Clinical trials: Patients With Bipolar Disorders
Bipolar Disorder, Bipolar Depression
Empagliflozin Adjunctive Therapy in Bipolar Depression
Bipolar disorder is a long-term mental health condition that causes mood changes, with depressive episodes being the most frequent and disabling.
- Conditions
- Bipolar Disorder, Bipolar Depression, Insulin Resistance
- Trial name
- EMPA-BD (NCT07472920)
- Testing
- Empagliflozin (EMPA)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Bipolar Disorder, Bipolar Depression
Functional Assessment of Patients With Acute Bipolar Depression After 8 Months of Follow-up
This study aims to study prospectively for 8 months a sample of bipolar patients with acute depressive episode in order to identify that factors associated with functional impairment, with especial attention to the presence of…
- Trial name
- NCT01255982
- Where
- 24 sites in Spain
- Volunteers
- 249 people
- Sponsor
- AstraZeneca
Benign Prostatic Hyperplasia
B-TURP vs BipolEP in Management of BPH Patients With Medium-sized Prostates
This is a comparative study of the efficacy and safety of endoscopic bipolar transurethral resection and enucleation of the prostate in management of benign prostatic hyperplasia patients with medium-sized prostates
- Trial name
- NCT06939062
- Testing
- Bipolar enucleation of the prostate (BipolEP), Bipolar transurethral resection of the prostate (B-TURP)
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Assiut University
Depression - Major Depressive Disorder, Depression Bipolar
Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided Intermittent Theta Burst Stimulation (iTBS) in Patients With Depression
Aim: The purpose of the study is to establish the non-inferiority of right-sided inhibitory 1 Hz stimulation compared to left-sided intermittent theta burst stimulation (iTBS) in unipolar and bipolar depression.
- Trial name
- NCT07026461
- Testing
- repetitive transcranial magnetic stimulation, intermittent theta burst stimulation
- Where
- 2 sites in Sweden
- Volunteers
- 350 people
- Sponsor
- Region Örebro County
Bipolar Disorder
One-Year Trial of Oral Ziprasidone in Bipolar Patients With Metabolic Syndrome
The purpose of this study is to explore the impact of Ziprasidone HCl on the distribution of metabolic syndrome (MS) risk factors in a population of Bipolar patients presenting with glucose intolerance, dyslipidemia and/or…
- Trial name
- NCT01113541
- Testing
- Ziprasidone HCL (oral)
- Where
- 10 sites in Canada
- Volunteers
- 13 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Depression, Bipolar
Safety, Tolerability, and Efficacy of Cariprazine in Participants With Bipolar Depression
The objective of this study was to evaluate the efficacy, safety, and tolerability of cariprazine relative to placebo for the treatment of participants with bipolar depression.
- Trial name
- NCT01396447
- Testing
- Cariprazine
- Where
- 88 sites in United States, Bulgaria and 4 more
- Volunteers
- 584 people
- Sponsor
- Forest Laboratories
Acute Psychotic Episode, Schizophrenia Spectrum and Other Psychotic Disorders
Copeptin in Outcome Prediction of an Acute Psychotic Episode
An acute psychotic episode is a severe psychiatric syndrome which might occur in different psychiatric diagnoses. The outcome prediction of relapse rate of a psychotic episode within a certain time frame is difficult and depends…
- Conditions
- Acute Psychotic Episode, Schizophrenia Spectrum and Other Psychotic Disorders, Affective Disorder, Bipolar Disorder
- Trial name
- CoPsych (NCT03235908)
- Testing
- Observation only
- Where
- Switzerland
- Volunteers
- 73 people
- Sponsor
- University Hospital, Basel, Switzerland
Depression, Bipolar Disorder
Effect of Quetiapine on Brain Activity Patterns in Patients With Heightened Risk of Bipolar Disorder
Bipolar disorder (BPD) is often misdiagnosed as unipolar depression. This leads to inadequate treatment and can have negative impact on the course of the disease.
- Trial name
- NCT02451306
- Testing
- Quetiapine
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- RWTH Aachen University
Bipolar Disorders
Omega-3 Fatty Acids in Bipolar Patients With a Low Omega-3 Index and Reduced Heart Rate Variability
This study sets out to test the hypothesis that parameters of heart rate variability, as a non-invasive measure of cardiovascular risk, can be improved by the addition of omega-3 fatty acids in euthymic bipolar patients with a…
- Trial name
- NCT00891826
- Testing
- Omega-3 fatty acids (EPAX 6015 TG), Corn oil
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Bipolar Disorder, Cognitive Symptom
A Study of Aerobic Exercise for Patients With Bipolar Disorder
This study will investigate the effects of aerobic exercise on mental states, cognition, BDNF, and long-term outcomes in patients with bipolar disorder.
- Trial name
- NCT03353337
- Testing
- aerobic exercise
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Social Cognition, Facial Emotion Recognition
Facial Emotion Recognition in Patients With Euthymic Bipolar Disorder I and II
The facial emotion recognition is a basic social skill for successful social interactions. Several meta-analyses and recent studies found impairments of the perception of facial emotions in patients with euthymic bipolar…
- Conditions
- Social Cognition, Facial Emotion Recognition, Facial Affect, Bipolar Disorder I and II
- Trial name
- REF-BIP (NCT05922956)
- Testing
- Facial emotion recognition test
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Bipolar Depression
Quetiapine Efficacy in Bipolar Depression Study
To reassure the clinical study data on Seroquel antidepressant efficacy in patients who are diagnosed as bipolar depression
- Trial name
- QUEEN (NCT00523601)
- Where
- 3 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- AstraZeneca
Bipolar Disorder
Study of Aripiprazole in the Treatment of Patients With Acute Symptoms in Bipolar Disorder
The purpose of this study is to learn if aripiprazole is effective for the treatment of patients with acute symptoms of Bipolar disorder.
- Trial name
- NCT00036101
- Testing
- aripiprazole
- Where
- 27 sites in United States
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Prostate Cancer
Extreme Bipolar Androgen Therapy With Darolutamide and Testosterone Cypionate in Patients With Metastatic Castration-Resistant Prostate Cancer (ExBAT Trial)
This is a multi-center, open-label, phase II, single-arm trial evaluating combination of darolutamide and high testosterone doses - extreme bipolar androgen therapy (ExBAT) - in patients with metastatic castration-resistant…
- Trial name
- ExBAT (NCT04558866)
- Testing
- Testosterone Cypionate, Darolutamide
- Where
- 6 sites in Brazil
- Volunteers
- 51 people
- Sponsor
- Latin American Cooperative Oncology Group
Bipolar Disorder in Remission, Major Depression in Remission
Seasonality, Chronotype, Impulsivity, and Suicidality in Mood Disorder Patients
The aim of the study is to examine the seasonal variation of suicidal ideation in patients with mood disorders and the trajectory of impulsivity and suicidal ideation in patients with higher seasonality.
- Trial name
- NCT07857213
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University - Cerrahpasa
Schizophrenia, Bipolar Disorder
Medication Adherence in Older Adults With Serious Mental Illness
The goal of this pilot study is to learn about how well older people with serious mental illness (including schizophrenia, schizoaffective disorder, bipolar disorder, major depression) follow prescribed medication regimens, and…
- Conditions
- Schizophrenia, Bipolar Disorder, Depression
- Trial name
- NCT00224380
- Testing
- Using Medications Effectively
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Bipolar Disorder
Cognitive-Behavior Therapy for Young Adults With Bipolar Disorder
The aim of the study is to develop and pilot test a cognitive-behavioral (CBT) intervention for young adults, ages 18-24 with bipolar disorder.
- Trial name
- NCT01176825
- Testing
- cognitive-behavior therapy (CBT)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Medication Adherence
CAE Plus LAI in Individuals With Bipolar Disorder at Risk for Treatment Non-adherence (BD-CAEL)
This is a prospective study using customized adherence enhancement (CAE) and long-acting injectable (LAI) antipsychotic in 30 individuals with bipolar disorder (BD) at risk for treatment non-adherence.
- Conditions
- Bipolar Disorder, Medication Adherence, Medication Non Adherence
- Trial name
- NCT03408873
- Testing
- Abilify Maintena, Customized Adherence Enhancement (CAE)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Martha Sajatovic
Bipolar Disorder
3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009)
Bipolar disorder is characterized by mood swings that range from high (manic) to low (depressed) states. Sometimes, symptoms of both depression and mania are present (mixed episodes).
- Trial name
- NCT00159796
- Testing
- Asenapine, Olanzapine
- Volunteers
- 489 people
- Sponsor
- Organon and Co
Bipolar Depression
Accelerated LFR for Bipolar Patients During the COVID-19 Pandemic
The current study aims to assess the feasibility, acceptance and clinical outcomes of a practical high-dose LFR protocol, including tapering treatments and symptom-based relapse prevention treatments, in patients with bipolar…
- Trial name
- NCT04427137
- Testing
- MagPro X100 Stimulator, B70 Fluid-Cooled Coil
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Centre for Addiction and Mental Health