Clinical trials: Patients With Chronic Migraine
Migraine Disorders, Photophobia
Thin Film Spectacle Coatings to Reduce Light Sensitivity and Headaches in Patients With Migraine
Approximately 9% of men and 18% of women suffer from migraine headaches. Almost all migraine sufferers report light sensitivity during a headache.
- Trial name
- NCT01828684
- Testing
- Therapeutic Lens Coating
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Bradley Katz
Chronic Migraine
A Study With Intranasal Kinetic Oscillation Stimulation (KOS) in the Prevention of Chronic Migraine
An open pilot study, non-controlled, single center investigation.
- Trial name
- NCT05273151
- Testing
- KOS (Intranasal kinetic oscillation stimulation)
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- Chordate Medical
Chronic Migraine
Use of a Treatment Benefit Questionnaire in Patients With Chronic Migraine Treated With OnabotulinumtoxinA (BOTOX®)
This study will evaluate the use of the Assessment of Chronic Migraine Impacts (ACM-I) Questionnaire in assessing the impact and benefit of treatment with onabotulinumtoxinA (BOTOX®) in adults with chronic migraine.
- Trial name
- NCT01833130
- Testing
- OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Allergan
Chronic Migraine
Laser Acupuncture for Chronic Migraine
A single-blind randomized controlled trial was conducted from October 2024 to May 2025. Chronic migraine patients were randomly assigned in a 1:1 ratio to receive either Laser acupuncture or sham treatment.
- Trial name
- LAFCM (NCT06219694)
- Testing
- Laser Acupuncture
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taichung Veterans General Hospital
Patients With Migraine Equal of /More Than 3 and Equal of/ Less Than 12 Migraine Attacks/4 Weeks for Each of the Last 6 Months Preceding the Screening
A Randomized,Double Blind, Placebo Controlled Study to Assess Efficacy,Safety and Tolerability of BGG492 in Migraine Prevention
It will provide a first evaluation of efficacy, safety and tolerability of BGG492 in patients with non-chronic migraine having more than 3 and less than 12 migraine attacks per 4 weeks.
- Trial name
- NCT01617941
- Testing
- BGG492
- Sponsor
- Novartis Pharmaceuticals
Headache Migraine Chronic
Spectacle Tints and Thin-Films for Migraine
Nearly all migraine sufferers report sensitivity to light during a headache and a significant proportion of sufferers report light sensitivity between attacks. Light is also a common trigger for migraine headaches.
- Trial name
- NCT02720211
- Testing
- Gray tinted spectacle lenses, Thin-Film spectacle lenses
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Migraine
A Study to Evaluate Treatment Satisfaction With Erenumab in Participants With Migraine
The main purpose of this study is to evaluate the effect of erenumab on medication-specific treatment satisfaction.
- Trial name
- NCT04825678
- Testing
- Erenumab
- Where
- 42 sites in United States
- Volunteers
- 240 people
- Sponsor
- Amgen
Chronic Migraine, Cluster Headache
Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache
The purpose of this study is to evaluate the safety and efficacy of intra-arterial (IA) delivery of Dexamethasone and Ketorolac into the arteries supplying the sphenopalatine ganglion (SPG) - a collection of neurons that plays an…
- Conditions
- Chronic Migraine, Cluster Headache, Trigeminal Neuralgia
- Trial name
- NCT04353505
- Testing
- Ketorolac, Dexamethasone
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Chronic Migraine Headache
CHROnic Migraine Embolization
To evaluate the effectiveness and safety of middle meningeal artery (MMA) embolization using non-adhesive materials SQUID 12 and SQUID 18 as a treatment method for patients with chronic resistant migraine.
- Trial name
- CHROME (NCT06848166)
- Testing
- liquid embolic agent SQUID 12, liquid embolic agent SQUID 18
- Where
- Kyrgyzstan
- Volunteers
- 30 people
- Sponsor
- Vedanta University Clinic
Migraine
The Effects of Transcutaneous Occipital Nerve Stimulation and Instrument-Assisted Soft Tissue Mobilization on Patients With Chronic Migraine
In this study, it was aimed to examine the effects of two different treatments applied to the neck region, which have been popular in recent years, on migraine.The study included 45 female patients aged 20-50 years with migraine…
- Trial name
- NCT05372796
- Testing
- IASTM, home exercise, Chattanooga direct Tens device (DJO UK Ltd, Guildford Surrey, United Kingdom)
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Emine Atıcı
Migraine Disorders
A Long-term Efficacy, Safety, and Tolerability Study of BOTOX® in Patients With Chronic Migraine
This open-label study will assess the long-term efficacy, safety, and tolerability of onabotulinumtoxinA administered for prophylaxis of headaches in patients with chronic migraine.
- Trial name
- NCT01516892
- Testing
- onabotulinumtoxinA
- Where
- 32 sites in United States, Australia and 1 more
- Volunteers
- 716 people
- Sponsor
- Allergan
Migraine Without Aura, Chronic Tension-Type Headache
Cortical Reorganisation in Patients With Primary Headache Disorders
Primary headache disorders are now accepted as physiological diseases, and advanced imaging-techniques have demonstrated a migraine generator in the brain stem and increased stimulus sensitivity in these patients.
- Trial name
- NCT00263991
- Testing
- EEC-techniques
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Danish Headache Center
Chronic Migraine, Headache, Block
Pulse Radiofrequency and Occipital Nerve Block for Chronic Migraine Patients
In this study, the effect of nerve blockade and radiofrequency treatment applied to the nerve on pain in chronic migraine patients will be investigated.
- Conditions
- Chronic Migraine, Headache, Block, Occipital Neuralgia
- Trial name
- NCT06247592
- Testing
- Greater occipital nerve block, Greater occipital nerve pulse radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Aydin Adnan Menderes University
Chronic Migraine, Headache
KETOMIGRAINE: Ketogenic Diet in Drug-resistant Chronic Migraineurs
Our protocol, named "KETOMIGRAINE", is based on the prescription of a Ketogenic Diet (KD) to twenty subjects with diagnosis of Chronic Migraine (CM), resistant to oral preventive treatments and non-responders to monoclonal…
- Trial name
- NCT05313503
- Testing
- ketogenic diet
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Chronic Migraine, Headaches
A Retrospective Study to Evaluate the Effectiveness and Benefit of onabotulinumtoxinA in Patients With Chronic Migraines
This study will evaluate the effectiveness and benefit of treatment with onabotulinumtoxinA in Chronic Migraine patients who have received a minimum of 7 treatment cycles.
- Trial name
- NCT01749410
- Testing
- onabotulinumtoxinA
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Allergan
Chronic Migraine
Trip-Tox, Effectiveness of Triptans Before and After Onabotulinumtoxin A Treatment in Chronic Migraine
Observational, longitudinal, prospective, prospective, comparative study of the effectiveness of triptans before and after onabotulintoxin A initiation in a single group of chronic migraine patients.
- Trial name
- NCT04871152
- Testing
- OnabotulinumtoxinA
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Chronic Migraine
Physiological Changes With SPG Stimulation in Migraine Patients
Hypothesis: Stimulation of the SPG at low frequencies (20 Hz)is believed to cause a physiological parasympathetic upregulation which increases VMCA, concentration and cephalic vessel diameter.
- Trial name
- NCT02510742
- Testing
- Neurostimulation
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Danish Headache Center
Refractory Chronic Migraine
A Feasibility Clinical Trial to Evaluate High Frequency Spinal Cord Stimulation for the Treatment of Patients With Chronic Migraine
The purpose of this study is to assess short- and long-term safety, tolerability and efficacy of cervical High Frequency Spinal Cord Stimulation (HF-SCS) in patients suffering from chronic migraine refractory to conventional…
- Trial name
- rCM HF-SCS (NCT01653340)
- Testing
- Senza™, High Frequency Spinal Cord Stimulator for Refractory Chronic Migraine
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- University of Roma La Sapienza
Migraine Disorders
Sustained onabotulinumtoxinA Therapeutic Benefits in Patients With Chronic Migraine
To assess whether there is a sustained benefit and good safety with repeated onabotulinumtoxinA sessions in chronic migraine over more than three years of treatment.
- Trial name
- NCT03606356
- Testing
- Onabotulinum toxin A
- Volunteers
- 56 people
- Sponsor
- Corfu Headache Clinic
Migraine
Head Awareness in Chronic Migraine Patients
Research indicates that different beliefs about the nature of back problems and their future consequences direct behaviors that may cause falsely stimulated neuroplastic changes.
- Trial name
- Awareness (NCT06857383)
- Testing
- Fremantle Headache Awareness Questionnaire
- Where
- 13 sites in Cyprus, Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Bozok University