Clinical trials: Patients at Risk of Colorectal Cancer
Colorectal Polyp
Effects of UNICLA-A2 Dairy Products on Patients at High-risk of Colorectal Cancer Development
Dietary intervention with UNICLA-A2 milk products containing beta casein A2 protein, and higher levels of omega-3 fatty acids and selenium may contribute to maintain the intestinal integrity, reduce inflammatory processes…
- Trial name
- NCT04824053
- Testing
- Milk from genetically selected homozygous- β-casein-A2 cows fed with forages and a concentrate enriched on linseed and selenized yeast as sources of PUFAs and selenium, Conventional milk, Yogurt made from milk of genetically selected homozygous- β-casein-A2 cows fed with forages and a concentrate enriched on linseed and selenized yeast as sources of PUFAs and selenium
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Colorectal Cancer, Surgical Resection of the Colorectal Tumor
The Immunoscore as a Prognostic Marker for Patients With a Colorectal Cancer
Medical and Scientific Background: Colorectal cancers (CRC) are the leading cancers in both genders. This cancer is of prognostic severity. The prognosis of this cancer has not been significantly improved.
- Trial name
- IMMUCOL (NCT01688232)
- Where
- 6 sites in France
- Volunteers
- 459 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colon Cancer, Precancerous Condition
Aspirin in Preventing Colorectal Cancer in Patients at Increased Risk of Colorectal Cancer
This randomized phase II trial is studying how well aspirin works in preventing colorectal cancer in patients at increased risk of colorectal cancer. Chemoprevention is the use of certain drugs to keep cancer from forming.
- Conditions
- Colon Cancer, Precancerous Condition, Rectal Cancer
- Trial name
- NCT00468910
- Testing
- acetylsalicylic acid, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
Community Based Screening for Colorectal Cancer in an Underserved High Risk Population in Nigeria
Patient age 45 year old and above who presented with rectal bleeding at three tertiary hospitals in South West Nigeria were invited for colonoscopy. The clinical information of the patients and the colonoscopy data were analyzed
- Trial name
- NCT03032874
- Testing
- Colonoscopy
- Where
- Nigeria
- Volunteers
- 100 people
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Colorectal Cancer, Hereditary Non-polyposis Colon Cancer
Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer
RATIONALE: Gathering medical and family history information from patients and family members may help doctors better understand hereditary colorectal cancer and hereditary polyposis syndrome and identify patients at high risk of…
- Conditions
- Colorectal Cancer, Hereditary Non-polyposis Colon Cancer, Precancerous Condition
- Trial name
- NCT00675636
- Testing
- study of socioeconomic and demographic variables, evaluation of cancer risk factors, study of high risk factors
- Where
- 3 sites in United States
- Volunteers
- 730 people
- Sponsor
- Vanderbilt University Medical Center
Colorectal Cancer
Screening TO Prevent ColoRectal Cancer (STOP CRC) Among At-Risk Chinese and Korean American Primary Care Patients
The objective of the study is to conduct a randomized controlled trial to determine the impact of a multi-level culturally-sensitive decision support intervention on colorectal cancer screening adherence among 400 Chinese and…
- Trial name
- NCT03481296
- Testing
- Advanced Control, Culturally-Adapted Decision Support Navigation Intervention
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Patients at Risk of Colorectal Cancer
The Comparison Between Computed Tomography and Colonoscope in Detecting Colorectal Tumors in Patients With FIT+
Colonoscopy is the mainstay modality of choice in colorectal cancer screening worldwide. However, the rate of colonoscopy for colorectal cancer screening is very low (approximately 5-10%) because of the limited local medical…
- Trial name
- CTOCOCREC (NCT06165328)
- Testing
- CT and colonoscopy
- Where
- Thailand
- Volunteers
- 241 people
- Sponsor
- Hat Yai Medical Education Center
Colorectal Cancer
Oxaliplatin, Leucovorin, and Fluorouracil Before and After Radiation Therapy and Surgery in Treating Patients With Rectal Cancer That Can Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- COPERNICUS (NCT01263171)
- Testing
- Leucovorin, fluorouracil, leucovorin calcium
- Where
- 7 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cardiff University
Colorectal Cancer
Colonography Versus Colonoscopy in High Risk Patient
to evaluate the acceptability of CT-colonography compared to colonoscopy for the detection of advanced adenomas in subpopulations at high risk of colorectal.
- Trial name
- COLO-TDM (NCT00748449)
- Testing
- Colonoscopy, CT-colonography
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer
Combination Chemotherapy With or Without Irinotecan in Treating Patients With Stage III Colon Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00005979
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- 30 sites in France
- Sponsor
- UNICANCER
Colorectal Cancer
A Patient Portal Tool, E-assist, for Supporting CRC Screening
To compare patient perceptions, intent to screen, and screening use among those using a patient portal with and without a colorectal cancer (CRC) screening decision support tool, e-assist.
- Trial name
- NCT02798224
- Testing
- e-assist: Colon Health, Healthwise Educational Program
- Where
- United States
- Volunteers
- 1,826 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer
Do Patients With Colorectal Cancer Understand That Their Family is at Risk?
The purpose of this study is to assess whether patients with colorectal cancer understand that their first-degree relatives are at increased risk of getting the cancer themselves and therefore should be screened early.
- Trial name
- NCT00145860
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- University of Chicago
Sporadic Colorectal Adenoma
Mesalazine Effects in Sporadic Colorectal Adenoma Patients
Several studies indicate that mesalazine might have a preventive effect on recurrence of adenomas in patients with and without inflammatory bowel disease.
- Trial name
- NCT01894685
- Testing
- Mesalazine
- Where
- Netherlands
- Volunteers
- 74 people
- Sponsor
- UMC Utrecht
Colorectal Neoplasms
Prophylactic Surgery Plus HIPEC With CO2 in Patients Affected by Colorectal Carcinoma. CHECK Study.
This is a phase III randomized, multicenter study with two different arm: experimental: prophylactic surgery plus HIPEC CO2 performed with mitomycin comparator: standard surgery Adjuvant treatment after surgery is mandatory…
- Trial name
- CHECK (NCT03914820)
- Testing
- HIPEC CO2 surgery, Standard surgery, Mitomycin
- Where
- 16 sites in Italy
- Volunteers
- 330 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Inflammation, Prevention and Control
Effect of High-Legume Diet on Colorectal Cancer Risk
This study, sponsored by the National Cancer Institute and Penn State University, will examine how a diet high in legumes (dried beans) influences risk factors for colon cancer and polyps.
- Conditions
- Inflammation, Prevention and Control, Colonic Neoplasms, Diet
- Trial name
- NCT00339469
- Testing
- LIFE
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Colon Adenocarcinoma, Stage IIA Colon Cancer AJCC v7
Oxaliplatin, Leucovorin, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer
This randomized phase III trial studies oxaliplatin, leucovorin, fluorouracil, and bevacizumab to see how well they work compared to oxaliplatin, leucovorin, and fluorouracil in treating patients who have undergone surgery for…
- Conditions
- Colon Adenocarcinoma, Stage IIA Colon Cancer AJCC v7, Stage IIB Colon Cancer AJCC v7, Stage IIC Colon Cancer AJCC v7
- Trial name
- NCT00217737
- Testing
- Bevacizumab, Fluorouracil, Leucovorin
- Where
- 928 sites in United States, Canada and 3 more
- Volunteers
- 2,431 people
- Sponsor
- National Cancer Institute (NCI)