Clinical trials: Patients Undergoing General Anesthesia
Post Induction Hypotension
Effects of Esketamine and Bilateral Lower Limb Elevation on Hemodynamic Stability During Induction of General Anesthesia in Elderly Patients Undergoing Thoracic Surgery
Video-assisted thoracoscopic surgery (VATS) is widely used in thoracic surgery due to small incisions, low stress response, and high patient tolerance.
- Trial name
- NCT07374458
- Testing
- Esketamine, Bilateral Lower Limb Elevation
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Airway Management
SafeLM Versus LMA Classic for Airway Management During Fibroadenoma Excision
This randomized controlled trial compares the airway management performance of the SafeLM video laryngeal mask with the LMA Classic in adult patients undergoing elective fibroadenoma excision under general anesthesia.
- Trial name
- NCT07835750
- Testing
- SafeLM Video Laryngeal Mask, LMA Classic
- Volunteers
- 132 people
- Sponsor
- Hanoi Medical University
Post-induction Hypotension
Pleth Variability Index as a Predictor for Post-induction Hypotension in Elderly Patients
Hypotension after induction of general anesthesia and before surgical stimulation is a prevalent anesthesia-related side effect.
- Trial name
- NCT04886089
- Testing
- Pleth variability index for prediction of post-induction hypotension
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Cairo University
Stress
Effects of TEAS on Stress Response During Extubation of General Anesthesia in Elderly Patients
Elderly patients have an increased risk of stress responses during extubation after general anaesthesia for an elective supratentorial craniotomy.
- Trial name
- NCT02533388
- Testing
- Hwato Electronic Acupuncture Treatment Instrument
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Atrial Fibrillation
General Anesthesia With ETT vs LMA in Patients Undergoing Ablation for Atrial Fibrillation
In recent years it has been shown that catheter ablation of symptomatic atrial fibrillation (PAF) is superior to antiarrhythmic drug therapy with regards to effectiveness and clinical outcomes.
- Trial name
- NCT02896595
- Testing
- General Anesthesia with endotracheal tube, General Anesthesia with laryngeal mask airway
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Spinal Disease
General Anesthesia and Regional Cerebral Oxygenation inSpine Surgery Prone Position
Elderly patients are reportedly at higher risk of postoperative cognitive dysfunction (POCD).The authors hypothesized that the incidence of POCD would be affected by several factors including, the age of the patient, the degree…
- Trial name
- NCT05148637
- Testing
- Maintenance of general anesthesia by Sevoflurane, Maintenance of general anesthesia by Desflurane, Anesthesia was maintained by inhalational anesthesia (total intravenous anesthesia by lidocaine, propfol and fentanyl infusions)
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University
Healthy
The Efficacy and Safety of Gantacurium Chloride for Injection in Tracheal Intubation in Healthy Adult Patients Undergoing Surgery Under General Anesthesia
This is a multicenter, randomized, controlled, observer-blinded, dose-response study to evaluate the efficacy in tracheal intubation and safety of gantacurium chloride for injection in healthy adult patients undergoing surgery…
- Trial name
- NCT00235976
- Testing
- Gantacurium Chloride for Injection (AV430A)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Avera Pharmaceuticals
Intubation, General Anesthesia
Does the Use of the GlideRite® Endotracheal Tube in Combination With the I-gel® Improve Intubation Success Rate?
The investigators aim to compare two different types of supraglottic devices for tracheal intubation in patients undergoing elective surgery under general anesthesia.
- Trial name
- NCT01265862
- Testing
- Tracheal intubation through LMA-Fastrach®, Tracheal intubation through I-gel®
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Post-induction Hypotension (PIH)
Preoperative Caval-Aortic Index and Pleth Variability Index for Predicting Post-Induction Hypotension in Colorectal Surgery
This prospective observational study evaluated whether the preoperative caval-aortic index and pleth variability index can predict post-induction hypotension in adult patients undergoing elective colorectal surgery under general…
- Trial name
- NCT07876362
- Testing
- Preoperative Caval-Aortic Index and Pleth Variability Index Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Geriatrics, Hypotension on Induction
Carotid Artery Corrected Flow Time and Inferior Vena Cava Collapsibility Index for Prediction of Hypotension After Induction of General Anesthesia in Geriatric Patients Undergoing Elective Surgery
In this observational study, we will assess cFT by Carotid ultrasound and IVC collapsibility index for prediction of hypotension after induction of general anesthesia in geriatric patients undergoing elective surgery.
- Conditions
- Geriatrics, Hypotension on Induction, General Anesthetic Drug Adverse Reaction, Elective Surgery
- Trial name
- NCT06814054
- Testing
- Carotid Artery Corrected Flow Time measurement, Inferior vena cava collapsibility index
- Where
- Egypt
- Volunteers
- 189 people
- Sponsor
- Tanta University
Predict Diificult Endotracheal Intubation
Role of Airwayultrasound in Predicting Difficult Endotracheal Intubation in Patients Undergoing General Anesthesia
Unpredictable difficult endotracheal intubation remains a challenge especially if difficult ventilation occurs. Difficult intubation is associated with many severe fatal complications including air way trauma, laryngospasm…
- Trial name
- NCT05961254
- Testing
- assesment of difficult endotracheal intubation by airway ultrasound
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Sohag University
Upper Airway Edema, Postextubation Stridor
Trendelenburg Angle and Upper Airway Ultrasound Findings in Laparoscopic Hysterectomy
This observational study was designed to evaluate whether the Trendelenburg position used during laparoscopic hysterectomy is associated with swelling of the upper airway.
- Conditions
- Upper Airway Edema, Postextubation Stridor, Laparoscopic Hysterectomy
- Trial name
- TAU-LH (NCT07794917)
- Testing
- Trendelenburg positioning during laparoscopic hysterectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Izmir City Hospital
Residual Neuromuscular Blockade, Diaphragm Dysfunction
Diaphragm Ultrasound and Neuromuscular Monitoring for Predicting Early Respiratory Events After Extubation
The goal of this prospective observational study is to learn whether diaphragm ultrasound and quantitative neuromuscular monitoring can predict early respiratory events after extubation in adults having elective surgery under…
- Conditions
- Residual Neuromuscular Blockade, Diaphragm Dysfunction, Postoperative Pulmonary Complications, Airway Extubation
- Trial name
- DIAPHEX (NCT07912437)
- Testing
- Diaphragm ultrasonography4
- Volunteers
- 100 people
- Sponsor
- Mustafa Duran
Diastolic Dysfunction, Coronary Artery Disease
Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index
The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.
- Conditions
- Diastolic Dysfunction, Coronary Artery Disease, General Anesthesia
- Trial name
- NCT00907439
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
General Anesthesia, Intraoperative Awareness
Neuro-Mimic Indicators of Anesthesia Depth During General Anesthesia
This prospective observational study will evaluate neuro-mimic indicators of anesthesia depth, including eyelid reflex, eyeball movements, and pupil responses, in patients undergoing elective surgery under general anesthesia.
- Conditions
- General Anesthesia, Intraoperative Awareness, Eye Movements
- Trial name
- NCT07199049
- Testing
- Neuro-Mimic Observation Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Patients Undergoing General Anesthesia
Respiratory and Hemodynamic Targets During General Anesthesia
This trial is an investigator-initiated, multicenter, randomized, factorial, single-blind trial of multiple hemodynamic and respiratory targets during general anesthesia.
- Trial name
- GA-TARGETS (NCT06047119)
- Testing
- Blood pressure, Positive end expiratory pressure, Tidal volume
- Where
- 6 sites in Denmark
- Volunteers
- 485 people
- Sponsor
- Lars Wiuff Andersen
General Anesthesia
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Anesthesia With Sevoflurane
Quantium Medical Company has an ElectoEcenphalograph-based (EEG-based) algorithm with two outputs: qCON for unconsciousness and qNOX for anti-nociception.
- Trial name
- Bis-qCon-Hal (NCT03359512)
- Testing
- qCON monitor
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Hopital Foch
Postoperative Nausea and Vomiting
Association Between Preoperative Metformin Exposure and Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia
The aim of this observational study is to investigate the potential effects of metformin on postoperative nausea and vomiting (PONV) in patients undergoing surgery under general anesthesia.
- Trial name
- Met-PONV (NCT07244575)
- Where
- China
- Volunteers
- 909 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Strabismus
Peribulbar Block for Prevention of Oculocardiac Reflex
Strabismus is a common ophthalmic problem in Egypt that usually requires surgical correction. This surgery primarily aims to improve alignment of visual axis but may be required only for cosmetic reasons.
- Trial name
- NCT04549844
- Testing
- Bupivacaine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Hypovolemia
Lung Recruitment Maneuver for Predicting Fluid Responsiveness in Children
Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the changes of dynamic variables through lung recruitment maneuver could predict…
- Trial name
- NCT03184961
- Testing
- lung recruitment maneuver
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital