Clinical trials: Patients After Cardiac Surgery
Right Ventricular Dysfunction
Right Ventricular Contractility Reserve Following Repair of Tetralogy of Fallot
Background: Residual pulmonary regurgitation following repair of tetralogy of Fallot, in particular the use of a transannular patch, has been shown to correlate with the development of right ventricular dysfunction.
- Trial name
- TOF-Cond (NCT00557934)
- Testing
- dobutamine
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University Hospital Tuebingen
Acute Kidney Injury
Study to Prevent Acute Kidney Injury After Cardiac Surgery Involving Cardiopulmonary Bypass
The objective of the study is to assess the safety and efficacy of ANG-3777 in preventing AKI compared to placebo when administered to patients at risk for developing acute kidney injury (AKI) following cardiac surgical…
- Trial name
- NCT02771509
- Testing
- ANG-3777
- Where
- 40 sites in United States, Brazil and 2 more
- Volunteers
- 275 people
- Sponsor
- Angion Biomedica Corp
Atrial Fibrillation
Medtronic Reveal XT Study
While surgical treatment for atrial fibrillation (AF) has been performed for over 20 years, virtually all of the historical series reported only the recurrence of symptomatic AF and have used only intermittent electrocardiogram…
- Trial name
- NCT01526343
- Testing
- Reveal XT implantation
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Washington University School of Medicine
Acute Respiratory Distress Syndrome
Effect of Low Tidal Volume Ventilation in Improving Oxygenation and Thus Reducing Acute Lung Injury in the Cardiac Surgical Patient
We propose that as low tidal volume ventilation has proven to be beneficial in patients with established ARDS it may have a role in preventing the onset of acute lung injury in the cardiac surgical population.
- Trial name
- NCT00538161
- Testing
- Ventilation strategy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Beth Israel Deaconess Medical Center
Analgesia
Bilateral Transversus Thoracic Muscle Plane Block as Analgesic in Open Heart Surgeries by US.
OPEN CARDIAC SURGERY may cause severe postoperative pain and promote a high risk of chronic pain if not treated adequately, that is caused by multiple factors; sternotomy, costotransverse and costovertebral joint distensions…
- Trial name
- NCT04116554
- Testing
- 0.25% bupivacaine., 0.9%saline
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Anesthesia, Analgesia
ESPB vs.Combination of ESPB and Superficial PIPB in Cardiac Surgery
Cardiac surgery is associated with significant postoperative pain. Pain control is an essential part of enhanced recovery protocols.
- Conditions
- Anesthesia, Analgesia, Acute Pain, Patient Controlled Analgesia
- Trial name
- NCT05191953
- Testing
- Bilateral ultrasound-guided ESPB, Bilateral ultrasound-guided ESPB and superficial PIPB
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ondokuz Mayıs University
Patients Undergoing Off-pump Coronary Artery by Pass Surgery
Predictive Value of Postoperative Prognostic Nutritional Index Trajectory on 1-year Mortality After Off-pump Coronary Artery Bypass Surgery
This study investigated the changing pattern of postoperative Prognostic Nutritional Index (PNI) after off-pump coronary artery bypass surgery using a trajectory analysis.
- Trial name
- NCT06435416
- Testing
- No intervention
- Where
- South Korea
- Volunteers
- 983 people
- Sponsor
- Gangnam Severance Hospital
Postoperative Cognitive Dysfunction, Post Operative Delirium
Comparison Between the Effect of Dexmedetomidine _midazolam and ketamine_midazolam Combination
Postoperative cognitive dysfunction (POCD) is one of the most common complications after anesthesia, with a prevalence of approximately 12% and a higher prevalence of up to 41.4% in older surgical patients during the entire…
- Trial name
- NCT07074262
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Beni-Suef University
Coronary Artery Disease
GUARD-AKI: Validation of AKI-Sapere in Cardiac Surgery Patients
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT03635606
- Where
- 3 sites in United States
- Volunteers
- 370 people
- Sponsor
- Sapere Bio
Acute Hypoxemic Respiratory Failure, Post-cardiac Surgery
Automated Analysis of EIT Data for PEEP Setting
First: to develop a computerized algorithm for automated analysis of the electrical impedance tomography (EIT) data. The algorithm calculates the "optimal" positive end-expiratory pressure (PEEP) and inspiratory pressure defined…
- Trial name
- NCT03653806
- Testing
- computerized algorithm for automated analysis
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Glycemic Control, Surgical Site Infections
A Quality Initiative to Improve Glycemic Control in Diabetic and Non-Diabetic Insulin Study
The aim of this study is to examine the effect of moderate glucose (blood sugar) control in diabetic and non-diabetic patients undergoing leg bypass surgery (LEB) or open abdominal aortic aneurysm (AAA) repair.
- Conditions
- Glycemic Control, Surgical Site Infections, Cardiac Complications, Length of Stay
- Trial name
- NCT01916733
- Testing
- standard insulin protocol post-op (continuous IV insulin)
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Vermont Medical Center
Vasoplegic Syndrome, Vasoplegia
Analysis of miRNAs Expression in Vasoplegic Syndrome After On-pump Coronary Artery Bypass Surgery
This study looks for a correlation between microRNAs (miRNAs) and vasoplegic syndrome after on-pump coronary artery bypass surgery.
- Conditions
- Vasoplegic Syndrome, Vasoplegia, Surgery-Complications, Surgery
- Trial name
- PREVENT (NCT05354193)
- Testing
- vasoplegic syndrome
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- University of Sao Paulo General Hospital
Cardiac Disease
Lidocaine as an Endotracheal Tube (ETT) Cuff Media
Researchers will compare the effects of lidocaine versus air, as a way to fill the breathing tube cuff which is gently inflated to hold in place the trachea (airway) during surgery.
- Trial name
- NCT03343080
- Testing
- 1.8% lidocaine plus 0.76% sodium bicarbonate, Air
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Surgery--Complications, Cardiac Valve Disease
Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement
This is a randomized clinical trial, double-blind, placebo-controlled study with the goal to assess the influence of using N-AcetylCysteyn (NAC) for prevention of AKI (Acute Kidney Injury) in post operatory of valve replacement…
- Conditions
- Surgery--Complications, Cardiac Valve Disease, Acute Kidney Injury, Oxygen Radical Damage
- Trial name
- NCT03440268
- Testing
- N Acetyl Cysteine
- Where
- Brazil
- Volunteers
- 154 people
- Sponsor
- University of Sao Paulo General Hospital
NIV Intolerance
Evaluation of Remifentanil and Dexmedetomidine in Patients With Noninvasive Mechanical Ventilation Intolerance
Currently, NIV(Noninvasive ventilation ) is widely used in patients with hypoxemia and atelectasis after cardiac surgery.About 15% of patients have intolerance during NIV.
- Trial name
- NCT04734418
- Testing
- Remifentanil, Dexmedetomidine
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease
Antegrade Autologous Blood Reinfusion After CPB
This prospective observational study aims to evaluate the effect of antegrade pump blood reinfusion using the crystalloid "chase" technique on postoperative transfusion requirements in adult patients undergoing cardiac surgery…
- Trial name
- NCT07420582
- Testing
- Antegrade Pump Blood Reinfusion, No Anterograde Pump Blood Reinfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Kocaeli City Hospital
Pain, Pain, Postoperative
Intervention Study to Enhance Patients' Pain Management After Cardiac Surgery
The main objective of this randomized controlled trial is to evaluate the effect of an intervention formed as a pain booklet provided to patients at discharge from hospital following cardiac surgery.
- Conditions
- Pain, Pain, Postoperative, Other Functional Disturbances Following Cardiac Surgery
- Trial name
- NCT01976403
- Testing
- Pain Booklet
- Where
- Norway
- Volunteers
- 416 people
- Sponsor
- Oslo Metropolitan University
Abdomen, Acute, Myocardial Injury After Non-cardiac Surgery
The Effects of Troponin I Surveillance Among Patients Undergoing Acute High-risk Abdominal Surgery
Treatment of disorders such as gastrointestinal tract (GI) perforation, ischemia and obstruction often require acute high-risk abdominal surgery, which is associated with a high risk of complications such as myocardial injury…
- Conditions
- Abdomen, Acute, Myocardial Injury After Non-cardiac Surgery, Troponin I, Myocardial Injury
- Trial name
- NCT05992961
- Testing
- Troponin I
- Where
- Denmark
- Volunteers
- 558 people
- Sponsor
- Nordsjaellands Hospital
PERCUTANEOUS CORONARY INTERVENTION, STENTS
The Surgery After Stenting (SAS) Registry
The SAS registry will include any patient with previous coronary stenting undergoing any type of surgery or operative endoscopic/endovascular procedure at the participating Centers.
- Conditions
- PERCUTANEOUS CORONARY INTERVENTION, STENTS, SURGERY
- Trial name
- SAS registry (NCT01997242)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Ultrasonography, Renal, Cardiac Surgery
Evaluation of Patients After Cardiac Surgery: Novel Ultrasound Parameters for Quantification of Renal Perfusion & Analysis of Phenylephrines' Effect on Invasive Haemodynamics and Echocardiographic Measures
To investigate the influence of PEEP (Positive end-expiratory pressure), changes in preload (patient position) and changes in afterload (phenylephrine) on ultrasound measures of renal perfusion in patients after uncomplicated…
- Conditions
- Ultrasonography, Renal, Cardiac Surgery, Hemodynamics, Phenylephrine
- Trial name
- NCT04419662
- Testing
- Phenylephrine, Combination of PEEP and positioning
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Aarhus University Hospital