Reported Outcomes"
Conventional dentures can be uncomfortable and limit oral functionality due to the polished surfaces covering the palate and rugae areas.
- Conditions
- Complete Edentulism, Satisfaction, Patient, Quality of Life
- Trial name
- NCT06881199
- Testing
- Complete denture with a metallic Co-Cr casted palate, Complete denture with an acrylic palate
- Where
- Jordan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Prematurity; Extreme, Prematurity; Decision Support
Health-Related Quality-of-Life and Household Financial and Wellbeing Impacts of Prematurity and Necrotising Enterocolitis (NEC).
PREM-IMPACT is a UK-based observational study exploring how caring for a very premature baby-particularly one affected by necrotising enterocolitis (NEC)-impacts families over the first year after hospital discharge.
- Conditions
- Prematurity; Extreme, Prematurity; Decision Support, Necrotising Enterocolitis, Preterm
- Trial name
- PREM-IMPACT (NCT07192393)
- Where
- 7 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- Imperial College London
Congenital Thrombotic Thrombocytopenic Purpura
Prospective Psychometric Evaluation Study of a Patient-reported Outcomes (PRO) Instrument for Congenital Thrombotic Thrombocytopenic Purpura (cTTP, Upshaw-Schulman Syndrome [USS], Hereditary Thrombotic Thrombocytopenic Purpura [hTTP]
The purpose of this study is to assess the psychometric properties of a recently developed congenital thrombotic thrombocytopenic purpura (cTTP)-specific patient-reported outcomes (PRO) instrument.
- Trial name
- NCT03519672
- Testing
- No intervention
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 41 people
- Sponsor
- Baxalta now part of Shire
Early-stage Breast Cancer
Outcomes and Cosmesis With Whole Breast Irradiation and Boost
This study is being done to evaluate cosmetic, patient-reported outcome measures (PROMs), and toxicities for women undergoing ultra-short whole breast irradiation (WBI) therapy with simultaneous integrated boost (SIB).
- Trial name
- NCT06295744
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Wisconsin, Madison
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