Clinical trials: Patients with Multiple Sclerosis
Multiple Sclerosis
Effectiveness of Cryotherapy on the Fatigue of Patients With Multiple Sclerosis
the aim of the study is to evaluate the effectiveness of partial-body cryotherapy (PBC) on the symptoms of patients with multiple sclerosis during a rehabilitation stay.
- Trial name
- CRYOSEP (NCT05219201)
- Testing
- partial-body cryotherapy chamber session
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Fondation Ildys
Multiple Sclerosis
Effectiveness of TMS on Spasticity and Balance for Patients With MS
Recently, non-invasive brain stimulation modalities such as transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation have become treatment options.
- Trial name
- NCT07451600
- Testing
- rTMS
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara Etlik City Hospital
Multiple Sclerosis
Effect of Sensory Integration Therapy on Gait Variability and Quality Of Life in Patients With Multiple Sclerosis
This study aims to evaluate the impact of sensory integration therapy on individuals with multiple sclerosis (MS) by examining its effects on gait variability and overall quality of life.
- Trial name
- NCT07390201
- Testing
- Conventional physical therapy program, Sensory integration therapy
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Cairo University
Multiple Sclerosis
Safety and Efficacy Study of Fingolimod in Taiwanese Adults (≥ 20years) With Relapsing Remitting Multiple Sclerosis
The purpose of the study is to describe the safety profile of fingolimod in the Taiwanese multiple sclerosis population. This study aims to collect the safety data in patients newly initiated on fingolimod for one year.
- Trial name
- SPRING (NCT04480853)
- Testing
- Fingolimod
- Where
- 3 sites in Taiwan
- Volunteers
- 14 people
- Sponsor
- Novartis Pharmaceuticals
Lower Urinary Track Symptoms, Multiple Sclerosis
Turkish Validity and Reliability of the Core Lower Urinary Tract Symptoms Questionnaire in Individuals With Multiple Sclerosis
The aim of this study is to study the validity and reliability of Core Lower Urinary Tract Symptoms Score in patients with multiple sclerosis.
- Trial name
- NCT06599866
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people
- Sponsor
- Kutahya Health Sciences University
Neurogenic Dysfunction of the Urinary Bladder, Multiple Sclerosis
Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction
A multi-center double-blinded placebo-controlled randomized clinical trial. The patients will be randomized into two groups. To investigate the efficacy of SNM to improve the key bladder diary variables compared to placebo (i.e.
- Conditions
- Neurogenic Dysfunction of the Urinary Bladder, Multiple Sclerosis, Sacral Neuromodulation, Bowel Dysfunction
- Trial name
- NCT05380856
- Testing
- Turning ON the neuromodulator, Turning OFF the neuromodulator
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Relapsing Multiple Scelrosis
Efficacy and Safety of Ofatumumab Compared to Teriflunomide in Patients With Relapsing Multiple Sclerosis.
To compare the efficacy and safety of ofatumumab administered subcutaneously (sc) every 4 weeks versus teriflunomide administered orally once daily in patients with relapsing multiple sclerosis
- Trial name
- ASCLEPIOS II (NCT02792231)
- Testing
- Ofatumumab subcutaneous injection, Teriflunomide capsule
- Where
- 178 sites in United States, Argentina and 28 more
- Volunteers
- 955 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Dose Escalation Study of the Pharmacodynamics, Pharmacokinetics, Safety, and Immunogenicity of BCD-132 in Patients With Relapsing-Remitting Multiple Sclerosis
BCD-132 is a humanized monoclonal antibody against CD20. BCD-132-1 is a Multicenter Open-Label Non-Comparative Dose Escalation Study (Phase 1) of the Pharmacodynamics, Pharmacokinetics, Safety, and Immunogenicity of BCD-132 (JSC…
- Trial name
- NCT03551275
- Testing
- BCD-132
- Where
- 5 sites in Russia
- Volunteers
- 24 people
- Sponsor
- Biocad
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis (Switzerland)
This prospective cohort study is part of the Clinnova programme and aims to (i) identify clinical imaging and omics characteristics associated with early Multiple Sclerosis (MS) and with transitioning phases to progressive MS, as…
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
- Trial name
- NCT06526364
- Testing
- All participants will be asked to provide data and samples for collection and analysis.
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
Multiple Sclerosis
Lifestyle Intervention for Patients With Multiple Sclerosis
The LIMS study is an observational study that investigates the effectiveness of an online lifestyle program for patients with multiple sclerosis (MS).
- Trial name
- LIMS (NCT05402501)
- Testing
- Lifestyle intervention program "Leef! met MS"
- Where
- Netherlands
- Volunteers
- 900 people
- Sponsor
- Amsterdam UMC, location VUmc
Relapsing-Remitting Multiple Sclerosis, Fatigue
Effects of Tysabri (BG00002) Over 12 Months on MS Related Fatigue in Participants With RRMS
The primary objective of this trial is to observe the Multiple Sclerosis (MS) related fatigue during treatment with Tysabri as measured by changes in the fatigue scale for motor and cognitive functions (FMSC) over the course of…
- Trial name
- TYNERGY (NCT00884481)
- Testing
- Natalizumab
- Where
- 27 sites in Austria, Denmark and 2 more
- Volunteers
- 195 people
- Sponsor
- Biogen
Multiple Sclerosis
Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia in Multiple Sclerosis Patients
Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping…
- Trial name
- NCT03856801
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Relapsing Multiple Sclerosis
Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS
The purpose of this study is to collect long-term safety, tolerability, effectiveness and health outcomes data in eligible subjects who have participated in a Novartis ofatumumab clinical MS study.
- Trial name
- ALITHIOS (NCT03650114)
- Testing
- Ofatumumab, Tetanus toxoid (TT) containing vaccine (Td, Tdap), 13-valent pneumococcal conjugate vaccine (13-PCV)
- Where
- 295 sites in United States, Argentina and 35 more
- Volunteers
- 1,882 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis, Peripheral Neuropathy
Effects of Meditation on Multiple Sclerosis and Peripheral Neuropathy
This study will evaluate the effects of mindfulness and concentration meditation on pain, fatigue, and physical functioning in patients with either multiple sclerosis or peripheral neuropathy.
- Trial name
- NCT00981643
- Testing
- Meditation instruction and practice
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Cleveland Clinic
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Cortical Lesions in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disease, leading to inflammation and degeneration of neurons in the entire central nervous system (CNS).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
- Trial name
- CLiMS (NCT03653585)
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
Chronic Kidney Diseases, Diabetes
KidneYou - Innovative Digital Therapy
The aim of the study is to assess the improvement of health in patients affected by CKD when they are exposed to non-pharmacological treatment strategies as nutritional program (NP), physical activity program (PA) and mindfulness…
- Conditions
- Chronic Kidney Diseases, Diabetes, Arterial Hypertension, Chronic Glomerulonephritis
- Trial name
- NCT05286632
- Testing
- KidneYou APP
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- Advice Pharma Group srl
Multiple Sclerosis, Pelvic Floor Disorders
Evaluation of the Influence of a Core Muscle Control-Based Rehabilitation Program Patients With Multiple Sclerosis
Given the structural relationship of the CORE as a whole, in this study we propose an intervention based on the global motor control of all the structures that make up the CORE to assess its effectiveness on urinary incontinence…
- Conditions
- Multiple Sclerosis, Pelvic Floor Disorders, Incontinence, Urinary
- Trial name
- NCT06384716
- Testing
- rehabilitation programme based on motor control of core muscles
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universidad Europea de Madrid
Multiple Sclerosis
Safety and Efficacy of an Immunoablative Nonmyeloablative Conditioning Protocol for Autologous Bone Marrow Transplantation (BMT) in Patients With Multiple Sclerosis (MS)
The purpose of this study is to evaluate the safety and efficacy of an immunoablative nonmyeloablative conditioning protocol for autologous bone marrow transplantation in patients with Multiple Sclerosis.
- Trial name
- NCT02529839
- Testing
- Autologous bone marrow transplantation, Fludarabine, Cyclophosphamide
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Multiple Sclerosis
Botulinum Toxin in Patients With Spastic Lower Limb Paresis Associated With Multiple Sclerosis
Spastic paraparesis is one of the most disabling functional deficits in the population with multiple sclerosis between 18 and 80 years of age and at any functional level.
- Trial name
- NCT04595045
- Testing
- Botulinum toxin type A infiltrations
- Where
- 2 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Aránzazu Vázquez Doce
Multiple Sclerosis, Back Pain
A Pilot Project for Multifidus Muscle Evaluation in Patients With Multiple Sclerosis
This research study plans to evaluate if multifidus muscle dysfunction is associated with back pain in patients with Multiple Sclerosis (MS).
- Trial name
- NCT05427045
- Testing
- home - exercise program
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arkansas
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