Clinical trials: Patients With Diabetes.
Diabetes Mellitus, Type 2
Safety and Tolerability of Vildagliptin Versus Placebo in Patients With Type 2 Diabetes and Moderate or Severe Renal Insufficiency
This clinical trial is designed to provide additional information on the safety and tolerability of vildagliptin (50 mg once daily (qd)) when used in patients with type 2 diabetes mellitus (T2DM) and moderate or severe renal…
- Trial name
- NCT00646542
- Testing
- Vildagliptin
- Where
- 12 sites in Argentina, Australia and 10 more
- Volunteers
- 525 people
- Sponsor
- Novartis
Hypertension, Hypertension Complicated With Type 2 Diabetes
Effects of Different Training Programs in Chronic Disease Patients
The study is a randomized 3-month community-based exercise intervention with a control group and 2 different exercise groups: walking group and Chinese square dancing group.Eighteen communities will be selected in Beijing, and…
- Conditions
- Hypertension, Hypertension Complicated With Type 2 Diabetes, Walking, Chinese Square Dancing
- Trial name
- NCT03785886
- Testing
- Walking group, Chinese square dancing group, Control group
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Beijing Sport University
Diabetes
Twelve -Month Study Observing How Insulin-naïve Patients With Type 2 Diabetes Mellitus Manage Diabetes Using Toujeo® After Oral Antidiabetic Drug Failure, the Side Effect of Toujeo®, and The Cost.
Primary Objective: Assess effectiveness of insulin glargine (U300) in achieving glycemic goal measured by hemoglobin A1c (HbA1c).
- Trial name
- ATOS (NCT03703869)
- Testing
- Insulin glargine (U300)
- Where
- 388 sites in Colombia, Egypt and 16 more
- Volunteers
- 4,589 people
- Sponsor
- Sanofi
Diabetes Mellitus, Obesity
Single Loop DJB Sleeve Gastrectomy for Poorly Controlled T2DM
Type 2 diabetes mellitus (T2DM) is a chronic progressive illness affecting a substantial percentage of the general population. While pharmacotherapy remains the mainstay of treatment, around 60% of patients cannot achieve the…
- Conditions
- Diabetes Mellitus, Obesity, Bariatric Surgery Candidate, Weight Loss
- Trial name
- NCT03125369
- Testing
- Sleeve gastrectomy + duodeno-jejunal bypass, Roux-Y gastric bypass
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Recurrence, Diabetic Foot
Prevention and Early Detection of Ulcer Recurrence in Patients With Type II Diabetes Mellitus
The goal of this clinical trial is to to evaluate the effectiveness of prevention strategies of recurrence in DFU's. It will also to detect the risk level of recurrence.
- Conditions
- Recurrence, Diabetic Foot, Thermography, Quality of Life
- Trial name
- NCT06434922
- Testing
- Prevention Strategies, Standard Strategiies
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Institute Technology and Health Muhammadiyah West Kalimantan
Diabetic Neuropathies
A Study for the Treatment of Diabetic Peripheral Neuropathic Pain
The purpose of the study is to determine if duloxetine can help patients with painful diabetic neuropathy.
- Trial name
- NCT00552175
- Testing
- Duloxetine hydrochloride - 40 mg, Duloxetine hydrochloride - 60 mg
- Where
- 25 sites in Japan
- Volunteers
- 339 people
- Sponsor
- Eli Lilly and Company
Kidney Disease, Diabetic Nephropathy
Using the Drug Spironolactone to Test If It Reduces Protein Leakage From the Kidney
The purpose of this study is to determine which combination of the tablets ramipril, irbesartan or spironolactone is best to lower protein leakage from the kidney.
- Conditions
- Kidney Disease, Diabetic Nephropathy, Glomerulonephritis, Proteinuria
- Trial name
- NCT00106561
- Testing
- Spironolactone, Irbesartan
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Melbourne Health
Heart Failure With Reduced Ejection Fraction
Benefits of Empagliflozin in Patients With Heart Failure and Reduced Ejection Fraction Without Diabetes Mellitus
The study is a short to mid-term randomized single-blind placebo controlled study that aimed to detect the effects of empagliflozin (a sodium-glucose cotransporter-2 inhibitor) compared to placebo on LV end-diastolic and…
- Trial name
- HFrEF (NCT06632561)
- Testing
- Empagliflozin 10 mg
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Ashraf Wasfy Beshay Aziz
Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2
Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction: Metabolic Effects. (KETO-HFpEF-Metabolic)
Heart failure (HF) is among the most common causes of death in patients with type 2 diabetes (T2D). Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial effects in patients with hearth failure with reduced ejection…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2, Ketonemia
- Trial name
- NCT05159570
- Testing
- Ketone ester
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Type 2 Diabetes Mellitus
Safety and Efficacy of Bexagliflozin in Type 2 Diabetes Mellitus Patients With Moderate Renal Impairment
This was a phase 3, multi-center, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of oral administration of bexagliflozin at 20 mg versus placebo in subjects with T2DM…
- Trial name
- NCT02836873
- Testing
- Bexagliflozin
- Where
- 56 sites in United States, France and 2 more
- Volunteers
- 312 people
- Sponsor
- Theracos
Diabetes Mellitus
Phase III Study to Evaluate Safety and Efficacy of Added Exenatide Versus Placebo to Titrated Basal Insulin Glargine in Inadequately Controlled Patients With Type II Diabetes Mellitus
Study D5553C00002 is a multicenter, randomized, double-blind, placebo-controlled, parallel group, Phase 3 study to compare the safety and efficacy of exenatide once weekly (EQW) added to titrated basal insulin glargine with or…
- Trial name
- NCT02229383
- Testing
- Exenatide
- Where
- 123 sites in United States, Hungary and 4 more
- Volunteers
- 464 people
- Sponsor
- AstraZeneca
Type 2 Diabetes, Postprandial Oxidative Stress
Postprandial Insulin Secretion, Oxidative Stress and Gastrointestinal Peptides in Patients With Type 2 Diabetes Versus Healthy Subjects
Insulin secretion, plasma lipids, oxidative stress markers and gastrointestinal peptides will be measured in patients with type 2 diabetes versus healthy subjects in a fasting status and in response to standard meals (at times…
- Trial name
- NCT01572402
- Testing
- Bagueutte Cheese Gourmet (Crocodille), Cous-cous sandwich, McCountry sandwich (McDonald's)
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical and Experimental Medicine
Diabetes Mellitus, Type 2
Effectiveness of Motivational Interviewing on Improving Care for Patients With Type 2 Diabetes in China
n 2015, the International Diabetes Federation estimated that there were nearly 110 million diabetes mellitus (DM) patients in China, which was the highest number recorded in the world.
- Trial name
- NCT04342845
- Volunteers
- 225 people
- Sponsor
- The University of Hong Kong
Diabete Mellitus, Retina Vein Occlusion
Serum Cholinesterases, Paraoxonase, and Cardiovascular Risk After Intravitreal Bevacizumab
Bevacizumab, an anti-VEGF (vascular endothelial growth factor) agent used in the treatment of diabetic retinopathy and macular edema associated with retinal vein occlusion, is commonly administered in ophthalmology clinics…
- Conditions
- Diabete Mellitus, Retina Vein Occlusion, Age Macular Degeneration
- Trial name
- NCT07550777
- Testing
- blood test
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Diabetes Mellitus, Type 2
Efficacy and Long-Term Safety of Vildagliptin as Monotherapy in Patients With Type 2 Diabetes
This is a 2-3 period parallel group study with an adaptive element in Type 2 diabetes patients receiving vildagliptin as monotherapy.
- Trial name
- NCT00821977
- Testing
- Vildagliptin
- Where
- 176 sites in United States, Canada and 6 more
- Volunteers
- 338 people
- Sponsor
- Novartis
Leg Ulcer, Venous Leg Ulcer
Time to Heal (Wound, Healing, Dialogue, Nutrition)
The objective of this study is to examine the feasibility, acceptability, fidelity, and outcome of a nurse-led nutritional intervention for patients with leg ulcers in a outpatient clinics.
- Conditions
- Leg Ulcer, Venous Leg Ulcer, Arterial Leg Ulcer, Foot Ulcer, Diabetic
- Trial name
- SNAK (NCT06255288)
- Testing
- SNAK intervention
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Hvidovre University Hospital
Type 2 Diabetes Mellitus
Pilot Study of the Effects of Erythritol on Endothelial Function in Patients With Type 2 Diabetes Mellitus
The study will determine whether acute and chronic consumption of a beverage containing erythritol will improve endothelial function in patients with type 2 diabetes mellitus.
- Trial name
- NCT01609088
- Testing
- Erythritol-containing beverage
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston University
Diabetes
Impact of Branched-chain Amino Acids in the Development of Insulin Resistance
The purpose of this study is to clarify the role of the branched-chain amino acids in the development of Insulin resistance in patients with diabetes
- Trial name
- BRAAWO (NCT03261362)
- Testing
- Branched-chain amino acids reduced intake
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- German Diabetes Center
Diabetes Mellitus, Type 2
Glycaemic Control and Other Clinical Parameters in Adult Type 2 Diabetes Patients on Basal Insulin Initiating Treatment With IDegLira in Routine Clinical Practice in Colombia
The purpose of this study is to investigate the glycaemic control and other clinical parameters in adult patients previously treated with basal insulin (with or without OADs) and switched to IDegLira in real-world clinical…
- Trial name
- SPIRIT (NCT05324462)
- Testing
- IDegLira
- Where
- 6 sites in Colombia
- Volunteers
- 175 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes, Obesity
Effect of Bile Acids on GLP-1 Secretion
The purpose of this study is to describe the physiological, pathophysiological and potentially therapeutic implications of bile-induced glucagon-like peptide-1 (GLP-1) secretion in human glucose homeostasis.
- Trial name
- NCT01666223
- Testing
- Colesevelam, Chenodeoxycholic Acid, saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen