Clinical trials: Patients With Bipolar Disorders
Schizophenia Disorder, Bipolar Disorder (BD)
Effects of Schizophrenia and Bipolar Disorder on Exercise Capacity, Pulmonary Function, and Quality of Life
This observational study aims to evaluate exercise capacity, pulmonary function, respiratory muscle strength, and quality of life in individuals diagnosed with schizophrenia and bipolar disorder.
- Trial name
- NCT07306468
- Testing
- Pulmonary Function Test, Respiratory Muscle Strength Evaluation, Quality of Life Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Schizophrenic Disorders, Schizoaffective Disorders
Effectiveness of a Physical Activity and Diet Program in Patients With Psychotic Disorder (CapiCor)
The aim is to evaluate the effectiveness of an intervention based on a program of physical activity and diet coordinated between primary care teams (PCT) and Mental Health Centres (MHC) to modify the weekly physical activity (PA)…
- Conditions
- Schizophrenic Disorders, Schizoaffective Disorders, Bipolar Disorders
- Trial name
- CapiCor (NCT01729650)
- Testing
- Physical and diet educational group
- Where
- Spain
- Volunteers
- 332 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Bipolar Disorder Mania
Study to Evaluate the Efficacy and Safety of Aripiprazole Administered With Lithium or Valproate Over 12 Weeks in the Treatment of Mania in Bipolar I Disorder
The purpose of the study is to determine whether aripiprazole provides additional clinical benefit to patients with Bipolar I disorder when combined with lithium or valproate over 12 weeks.
- Trial name
- NCT00665366
- Testing
- Aripiprazole, Lithium, Valproate
- Where
- 73 sites in Austria, Czechia and 11 more
- Volunteers
- 493 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Bipolar Disorder
A Study to Evaluate the Efficacy and Safety of Risperidone for the Prevention of Mood Episodes in the Treatment of Patients With Bipolar I Disorder
The purpose of this randomized, double blind, double dummy, multicenter study was to evaluate the efficacy of risperidone long-acting injectable (LAI) monotherapy in comparison with placebo in the prevention of a mood episode in…
- Trial name
- NCT00391222
- Testing
- Olanzapine, Risperidone Long Acting Injectable (LAI)
- Where
- 63 sites in China, Colombia and 13 more
- Volunteers
- 585 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Bipolar Disorder
Efficacy of N-Acetyl-Cysteine in Bipolar Disorder and Tobacco Use Disorder
Effects of N-Acetyl-Cysteine in patients with bipolar depression (primary outcome is Hamilton Depression Rating Scale) with and without tobacco use disorder and on inflammatory and oxidative stress biomarkers
- Trial name
- NACBD (NCT02252341)
- Testing
- N-Acetyl-Cysteine
- Where
- Brazil
- Volunteers
- 130 people
- Sponsor
- Universidade Estadual de Maringá
Cardiovascular Risk, Depression, Unipolar
LIVES: Personalized Lifestyle Intervention for Patients With Depression
Persons with affective disorder have a considerably increased risk of cardiovascular disease. To a considerable extent, this is due to an unhealthy life style.
- Conditions
- Cardiovascular Risk, Depression, Unipolar, Depression, Bipolar
- Trial name
- LIVES (NCT05767073)
- Testing
- Lifestyle InterVEntion (LIVE)
- Where
- 2 sites in Netherlands
- Volunteers
- 38 people
- Sponsor
- University Medical Center Groningen
Bipolar Disorder
Geodon in Weight Loss Study for Bipolar Disorders
This research study is designed to determine if replacing your current antipsychotic and/or mood stabilizer with ziprasidone (Geodon) will impact weight.
- Trial name
- NCT00472641
- Testing
- Ziprasidone/Geodon
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Bipolar Disorder
To Evaluate the Efficiency and Safety of Quetiapine Fumarate in the Treatment of Acute Manic Patients With Bipolar Disorder.
This is an open label, randomised, parallel-group study to compare the efficacy and safety of quetiapine and valproate used as monotherapy in the treatment of mania in patients hospitalised for an acute manic episode.
- Trial name
- NCT00742638
- Testing
- Quetiapine fumarate, Sodium valproate
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Major Depression, Bipolar Depression
Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression
The primary objectives of this study are to investigate the potential for ketamine anesthesia to increase the antidepressant efficacy of Electroconvulsive therapy (ECT) and to decrease acute ECT-induced adverse cognitive effects.
- Trial name
- NCT01309581
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- James Murrough
Bipolar Disorder
Efficacy and Safety of Task-activated rTMS in Improving Cognitive Function in Patients With Bipolar Disorder
1. To clarify the efficacy and safety of task-based repetitive transcranial magnetic stimulation (rTMS) on cognitive function in patients with stable bipolar disorder. 2.
- Trial name
- NCT06782763
- Testing
- Repetitive transcranial magnetic stimulation device
- Where
- China
- Volunteers
- 82 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Schizophrenia, Bipolar 1 Disorder
A Trial to Measure the Difference in All-cause Hospitalizations for Participants Who Are Using Abilify MyCite Versus Virtual Matched Controls in Adults With Schizophrenia, Bipolar 1 Disorder, and Major Depressive Disorder
The primary objective of this pragmatic clinical trial (Main Study) was to assess the difference between all-cause hospitalizations in participants using Abilify MyCite versus virtual matched controls.
- Conditions
- Schizophrenia, Bipolar 1 Disorder, Major Depressive Disorder
- Trial name
- NCT03643159
- Testing
- Abilify MyCite - Digital Medicine System, Aripiprazole or other oral antipsychotics
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Bipolar Disorder (BD), Major Depressive Episode (MDE)
Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder
The goal of this interventional clinical trial is to assess the diagnostic performance of a composite diagnostic medical devise based on blood-based in vitro diagnostic device and Mood Disorder Questionnaire (MDQ) in identifying…
- Conditions
- Bipolar Disorder (BD), Major Depressive Episode (MDE), Primary Care, Major Depression
- Trial name
- BIPOVITE (NCT07031817)
- Testing
- Venous blood sample for measuring blood biomarkers related to bipolar disorder, Standardized psychiatric assessment tools
- Where
- France
- Volunteers
- 623 people
- Sponsor
- University Hospital, Montpellier
Bipolar I Disorder, Mania
A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features
1) To evaluate the efficacy and safety of cariprazine at a target dose of 3.0 mg/day compared with placebo in prevention of relapse in patients with bipolar I disorder whose current episode (i.e.
- Conditions
- Bipolar I Disorder, Mania, Depression
- Trial name
- NCT03573297
- Testing
- Cariprazine
- Where
- 108 sites in United States, Bulgaria and 9 more
- Volunteers
- 901 people
- Sponsor
- AbbVie
Affective Psychosis, Bipolar, Depression, Bipolar
Phase III/Seroquel SR Bipolar Depression Monotherapy - US
The purpose of this study is to determine the safety and efficacy of sustained-release quetiapine fumarate (Seroquel®) in the treatment of patients with Acute Bipolar Depression for 8 weeks.
- Conditions
- Affective Psychosis, Bipolar, Depression, Bipolar, Manic-Depressive Psychosis, Psychoses, Manic-Depressive
- Trial name
- NCT00422214
- Testing
- Quetiapine fumarate (Seroquel) SR
- Where
- 54 sites in United States
- Volunteers
- 400 people
- Sponsor
- AstraZeneca
Quality of Life, Treatment Compliance
Effect Of Treatment Compliance Training Given To Patients With Bipolar Disorder
In bipolar disorder, treatment noncompliance is associated with high rates of recurrence and hospitalization. Furthermore, it is reported that that treatment noncompliance disturbs the social functioning of patients and reduces…
- Trial name
- NCT04393987
- Testing
- Treatment Compliance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Uşak University
Bipolar Disorder
Self-Monitoring and Psychoeducation in Bipolar Patients With a Smart-phone Application
Bipolar disorder is a frequent condition in the general population with a high morbimortality, which consists in dysfunctional temporal fluctuations between different mood phases ranging from depression to manic episodes with…
- Trial name
- SIMPLE (NCT02258711)
- Testing
- SIMPLE 2.0
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Hospital Clinic of Barcelona
Bipolar Disorder
AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium
Lithium (Li) is the leading treatment for BD, protecting against both maniac and depressive relapse, and reducing the risk of suicide and mortality.
- Trial name
- AMIND (NCT05044611)
- Testing
- Anhydrous Amiloride Hydrochloride
- Where
- 2 sites in France
- Volunteers
- 148 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma
Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer
This phase I trial tests the change in androgen receptor sensitivity, side effects and effectiveness of bipolar androgen therapy, using testosterone, in patients with castration resistant prostate cancer that has spread to other…
- Conditions
- Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
- Trial name
- NCT06305598
- Testing
- Biopsy, Bone Scan, Computed Tomography
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Roswell Park Cancer Institute
Bipolar Disorder, Depression
Effect of Immersive Virtual Reality-based Cognitive Remediation in Patients With Mood - or Psychosis Spectrum Disorders
The goal of this clinical trial is to investigate the effect of a four-weeks, intensive virtual reality (VR)-based cognitive remediation (training) programme involving simulated daily-life challenges on cognition and functional…
- Conditions
- Bipolar Disorder, Depression, Psychotic Disorders, Cognitive Impairment
- Trial name
- NCT06038955
- Testing
- Virtual reality Based Cognitive Remediation, Virtual reality control training
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Bipolar Disorder Family Members
A Psychoeducation Intervention for Caregivers of Patients With Bipolar Disorder
Bipolar disorder is a debilitating chronic illness characterized by periods of elation and depression. Since deinstitutionalization of the mentally ill over 40 years ago, families have become major caregivers for patients with…
- Trial name
- NCT02446509
- Testing
- Psychoeducation, Psychoeducation - Delayed
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston