Clinical trials: Patients with Multiple Sclerosis
Multiple Sclerosis (MS), Unipolar Depression
Mood Disorders in Multiple Sclerosis Patients
This study investigates the frequency of unipolar and bipolar mood disorders in patients with multiple sclerosis. MS is a chronic condition that affects the central nervous system, and previous research suggests that mood…
- Conditions
- Multiple Sclerosis (MS), Unipolar Depression, Bipolar Disorder, Mood Disorders
- Trial name
- MSMD (NCT06652308)
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Islamic Azad University, Sanandaj
Radiologically Isolated Syndrome (RIS), Multiple Sclerosis
Evaluation of the Prevalence of Oculomotor Disorders in Patients With Radiologically Isolated Syndrome
This study aims to investigate the prevalence of subclinical oculomotor disorders in a population of patients with radiologically isolated syndrome.
- Trial name
- OCRIS (NCT03636789)
- Testing
- Neurological consultation
- Where
- 6 sites in France
- Volunteers
- 61 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Multiple Sclerosis, Primary Progressive
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis
A study to evaluate the efficacy and safety of fenebrutinib on disability progression in adult participants with Primary Progressive Multiple Sclerosis (PPMS).
- Trial name
- FENtrepid (NCT04544449)
- Testing
- Fenebrutinib, Ocrelizumab
- Where
- 190 sites in United States, Argentina and 26 more
- Volunteers
- 985 people
- Sponsor
- Hoffmann-La Roche
Overactive Bladder Syndrome, Multiple Sclerosis
Efficacy of Lower Limb Exercises on Overactive Bladder Symptoms in Patients With Multiple Sclerosis
The aim of the study (OVERACT_V1) is to verify if the isometric contraction of ankle plantarflexor and Hamstring muscles, induces a significant reduction of overactive bladder symptoms in patients with Multiple sclerosis.
- Conditions
- Overactive Bladder Syndrome, Multiple Sclerosis, Muscle Strain
- Trial name
- NCT03322748
- Testing
- Usual physical therapy+ strengthening of lower limbs muscles, Usual physical therapy
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis
Protection Against Severe Coronavirus Disease 2019 in Patients With Multiple Sclerosis Stratified According to Disease Modifying Treatment
The investigators will conduct retrospective observational cohort study at the Nationaal Multiple Sclerose Centrum (NMSC) Melsbroek (Belgium), which is a large center specifically focusing on neurological management…
- Trial name
- PASCOMS (NCT05834335)
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- National MS Center Melsbroek
Multiple Sclerosis, Relapsing-Remitting
The Effects of Aerobics Training on Balance in Patients With Multiple Sclerosis
Standing Balance, with and without blindfold, will be measured on patients with Multiple Sclerosis using a Biodex Balance Scale.
- Trial name
- NIA (NCT01453868)
- Testing
- Non Impact Aerobics, Passive : lecture series
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Nelson Mandela Metropolitan University
Multiple Sclerosis
Betaseron 16-Year Long-Term Follow-Up (LTF) in Patients With Relapsing-Remitting Multiple Sclerosis
The purpose of this follow-up study is to look carefully at the long-term course of multiple sclerosis (MS) and possibly the long-term effects of Betaseron in the patients who were previously enrolled in the original North…
- Trial name
- NCT00206635
- Testing
- Interferon beta-1b (Betaseron, BAY86-5046)
- Where
- 9 sites in United States, Canada
- Volunteers
- 432 people
- Sponsor
- Bayer
Multiple Sclerosis
Evaluation of Potential Predictors of Adherence by Investigating a Representative Cohort of Multiple Sclerosis (MS) Patients in Germany Treated With Betaferon
This study aims to evaluate potential predictors of adherence by investigating a representative cohort of MS patients in Germany treated with Betaferon
- Trial name
- BETAPREDICT (NCT02486640)
- Testing
- Interferon beta-1b (Betaferon, BAY86-5046), Betaconnect Autoinjector
- Where
- Germany
- Volunteers
- 162 people
- Sponsor
- Bayer
Multiple Sclerosis
Effect of Interferon Beta-1a (Avonex®) on Changes of Non-conventional MRI Measures in Patients With MS
Phase IV open label, single-blind study, post-marketing, 1-year MRI observational study evaluating effect of Avonex® monotherapy (6.0 MIU administered i.m.
- Trial name
- NCT00463710
- Testing
- Avonex® monotherapy (6.0 MIU administered i.m. each week)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- State University of New York at Buffalo
Sleep Quality, Multiple Sclerosis
The CanISleepinMS Study: Effect of Cannabidiol (CBD) on Sleep Quality in Patients With Multiple Sclerosis
Evaluating the effect of 300 mg purified cannabidiol (CBD) on sleep quality in patients with multiple sclerosis (MS).
- Conditions
- Sleep Quality, Multiple Sclerosis, Insomnia
- Trial name
- CanISleepinMS (NCT07840924)
- Testing
- Cannabidiol Oil
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Wageningen University
Progressive Multiple Sclerosis
Evaluation of the Incidence of Relapses in Patients With Biotin-treated Progressive Multiple Sclerosis
Background: High dose biotin is a therapeutic option for French progressive Multiple Sclerosis (MS) patients, without relapse for at least one year, since June 1, 2016.
- Trial name
- IPBio-SeP (NCT03552211)
- Testing
- biotin, propensity score
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Multiple Sclerosis
Optical Coherence Tomography: Glatiramer in Clinically Isolated Syndrome or Early Relapsing Remitting Multiple Sclerosis (MS)
This is a study in patients with clinically isolated syndrome (CIS) and early relapsing remitting multiple sclerosis (RRMS) to assess the effects of glatiramer acetate (GA) subcutaneously on the condition of the optical nerve in…
- Trial name
- OCTIMS (NCT00910598)
- Testing
- glatiramer acetate
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Amphia Hospital
Multiple Sclerosis, Sensory Impairments
Validity and Reliability of Lower Extremity Position Test in Patients with Multiple Sclerosis
Sensory disorders are one of the most important problems in individuals with MS, and these disorders are among the first symptoms of MS. Loss of sense of proprioception is particularly common in patients with MS.
- Conditions
- Multiple Sclerosis, Sensory Impairments, Proprioceptive Disorders, Validity
- Trial name
- NCT05663541
- Testing
- Lower extremity position test
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Pamukkale University
Multiple Sclerosis
A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy
The purpose of this study is to assess the imaging biomarkers, patient outcomes, safety, tolerability, and treatment satisfaction of ocrelizumab (OCR) combined with recombinant human hyaluronidase (rHuPH20) administered…
- Trial name
- OSSIA (NCT07609719)
- Testing
- OCR SC
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 100 people
- Sponsor
- Genentech, Inc.
Multiple Sclerosis
Therapeutic Benefit of Incobotulinum Toxin A for Spasticity of the Triceps Surae in Patients With Multiple Sclerosis
Introduction/Objectives: In this observational study, we assessed the benefit following an injection of 200 international units (IU) of incobotulinum toxinA in patients with multiple sclerosis (MS) with spasticity of the triceps…
- Trial name
- GAITOX (NCT04265092)
- Testing
- Incobotulinum toxin A
- Volunteers
- 22 people
- Sponsor
- Pôle Saint Hélier
Amyotrophic Lateral Sclerosis
A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study was to assess the effect of CK-2127107 (hereafter referred to as reldesemtiv) versus placebo on respiratory function and other measures of skeletal muscle function in patients with ALS.
- Trial name
- FORTITUDE-ALS (NCT03160898)
- Testing
- Reldesemtiv
- Where
- 64 sites in United States, Australia and 4 more
- Volunteers
- 458 people
- Sponsor
- Cytokinetics
Multiple Sclerosis, Spasticity, Muscle
A Study to Investigate the Safety and Effectiveness of Arbaclofen Extended-Release Tablets for Patients With MS
Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disease of the central nervous system (CNS) that is regarded as the foremost cause of non-traumatic neurologic disability in adults in North America.
- Trial name
- OS440-3004 (NCT03290131)
- Testing
- Arbaclofen
- Where
- 30 sites in Belarus, Bosnia and Herzegovina and 5 more
- Volunteers
- 536 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Multiple Sclerosis
Inductive Therapeutic Exercise in Multiple Sclerosis
ETOTUR is a research project comprising two complementary stages. The first is an observational study in approximately 50 healthy adults to develop and validate a mobile tool for quantitative assessment of muscle tone using the…
- Trial name
- ETOTUR (NCT07847853)
- Testing
- Experimental: Inductive Therapeutic Exercise (ETI)
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Fundación San Juan De Dios
Nutrition Habits in Multiple Sclerosis
Relationship Between the Nutritional Habits and Relapsing and Disability Rates in Patient With Multiple Sclerosis.
patient with multiple sclerosis will undergo and completed comprehensive survey measuring body mass index and assessment of obesity ,health related quality of life,disability,relapsing and complete data on their dietary habits.
- Trial name
- NCT04110171
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Amyotrophic Lateral Sclerosis
Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year
This study assessed the effect of tirasemtiv versus placebo on respiratory function in patients with ALS.
- Trial name
- VITALITY-ALS (NCT02496767)
- Testing
- Tirasemtiv
- Where
- 81 sites in United States, Belgium and 9 more
- Volunteers
- 744 people
- Sponsor
- Cytokinetics
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