Clinical trials: Patients After Cardiac Surgery
Cardiovascular Diseases, Surgery
Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients
Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management…
- Conditions
- Cardiovascular Diseases, Surgery, Hypotension, Hypotension on Induction
- Trial name
- PRAM-in-HYPO (NCT05960604)
- Testing
- Passive leg raising
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 660 people
- Sponsor
- Recep Tayyip Erdogan University
Sternotomy Wound
Wound Inflammatory Cells After Cardiac Surgery
One hundred patients, aged from 41 to 78 years, underwent open heart surgery in the years 1998-1999 and were studied by using the Cellstick device for harvesting wound inflammatory cells during the first 24 hours after surgery.
- Trial name
- NCT02875509
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Pain, Acute, Pain, Chronic
Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients
This study is a single-center, phase II, randomized, placebo-controlled, Bayesian-designed, double-blinded trial Goal and Questions: The primary goal is to evaluate if a combination of taurine and butyrate can reduce chronic…
- Conditions
- Pain, Acute, Pain, Chronic, Chronic Post Operative Pain
- Trial name
- NCT07144033
- Testing
- Butyrate and Taurine
- Where
- Hong Kong
- Volunteers
- 216 people
- Sponsor
- Chinese University of Hong Kong
Coronary Artery
Combination Effects of High-dose Statin and Trimetazidine on Patients With Aspirin Mono Antiplatelet Therapy 12-months After Coronary Artery Bypass Surgery
Trimetazidine is a metabolic agent without any negative inotropic or vasodilatory properties. In addition, previous reports showed that trimetazidine was effective in reducing intracoronary platelet aggregation and preventing…
- Trial name
- NCT01857921
- Testing
- Pravastatin 20mg/day for 12 months after randomization, Atorvastatin 40 mg and trimetazidine MR 70 mg/day for 12 months after randomization
- Where
- South Korea
- Volunteers
- 290 people
- Sponsor
- Yonsei University
Hypoxemia
The Correlation Between Sleep Quality and Atrial Fibrillation Undergoing High-flow Nasal Cannula Oxygen (HFNC)
The investigators hypothesized that heated humidified high-flow nasal cannula oxygen(HFNC) along with high quality of sleep, in comparison with noninvasive positive pressure ventilation (NIV), could reduce the release of…
- Trial name
- NCT02713737
- Testing
- heated humidified high-flow nasal cannula, noninvasive ventilation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Hip Fracture, Myocardial Ischemia
Pilot Study of Atorvastatin for Orthopedic Surgery Patients
Up to 35% of hip fracture patients have been shown to experience heart injury after surgery, and as many as 10% have a heart attack or die in the three months after surgery.
- Conditions
- Hip Fracture, Myocardial Ischemia, Inflammation
- Trial name
- POST-OP Pilot (NCT02197065)
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Hospital for Special Surgery, New York
Single Ventricle Heart Disease After Fontan Surgery
Study of Effects of Sildenafil on Patients With Fontan Heart Circulation
The study will investigate the cardiovascular effects of sildenafil on patients with Fontan circulation. Recent studies suggest that sildenafil may improve exercise in patients with Fontan circulation.
- Trial name
- NCT01815502
- Testing
- Cardiac catheterization
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Thrombosis
Risk of Developing Antibodies to Heparin-PF4 After Heart Surgery
Heparin is a drug that is widely used to prevent and treat blood clotting. Individuals undergoing cardiopulmonary bypass surgery are administered high doses of heparin, and some of them develop antibodies to the drug.
- Trial name
- HIT (NCT00237328)
- Testing
- Heparin
- Where
- 4 sites in United States
- Volunteers
- 1,015 people
- Sponsor
- Duke University
Coronary Artery Bypass Grafting (CABG) Surgery
Individualized Orem-Based Nursing Intervention After Coronary Artery Bypass Grafting
This randomized controlled trial will evaluate the effectiveness of an individualized self-care and nursing intervention program based on Orem's Self-Care Theory among patients following coronary artery bypass grafting (CABG).
- Trial name
- CABG-OREM (NCT07839598)
- Testing
- Individualized Nursing Intervention Program Based on Orem's Self-Care Theory, Usual postoperative care
- Where
- Jordan
- Volunteers
- 440 people
- Sponsor
- Jerash Private University
Acetaminophen, Delirium in Old Age
Impact of Acetaminophen on Postoperative Delirium Elderly Patients After Non-cardiac Surgery
To investigate the impact of acetaminophen analgesia on the frequency of postoperative delirium and 28 days mortality in elderly patients after noncardiac surgery.
- Trial name
- NCT03763084
- Testing
- Acetaminophen, Sufentanil
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Xiangya Hospital of Central South University
Sedation After Cardiac Surgery
Investigation of Sedation Depth Via BIS Monitoring in ICU After Cardiac Surgery
This study is a non-interventional, observational research project focused on monitoring sedation levels in patients who have undergone cardiac surgery.
- Trial name
- BISICU (NCT07350109)
- Where
- 2 sites in Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Coronary Artery Bypass Surgery, Right-Sided Heart Failure
The SWEDEGRAFT Right-Heart-Substudy
BACKGROUND Right ventricular dysfunction is a common echocardiographic finding after cardiac surgery. Pericardial disruption has been suggested as the most probable cause as the phenomenon occurs within minutes after pericardial…
- Trial name
- NCT05049421
- Testing
- Echocardiography
- Where
- Denmark
- Volunteers
- 207 people
- Sponsor
- Aarhus University Hospital Skejby
Major Adverse Cardiac Events, Cerebrovascular Accident
Construction of a Prediction Model for MACCE in Elderly Patients After Elective Non-cardiac Surgery
Severe cardiovascular and cerebrovascular complications, including cardiac death, non-fatal angina/myocardial infarction, non-fatal heart failure, stroke, severe arrhythmia, etc., are one of the main types of postoperative…
- Conditions
- Major Adverse Cardiac Events, Cerebrovascular Accident, Postoperative Complications, Models
- Trial name
- NCT06391632
- Testing
- Revised Cardiac Risk Index
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Renal Failure
Uremic Toxins in the ICU: Patients After Cardiac Surgery
Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients after cardiac surgery.The sampling of blood and dialysate will be done during dialyses with…
- Trial name
- NCT00752804
- Testing
- Dialysis during 4 hours, Dialysis during 6 hours, Dialysis during 8 hours
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- University Hospital, Ghent
Periodontitis, Heart Valve Disease
Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality After Aortic and Mitral Valve Surgery
This retrospective observational study aims to evaluate the effect of preoperative periodontal treatment on postoperative infection and mortality in patients undergoing aortic and mitral valve surgery.
- Conditions
- Periodontitis, Heart Valve Disease, Postoperative Infection, Cardiovascular Disease
- Trial name
- Perio-CVS (NCT07626801)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul University - Cerrahpasa
Anesthesia, Analgesia
ESPB vs.Combination of ESPB and Superficial PIPB in Cardiac Surgery
Cardiac surgery is associated with significant postoperative pain. Pain control is an essential part of enhanced recovery protocols.
- Conditions
- Anesthesia, Analgesia, Acute Pain, Patient Controlled Analgesia
- Trial name
- NCT05191953
- Testing
- Bilateral ultrasound-guided ESPB, Bilateral ultrasound-guided ESPB and superficial PIPB
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ondokuz Mayıs University
Post Coronary Bypass Surgery Patients
Rivaroxaban Post Coronary Bypass Surgery
Post coronary bypass patients were randomized to receiving aspirin alone or aspirin and low dose rivaroxaban
- Trial name
- NCT06019741
- Testing
- Rivaroxaban and aspirin 80, Aspirin 80
- Where
- Iran
- Volunteers
- 234 people
- Sponsor
- Shiraz University of Medical Sciences
Heart Failure，Congestive
Evaluation of Post-operative, Nurse-based Heart Failure Care in Non-cardiac Surgery
Patients with heart failure NYHA >= II receiving non-emergent non-cardiac in-patient surgery will be randomized to receive either standard post-operative care (surgeon has to ask actively for specialist cardiological support) or…
- Trial name
- NCT03202329
- Testing
- standard care, Nurse-based care
- Where
- 2 sites in Germany
- Volunteers
- 525 people
- Sponsor
- Birgit Assmus
Cardiac Surgery Associated - Acute Kidney Injury
Efficacy and Safety of ENN0403 in Patients At High Risk for Acute Kidney Injury Following Elective Cardiac Surgery
The is a two-stage study. Stage 1 is to evaluate the safety, tolerability, PK and PD of ENN0403 in patients at high risk of AKI following elective cardiac surgery requring cardiopulmonary bypass.
- Trial name
- NCT06632613
- Testing
- ENN0403 capsules, low dose, ENN0403 capsules, high dose
- Where
- China
- Volunteers
- 200 people
- Sponsor
- EnnovaBio
Pulmonary Atelectasis
Interest of Positive Expiratory Pressure (PEP) Delivery by EzPAP® After Cardiac Surgery in the Management of Postoperative Atelectasis
Pulmonary atelectasis is a frequent respiratory postoperative complication in cardiac surgery. Classically, the treatment of these patients is based on manual chest physiotherapy.
- Trial name
- PEPKIN (NCT02262182)
- Testing
- KP group, KM group
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital