Clinical trials: Patients With Major Depressive Disorder
Major Depressive Disorder (MDD), Depressive Episodes
Effectiveness of Clustered Versus Tapered Repetitive Transcranial Magnetic Stimulation (rTMS) as Maintenance Therapy Following Successful Acute rTMS Treatment in Patients With Depressive Syndrome
The goal of this clinical trial is to compare two maintenance transcranial magnetic stimulation (rTMS) strategies following successful acute theta burst stimulation (TBS) treatment in adults with depressive syndrome.
- Conditions
- Major Depressive Disorder (MDD), Depressive Episodes, Depressive Syndrome
- Trial name
- ERTE (NCT07727005)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Theta Burst Stimulation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Major Depressive Disorder, Insulin Resistance
Pioglitazone in Patients With Mood Disorders
The purpose of this study is to see how an insulin sensitizing medication, Pioglitazone, can cause changes in mood in some depressed patients. Study participants receive assessment of their cognitive and metabolic functioning.
- Trial name
- NCT01559857
- Testing
- Pioglitazone, Sugar Pill
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Stanford University
Major Depressive Disorder
A Phase 2 Trial of OPC-64005 for Major Depressive Disorder
The objective of the trial is to compare the efficacy of OPC-64005 at 20 mg vs placebo and to assess the safety and pharmacokinetics of OPC-64005 at 10 and 20 mg in patients with major depressive disorder (MDD).The primary…
- Trial name
- NCT04244253
- Testing
- OPC-64005 20 mg , Once-daily, OPC-64005 10 mg , Once-daily
- Where
- Japan
- Volunteers
- 273 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Depressive Disorder (Per DSM-V Criteria, Mild-to-moderate), Acute Coronary Syndrome (ACS)
Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention:A Prospective, Double-Blind,Randomized Controlled Study
This is a randomized, controlled study. ACS follow- up patients aged 18 to 80 years old with hemodynamic stability, who are 14 days to 1 year after PCI, are screened through the HAMD score and the HAMA score.
- Conditions
- Depressive Disorder (Per DSM-V Criteria, Mild-to-moderate), Acute Coronary Syndrome (ACS), Percutaneous Coronary Intervention (PCI), Depressive Disorder
- Trial name
- NCT07454070
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Intervention
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jing Han
Major Depressive Disorder, MDD
A Non Interventional Study to Investigating the Ratio of Mis-diagnosed Bipolar Symptoms in Patient With Major Depressive Disorder (MDD)
The study will only detect hypomanic symptoms in treatment resistant MDD patients by mean of HCL-32 administration. Further re-evaluation of MDD diagnosis is not a direct aim of the study.
- Trial name
- Improve (NCT01344733)
- Where
- 29 sites in Italy
- Volunteers
- 660 people
- Sponsor
- AstraZeneca
Major Depressive Disorder
Study With Vortioxetine on Emotional Functioning in Patients With Depression
The study will evaluate effectiveness of flexible dose vortioxetine 10-20 mg/day on emotional functioning in patients with MDD with an inadequate response to SSRIs/SNRIs.
- Trial name
- COMPLETE (NCT03835715)
- Testing
- Vortioxetine
- Where
- 23 sites in France, Italy and 2 more
- Volunteers
- 150 people
- Sponsor
- H. Lundbeck A/S
Major Depression, Diabetes Mellitus
Efficacy Study of Escitalopram for Depression in Patients With Diabetes
Patients with diabetes and major depression treated with Escitalopram might experience significant improvement in depression and anxiety scores; functional ability; diabetes-related self-care; and pain symptoms
- Trial name
- EFDID (NCT00650897)
- Testing
- Escitalopram
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Major Depressive Disorder
Enhancing Psychotherapy for Mood Disorders With Whole Body Hyperthermia
According to the 2005 National Comorbidity Survey-Replication study, approximately 20.9 million American adults, or 9.5 percent of the population over the age of 18 suffer from mood disorders including major depressive disorder…
- Trial name
- NCT02021149
- Testing
- High intensity whole-body infrared heating, Psychotherapy, Questionnaires
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Charles (Chuck) Raison
Major Depression
Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed Patients
The purpose of this study is to evaluate clinical efficacy (affective and cognitive) in patients with moderate depression between TMS over the left Dorsolateral Prefrontal Cortex (DLPFC) with simulated TMS, as well as clinical…
- Trial name
- NCT02213016
- Testing
- Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Nacional Autonoma de Mexico
Major Depressive Disorder
Acupuncture for Patients With Major Depressive Disorder
Several studies investigating acupuncture for major depressive disorder (MDD) have been carried out. However, investigators found the results were in high heterogeneity and poor methodological quality.
- Trial name
- NCT05106868
- Testing
- acupuncture
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Perinatal Depression
Early Detection of Perinatal Depression With Wearable Technology
The goal of this feasibility study is to learn whether wearable devices and self-report surveys can help researchers better understand changes in mood during pregnancy and after birth in young pregnant individuals with a history…
- Trial name
- BLUESMAPPED (NCT07784244)
- Testing
- Oura Ring (Photoplethysmography-based wearable ring), EmbracePlus Watch (Electrodermal activity wristband sensor)
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Lung Non-Small Cell Carcinoma, Unipolar Depression
Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer
This phase II trial tests the safety and side effects of psilocybin in combination with therapy for the treatment of major depressive disorder in patients with non-small cell lung cancer.
- Trial name
- NCT07216404
- Testing
- Biospecimen Collection, Counseling, Interview
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Alan Davis
Major Depressive Disorder
Role of Pentoxifylline as an Adjuvant Therapy for Adult Patients With Major Depressive Disorder
This study aimed to evaluate the therapeutic benefits of pentoxifylline (PTX) in treatment of adult patients with MDD as it has anti-inflammatory and phosphodiastrase inhibition activities.
- Trial name
- NCT03554447
- Testing
- Escitalopram 20 mg tablet plus Pentoxifylline 400Mg Tablet
- Volunteers
- 80 people
- Sponsor
- Mahmoud Samy Abdallah
Major Depressive Disorder
A Study of MD-120 in Patients With Depression
The purpose of this study is to verify the efficacy and evaluate the safety of 8-week once-daily oral administration of MD-120 in Japanese patients with depression.
- Trial name
- NCT04345471
- Testing
- Desvenlafaxine 100 mg, Desvenlafaxine 50 mg
- Where
- Japan
- Volunteers
- 615 people
- Sponsor
- Mochida Pharmaceutical Company, Ltd.
Major Depressive Disorder
Creatine Augmentation Treatment in Major Depressive Disorder Subjects
Given 1) the established safety with short-term or long-term supplementation of Cr, 2) its potential usefulness in improving brain energy metabolism, 3) the reported abnormality in brain energy metabolism in MDD subjects, and 4)…
- Trial name
- NCT00729755
- Testing
- Creatine monohydrate
- Where
- 4 sites in South Korea
- Volunteers
- 59 people
- Sponsor
- Ewha Womans University
Treatment Resistant Depression
Berlin Deep Brain Stimulation Depression Study
In this study efficacy and safety of deep brain stimulation of the cingulate cortex in 20 patients with treatment resistant major depression will be investigated.
- Trial name
- BDDS (NCT00531726)
- Testing
- DBS of Cg25
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Charite University, Berlin, Germany
Depression
Fevarin® Effectiveness in Treatment of Depression in Patients With Neurological Disorder
Prospective, multicenter, non-comparative, observational program to describe prevalence of depressive symptoms in a variety of neurological disorders and effects of Fevarin® on the severity of anxiety and depression, sleep state…
- Trial name
- FRIENDS (NCT02043197)
- Where
- 29 sites in Russia
- Volunteers
- 300 people
- Sponsor
- Abbott
Depression - Major Depressive Disorder, Alcohol Use Disorder
ACT_for Alcohol Use Disorder and Depression
Alcohol use disorders (AUDs) and depressive disorders frequently coexist, complicating the clinical management of patients suffering from them.
- Trial name
- NCT06620276
- Testing
- Acceptance and Commitment Therapy, Ketamine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Depressive Disorder, Major Depression
A Study of SR58611A in the Prevention of Depression Relapse in Patients With Major Depressive Disorder
The purpose of the study is to assess whether treatment with SR58611A can prevent relapse of depressive symptoms in patients with major depressive disorder.
- Trial name
- CALYPSO (NCT00345098)
- Testing
- SR58611A
- Where
- 13 sites in Argentina, Bulgaria and 11 more
- Volunteers
- 704 people
- Sponsor
- Sanofi
Major Depressive Disorder
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-062)(COMPLETED)
A clinical study to determine the efficacy and safety of MK0869 in the treatment of depression
- Trial name
- NCT00048607
- Testing
- aprepitant, Comparator: paroxetine HCL
- Volunteers
- 600 people
- Sponsor
- Merck Sharp & Dohme LLC