Clinical trials: Patient-controlled Intravenous Analgesia
S-ketamine, Analgesia, Patient-Controlled
The Effect of S-ketamine Combined With Sufentanil for Postoperative Analgesia in Patients Following Cesarean Section
This randomized controlled trial is designed to investigate the effect of low-dose of S-ketamine combined with sufentanil for postoperative patient-controlled intravenous analgesia in patients following cesarean section.
- Conditions
- S-ketamine, Analgesia, Patient-Controlled, Cesarean Section
- Trial name
- NCT05299866
- Testing
- S-ketamine
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Ling Dong
Pain, Postoperative, Opioid Use
Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.
The goal of this clinical trial is to determine whether treating pain after surgery with ketamine is more effective when administered intravenously as a continuous infusion or through a patient-controlled analgesia (PCA) pump.
- Conditions
- Pain, Postoperative, Opioid Use, Major Surgery
- Trial name
- NCT06774274
- Testing
- Ketamine infusion, PCA Ketamine
- Where
- Colombia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Obese Patients
External Oblique Intercostal Block With or Without Intravenous Lidocaine Infusion for Analgesia in Patients Undergoing Gastric Bypass Surgery
Adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption (ANI guided rescue) compared to placebo, without increasing…
- Trial name
- NCT07809425
- Testing
- Investigatore hypothesize that adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption., Bilateral EOIB + fentanyl 1 μg/kg loading + normal saline loading (equivalent volume) + normal saline infusion (equivalent rate).
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Menoufia University
Patient-Controlled Analgesia
Comparison of Patient-Controlled Analgesia With Different Background Infusion
In this study, the investigators investigated the efficacy, usefulness and analgesic consumption of three different patient-controlled analgesia(PCA) programmes:bolus dose alone without background infusion, bolus dose with low…
- Trial name
- NCT03221491
- Testing
- Patient-Controlled Analgesia(PCA)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Weifeng Tu
Arthroplasty, Replacement, Knee, Pain, Postoperative
Continuous Adductor Canal Infusion vs. Single-injection Adductor Canal Block for Total Knee Arthroplasty
Multimodal analgesia (MMA) has been endorsed to improve postoperative analgesia and functional activity after surgery, and integrating regional analgesia to reduce the consumption of opioid has also been used in postoperative…
- Conditions
- Arthroplasty, Replacement, Knee, Pain, Postoperative, Multimodal Analgesia
- Trial name
- NCT05669898
- Testing
- Pain scores (numerical rating scale at rest and motion): will be assessed with numerical rating scale at both rest and motion on both knees., Brief Pain Inventory (Short Form), WOMAC Osteoarthritis index, and Lower extremity functional scale, Rehabilitation physiotherapy
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Surgery, Pain Management
Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery
Perioperative pain management affects patient recovery. However, the rate of moderate to severe postoperative pain is as high as 73.8%, which hinders recovery and increases the risk of complications.
- Conditions
- Surgery, Pain Management, Opioid Consumption, Patient-controlled Analgesia
- Trial name
- NCT07361822
- Testing
- Fixed-rate basal infusion mode, Variable-rate feedback infusion mode
- Where
- China
- Volunteers
- 1,170 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Nausea and Vomiting
Effect of Ketamine Added to Intravenous Patient-controlled Analgesia on Postoperative Pain, Nausea and Vomiting in Patients Undergoing Lumbar Spinal Surgery
Ketamine added to intravenous patient-controlled analgesia may be effective on prevention of postoperative nausea and vomiting by reducing opioid requirement after surgery.
- Trial name
- NCT01394406
- Testing
- Ketamine, Saline
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Analgesia
A Comparison of Analgesic Efficacy Between a Single Dose of ORG 28611, Morphine, and Placebo After Dental Impaction Surgery (Study P05800)
Patients will receive a single intravenous (IV) infusion administered over 3 minutes of either ORG 28611 (SCH 900111), 0.12 mg/kg morphine sulphate, or placebo, within 6 hours after dental surgery, when they experience moderate…
- Trial name
- NCT00782951
- Testing
- Org 28611, morphine sulfate
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Postoperative Pain
Perioperative Lidocaine Administration in Thoracoscopic Surgery for Improved Postoperative Pain Control
Placebo-controlled study to analyze the effect of perioperative intravenous lidocaine administration on total morphine consumption (TMC) and on pain intensity in thoracoscopic surgery .
- Trial name
- NCT03677817
- Testing
- Lidocaine, NaCl 0,9%
- Where
- Switzerland
- Volunteers
- 113 people
- Sponsor
- University Hospital, Basel, Switzerland
Pain, Ventilatory Depression
Hydromorphone Pharmacokinetic-Pharmacodynamic Fingerprint
The primary objective of the proposed work is development of a high resolution pharmacokinetic-pharmacodynamic (PK-PD) model of hydromorphone for experimental pain stimuli, ventilatory depression, and surrogate biomarkers of…
- Trial name
- NCT01123486
- Testing
- hydromorphone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Pain
Analgesia for 2nd Trimester Termination of Pregnancy
There has been very little investigation into the management of pain from 2nd trimester termination of pregnancy or unexpected fetal loss.
- Trial name
- NCT01563835
- Testing
- bupivacaine, fentanyl, fentanyl
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postoperative Pain Management
Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients
This randomized, double-blind, controlled clinical trial evaluates whether adding dexmedetomidine to an oliceridine-based patient-controlled intravenous analgesia (PCIA) regimen can improve postoperative pain control and…
- Trial name
- DEX-PCIA (NCT07306702)
- Testing
- Oliceridine, Dexmedetomidine
- Where
- China
- Sponsor
- Shenyang Sixth People's Hospital
Patient-Controlled Analgesia
Effect of Dexmedetomidine for Postoperative Intravenous Patient Controlled Analgesia
The purpose of this study is to explore the effectiveness of dexmedetomidine as an adjunctive analgesic, combined with dezocine and flubiprofen, used in intravenous Patient-Controlled Analgesia (PCA) after open colorectal surgery.
- Trial name
- NCT03014713
- Testing
- Dezocine, Flubiprofen, Dexmedetomidine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Weifeng Tu
Post-operative Pain, Gallstone Disease
Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial
Chronic pain after laparoscopic cholecystectomy (LC) is a common complication with an incidence ranging between 3-56%. In many cases, however, the cause chronic pain after LC remains unknown and visceral hyperalgesia and central…
- Trial name
- NCT02300480
- Testing
- CTB group, PCIA group
- Where
- China
- Volunteers
- 140 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Post-operative Pain, Narcotics Consumption
The Efficacy of Scalp Block in Craniotomy
The aim of the study is to compare the effectiveness and safety of scalp block versus intravenous fentanyl in pain control intraoperatively in craniotomy patients.
- Conditions
- Post-operative Pain, Narcotics Consumption, Pain Assessment, Intraoperative Hemodynamic Instability
- Trial name
- NCT06951230
- Testing
- Fentanyl injection, scalp block
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postoperative Pain
Patient-Controlled Epidural Analgesia (PCEA) for Patients Who Have Had Major Open Gynecologic Surgery
Recovery after major abdominal surgery can be longer than other types of surgery. This is because often after abdominal surgery, the bowel does not work normally. When this happens, patients are unable to pass gas.
- Trial name
- NCT00136682
- Testing
- patient-controlled epidural analgesia (PCEA), patient-controlled intravenous analgesia (PCA)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ureteroneocystostomy
The Effect of Intravenous (IV) Patient Controlled Analgesic (PCA) With Ketorolac or Fentanyl Combined With Caudal Block for Postoperative Analgesia in Small Children Undergoing Intravesical Ureteroneocystostomy
The effect of IV PCA with ketorolac or fentanyl combined with caudal block for postoperative analgesia in small children undergoing intravesical ureteroneocystostomy.
- Trial name
- NCT01081535
- Testing
- ketorolac, fentanyl
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Post Operative Analgesia, Opioid Consumption, Postoperative
Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption
Acetaminophen (Tylenol) is a commonly used medication after surgery to control pain. Tablets for oral use and suppositories for rectal use are the most frequently employed forms of acetaminophen after surgery.
- Conditions
- Post Operative Analgesia, Opioid Consumption, Postoperative, Acetaminophen, Abdominal Surgeries
- Trial name
- ACETAPOP (NCT06923540)
- Testing
- IV Acetaminophen
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
PONV
Effect of Combination Dexmedetomidine Added to Fentanyl-based Intravenous Patient-controlled Analgesia on Nausea Vomiting in Highly Susceptible Patients Undergoing Lumbar Spinal Surgery: Prospective Double Blinded Randomized Controlled Trial
The aim of this study is to test the hypothesis that addition of dexmedetomidine to fentanyl-based intravenous patient controlled analgesia (PCA) reduces requirement of fentanyl bolus and consequent postoperative nausea and…
- Trial name
- NCT01840254
- Testing
- dexmedetomidine, normal saline
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Yonsei University
Carcinologic Ear, Nose, and Throat (ENT) Surgery
Intravenous Lidocaine in Carcinologic ENT Surgery: A Trial for Evaluation of Opioid Saving Strategy and Chronic Post-surgical Pain (ELICO)
Lidocaine, local anesthetic used for more than five decades, is being intravenously administered aiming at managing pain in different types of surgeries with promising results.
- Trial name
- ELICO (NCT02894710)
- Testing
- Lidocaine 20mg/ml
- Where
- 2 sites in France
- Volunteers
- 143 people
- Sponsor
- Hospices Civils de Lyon