Clinical trials: Patients with Multiple Sclerosis
Multiple Sclerosis
Effects of Home-based Respiratory Muscle Training With New Load Adjustment Test in People With Multiple Sclerosis
The main objective of the present study is to verify whether respiratory muscle training programme (IMT+EMT; included both inspriratory and expiratory muscles with load adjustment based on the principles of the 1-repetition…
- Trial name
- NCT07269054
- Testing
- Respiratory muscle training + 1-repetition maximum test, Respiratory muscle training + reference test
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Tamara del Corral Núñez-Flores
Multiple Sclerosis
Effect of High Intensity Interval Training in Patients With Multiple Sclerosis
In this study, we are aiming to systematically review the literature on the effect of HIIT on MS patients as improving physical performance, cognitive function, aerobic fitness and muscle strength.
- Trial name
- NCT05954195
- Testing
- high intensity interval training
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Cairo University
ALS, Amyotrophic Lateral Sclerosis
A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS)
This study will look at whether Pimozide may help to slow the progression of Amyotrophic Lateral Sclerosis. 100 people from several Canadian centres with ALS who have provided their consent will be randomly assigned into one of 2…
- Trial name
- Pimozide2 (NCT03272503)
- Testing
- Pimozide 2mg/day (current) or 4 mg/day (study initiation)
- Where
- 9 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Relapsing Multiple Sclerosis (RMS)
Kesimpta (Ofatumumab) in Greek Multiple Sclerosis Patients - an Observational Study
This study is a single-country, non-interventional, multicenter, observational study, mainly based on primary data collection to assess the effect of ofatumumab on clinical parameters of Multiple Sclerosis (MS) in a routine…
- Trial name
- CHRONOS (NCT06486779)
- Testing
- Ofatumumab
- Where
- 15 sites in Greece
- Volunteers
- 160 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
How to Develop the Highest Possible Leading-edge Interdisciplinary Care Model for People With MS, That Will be Relevant to All Stakeholders and Declinable to Different Local Contexts With the Ultimate Goal of Ensuring the Highest Level of Quality of Care in MS.
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating and degenerative disease of the central nervous system. It is currently not curable, although several disease-modifying treatments (DMT) reduce the occurrence of…
- Trial name
- MUSICALISE (NCT07289724)
- Testing
- Focus group, individual interview
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis
Managed Access Program (MAP) for Patients Diagnosed With Secondary Progressive Multiple Sclerosis With Active Disease
The purpose of this MAP Cohort Treatment Plan is to allow access to siponimod for eligible patients diagnosed with Secondary Progressive Multiple Sclerosis with active disease.
- Trial name
- NCT04540861
- Testing
- Siponimod
- Sponsor
- Novartis Pharmaceuticals
Muscle Weakness, Fatigue
Assessing Fatiguability of Tongue Muscles in MS
Multiple Sclerosis (MS) patients with subjective dysphagia will be tested for tongue strength fatigue using a strictly defined fatigue paradigm.
- Conditions
- Muscle Weakness, Fatigue, Multiple Sclerosis, Deglutition Disorders
- Trial name
- NCT03817073
- Testing
- Iowa Oral Performance Instrument (IOPI)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Thomas More Kempen
Multiple Sclerosis, Neurogenic Bladder
Clinical Study of Solifenacin Succinate in Patients With Bladder Symptoms Due to Spinal Cord Injury or Multiple Sclerosis
A clinical study to evaluate the efficacy and safety of solifenacin in patients with bladder symptoms due to spinal cord injury or multiple sclerosis
- Conditions
- Multiple Sclerosis, Neurogenic Bladder, Spinal Cord Diseases
- Trial name
- SONIC (NCT00629642)
- Testing
- Solifenacin Succinate, Oxybutynin Hydrochloride
- Where
- 39 sites in Australia, Belgium and 9 more
- Volunteers
- 249 people
- Sponsor
- Astellas Pharma Inc
Neuromyelitis Optica Spectrum Disorders, Myasthenia Gravis
Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/B Cell Maturation Antigen （CD19/BCMA） in Patients With r/r Neurological Autoimmune Diseases
This is an open label, single-site, dose-escalation study in up to 12 participants with relapsed or refractory Neurological Autoimmune Diseases.
- Conditions
- Neuromyelitis Optica Spectrum Disorders, Myasthenia Gravis, Multiple Sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
- Trial name
- NCT06939166
- Testing
- UCAR T-cell
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Tianjin Huanhu Hospital
Multiple Sclerosis
A Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Multiple Sclerosis (MS)
The main purpose of this study is to assess the bioequivalence of ocrelizumab SC test formulation to the marketed ocrelizumab SC reference formulation in participants with either relapsing multiple sclerosis (RMS) or primary…
- Trial name
- PORTAMENTO (NCT07074886)
- Testing
- Ocrelizumab Test Formulation, Ocrelizumab Reference Formulation
- Where
- 49 sites in United States, Argentina and 7 more
- Volunteers
- 193 people
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis
Stress Management for Patients With Multiple Sclerosis
There is a growing body of literature showing that stressful life events can increase the risk of developing exacerbations and new brain lesions among people with multiple sclerosis.
- Trial name
- NCT00147446
- Testing
- Individual Stress Management, Wait List Control
- Where
- 3 sites in United States
- Volunteers
- 121 people
- Sponsor
- Northwestern University
Multiple Sclerosis, Sarcopenia
Sarcopenia and Related Factors in Patients With Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic disease affecting the central nervous system, exhibiting autoimmune and neurodegenerative properties.
- Trial name
- NCT07116070
- Testing
- Clinical Assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Selcuk University
Relapsing Multiple Sclerosis, Multiple Sclerosis
A Study of Pirtobrutinib (LY3527727 [LOXO-305]) Versus Placebo in Participants With Relapsing Multiple Sclerosis
The main purpose of this study is to assess efficacy and safety of pirtobrutinib in participants with relapsing multiple sclerosis.
- Trial name
- NCT06104683
- Testing
- Pirtobrutinib
- Where
- 4 sites in United States, Puerto Rico
- Sponsor
- Loxo Oncology, Inc.
Multiple Sclerosis, Relapsing-Remitting
A Study of Allogeneic Human UC-MSC and Liberation Therapy (When Associated With CCSVI) in Patients With RRMS
STUDY OBJECTIVES: Primary Objective: Assessment of treatment safety based on incidence of any treatment emergent/treatment associated adverse events prior to discharge and at 1, 3, 6 and 12 months post treatment.
- Trial name
- NCT02587715
- Testing
- Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells, Liberation therapy
- Where
- Trinidad and Tobago
- Volunteers
- 69 people
- Sponsor
- Novo Cellular Medicine Institute LLP
Multiple Sclerosis, Exercise Program
Effect of Home Exercise Program on Various Parameters in Patients With Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic, inflammatory, neurodegenerative, and autoimmune disease that progresses with progressive neurological dysfunction and affects the central nervous system.
- Conditions
- Multiple Sclerosis, Exercise Program, Telerehabilitation, Autoimmune Disorder
- Trial name
- NCT05447143
- Testing
- Fatigue Severity Scale, Berg Balance Test, Time up and go- 25 steps walking test
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Muğla Sıtkı Koçman University
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Relapsing Remitting Multiple Sclerosis
Study to Assess Immune Function and MRI Disease Activity in RRMS Patients When Switching From Natalizumab to Gilenya
A trial in patients with relapsing remitting multiple sclerosis (RRMS) Main objectives: To evaluate changes in the reconstitution of immune surveillance over time upon switching from natalizumab to fingolimod assessed by a change…
- Trial name
- ToFingo2 (NCT02325440)
- Testing
- Fingolimod, Natalizumab
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital Muenster
Multiple Sclerosis
Hybrid Rehabilitation Approach Through Group Exercise and Telerehabilitation in Patients With Multiple Sclerosis
The aim of the study is to determine the benefits of outpatient group rehabilitation with subsequent telerehabilitation. The patient will participate in a 12-week circuit training, including training once a week in a group of six…
- Trial name
- NCT05469568
- Testing
- Circuit training followed by telerehabilitation, Usual care
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Brno University Hospital
Multiple Sclerosis
Effect of Pilates Training in Patients With Multiple Sclerosis
Knee flexor and extensor muscle weakness in MS patients causes a decrease in walking distance and is an important determinant of walking capacity.
- Trial name
- NCT04548206
- Testing
- Pilates training, control
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Gazi University
Multiple Sclerosis (MS)
Long-Term Outcomes and Durability of Effect Following Treatment With Cladribine Tablets for MS (CLASSIC-MS)
The objective of this study was to collect data both retrospectively and prospectively in order to evaluate the long-term outcomes, durability of effect, and real-world treatment patterns following treatment with Cladribine…
- Trial name
- NCT03961204
- Testing
- Data Collection
- Where
- 99 sites in United States, Australia and 27 more
- Volunteers
- 662 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
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