Clinical trials: Patients with Multiple Sclerosis
Non-Active Secondary Progressive Multiple Sclerosis
Nasal Foralumab in Patients With Non-Active Secondary Progressive Multiple Sclerosis
Only subjects that have completed TILS-021, a Phase 2a Randomized, Double-Blind, Placebo-Controlled, Multicenter Dose-Ranging Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patients are eligible…
- Trial name
- TILS-022 (NCT06890923)
- Testing
- Foralumab TZLS-401 100 µg
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Tiziana Life Sciences LTD
Multiple Sclerosis
Pharmacogenetics of Liver Toxicity in Patients With Multiple Sclerosis Treated With Fingolimod
To investigate whether polymorphic differences can be identified between Multiple Sclerosis patients developing elevated liver enzymes (defined as ALT, AST, GGT or bilirubinemia levels five above the upper normal limit on at…
- Trial name
- NCT05516303
- Testing
- Genetic polymorphism, Measurement of fingolimod and fingolimod-phosphate concentrations
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Caen
Motor Activity
The Reliability of the Nine Hole Peg Test in Patients With Multiple Sclerosis
The main aim of the project is to establish inter-rater reliability, internal variability and variability of results got in two different ways of the Nine Hole Peg Test administered according to the new Czech extended version…
- Trial name
- NCT05012241
- Testing
- Nine Hole Peg Test
- Where
- 2 sites in Czechia
- Volunteers
- 33 people
- Sponsor
- Charles University, Czech Republic
Patients with Multiple Sclerosis
Cerebellar RTMS in Patients with Multiple Sclerosis
To determine the efficacy of high frequency cerebellar repetitive transcranial magnetic stimulation on coordination in patients with multiple sclerosis.
- Trial name
- NCT06265922
- Testing
- High frequency repetitive transcranial magnetic stimulation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Multiple Sclerosis
Consolidation Therapy With Cladribine in Relapsing Multiple Sclerosis Patients
To investigate the impact on IgG and IgM concentration, infection risk and effectiveness of switching from anti-CD20 to cladribine compared to continued anti-CD20 treatment over 2 years in relapsing MS patients.
- Trial name
- OCR_CLAD (NCT06854094)
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Multiple Sclerosis
An Observational Study to Assess the Quality of Life of the Patients With Multiple Sclerosis and Their Caregivers
This is an observational, non controlled, non-interventional, multicentric, prospective study planned to be conducted in 450 subjects diagnosed with MS and their caregivers in 20 centres of Argentina.
- Trial name
- NCT01075737
- Where
- Argentina
- Volunteers
- 141 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Multiple Sclerosis
Depression and Fatigue in MS Patients Treated With Betaferon.
This study aims to evaluate the occurence and severity of fatigue and depression in multiple sclerosis patients and the impact of Betaferon treatment on symptoms alterations.
- Trial name
- FADO (NCT01354665)
- Testing
- Interferon beta-1b (Betaferon, BAY86-5046)
- Where
- Poland
- Volunteers
- 567 people
- Sponsor
- Bayer
Multiple Sclerosis, Relapsing-Remitting
RC18 in Patients With Relapsing Remitting Multiple Sclerosis：a Phase II Trial
To observe the safety and effectivity of a Recombinant Human B Lymphocyte Stimulator Receptor : Immunoglobulin G( IgG ) Fc Fusion Protein for injection (RC18) in patients with relapsing remitting multiple sclerosis, analyze the…
- Trial name
- NCT04625153
- Testing
- RC18 160mg, RC18 240mg
- Where
- China
- Volunteers
- 8 people
- Sponsor
- RemeGen Co., Ltd.
Multiple Sclerosis
Phase I Study of High-Dose Cyclophosphamide and Total Body Irradiation With T Lymphocyte-Depleted Autologous Peripheral Blood Stem Cell or Bone Marrow Rescue in Patients With Multiple Sclerosis
OBJECTIVES: I. Determine the efficacy, in terms of disease progression, of high-dose cyclophosphamide and total body irradiation with T lymphocyte-depleted autologous peripheral blood stem cell or bone marrow rescue in patients…
- Trial name
- NCT00017628
- Testing
- cyclophosphamide, filgrastim, methylprednisolone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Northwestern Memorial Hospital
Multiple Sclerosis
Phase IIa Study of Ublituximab in Participants With Relapsing Forms of Multiple Sclerosis
This study evaluates the use of single agent ublituximab, a novel monoclonal antibody, in participants with relapsing forms of multiple sclerosis.
- Trial name
- NCT02738775
- Testing
- Ublituximab
- Where
- 12 sites in United States
- Volunteers
- 49 people
- Sponsor
- TG Therapeutics, Inc.
Interventional Study
The Novel Use of Treadmill Plus Music in MS Patients Gate Rehabilitation
Multiple sclerosis (MS) is characterized by demyelination andaxonal loss of the central nervous system, which progressively results in neurologic dysfunction and is often accompanied by gaite limitations, reduced fitness, and…
- Trial name
- SMUSIC (NCT04019912)
- Testing
- Gait Training plus music, Traditional Gait Training
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Multiple Sclerosis
Study of Efficacy and Safety of Drugs BCD-033 and Rebif for Treatment of Patients With Multiple Sclerosis
Study design is double-blind, randomized, placebo-controlled study in 3 parallel groups with the use of active comparator and placebo. Total duration of therapy of about 2 years.
- Trial name
- NCT02727907
- Testing
- BCD-033 (interferon beta 1a), Rebif (interferon beta 1a)
- Where
- Russia
- Volunteers
- 163 people
- Sponsor
- Biocad
Multiple Sclerosis, Obesity
Development of a Telehealth Obesity Intervention for Patients With MS: Modifying Diet and Exercise in MS
We will tailor a telehealth obesity intervention for obese patients with MS (figure 2). Half of the patients will be randomly assigned to 24 weekly hour-long group weight loss sessions and 6 monthly individual sessions; half will…
- Trial name
- MoDEMS (NCT04255953)
- Testing
- behavioral telehealth, Treatment as Usual
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Jared Bruce
Multiple Sclerosis
Acute Effect of Fascial Mobilization on Gait in Patients With Multiple Sclerosis
Ten patients who were referred to receive physiotherapy and 10 healthy volunteers will be participants of the study.Following the initial evaluation, participants with multiple sclerosis will take the fascial mobilization for…
- Trial name
- NCT02628834
- Testing
- Fascial mobilization, Stretching Exercise
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Relapsing Remitting Multiple Sclerosis
Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment
In this study the investigators wish to test the hypothesis that the repertoire of solutes secreted by leukocytes isolated from patients with relapsing-remitting forms of Multiple Sclerosis (MS) following 6 months of treatment…
- Trial name
- NCT05171972
- Testing
- Ofatumumab
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Multiple Sclerosis
Safety and Tolerability of Interferon-Beta-1a and Estroprogestins Association in MS Patients
Clinical and experimental evidences suggests an immunomodulatory effect of sex hormones in multiple sclerosis. The role of oral estroprogestins in the pathogenesis and in the clinical course of the disease is actually unknown.
- Trial name
- NCT00151801
- Testing
- estroprogestins, interferon-beta 1a
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- S. Andrea Hospital
Stroke, Multiple Sclerosis
Upper Limb Muscle Strength Models for Patients With Motor Impairment.
Upper limb motor impairments are common. They affect quality of life and can lead to dependency. They are mainly due to neurological conditions such as stroke, multiple sclerosis, and traumatic spinal cord injury.
- Conditions
- Stroke, Multiple Sclerosis, Spinal Cord Injuries
- Trial name
- MusMapS (NCT06608121)
- Testing
- Upper limb isokinetic forces measurements
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Pôle Saint Hélier
Multiple Sclerosis
Gait Evaluation in Multiple Sclerosis Patients Treated With Glatiramer Acetate
Hypothesis: Treatment with Glatiramer acetate prevents deterioration of gait in multiple sclerosis (MS) patients. During the study patients will undergo a 3 dimensional gait analysis before starting treatment with glatiramer…
- Trial name
- NCT00331747
- Testing
- Glatiramer acetate
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Multiple Sclerosis
Efficacy and Safety of FTY720 in Patients With Relapsing Multiple Sclerosis
This study evaluated the safety, tolerability and effect on MRI lesion parameters of FTY720 in patients with relapsing multiple sclerosis.
- Trial name
- NCT00333138
- Testing
- FTY720
- Where
- 26 sites in Canada, Denmark and 9 more
- Volunteers
- 281 people
- Sponsor
- Novartis
Multiple Sclerosis, MS
Evaluation of the Efficacy of Transcranial Direct Current Stimulation in Reducing Fatigue and Improving Quality of Life in Patients With Multiple Sclerosis: A Randomized Clinical Trial
The goal of this clinical trial is to evaluate whether the application of three 2-week cycles of tDCS combined with motor therapy is more effective in reducing fatigue in adult patients with multiple sclerosis, compared to the…
- Trial name
- tDCS (NCT06873464)
- Testing
- Three cycles of tDCS combined with motor tasks, Two cycles of tDCS combined with motor tasks
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- European University of Madrid
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