Clinical trials: Patients Undergoing General Anesthesia
Anesthesia
A Multicenter, Open, Controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of Cipepofol Injection for General Anesthesia in Pediatric Patients Undergoing Elective Surgery
A multicenter, open, controlled, Phase III clinical study to evaluate the efficacy and safety of Cipepofol injection for general anesthesia in pediatric patients undergoing elective surgery
- Trial name
- NCT06391931
- Testing
- Cipepofol, Propofol
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Hypotension During Surgery
Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial
Elderly patients are frequently burdened with age-associated comorbidities and frailty, accompanied by physiological changes such as vascular stiffening, cardiac dysfunction, and impaired autonomic regulation.
- Trial name
- TAPH (NCT07328958)
- Testing
- titrated anesthesia
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Aortic Aneurysm, Postoperative Nausea and Vomiting
AoA Guided Thoracic Epidural Analgesia for Abdominal Aortic Repair
The aim of this randomized trial is to assess the efficacy of analgesia using either thoracic epidural or intravenous infusions for open lumbar infrarenal aortic aneurys repair and compare Numerical Rating Scale (NRS) with…
- Conditions
- Aortic Aneurysm, Postoperative Nausea and Vomiting, Postoperative Pain, Haemodynamic Stability
- Trial name
- AoA-AAA (NCT06609993)
- Testing
- intravenous rescue opioid analgesia using fentanyl, intravenous rescue atropine administration, intravenous rescue urapidil administration
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Michał Stasiowski
Airway Management, Shoulder Surgery
Ventilation Safety in Beach Chair Shoulder Surgery: SafeLM Versus I-gel
This study aims to compare the performance of SafeLM™ video laryngeal mask airway and i-gel® supraglottic airway device in patients undergoing shoulder surgery in the beach chair position under general anesthesia.
- Conditions
- Airway Management, Shoulder Surgery, General Anesthetic, Supraglottic Airway
- Trial name
- SAFE-BCP (NCT07501468)
- Testing
- SafeLM™ video laryngeal mask airway, i-gel® supraglottic airway device
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
Inflammatory Response in Total Knee Arthroplasty
Spinal Versus General Anesthesia and Inflammatory Response Measured by Delta Neutrophil Index in Total Knee Arthroplasty: An Observational Study
This study aims to compare the effects of spinal versus general anesthesia on the inflammatory response measured by Delta Neutrophil Index (DNI) in patients undergoing total knee arthroplasty.
- Trial name
- DNA-TKA (NCT07214558)
- Testing
- Routine Clinical Anesthesia Practice
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
General Anesthesia
Comparison of Sevoflurane and Desflurane on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study
This prospective randomized controlled study will compare the effects of sevoflurane and desflurane on the Analgesia Nociception Index (ANI) in adult patients undergoing general anesthesia.
- Trial name
- NCT07511634
- Testing
- Desflurane, Sevoflurane
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Pusan National University Yangsan Hospital
Abdominal Cancer Surgeries
Hemodynamic and Cardiac Effects of Dexmedetomidine Versus Fentanyl by Intravenous Infusion as Adjuncts to General Anesthesia in Patients Undergoing Major Abdominal Cancer Surgeries.
________________________________________ Background : Major abdominal cancer surgery is among the most invasive procedures, often associated with extensive tissue damage, severe postoperative pain, and delayed recovery.
- Trial name
- NCT07214714
- Testing
- Fentanyl (IV), Dexmedetomidine
- Volunteers
- 70 people
- Sponsor
- Assiut University
Post-operative Delirium
Interest in Combining Intraoperative ElectroEncephaloGram (EEG) With Assessment of Frailty to Predict Postoperative Delirium in Patients Aged >75 Years Undergoing Major Non-cardiac Surgery
Post-operative delirium (POD) is known to be independently associated with pre-operative frailty, pre-operative cognitive status and per-operative ElectroEncephaloGram (EEG).
- Trial name
- NCT06510140
- Testing
- Detection of the Post-operative delirium (POD)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
At the initiation of induction for non-intubated general anesthesia, ciprofol or propofol will be administered intravenously at a rate of 10 mL/min.
- Trial name
- NCT07670923
- Testing
- Propofol Injection, Ciprofol Injection
- Where
- China
- Volunteers
- 108 people
- Sponsor
- General Hospital of Ningxia Medical University
Asthma
Influence of Propofol on Alveolar Macrophage in Asthmatic Patients
The change of airway responsiveness and alveolar macrophage (AM) immunity occurs during the pathogenesis of asthma. Macrophage-associated airway protection in patients with asthma is affected positively or negatively by propofol…
- Trial name
- PAMAP (NCT00676416)
- Testing
- 2,6-Diisopropylphenol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanjing Medical University
Sore-throat
Incidence of Postoperative Sore-throat Incidence
Postoperative sore throat is a distressing but frequent symptom presented by the patients on the floor upon awakening from General Anesthesia, where endotracheal intubation is part of the Anesthetic protocol.
- Trial name
- InciPost (NCT05354154)
- Testing
- endotracheal intubation
- Where
- Pakistan
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Obesity, General Anesthesia
Hemodynamics Stability During Opioid Free Anesthesia for Patients with Obesity
The study evaluated the impact of Opioid-Free Anesthesia (OFA) and Fentanyl Anesthesia (FNT) on the hemodynamics of the circulatory system (HR, esCCO, esCCI, esSVI, BP: SYS, DIA, MEAN) in obese patients with a BMI > 40 undregoing…
- Conditions
- Obesity, General Anesthesia, Opioid Free Anaesthesia
- Trial name
- NCT06714981
- Testing
- Opioid Free Anaesthesia, Opioid based Anesthesia
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Laryngeal Disease, Pharyngeal Diseases
Comparison of Remimazolam and Propofol for Recovery of Ambulatory Upper Airway Surgery
The purpose of this study is to compare the effects of remimazolam and propofol on postoperative recovery time, complications, and safety in patients undergoing ambulatory upper airway surgery under general anesthesia.
- Conditions
- Laryngeal Disease, Pharyngeal Diseases, Oral Cavity Disease, Nasal Disease
- Trial name
- NCT06507202
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Chung-Ang University Gwangmyeong Hospital
Anesthesia, Hip Osteoarthritis
The Assessments of the Postoperative Recovery on Elderly Patients Received General Anesthesia or Peripheral Nerve Blocks
Postoperative recovery is always worrisome to the elder patients undergoing Total Hip Replacement (THR). Peripheral Nerve Blocks (PNBs), lumbar plexus block combined with sciatic nerve blocks, may be alterative anaesthesia style…
- Trial name
- NCT01782612
- Testing
- Multimodal analgesic techniques, Total uni-Hip Replacement
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Junle Liu
Neuromuscular Blockade
Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation in Adults
The study will enroll adult patients scheduled for elective surgery requiring general anesthesia with tracheal intubation. Participants will be randomly assigned to receive either HRS-9190 for Injection or Rocuronium.
- Trial name
- NCT07252921
- Testing
- HRS-9190
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Emergence Agitation
Effect of Lollipop on Emergence Delirium in Pediatric Patients Undergoing General Anesthesia
This study aims to evaluate the effectiveness of lollipop administration after surgery in reducing emergence agitation in pediatric patients undergoing anesthesia with sevoflurane at RS Ngoerah.
- Trial name
- LOLLIPOP-ED (NCT07571707)
- Testing
- Lollipop
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Udayana University
Patients Undergoing General Anesthesia
Intraoperative Body Temperature Measurement Using Infrared Camera: Comparison With Esophageal, and Skin Temperatures
"A method of monitoring body temperature during surgery is to measure esophageal temperature using a catheter. Although this method is known as a method to accurately measure core temperature, it is not recommended for local…
- Trial name
- NCT04964232
- Testing
- Infrared Camera, Esophageal Temperature Probe, Skin temperature probe
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Positive End-expiratory Pressure (PEEP), Intracranial Pressure
The Effects of Positive End-expiratory Pressure (PEEP) on Optic Nerve Sheath Diameter in Laparoscopic Cholecystectomy
This prospective interventional study will evaluate the effects of applying positive end-expiratory pressure (PEEP) at 10 cmH₂O on optic nerve sheath diameter (ONSD) in patients undergoing elective laparoscopic cholecystectomy…
- Conditions
- Positive End-expiratory Pressure (PEEP), Intracranial Pressure, Optic Nerve Sheath Diameter, Mechanical Ventilation
- Trial name
- PEEPON (NCT06979999)
- Testing
- Positive End-Expiratory Pressure (PEEP)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Nigde Omer Halisdemir University
Residual Neuromuscular Blockade
Effect of Calcium Chloride on Recovery From Neuromuscular Blockade
The purpose of this study is to evaluate the effect of calcium chloride against residual neuromuscular blockade at the end of general anesthesia
- Trial name
- NCT02213848
- Testing
- Calcium, control
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital