Clinical trials: Patients With Tumor
Triple Negative Breast Neoplasms
Capecitabine Plus Pembrolizumab in Patients With Triple Negative Breast Cancer After Chemo-immunotherapy and Surgery
The goal of this clinical trial is to evaluate the efficacity and safety of pembrolizumab and capecitabine on the invasive disease-free survival, in participants who have triple negative breast cancer (TNBC) with residual disease…
- Trial name
- CAPPA (NCT05973864)
- Testing
- Pembrolizumab injection, Capecitabine tablets, Local radiotherapy
- Where
- 20 sites in France
- Volunteers
- 220 people
- Sponsor
- UNICANCER
Lung Adenocarcinoma, Lung Cancer
A Phase 1/2 Trial of Trametinib and Erlotinib in Patients With EGFR-Mutant Lung Adenocarcinomas and Acquired Resistance to Erlotinib
The purpose of this study is to determine the safety, tolerability and overall response rate of trametinib when given in combination with erlotinib in patients with Stage IV or recurrent lung adenocarcinoma that cannot be treated…
- Conditions
- Lung Adenocarcinoma, Lung Cancer, Lung Cancer Metastatic, Lung Cancer Stage IV
- Trial name
- NCT03076164
- Testing
- Trametinib, Erlotinib
- Where
- 7 sites in United States
- Volunteers
- 24 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Phase Chronic Myeloid Leukemia
Ruxolitinib in Combination With Nilotinib in Chronic Myeloid Leukemia (CML) Patients
This study is designed to determine the maximal tolerated dose of Ruxolitinib in combination with nilotinib in patients with chronic myeloid leukemia (CML).
- Trial name
- NCT01702064
- Testing
- Nilotinib, Ruxolitinib
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Breast Cancer
Effect of Early vs Late Drainage Removal in Women After Radical Mastectomy With Axillary Clearance
The aim of the study is to assess whether early drainage removal in patients with less than 150ml of lymph in postoperative day 1 can reduce total lymphorrhoea
- Trial name
- CHLONKA (NCT01221064)
- Testing
- Early drainage removal, Late drainage removal
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Gdansk
Osteomalacia
Ga-DOTATATE PET for Phosphaturic Mesenchymal Tumors in Patients With Tumor Induced Osteomalacia
The researchers are trying to evaluate a newer imaging technique (Ga-DOTATATE PET/CT) to see if it is more sensitive to localize the source of the hormone, which has caused the low phosphate levels.
- Trial name
- NCT03736564
- Testing
- 68Ga-DOTATATE PET/CT
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Venous Thromboembolism, Esophagus Cancer
Venous Thromboembolism and Bleeding Risk in Patients With Esophageal Cancer
This study aims to assess the 6- and 12-month venous thromboembolism (VTE) and bleeding incidence from the start of cancer diagnosis in a retrospective cohort of patients with esophageal cancer.
- Conditions
- Venous Thromboembolism, Esophagus Cancer, Bleeding, Chemotherapy Effect
- Trial name
- VENETIA (NCT03646409)
- Testing
- Venous thromboembolic event, arterial thromboembolic event, bleeding events
- Where
- Netherlands
- Volunteers
- 542 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Prostate Cancer
Weekly Docetaxel and Bortezomib in the Treatment of Advanced Hormone-Refractory Prostate Cancer
Evaluation of the effectiveness of weekly docetaxel/bortezomib as first-line chemotherapy for patients with advanced hormone-refractory prostate cancer.
- Trial name
- NCT00193232
- Testing
- Docetaxel, Bortezomib
- Volunteers
- 50 people
- Sponsor
- SCRI Development Innovations, LLC
Acute Myeloid Leukemia, Adult
RWE of 1st Line Treatment in Adults With AML From 18 to 70 Years Old.
This is a multicenter, observational real world clinical trial with prospective follow up that will evaluate the treatment outcome of Acute Myeloid Leukemia (AML) patients in the first line with intensive chemotherapy based…
- Trial name
- NCT05127798
- Testing
- Evaluation of first line treatment with intensive treatment outcome in adult patients with AML.
- Where
- 2 sites in Argentina
- Volunteers
- 50 people
- Sponsor
- Grupo Argentino de Tratamiento de la Leucemia Aguda
Advanced Malignant Tumors
A Phase I Study of SSGJ-612 in Patients With Advanced Solid Tumors
This study is an open-label phase I study to evaluate the safety, pharmacokinetics, and antitumor activity of SSGJ-612 in patients with advanced malignant solid tumors expressing HER2.
- Trial name
- NCT07032298
- Testing
- SSGJ-612
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Colorectal Neoplasms
MK-2206 and AZD6244 in Patients With Advanced Colorectal Carcinoma
Background: MK-2206 and AZD6244 (Selumetinib) are experimental cancer treatment drugs that block the effect of certain proteins that cancer cells need to grow and survive.
- Trial name
- NCT01333475
- Testing
- MK-2206 + AZD6244
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Lymphoma, B-Cell
Pilot Study of Anti-CD20-CAR-engineered T Cells in Patients With Chemotherapy Resistant or Refractory CD20+ Lymphoma
Chimeric antigen receptor (CAR) T cells targeting CD20 will be evaluated for safety and efficacy in patients with CD20+ B cell lymphoma.
- Trial name
- NCT02965157
- Testing
- CART20
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Beijing Biohealthcare Biotechnology Co.,Ltd
Hodgkin Lymphoma
ANIMATE: Phase II Study of Nivolumab Monotherapy for Relapsed/Refractory Hodgkin Lymphoma
This is a single-arm, phase II, multi-centre study of the safety and efficacy of the PD-1 inhibitor, nivolumab, as second-line or third-line salvage therapy as a bridge to stem cell transplant (SCT) in relapsed/ refractory…
- Trial name
- ANIMATE (NCT03337919)
- Testing
- Nivolumab
- Where
- 10 sites in United Kingdom
- Volunteers
- 78 people
- Sponsor
- University College, London
Solid Tumors
GEN1046 Safety Trial in Patients With Malignant Solid Tumors
The goal of this trial is to learn about the antibody acasunlimab (an antibody also known as GEN1046) when it is used alone and when it is used together with standard of care treatment (docetaxel) or another antibody cancer drug…
- Trial name
- NCT03917381
- Testing
- Acasunlimab, Acasunlimab in combination with docetaxel (in a single expansion cohort), Acasunlimab in combination with pembrolizumab (in a separate expansion cohort)
- Where
- 57 sites in United States, Czechia and 8 more
- Volunteers
- 429 people
- Sponsor
- Genmab
Brain Oligometastases
HF-SRT vs. HS-WBRT in Treating Patients With Brain Oligometastases
[Background] For newly-diagnosed patients with brain metastases (BMs), conventional whole-brain radiotherapy (WBRT) might still remain a common palliative management.
- Trial name
- NCT05807165
- Testing
- Hypofractionated Stereotactic Radiotherapy (HF-SRT), Hippocampus-Sparing Whole-Brain Radiotherapy (HS-WBRT) plus memantine
- Where
- Taiwan
- Volunteers
- 115 people
- Sponsor
- Chang Gung Memorial Hospital
Lung Cancer
Impact of PD1-lymphocytes in Bronchoalveolar Lavage of Patients With Lung Cancer
The aim of this trial is to assess PD1-lymphocytes in bronchoalveolar lavage in patients with lung cancer, ILD and asthma.
- Trial name
- NCT04827667
- Testing
- bronchoalveolar lavage
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- University of Vienna
Nasopharyngeal Carcinoma, Radiation-induced Xerostomia
Impact on Xerostomia for Nasopharyngeal Carcinoma Patients Treated With or Without Superficial Parotid Lobe-sparing Intensity-modulated Radiotherapy
This is a prospective phase II clinical randomized controlled study, the purpose of this study is to assess whether superficial parotid lobe-sparing intensity-modulated radiotherapy (SPLS-IMRT) can decrease the incidence of…
- Trial name
- NCT05020067
- Testing
- superficial parotid lobe-sparing intensity-modulated radiotherapy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sun Yat-sen University
Cervical Cancer
Topotecan and Paclitaxel in Treating Patients With Recurrent or Metastatic Cancer of the Cervix
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003065
- Testing
- filgrastim, paclitaxel, topotecan hydrochloride
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Herbert Irving Comprehensive Cancer Center
Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8
Durvalumab and Tremelimumab Before Surgery in Treating Patients With Hormone Receptor Positive, HER2 Negative Stage II-III Breast Cancer
This early phase I trial studies the side effects of durvalumab and tremelimumab before surgery in treating patients with hormone receptor positive, HER2 negative stage II-III breast cancer.
- Conditions
- Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- NCT03132467
- Testing
- Durvalumab, Tremelimumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Music Therapy, Breast Cancer, Anxiety, Fatigue
Music Therapy in Patients With Breast Cancer- a Randomized Controlled Trial
Comprehensive inpatient rehabilitation for breast cancer consist of interdisciplinary team care but few researchers investigate the efficacy of music therapy, which have shown some benefits in breast cancer rehabilitation.
- Trial name
- NCT04540471
- Testing
- music, comprehensive in-patient education program
- Where
- Taiwan
- Sponsor
- Chang Gung Memorial Hospital
Lymphoma, T-Cell, Peripheral
GDP in Frontline Chemotherapy for Patients With PTCL-NOS
This study is to evaluate the efficacy and safety of GDP (gemcitabine, dexamethasone, and cisplatin) chemotherapy in patients with peripheral T-cell lymphoma-NOS as frontline treatment.
- Trial name
- NCT02404571
- Testing
- GDP chemotherapy
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Chinese Academy of Medical Sciences
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