Clinical trials: Patients Undergoing General Anesthesia
Opioid Free Anesthesia
A Comparative Study Between Analgesic Effect of Opioid Free and Opioid Based Anesthesia in Radical Nephrectomy Surgery
Patients undergoing nephrectomy have a high incidence of postoperative pain. In the perioperative period, these patients are often treated with patient-controlled opioids, epidural analgesia, or both.
- Trial name
- NCT05312541
- Testing
- pre emptive local anaesthetic wound infiltration
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Obesity, Anesthesia
Pre-oxygenation Methods in Bariatric Patients
The purpose of the study is to compare effectiveness of different methods of achieving pre-oxygenation in bariatric patients. The investigators intend to compare facemask pre-oxygenation with a high-flow humidified nasal oxygen.
- Conditions
- Obesity, Anesthesia, Bariatric Surgery Candidate
- Trial name
- NCT03428256
- Testing
- Optiflow and THRIVE technique, Standard anaesthetic face mask
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Tissue Perfusion, Lower Extremity Surgery
Comparison of the Effects of General Anesthesia and Spinal Anesthesia on Tissue Perfusion in Patients Undergoing Lower Extremity Surgery
This prospective, single-center observational study compares the effects of general anesthesia and spinal anesthesia on tissue perfusion in patients undergoing lower extremity surgery with tourniquet use.
- Conditions
- Tissue Perfusion, Lower Extremity Surgery, Tourniquet-Induced Ischemia-Reperfusion Injury, General Anesthesia
- Trial name
- Perf-LEX (NCT07474480)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Laparoscopic Cholecystectomy Surgery
Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia
Laparoscopic cholecystectomy (LC) is considered the standard treatment for gallbladder disease.1 Compared to open cholecystectomy, LC is the preferred treatment approach because it is associated with less surgical trauma, shorter…
- Trial name
- NCT06838650
- Testing
- Dexmedetomidine, Saline
- Volunteers
- 100 people
- Sponsor
- Assiut University
Postoperative Pain Management
Ultrasound-guided Erector Spinae Plane Block Versus Transversus Abdominis Plane Block for Postoperative Analgesia of Adult Patients Undergoing Ovarian Cancer Surgery
Postoperative pain is one of the greatest patient concerns following any surgery. Although an increased emphasis has been placed on pain management, approximately 80% of surgical patients report postoperative pain with 86% of…
- Trial name
- NCT04434339
- Testing
- erector spinae block, transversus abdominis block
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intraoperative Ventilation, Respiratory Mechanics
Peak Airway Pressure and Respiratory Mechanics During PRVC Ventilation in Laparoscopic Surgery
This study aims to evaluate peak airway pressure and respiratory mechanics during pressure-regulated volume control (PRVC) ventilation in patients undergoing elective laparoscopic abdominal surgery.
- Trial name
- NCT07543939
- Testing
- PRVC Ventilation
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- Specialized Medical Center (SMC)
Inflammatory Response
Effect of Intravenous Ibuprofen on Inflammatory Responses in Patients Undergoing Surgery With General Anesthesia.
The administration of anti-inflammatory drugs such as ibuprofen before and after surgery has not been studied extensively. Subjects are being asked to participate in this study because they are scheduled for surgery and because…
- Trial name
- NCT01377441
- Testing
- Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- NYU Langone Health
Aneurysm Abdominal, Endovacular Repair
Post Implantation Syndrome and Administration on NSAIDs in Patients Undergoing EVAR for AAA
INTRODUCTION Post-implantation syndrome is the clinical and biochemical expression of an inflammatory response following endovascular repair of an aortic aneurysm.
- Trial name
- NCT03727412
- Testing
- Drugs, Generic (Naprosyn)
- Where
- Greece
- Volunteers
- 186 people
- Sponsor
- University of Thessaly
Osteoarthritis
Early Mobilization After Total Knee Arthroplasty
Patients undergoing elective total knee arthroplasty are randomized to either intrathecal anesthesia, wound infiltration with local anesthetics and standardized postoperative care (NA = neuraxial anesthesia) or general…
- Trial name
- NCT01604382
- Testing
- General Anesthesia, Neuraxial anesthesia
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Anesthesia
The PROTECT Trial: PROpofol Titration to Enhance haemodynamiC sTability
The aim of this multicentre, single-blinded, expertise-based randomised controlled trial is evaluate whether slowly increasing the dose of the anaesthetic drug propofol based on a patient's needs leads to more stable blood…
- Trial name
- NCT06980688
- Testing
- Propofol titration, Conventional propofol induction
- Where
- 4 sites in Switzerland
- Volunteers
- 320 people
- Sponsor
- University Hospital, Basel, Switzerland
Neurocognitive Disorders, Neutrophil-Lymphocyte Ratio
NLR and PRL in Neurocognitive Disorders
Preliminary evidence suggest a possible relationship between Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) and perioperative neurocognitive disorders (NCD).
- Conditions
- Neurocognitive Disorders, Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio
- Trial name
- NCT04736290
- Testing
- NLR, PLR
- Where
- Greece
- Volunteers
- 288 people
- Sponsor
- University of Thessaly
General Anesthesia
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Intravenous Anesthesia
Quantium Medical Company has an ElectroEncephalograph-based (EEG-based) algorithm with two outputs: qCON for unconsciousness and qNOX for anti-nociception.
- Trial name
- Bis-qCON-IV (NCT03753217)
- Testing
- qCON Monitor
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Hopital Foch
Postoperative Pain, Postoperative Nausea and Vomiting
Effectiveness of Low-Dose Ketamine and Intravenous Lidocaine Versus Fentanyl for Postoperative Pain
Background: Rational approaches to perioperative patient management have been used to meet intraoperative analgesic needs and avoid opioid-related adverse effects.
- Trial name
- Vs(versus) (NCT07213687)
- Testing
- Low dose intravenous ketamine
- Where
- Ethiopia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dilla University
Effect of Drugs
Dexmedetomidine Adjuvant to General Anesthesia of Abdominal Hysterectomy
To assess the effect of perioperative Dexmedetomidine infusion on Interleukin 6 and cortisol level in patients undergoing general anesthesia for total abdominal hysterectomy
- Trial name
- NCT03600506
- Testing
- Dexmedetomidine
- Volunteers
- 52 people
- Sponsor
- Suez Canal University
Postoperative Nausea and Vomiting
Intravenous Haloperidol Versus Ondansetron for Treatment of Established Post-operative Nausea and Vomiting
This study aims to prove that at a dose of 1 mg Haloperidol possesses a high success rate in controlling established postoperative nausea and vomiting (PONV) in the first 24 hours following administration similar to the standard…
- Trial name
- NCT02143531
- Testing
- 4 mg of Ondansetron IV, 1mg of Haloperidol IV
- Where
- Lebanon
- Volunteers
- 120 people
- Sponsor
- American University of Beirut Medical Center
Pulmonary Aspiration of Gastric Contents
Comparison of Different Preoperative Fasting Times in Pediatric Patients Undergoing Elective General Anaesthesia
Rationale of this study is to provide an evidence on minimal safe clear fluid fasting duration without the risk of aspiration of gastric contents during elective pediatric procedures under general anesthesia.
- Trial name
- NCT05922072
- Testing
- Nasogastric aspiration for measurement of Residual Gastric Volume, Nasogastric Aspiration for Measurement of Gastric pH
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- King Edward Medical University
Dexmedetomidine, Postoperative Delirium
Different Administration Routes of Dexmedetomidine on Postoperative Delirium
Intravenous dexmedetomidine has been reported to decrease the occurrence of postoperative delirium (POD) in elderly patients. Nevertheless, some previous studies have indicated that intratracheal dexmedetomidine and intranasal…
- Conditions
- Dexmedetomidine, Postoperative Delirium, General Anesthesia
- Trial name
- NCT05952050
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery
The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury
In this prospective, randomized, single-blind study, we aim to compare the effects of general anesthesia and spinal anesthesia on postoperative myocardial injury in elderly patients undergoing hip surgery.
- Conditions
- Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery, Anesthesia, General, Anesthesia, Spinal
- Trial name
- NCT06343259
- Testing
- General Anesthesia, Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Cognitive Decline, Urinary Bladder Cancer
Association of POCD With Circulating Biomarkers in Patients Undergoing TUR of Bladder Tumor
Bladder tumor is one of the most widespread tumors in the world, with increasing prevalence at the global level. One of the procedures in patients with bladder tumors is transurethral resection of the bladder (TURM) most often…
- Conditions
- Cognitive Decline, Urinary Bladder Cancer, Frail, Biomarker
- Trial name
- NCT07165236
- Where
- Croatia
- Volunteers
- 42 people
- Sponsor
- Osijek University Hospital
Anesthesia, General, Major Abdominal Surgeries
The Impact of Multimodal Brain Monitoring on Postoperative Outcomes in Elderly Patients Undergoing Major Abdominal Surgery
The purpose of this clinical trial is to investigate the effect of multimodal brain monitoring under general anesthesia on postoperative outcomes in elderly patients undergoing abdominal surgery.The research hypothesis is that…
- Trial name
- NCT07713355
- Testing
- Multimodal brain monitoring guided anesthesia, Bispectral Index(BIS) monitoring guided anesthesia
- Where
- 4 sites in China
- Volunteers
- 368 people
- Sponsor
- Xuanwu Hospital, Beijing