Clinical trials: Patients With Cancer
Neuroblastoma, Recurrent, Refractory
Chimeric Natural Killer Receptor-Universal T Cells for Relapsed or Refractory Neuroblastoma
This is a single arm, open-label, multi-center, pilot studies (Investigator Initiated Trial, IIT) to evaluate the safety, preliminary efficacy, pharmacokinetics of universal T-cells engineered with chimeric natural killer…
- Trial name
- NCT06751134
- Testing
- Chimeric Natural Killer Receptor Universal T-cells (CNK-UT)
- Where
- 2 sites in China
- Volunteers
- 12 people
- Sponsor
- Nanjing Children's Hospital
Lymphoma, Mantle-Cell
Immunochemotherapy With Rituximab-Bendamustine-Cytarabine (R-BAC) for Patients With Mantle Cell Lymphoma
The objective of the study is to demonstrate the safety, tolerability, and activity of Rituximab-Bendamustine-Cytarabine(R-BAC) regimen in patients with mantle cell lymphoma (MCL) aged 65 years or more, as well as in younger…
- Trial name
- NCT00992134
- Testing
- Rituximab, Bendamustine, Cytarabine
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- St. Bortolo Hospital
Muscle Invasive Bladder Cancer (MIBC)
MRI-Guided Bladder Preservation Program For Patients With Muscle Invasive Bladder Cancer
The goal of this clinical trial is to learn if the use of MRI-guided irradiation increases the rates of bladder preservation as well as to decrease complications in patients with muscle invasive bladder cancer who wish to retain…
- Trial name
- NCT07026864
- Testing
- MR-guided Radiation Therapy
- Volunteers
- 31 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Kidney Cancer
Sunitinib Before or After Surgery in Treating Patients With Metastatic Kidney Cancer
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00626509
- Testing
- sunitinib malate, adjuvant therapy, neoadjuvant therapy
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Gruppo Italiano Carcinoma Renale
Metastatic Liver Cancer
Study of Capecitabine in Combination With SIR-Spheres in Patients With Advanced Cancer
This trial is testing the safety of combining the oral chemotherapy drug capecitabine with radio-labeled microspheres injected directly into the liver.
- Trial name
- NCT00604409
- Testing
- SIRT, capecitabine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Fox Chase Cancer Center
Esophageal Cancer, Intensity-modulated Radiation Therapy
The Effect of Prophylactic TPO Combined with BMS-IMRT to Esophageal Cancer Patients
The goal of this interventional study is to explore the protective effect of prophylactic TPO combined with bone marrow sparing (BMS)-IMRT in patients with esophageal cancer undergoing concurrent chemoradiotherapy.
- Conditions
- Esophageal Cancer, Intensity-modulated Radiation Therapy, Concurrent Chemoradiotherapy, Thrombocytopenia
- Trial name
- NCT05944809
- Testing
- rhTPO
- Where
- China
- Volunteers
- 32 people
- Sponsor
- JIANYANG WANG
Leukemia, Lymphoma
Infusion of Allogeneic CD19-Specific T Cells From Peripheral Blood
The goal of this clinical research study is to learn if researchers can successfully and safely give HSCT patients an infusion of white blood cells (called T-cells) that have been genetically changed.
- Trial name
- NCT01497184
- Testing
- HSCT, DLI
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- M.D. Anderson Cancer Center
Advanced Solid Tumors, Pharmacokinetics of 14C-OSI-906
A Study to Look at How a Single Oral Dose of 14C-OSI-906 is Absorbed, Broken Down and Eliminated in the Body
The purpose of this study is to evaluate the pharmacokinetics, in particular the routes of excretion and extent of metabolism of OSI-906 after a single oral dose of 14C-labeled OSI-906.
- Trial name
- NCT01529684
- Testing
- radio-labeled OSI-906, OSI-906
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Brain Tumors
Study of Massage Therapy Within a Brain Tumor Setting
The purpose of this study is to assess the feasibility and acceptability of massage therapyto examine the effects of massage therapy to explore whether psychological outcomes are associated with changes in patient reported QoL.
- Trial name
- NCT00873184
- Testing
- Massage Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Colorectal Cancer
FOLFIRI or FOLFOX With or Without Cetuximab in Patients With Metastatic Adenocarcinoma of the Colon or Rectum
This is a randomized phase II study trial that has served as a screening trial to test the increased efficacy of chemotherapy + cetuximab versus chemotherapy alone among patients with untreated, advanced or metastatic colon…
- Trial name
- NCT00077233
- Testing
- cetuximab, 5-FU, irinotecan
- Where
- 77 sites in United States
- Volunteers
- 238 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Refractory Multiple Myeloma, Stage I Multiple Myeloma
Temsirolimus and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myeloma
This phase I trial is studying the side effects and best dose of temsirolimus when given together with dexamethasone in treating patients with recurrent or refractory multiple myeloma.
- Conditions
- Refractory Multiple Myeloma, Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
- Trial name
- NCT00693433
- Testing
- dexamethasone, temsirolimus, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Lymphoma
Busulfan, Melphalan, and Thiotepa in Treating Patients Who Are Undergoing an Autologous Stem Cell Transplant for Hodgkin's or Non-Hodgkin's Lymphoma
RATIONALE: Chemotherapy, such as busulfan, melphalan, and thiotepa, may destroy cancerous blood-forming cells (stem cells) in the blood and bone marrow.
- Trial name
- NCT00238433
- Testing
- filgrastim, busulfan, melphalan
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- OHSU Knight Cancer Institute
Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia
Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL
This phase III trial compares the effect of adding sonrotoclax to zanubrutinib versus zanubrutinib alone for the treatment of patients with untreated chronic lymphoblastic leukemia (CLL)/small lymphocytic lymphoma (SLL).
- Trial name
- NCT07321652
- Testing
- Zanubrutinib, Sonrotoclax, Computed Tomography
- Where
- 261 sites in United States
- Volunteers
- 466 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer
Palbociclib Plus Letrozole in Hormone Receptor Positive Residual Disease After Neoadjuvant Chemotherapy
PROMETEO II is a single-arm window of opportunity trial to evaluate biologic and anti-proliferative effects of palbociclib and letrozole in HR+/HER2-negative operable breast cancer (BC) patients with residual disease after…
- Trial name
- PROMETEO II (NCT04130152)
- Testing
- Palbociclib, Letrozole
- Where
- 8 sites in Spain
- Volunteers
- 22 people
- Sponsor
- SOLTI Breast Cancer Research Group
Myelodysplastic Syndrome (MDS)
Safety of Peptide Vaccination for Patients With Myelodysplastic Syndrome
This study will test whether certain patients with myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) or chronic myeloid leukemia (CML) can safely be vaccinated with two peptide vaccines derived from proteins called…
- Trial name
- NCT00270452
- Testing
- WT1 and PR1 Peptide Vaccine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Thyroid Gland Anaplastic Carcinoma
Intensity-Modulated Radiation Therapy and Paclitaxel With or Without Pazopanib Hydrochloride in Treating Patients With Anaplastic Thyroid Cancer
This randomized phase II trial studies the side effects and how well intensity-modulated radiation therapy (IMRT) and paclitaxel with or without pazopanib hydrochloride works in treating patients with anaplastic thyroid cancer.
- Trial name
- NCT01236547
- Testing
- Intensity-Modulated Radiation Therapy, Paclitaxel, Pazopanib Hydrochloride
- Where
- 130 sites in United States
- Volunteers
- 123 people
- Sponsor
- National Cancer Institute (NCI)
Liposarcoma
Efatutazone Dihydrochloride in Treating Patients With Previously Treated Myxoid Liposarcoma That Cannot Be Removed by Surgery
This phase II trial studies how well efatutazone dihydrochloride works in treating patients with previously treated myxoid liposarcoma that cannot be removed by surgery.
- Trial name
- NCT02249949
- Testing
- efatutazone
- Where
- 127 sites in United States
- Volunteers
- 15 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Multiple Myeloma
To Evaluate the Efficacy and Safety of QL2109 and DARZALEX FASPRO® in Multiple Myeloma
This is a randomized, double-blind, multicenter trial，parallel control designed to evaluate treatment with pomalidomide + QL2109 + dexamethasone compared with pomalidomide + DARZALEX FASPRO® + dexamethasone in the participants…
- Trial name
- NCT06742138
- Testing
- QL2109, Pomalidomide, Dexamethasone
- Volunteers
- 284 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Bone-Metastatic, Castration-Resistant Prostate Cancer
Safety and Efficacy Study of KX2-391 for Treatment of Bone-Metastatic, Castration-Resistant Prostate Cancer
The standard of care for patients with bone-metastatic, castrate-resistant prostate cancer is chemotherapy. If a patient elects not to choose chemotherapy, 70% will progress within 6 months.
- Trial name
- NCT01074138
- Testing
- KX2-391
- Where
- 5 sites in United States
- Volunteers
- 31 people
- Sponsor
- Athenex, Inc.
Prostate Cancer
Hormone Therapy in Treating Patients With Advanced Prostate Cancer
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Hormone therapy using triptorelin may fight prostate cancer by reducing the production of androgens.
- Trial name
- NCT00003026
- Testing
- bicalutamide, flutamide, triptorelin
- Where
- 17 sites in Belgium, Israel and 5 more
- Volunteers
- 966 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
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