Clinical trials: Patients After Cardiac Surgery
Chronic Postoperative Pain
PANDORA: Paravertebral AdjuNctive DexamethasOne Palmitate Reducing Chronic Pain After Caridiac Surgery
The goal of this single-center, prospective, double-blind randomized controlled clinical trial is to explore preventive interventions for chronic postoperative pain (CPSP) in patients undergoing minimally invasive cardiac…
- Trial name
- NCT05920967
- Testing
- Dexamethasone Palmitate, Dexamethasone Sodium Phosphate
- Where
- China
- Volunteers
- 562 people
- Sponsor
- Xijing Hospital
Heart Failure With Reduced Ejection Fraction
Respiratory Sinus Arrhythmia (RSA) Pacing Post-CABG Surgery in Patients With HFrEF
The goal of this clinical trial is to test a new type of pacemaker in heart failure patients following a heart bypass operation.
- Trial name
- RSA-PACE (NCT06359938)
- Testing
- Atrial pacing with respiratory sinus arrhythmia (RSA) variability, Monotonic right atrial overdrive pacing
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Ceryx Medical Ltd
Patients With Coronary Artery Disease Scheduled for by Pass Surgery
Atrial Fibrillation and By-pass Surgery
The aim of the study is to evaluate whether combined therapy with beta-blocker, amiodarone and statine is better than beta-blocker alone for the prevention of atrial fibrillation after coronary by-pass surgery.
- Trial name
- NCT01955759
- Testing
- Amiodarone tab 200 mg x 3, rosuvastatin 20 mg tab x1, beta blockers Bisoprolol in adjusted dose
- Where
- Bosnia and Herzegovina
- Volunteers
- 260 people
- Sponsor
- Heart Center BH Tuzla
Post Cardiac Surgery Systemic Inflammatory Response
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery
Protocol Summary STUDY DESIGN A pilot, prospective, double blind, randomized, placebo controlled study. STUDY POPULATION Patients assigned to elective CABG with cardiopulmonary bypass (CPB) at the Department of Cardiothoracic…
- Trial name
- NCT02191839
- Testing
- Alpha 1-Antitrypsin
- Volunteers
- 20 people
- Sponsor
- Soroka University Medical Center
Coronary Artery Disease, Coronary Artery Bypass
Early Mobilization After CABG Surgery
The goal of this clinical trial is to learn if a structured early exercise program can help patients recover better in people who have just had coronary artery bypass surgery.
- Trial name
- EMAC (NCT07230561)
- Testing
- Structured Early Mobilization Training, Standard Hospital Nursing Care
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Ta-Chung Chao
Hypertension, Pulmonary, Hemolysis
Use of Inhaled Nitric Oxide to Prevent Pulmonary Hypertension Associated to Stored Blood Transfusion
The objective of this study is to assess if prolonged storage time of a packed red blood cell unit may cause pulmonary vasoconstriction after transfusion, in a susceptible population such as cardiac surgery patients.
- Trial name
- NCT02217683
- Testing
- Nitric Oxide
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Cardiovascular Disease, Aortic Valve Stenosis
Evaluating the Risk of Cognitive Impairment After Surgical and Transcatheter Aortic Valve Replacement
The investigators are conducting a pilot study to compare cognitive outcomes among Veterans with severe aortic valve stenosis who are scheduled to undergo either aortic valve replacement.
- Conditions
- Cardiovascular Disease, Aortic Valve Stenosis, Cognitive Assessments, Valve Surgery
- Trial name
- CAVIAR (NCT02971020)
- Testing
- Observational/Cognitive Assessment
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Minnesota Veterans Medical Research and Education Foundation
Blood Pressure, Perioperative Hypotension
Impact of Continuous Non-invasive Blood Pressure Monitoring on Hypotension in Patients Having Non-cardiac Surgery
This is a randomized trial (1) investigating whether continuous non-invasive finger-cuff blood pressure monitoring reduces the area under a mean arterial pressure (MAP) of 65 mmHg within the first 15 minutes of anesthetic…
- Trial name
- NCT04736862
- Testing
- Continuous non-invasive blood pressure monitoring, Intermittent non-invasive blood pressure monitoring
- Where
- Germany
- Volunteers
- 242 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Post Coronary Bypass Surgery Patients
Rivaroxaban Post Coronary Bypass Surgery
Post coronary bypass patients were randomized to receiving aspirin alone or aspirin and low dose rivaroxaban
- Trial name
- NCT06019741
- Testing
- Rivaroxaban and aspirin 80, Aspirin 80
- Where
- Iran
- Volunteers
- 234 people
- Sponsor
- Shiraz University of Medical Sciences
CABG
Effect of GLP - 1 (7-36 Amide) on Myocardial Function Following Coronary Artery Bypass (CABG) Surgery
This research is being done to see if giving a hormone called GLP-1 can improve heart function and reduce length of stay in the Cardiac Surgical Intensive Care Unit (CSICU) in people who have non-emergent coronary artery bypass…
- Trial name
- GLP-1 CABG (NCT00966654)
- Testing
- GLP-1 (7-36) amide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Postoperative Nausea and Vomiting
Prophylactic Ondansetron in Post-op Cardiac Surgery Patients to Prevent Post-operative Nausea and Vomiting
To evaluate the effectiveness of a prophylactic dose of ondansetron in decreasing the incidence of post-operative nausea and vomiting in cardiac surgery patients after cessation of post-operative sedation.
- Trial name
- NCT02966041
- Testing
- Ondansetron, Saline
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- University of British Columbia
Geriatric, General Anesthesia Induced Hypotension
What Causes Low Blood Pressure After Anesthesia in Older Adults Having Non-Heart Surgery ?
The purpose of this study is to identify risk factors contributing to post-induction hypotension in geriatric patients undergoing elective non-cardiac surgery under general anesthesia at Dr.
- Conditions
- Geriatric, General Anesthesia Induced Hypotension, Elective Surgery, Hypotension
- Trial name
- GERIHYPO (NCT07019805)
- Testing
- Standard General Anesthesia Induction Using Propofol, Fentanyl and Midazolam, Blood Pressure Continous Monitoring, syrnge pump for the anesthesia agent, and vasoconstrictor drug
- Where
- Indonesia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Coronary Artery Bypass, Off-Pump, Minimally Invasive Cardiac Surgery
MInithoraCotomy vs Sternotomy for Multivessel Coronary Artery Bypass Grafting: A Partially Randomized Patient Preference Trial Assessing Quality of Life and Patency Outcomes
This trial will address essential questions of the efficacy and safety of MICS-CABG in addition to the quality of life and patency rate of the grafts.
- Trial name
- NCT04795193
- Testing
- Minimal invasive coronary surgery, Off-pump coronary artery bypass surgery
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Peking University Third Hospital
Anesthesia, Neurocognitive Disorders
Neurocognitive Disorders After Major Surgery in Elderly
The objective of the study is to investigate, in patients aged 70 years and over undergoing major non-cardiac surgery, the effect of electroencephalic (EEG)-guided anesthesia on postoperative neurocognitive disorders when…
- Trial name
- POEGEA (NCT04825847)
- Testing
- BIS monitor, Control group
- Where
- Canada
- Volunteers
- 314 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Postoperative Complications
Role of Cerebral Oximetry in Reducing Postoperative Morbidity Following Cardiac Surgery
Cerebral oximetry employing near-infrared spectroscopy (NIRS) is a non-invasive modality used to estimate regional cerebral oxygen content saturation (rSO2).
- Trial name
- NCT02155868
- Testing
- Correction rSO2 desaturation., Standard treatment
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Female, Male
Towards a Sex-specific "Female Enhanced Recovery After Cardiac Surgery'' (F-ERAS) Pathway:
The aim of this study is to evaluate the differences between men and women undergoing cardiac surgery. We will look at perioperative factors such as body weight, body surface area, previous medical history, pharmacokinetics…
- Conditions
- Female, Male, Surgery,Cardiac
- Trial name
- F-ERAS (NCT06175650)
- Testing
- Cardiac surgery
- Where
- Netherlands
- Volunteers
- 5,500 people
- Sponsor
- Jennifer Breel
Thoracic Surgery
Positive Expiratory Pressure With Blow-bottle Device Versus EPAP After Postoperative Cardiac Surgery
Cardiac surgery is a recommended therapeutic option as a form of secondary prevention for the treatment of cardiovascular diseases, but may present postoperative alterations such as reduction of pulmonary volumes and flows…
- Trial name
- NCT03639974
- Testing
- PEP in a blow-bottle device, EPAP, conventional physiotherapy
- Where
- Brazil
- Volunteers
- 163 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Coronary Artery Bypass Graft Surgery Patients
Improving Outcomes and Quality of Life After CABG
The principal objective to this randomized trial is to compare the efficacy of two strategies of intra-operative hemodynamic management during cardiopulmonary bypass among patients undergoing primary elective coronary artery…
- Trial name
- NCT00256620
- Testing
- Mean arterial pressure during cardiopulmonary bypass 80 mmHg vs. customized
- Where
- United States
- Volunteers
- 412 people
- Sponsor
- Weill Medical College of Cornell University
Perioperative Myocardial Infarction, Perioperative Myocardial Injury
Monitoring of Vital Signs for Phenotyping of Perioperative Myocardial Infarction/Injury After Noncardiac Surgery
The goal of this observational prospective cohort study is to learn about the pathophysiology of perioperative myocardial infarction/injury in high-risk patients undergoing major non-cardiac surgery.
- Trial name
- PMI-VITAL (NCT05866874)
- Where
- Switzerland
- Volunteers
- 875 people
- Sponsor
- University Hospital, Basel, Switzerland
Male Infertility, Heart Valve Disease
Warfarin Effects on Male Fertility After Cardiac Surgery
Young male patients undergoing cardiac surgery may require oral anticoagulation with warfarin either lifelong, such as after mechanical valve replacement, or for a limited postoperative period, for example following valve repair…
- Trial name
- NCT07330869
- Testing
- Semen analysis, sperm DNA fragmentation and hormonal evaluation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Città di Lecce Hospital, GVM Care & Research