Clinical trials: Patients With Cancer
Melanoma
A Phase III Study to Test the Benefit of a New Kind of Anti-cancer Treatment in Patients With Melanoma, After Surgical Removal of Their Tumor
The purpose of this clinical trial is to evaluate the benefit of the immunotherapeutic product GSK 2132231A in preventing disease relapse when given to melanoma patients, after surgical removal of their tumor.
- Trial name
- NCT00796445
- Testing
- GSK 2132231A
- Where
- 257 sites in United States, Argentina and 30 more
- Volunteers
- 1,351 people
- Sponsor
- GlaxoSmithKline
Colitis, Ulcerative, Crohn Disease
Sub-optimal Response to Anti-Tumor Necrosis Factor's in Inflammatory Bowel Disease in Emerging Markets
The purpose of this study is to establish the incidence of sub-optimal response to anti-TNF therapy in UC and CD participants.
- Conditions
- Colitis, Ulcerative, Crohn Disease, Inflammatory Bowel Diseases
- Trial name
- NCT03090139
- Testing
- Anti-TNF Therapy
- Where
- 76 sites in Argentina, China and 8 more
- Volunteers
- 1,731 people
- Sponsor
- Takeda
Colorectal Cancer
Perfusion and Diffusion Magnetic Resonance Imaging, and Phosphorylation of Circulation Endothelial Cells to Determine Anti-anogenic Effect of Chemotherapeutic Regimens in Colorectal Liver Metastasis Patients
The purpose of our study is to establish the accuracy of the perfusion MRI parameters and the availability of the VEGFR2 signaling assay using phosphospecific flow cytometry in predicting the response of liver metastasis from…
- Trial name
- NCT01318239
- Testing
- DCE MRI
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Yonsei University
Cancer Cachexia Syndrome
Lenalidomide for Lean Body Mass and Muscle Strength in Inflammatory Cancer Cachexia Syndrome
Cancer cachexia syndrome (CCS) is frequent, causing high morbidity and mortality in affected ones. The mechanism is catabolism caused by the tumour. CRP is a surrogate marker for catabolism.
- Trial name
- NCT01127386
- Testing
- Lenalidomide, basic cachexia management (prokinetics, physical activity counselling, nutritional counselling)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Florian Strasser, MD ABHPM
Endometrial Cancer, Near Infrared Fluorescence Imaging
CYTALUX for Intraoperative Imaging of Patients With Endometrial Cancer
The research study is being done to assess the safety and ability of an investigational drug called CYTALUX (pafolacianine) and a special camera system for the detection of cancer in patients undergoing surgical resection for…
- Conditions
- Endometrial Cancer, Near Infrared Fluorescence Imaging, CYTALUX (Pafolacianine) Injection, Planned Diagnostic Laparoscopies
- Trial name
- CYTALUX ISS (NCT07278986)
- Testing
- CYTALUX™ (pafolacianine), 1788 4K Camera System with Advanced Imaging Modality
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Melanoma Neoplasms
Assessment of Circulating Tumor Cells and microRNAs in Patients With Metastatic Non-cutaneous Melanoma
the study aims to implement new approaches for the identification of circulating tumor cells and circulating microRNAs, which aim to silence the expression of genes and thus prevent the production of proteins in patients with…
- Trial name
- NCT06863870
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Meningioma
Gleolan for Visualization of Newly Diagnosed or Recurrent Meningioma
This Phase 3 open-label single-arm study is designed to investigate the safety, diagnostic performance, and clinical usefulness of Gleolan for the real time detection and visualization of meningiomas during tumor resection…
- Trial name
- MEN-301 (NCT04305470)
- Testing
- Gleolan
- Where
- 17 sites in United States, Austria and 1 more
- Volunteers
- 108 people
- Sponsor
- NX Development Corp
Bladder Cancer TNM Staging Primary Tumor (T) Ta, Bladder Cancer TNM Staging Primary Tumor (T) T1
Intravesical Adjuvant Electromotive Mitomycin-C
In laboratory and clinical studies, intravesical electromotive drug administration increased mitomycin bladder uptake, improving clinical efficacy in high-risk non-muscle invasive urothelial bladder cancer.
- Conditions
- Bladder Cancer TNM Staging Primary Tumor (T) Ta, Bladder Cancer TNM Staging Primary Tumor (T) T1, Bladder Cancer Transitional Cell Grade
- Trial name
- EMDA/MMC (NCT01920269)
- Testing
- Trans-urethral resection, intravesical passive diffusion mitomycin, intravesical electromotive mitomycin
- Where
- Italy
- Volunteers
- 331 people
- Sponsor
- University of Rome Tor Vergata
Gastrointestinal Tumors, Colorectal Adenocarcinomas
Study to Test the Safety and Tolerability of PF-07062119 in Patients With Selected Advanced or Metastatic Gastrointestinal Tumors.
A phase 1, open-label, dose escalation and expansion study of PF-07062119 in patients with selected advanced or metastatic gastrointestinal tumors
- Conditions
- Gastrointestinal Tumors, Colorectal Adenocarcinomas, Gastric Adenocarcinomas, Esophageal Adenocarcinomas
- Trial name
- NCT04171141
- Testing
- PF-07062119, Anti-PD1, Anti-VEGF
- Where
- 19 sites in United States, Australia and 1 more
- Volunteers
- 79 people
- Sponsor
- Pfizer
Leukemia, Lymphoma
Chemotherapy Given With Amifostine and Filgrastim in Treating Patients With Recurrent or Metastatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs such as amifostine may protect normal cells from the side effects of chemotherapy.
- Conditions
- Leukemia, Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00003294
- Testing
- filgrastim, amifostine trihydrate, carboplatin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Roswell Park Cancer Institute
Chronic Pain
Effect of Tramadol Versus Morphine on PD1 and PD1-ligand in Patients With Chronic Cancer Pain
this work is looking for comparison between the effect of tramadol versus morphine on PD1 and PD1-ligand in patients with chronic cancer pain
- Trial name
- NCT04589494
- Testing
- Tramadol Hydrochloride
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Assiut University
Fatigue, Hot Flashes
Acupuncture in Treating Hot Flashes in Patients With Prostate Cancer
RATIONALE: Acupuncture may help relieve hot flashes in patients with prostate cancer. PURPOSE: This clinical trial is studying how well acupuncture works in treating hot flashes in patients with prostate cancer who are undergoing…
- Conditions
- Fatigue, Hot Flashes, Prostate Cancer
- Trial name
- NCT00244894
- Testing
- acupuncture therapy, fatigue assessment and management, hot flashes attenuation
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- OHSU Knight Cancer Institute
Leukemia, B-cell, Lymphoma, Hodgkins
Administration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With Recurrent or Persistent B-cell Malignancies After Allogeneic Stem Cell Transplantation
Background: Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a procedure that transplants bone marrow cells (stem cells) from a matching donor into a recipient in order to allow the donor stem cells to produce…
- Conditions
- Leukemia, B-cell, Lymphoma, Hodgkins, Lymphoma, Non-hodgkins, Lymphoma, B-Cell
- Trial name
- NCT01087294
- Testing
- Allogeneic stem cell transplant, Anti-CD19-chimeric-antigen-receptor-transduced T cells, Leukapheresis
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- National Cancer Institute (NCI)
Gastric Cancer
Prophylactic Preoperative HIPEC in Advanced Gastric Cancer at High Risk of Peritoneal Recurrence
The study was designed to evaluate the efficacy of perioperative FLOT chemotherapy in combination with perioperative hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with advanced gastric cancer at high risk of…
- Trial name
- CHIMERA (NCT04597294)
- Testing
- FLOT + HIPEC + Surgery, FLOT + Surgery
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Jagiellonian University
Stomach Neoplasm, Gastric (Stomach) Cancer
A Phase Ib/II Trial of Neoadjuvant Zolbetuximab Plus Docetaxel, Oxaliplatin and S-1 Chemotherapy in Patients With Locally Advanced Gastric Cancer
Claudin 18.2 is a promising therapeutic target overexpressed on the surface of gastric cancer cells. The addition of zolbetuximab, the monoclonal antibody targeting Claudin 18.2 to chemotherapy in two recent Phase 3 studies…
- Trial name
- NEO-CLAUD (NCT06732856)
- Testing
- zolbetuximab, Oxaliplatin, Docetaxel
- Where
- 2 sites in South Korea
- Volunteers
- 57 people
- Sponsor
- Asan Medical Center
Hematologic Malignancies
This Study is a FIH Study Which is Required to Understand the PK Characteristics, MTD, RP2D and Safety Profile.
This study is a first-in-human (FIH) study which is required to understand the safety, tolerability, pharmacokinetics and preliminary efficacy of RJK-RT2831 injection in patients with hematologic malignancies
- Trial name
- NCT06756451
- Testing
- RJK-RT2831 dose-escalation phase Ia, RJK-RT2831 Dose Expansion Phase Ib
- Where
- 16 sites in China
- Volunteers
- 71 people
- Sponsor
- Nanjing RegeneCore Biotech Co., Ltd.
Breast Cancer
Alpelisib And Sacituzumab Govitecan For Treatment Of Breast Cancer
This study evaluates the safety and efficacy of sacituzumab govitecan plus alpelisib for treatment of metastatic or locally recurrent HER2-negative breast cancer.
- Trial name
- ASSET (NCT05143229)
- Testing
- Alpelisib, Sacituzumab govitecan
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of Kansas Medical Center
Squamous Cell Carcinoma of the Head and Neck
A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer)
This is a Phase Ib/II, open-label, multicenter, randomized, umbrella study in participants with locally advanced squamous cell carcinoma of the head and neck (SCCHN).
- Trial name
- NCT05459129
- Testing
- Atezolizumab, Tiragolumab, Carboplatin
- Where
- 6 sites in United States, Israel and 1 more
- Volunteers
- 12 people
- Sponsor
- Hoffmann-La Roche
Hypogonadism, Male, Fatigue Syndrome, Chronic
Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone
The overall goal of this study is to evaluate the effect of a testosterone drug called Depo-Testosterone (or 'testosterone cypionate'), an FDA-approved drug for improving fatigue, sexual function, quality of life, body…
- Trial name
- NCT04049331
- Testing
- Testosterone Undecanoate 750 MG/3 ML Intramuscular Solution [AVEED]
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Liver Cancer, Dropout, Patient
A Worldwide Score for Hepatocellular Cancer and Liver Transplantation
The present study has been developed with multiple aims: 1) to refine available models for liver transplantation which would be able to cover the fate of HCC candidates from an ITT point of view; 2) to develop such an approach on…
- Conditions
- Liver Cancer, Dropout, Patient, Recurrence
- Trial name
- TRAIN-SCORE (NCT03595345)
- Testing
- Liver transplantation
- Where
- Belgium
- Volunteers
- 3,100 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.