Clinical trials: Patients Undergoing General Anesthesia
Postoperative Nausea and Vomiting
Aprepitant PO vs Ondansetron IV for Prevention of Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) persists as one of the more common complications of surgery. Although rarely life-threatening, it is the postoperative outcome that is most unfavorable to patients, even more undesirable…
- Trial name
- NCT00699894
- Testing
- aprepitant 40 mg, ondansetron 4 mg
- Where
- United States
- Sponsor
- Northwell Health
Induction and Maintenance of General Anesthesia
A Study to Evaluate the Efficacy and Safety of HSK3486 in the Induction of General Anesthesia
This is a multi-center, randomized, single-blind, propofol injectable emulsion parallel-controlled Phase III clinical study. A total of patients undergoing elective surgery are intended to be enrolled and randomly assigned to…
- Trial name
- NCT04511728
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Inguinal Hernia
Awake Caudal Catheter vs General Anesthesia
It is well established that preterm inguinal hernias discovered in the NICU pose a significant surgical risk due to the associated co-morbid conditions that accompany these patients.
- Trial name
- NCT05919732
- Testing
- Bupivacaine, Dexmedetomidine, Caffeine, Tylenol, Propofol, rocuronium, caffeine, Tylenol, bupivacaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nemours Children's Clinic
Surgery, Anesthesia
Intravenous Sedation Versus General Anesthesia in Patients Undergoing Minor Gynecologic Surgery
The use of deep sedation may improve the quality of recovery of patients undergoing minor gynecologic procedures. These patients may also have shorter hospital stays and potentially lower healthcare costs.
- Conditions
- Surgery, Anesthesia, Pain
- Trial name
- NCT01890707
- Testing
- General Anesthesia, Deep Sedation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Apneic Oxygenation, High-flow Nasal Cannulae
High-flow Nasal Oxygenation in Obese Patients During Apnea
Before going off to sleep patients are given oxygen to saturate blood with oxygen to extend time before a decrease in the level of oxygen in the blood occurs.
- Conditions
- Apneic Oxygenation, High-flow Nasal Cannulae, Bariatric Surgery, Anesthesia Induction
- Trial name
- NCT03195504
- Testing
- HFNC, CON (control)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Postoperative Recovery, Pediatric Anesthesia
Timing of Aminophylline and Recovery in Pediatric Ambulatory Surgery
Beyond its established use as a bronchodilator and therapy for apnea of prematurity, aminophylline has demonstrated utility in reversing the effects of anesthetics, enhancing recovery by accelerating respiratory and cognitive…
- Conditions
- Postoperative Recovery, Pediatric Anesthesia, Ambulatory Surgery
- Trial name
- ELEAR-PAP (NCT07011134)
- Testing
- Group (E): receive aminophylline early intraoperatively,, Group (L) received aminophylline late intraoperatively, Group (C) will receive normal saline post-anesthetic discontinuation.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Hany Mohammed El-Hadi Shoukat Mohammed
Myocardial Injury
Effects of Remimazolam on Postoperative Myocardial Injury
This study is designed as a prospective, double-blind, randomized controlled trial to investigate the effect of remimazolam on intraoperative cardiac output (CO) in elderly patients undergoing general anesthesia, and to evaluate…
- Trial name
- NCT07725185
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Thoracic Surgery, General Anesthesia
Expiratory Flow Limitation in Thoracic Surgery (EFLinTOR)
Background and rationale of the study: During general anesthesia, the residual functional capacity (FRC) is reduced. If the FRC is lower than the minimum volume necessary to maintain the airway opening (closing capacity, CC), a…
- Trial name
- (EFLinTOR) (NCT03814538)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Parma
Oxidative Stress, Morbid Obesity
A Comparison of the Effects of Desflurane and TIVA on Antioxidant System in Morbidly Obese Patients
With the development of technology, the safety of anesthesia devices and the progression of monitoring techniques affect the anesthetic management.
- Trial name
- OxSys (NCT03814577)
- Testing
- Total Antioxidant Status, Total Oxidant Status, Bispectral Index
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Inonu University
Post-Induction Hypotension
Prediction of Post-Induction Hypotension Using Plethysmographic Variability Index During Diagnostic Laryngoscopy
This prospective observational study aims to evaluate whether non-invasive hemodynamic parameters, including the plethysmographic variability index (PVI) and perfusion index (PI), can predict post-induction hypotension in…
- Trial name
- NCT07458893
- Testing
- Plethysmographic Variability Index (PVI) and Perfusion Index (PI) Monitoring
- Volunteers
- 110 people
- Sponsor
- University of Gaziantep
Hypotension on Induction, Frailty
EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery
Post-induction hypotension (PIH) is a common and clinically significant hemodynamic complication following general anesthesia induction.
- Conditions
- Hypotension on Induction, Frailty, Anesthesia, General
- Trial name
- PIXEL (NCT07642765)
- Testing
- EASIX Score Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Konya City Hospital
Vitreoretinal Surgeries, Postoperative Nausea and Vomiting
Different Peribulbar Blocks With SPI-guided Anaesthesia for VRS (P&MSPIVRS)
The aim of this randomized trial is to assess the efficacy of preventive analgesia using different peribulbar blocks (PBB) under SPI-guided anaesthesia for vitreoretinal surgery (VRS), presence of PONV (postoperative nausea and…
- Conditions
- Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain, Oculocardiac Reflex
- Trial name
- PBBVRS (NCT03413371)
- Testing
- paracetamol, 0,5 % bupivacaine with of 2% lidocaine, 1 % Ropivacaine
- Where
- Poland
- Volunteers
- 184 people
- Sponsor
- Medical University of Silesia
Coronary Artery Disease
Etomidate Versus Propofol in CABG Surgery
The objective of this single-blinded randomized controlled interventional clinical trial is to learn about the efficacy and long-term safety of etomidate compared to propofol as an anesthesia induction agent in patients…
- Trial name
- ETOPRO (NCT06068764)
- Testing
- Etomidate, Propofol
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hartford Hospital
Anesthesia, Intravenous, Hemodynamic Stability
Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery
This single-center study at CHA Ilsan Medical Center compares intraoperative hemodynamics between remimazolam- and propofol-based total intravenous anesthesia (TIVA) in patients undergoing robot-assisted gynecologic surgery…
- Conditions
- Anesthesia, Intravenous, Hemodynamic Stability, Gynecologic Surgery
- Trial name
- By_HD (NCT07251101)
- Testing
- Remimazolam, Propofol
- Where
- 2 sites in South Korea
- Volunteers
- 58 people
- Sponsor
- Ilsan Cha hospital
Deep Extubation
Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia
It has been reported that deep extubation can reduce cardiopulmonary complication against endotracheal tube extubation during emergence from general anesthesia.
- Trial name
- NCT01924871
- Testing
- Desflurane with remifentanil, Desflurane
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Chung-Ang University Hospital
Pre-Eclampsia
Peri-operative Dexmedetomidine Infusion in Pre-eclamptic Patients
The purpose of this study is to investigate the effects of dexmedetomidine infusion on the stress response to intubation, postoperative analgesia, and renal functions (urinary output [UOP], creatinine and glomerular filtration…
- Trial name
- NCT03391609
- Testing
- Dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Hypotension
Pre-induction Norepinephrine in Septic Patients Undergoing Surgery
This randomized controlled trial aims to evaluate the effect of early pre-induction norepinephrine infusion on perioperative hemodynamic stability in septic patients with SOFA score ≥2 undergoing surgery under general anesthesia.
- Trial name
- NCT07869693
- Testing
- Norepinephrine, Standard Care
- Volunteers
- 90 people
- Sponsor
- Assiut University
Airway Management, Anesthesia, General
Video Laryngeal Mask SaCoVLM Versus LMA Supreme and Ambu AuraGain in Children
This randomised controlled trial compares three supraglottic airway devices (laryngeal masks) in children with a body weight of 3-30 kg undergoing elective surgery under general anaesthesia: the SaCoVLM video laryngeal mask (UE…
- Conditions
- Airway Management, Anesthesia, General, Pediatric Anesthesia
- Trial name
- SACOVLM-PEDI (NCT07891832)
- Testing
- SaCoVLM video laryngeal mask, LMA Supreme, Ambu AuraGain
- Where
- Czechia
- Volunteers
- 135 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Patients Undergoing General Anesthesia
Comparative Study of TetraGraph and Mechanomiograph Neuromuscular Monitors in Clinical Settings
Background: Neuromuscular monitoring plays a critical role in reducing postoperative residual neuromuscular blockade (PRNB), a significant risk factor for respiratory complications.
- Trial name
- EMGvsMMG (NCT06792058)
- Testing
- Mechanomiograph: The "gold standard" of quantitative monitoring, Electromiograph
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- University of Debrecen
Sex Differences, Postoperative Sleep Quality
Sex Difference Effects on Postoperative Sleep, Inflammation and Cognition in Patients Undergoing General Anesthesia
Video-Assisted Thoracoscopic Surgery(VATS) is among the most common and disabling persistent pain and inflammation conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men.
- Conditions
- Sex Differences, Postoperative Sleep Quality, Postoperative Pain, Inflammation Function
- Trial name
- NCT05059548
- Testing
- Video-Assisted Thoracoscopic Surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shengjing Hospital