Clinical trials: Pediatric Asthma, open to volunteers
Pediatric Asthma
Towards Digital Management of Paediatric Asthma
This pilot study aims to explore whether a digital approach to managing childhood asthma using connected inhalers and video consultations triggered by alerts from these devices - could work as well as standard in-person care.
- Trial name
- FrenchCare (NCT06902766)
- Testing
- Active telemonitoring using real-time data from digital inhalers., Standard
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pediatric Asthma
The Puerto Rico Asthma Integrated Response Program ("PR-AIR")
The purpose of this study is to adapt and deliver an evidence-based multi-level intervention to reduce asthma disparities, and that promote and improve population health in the high-burden communities of San Juan, Puerto Rico.
- Trial name
- PR-AIR (NCT05999032)
- Testing
- CASE in person version (High Intensity Package), CASE-V remote version (Low Intensity Package), CASE and HARP in person (High Intensity package)
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 480 people
- Sponsor
- Rhode Island Hospital
Asthma (Diagnosis), Inhaler Technique
Using a Digital Spacer for Inhaler Technique Education in Pediatric Asthma
This pilot study evaluates the feasibility, usability, and potential effect of the aflo™ Smart Spacer platform in children aged 6-18 with uncontrolled asthma using pMDIs and spacers.
- Conditions
- Asthma (Diagnosis), Inhaler Technique, Pediatric Asthma
- Trial name
- INSPIRE-KIDS (NCT07803042)
- Testing
- Aflo™ Smart Spacer
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Asthma, Pediatric Asthma
Asthma Lung Sounds With Wearable Stethoscope
The goal of this clinical trial is to evaluate a prototype wearable stethoscope designed to record lung sounds and assess asthma control in children and adolescents with asthma aged 4 to 17 years who are able to perform…
- Conditions
- Asthma, Pediatric Asthma, Airway Obstruction Upper
- Trial name
- NCT07792330
- Testing
- Prototype Wearable Stethoscope
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital Los Angeles
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Pediatric Asthma, Acute Asthma
Bilevel Positive Airway Pressure (BPAP) for Severe Asthma
The goal of this clinical trial is to assess the feasibility of early initiation of bilevel positive airway pressure (BPAP) in the emergency department (ED) for children with severe asthma exacerbations.
- Conditions
- Pediatric Asthma, Acute Asthma, BiPAP, Non-invasive Positive Pressure Ventilation
- Trial name
- NCT07582211
- Testing
- Bilevel positive airway pressure ventilation
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Columbia University
Pediatric Asthma, Critical Illness
Azithromycin for Critical Asthma - Pediatrics
The CR-AZI Study will assess the immunomodulatory effects of Azithromycin for pediatric Critical Asthma.
- Trial name
- CR-AZI Kids (NCT06223828)
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins All Children's Hospital
Asthma in Children, Obesity
Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)
This is single-center cross-sectional mechanistic study in lean and obese children with moderate-severe asthma, followed by a randomized, SHAM-controlled trial of Inspiratory Training (IT).
- Conditions
- Asthma in Children, Obesity, Pediatric Obesity, Pediatric Asthma
- Trial name
- MICA (NCT05945355)
- Testing
- Pro2 - Low Dose - 40% of participant's MIP, Pro2 - High Dose - 75% of participant's MIP
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Duke University
Type 1 Diabetes, T1D
DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions
This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with…
- Conditions
- Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- DASH-Obesity (NCT07638345)
- Testing
- Adhera Caring Digital Program-Obesity (ACDP-O)
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Pediatric Asthma
Humidity Asthma Interventions for Low Socioeconomic Status Children
The goal of this intervention study is to assess the effectiveness of low-cost humidity and mold reduction interventions in the home for reducing pediatric asthma.
- Trial name
- INHALE (NCT07453667)
- Testing
- Healthy home intervention
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Case Western Reserve University
Hyperlipidemias, Diabetes
Social Needs Screening and Chronic Diseases Study (WE CARE)
The goal of this clinical trial is to learn if the implementation of the WE CARE social determinants of health (SDOH) screening and referral intervention with an antiracist lens in primary care settings can lead to a meaningful…
- Conditions
- Hyperlipidemias, Diabetes, Depression, Pediatric Asthma
- Trial name
- NCT06903897
- Testing
- WE CARE SDOH System, Standard Pediatric Care
- Where
- 3 sites in United States
- Volunteers
- 68,000 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Preterm Birth, Preeclampsia
The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health
The 'Standard of Care Plus' ('PLUS') model in the ROOT Study consists of analyzing select micronutrient and gene variants of pregnant females to construct trimester-specific and personalized nutrition and lifestyle…
- Conditions
- Preterm Birth, Preeclampsia, Gestational Diabetes Mellitus (GDM), Small for Gestational Age (SGA)
- Trial name
- ROOT (NCT07559773)
- Testing
- 'Standard of Care PLUS'
- Volunteers
- 500 people
- Sponsor
- GrowBaby Life Project
Acute Otitis Media (AOM), Strep Pharyngitis
Evaluation of the Medentum Diagnostik Platform for Pediatric ENT Conditions and Asthma
This study evaluates the diagnostic performance, usability, and clinical utility of the Medentum Diagnostik platform, a multisensor device with integrated software and artificial intelligence, in pediatric patients with asthma…
- Conditions
- Acute Otitis Media (AOM), Strep Pharyngitis, Asthma Exacerbation, Pediatric Asthma
- Trial name
- NCT07500532
- Testing
- Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of AOM and strep pharyngitis, Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of wheeze/asthma exacerbation, Routine Asthma Management (in-person and telehealth visits)- Control Group
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Medentum Innovations
Bronchiolitis Acute, Lower Respiratory Tract and Lung Infections
Modern Technologies in Lower Respiratory Tract Infections in Children
Lower respiratory tract infections (LRTIs) are a significant cause of childhood morbidity and mortality globally, particularly in low-income countries.
- Conditions
- Bronchiolitis Acute, Lower Respiratory Tract and Lung Infections, Pediatric Lung Ultrasound, Tidal Volume
- Trial name
- MoT-LRTI (NCT07381790)
- Testing
- lung ultrasound, Tidal-flow volume loops
- Where
- 2 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Helse Møre og Romsdal HF
Overweight, Childhood, Obesity, Childhood
Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person vs. ONline
The goal of this study is to evaluate the effectiveness of CHAMPION ("Comparative-effectiveness of a Healthy lifestyle and Asthma Management Program, In-person vs ONline"), a primary care-based intervention to address childhood…
- Conditions
- Overweight, Childhood, Obesity, Childhood, Asthma in Children
- Trial name
- CHAMPION (NCT06432790)
- Testing
- CHAMPION
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Subject Presenting Wheeze, Asthma
AeviceMD for Detection of Wheeze in Pediatric and Adult Populations
Respiratory signs and symptoms consisting of wheeze, cough, and breathlessness are obtained in a manual fashion through history taking and physical examination by the healthcare professional.
- Conditions
- Subject Presenting Wheeze, Asthma, Bronchial Disease, Respiratory Tract Diseases
- Trial name
- NCT06691971
- Testing
- AeviceMD
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Aevice Health Pte. Ltd.
Pediatric Asthma
The Airports, Air Quality, and Asthma (AAA) Study
For children with asthma, exposure to indoor air pollution increases the risk of a serious asthma exacerbation, which can be life-threatening.
- Trial name
- NCT07047430
- Testing
- Portable air cleaner with HEPA filter, Less effective portable air cleaner (no HEPA)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Pediatric Asthma
Cohort Multiple Randomized Controlled Trial in Pediatric Asthma
The overarching goal of this study is to optimize pediatric asthma care and to continuously evaluate variations/innovations of the care (including transformation to remote eHealth care).
- Trial name
- CIRCUS (NCT06278662)
- Testing
- video directly observed therapy (vDOT)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Mattienne van der Kamp
Pediatric Asthma, Rhinitis, Allergic
The Impact of Airway Allergic Diseases on Children's and Parents' Quality of Life
This prospective observational study aims to assess the health-related quality of life (HRQoL) of 200 children (ages 5-16) with bronchial asthma, allergic rhinitis, or both, and their 200 parents, comparing 100 children receiving…
- Conditions
- Pediatric Asthma, Rhinitis, Allergic, Quality of Life
- Trial name
- NCT06535087
- Testing
- Subcutaneous immunotherapy / Standard Treatment for Asthma and Rhinitis
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Wenjing Zhou