Clinical trials: Pediatric Cancers
Pediatric Cancer
Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell…
- Trial name
- NCT05120518
- Testing
- Collection of post mortem tissue donation
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Preterm Birth, Pediatric Cancer
eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness
The overall aim is twofold: 1) to stretch the borderline regarding the present knowledge of clinical and economic cost-effectiveness of eHealth as an aid for facilitating and supporting self-management in families with long-term…
- Conditions
- Preterm Birth, Pediatric Cancer, Hirschsprung Disease, Congenital Malformation
- Trial name
- eChildHealth (NCT04150120)
- Testing
- e-health device with application, Mobile phone text messaging, early detection of cerebral palsy using a mobile phone application
- Where
- 7 sites in Denmark, Ethiopia and 1 more
- Volunteers
- 720 people
- Sponsor
- Lund University
Brain Tumor, Pediatric
Clinical Safety Study on 5-Aminolevulinic Acid (5-ALA) in Children and Adolescents With Brain Tumors
In this prospective, open, single-armed, multicenter, phase II study for application of 5-ALA in children and adolescents with brain tumors 80 patients will be investigated.
- Trial name
- NCT04738162
- Testing
- 5-Aminolevulinic Acid Hydrochloride, Oral
- Where
- 7 sites in Germany, Netherlands
- Volunteers
- 78 people
- Sponsor
- Universität Münster
CNS Tumor, Solid Tumor
Pedi-STAR: Surface Target Antibody-drug Conjugate (ADC) Antigen Expression in Relapsed/Refractory Pediatric Solid and CNS Tumors
This study is looking to learn whether a tumor testing approach can feasibly measure antibody-drug conjugate (ADC) target proteins in children and young adults with relapsed or refractory solid tumors or central nervous system…
- Conditions
- CNS Tumor, Solid Tumor, Relapsed Cancer, Refractory Cancer
- Trial name
- NCT07793994
- Testing
- Bulk RNA Sequencing, Immunohistochemistry (IHC)
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Dana-Farber Cancer Institute
Thyroglossal Duct Cysts
Assessing Post-operative Outcomes After Children's Sistrunk Procedure With or Without a Drain
Purpose of the Study: This study looks at how kids recover after a type of neck surgery called the Sistrunk procedure. Some kids have a small tube (called a drain) placed during surgery, and some do not.
- Trial name
- NCT07148895
- Testing
- Post-surgical drain, No post-surgical drain
- Where
- 5 sites in United States
- Volunteers
- 178 people
- Sponsor
- University of Rochester
Pediatric Cancer, Hematologic Malignancies
Murottal as Adjunctive Intervention in Pediatric
This study aims to evaluate whether listening to the recitation of Surah Ar-Rahman (Murottal) before bedtime can help improve anxiety and sleep quality in hospitalized children with blood cancer.
- Conditions
- Pediatric Cancer, Hematologic Malignancies, Anxiety, Sleep Disturbances in Children
- Trial name
- NCT07861477
- Testing
- Murottal Intervention
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Universitas Airlangga
Acute Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia, Adult
International Trial of Selumetinib in Combination With Dexamethasone for the Treatment of Acute Lymphoblastic Leukaemia
This trial is to investigate the combination of selumetinib and dexamethasone in the treatment of acute lymphoblastic leukaemia (ALL) in both adults and children.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia, Adult, Acute Lymphoblastic Leukemia, Pediatric, Acute Lymphoblastic Leukemia, in Relapse
- Trial name
- SeluDex (NCT03705507)
- Testing
- Selumetinib, Dexamethasone
- Where
- 17 sites in Denmark, Netherlands and 1 more
- Volunteers
- 12 people
- Sponsor
- University of Birmingham
Genes, Sporadic Chordoma
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes
Background: Chordoma is a rare, slow growing, often fatal bone cancer derived from remnants of the embryonic notochord. It occurs mostly in the axial skeleton (skull base, vertebrae, sacrum and coccyx), is more frequent in males…
- Trial name
- NCT01200680
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- National Cancer Institute (NCI)
Paediatric Oncology, Nurses
RCT to Evaluate the Efficacy of the NSSCEP in Reducing Burnout Among Jordanian Pediatric Oncology Nurses
The goal of this clinical trial is to learn if the Nurses' Stress Self-Care Educational Program (NSSCEP) can reduce burnout and occupational stress in Jordanian pediatric oncology nurses.
- Conditions
- Paediatric Oncology, Nurses, Burnout, Occupational Stress
- Trial name
- NSSCEP (NCT07175103)
- Testing
- Nurses' Stress Self-Care Educational Program (NSSCEP), General Technical Skills Program
- Where
- Jordan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Malignant Central Nervous System Neoplasm, Primary Central Nervous System Neoplasm
Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors
This early phase I trial studies the feasibility of giving memantine for the reduction of cognitive impairment after radiation therapy in pediatric patients with central nervous system tumors.
- Trial name
- NCT04217694
- Testing
- Cogstate Assessment Battery, Memantine, Memantine Hydrochloride
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Acute Lymphoblastic Leukemia, Pediatric
Behavioral Parenting Skills as a Novel Target for Improving Pediatric Medication Adherence: Study 3
The current study will assess the acceptability and feasibility of the CareMeds intervention with a larger sample (N = 100) across multiple sites in Buffalo, NY, and Atlanta, GA.
- Trial name
- NCT06074666
- Testing
- CareMeds Intervention, Usual Care Group
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Roswell Park Cancer Institute
Oral Mucositis
Oral Care With Propolis in Pediatric Oncology Patients
According to the data from the World Health Organization, approximately 14 million people are diagnosed with cancer every year, and this number is expected to increase further in the next 10 years.
- Trial name
- NCT05400031
- Testing
- propolis
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Izmir Katip Celebi University
Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor
Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma
This phase I trial is studying the side effects and best dose of ispinesib in treating young patients with relapsed or refractory solid tumors or lymphoma.
- Conditions
- Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor, Childhood Craniopharyngioma
- Trial name
- NCT00363272
- Testing
- ispinesib, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Snoezelen, Pediatric Cancer
Proof-of-Concept Study of the SNOEZELEN Device on Anxiety Symptoms in Patients Hospitalized for Chemotherapy in a Pediatric Oncology Department
The goal of this clinical trial is to evaluate whether the Snoezelen multisensory relaxation approach can reduce anxiety symptoms in children and adolescents aged 8 to 17 years hospitalized for chemotherapy in a pediatric…
- Conditions
- Snoezelen, Pediatric Cancer, Symptomatologie Anxieuse, Chimiothérapie
- Trial name
- SNOOZE (NCT07202507)
- Testing
- self-report questionnaires, research interviews
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Oscar Lambret
Acute Myeloid Leukemia (AML), Acute Lymphoid Leukemia (ALL)
A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant
The purpose of this study is to see if conditioning regimens that include personalized rabbit ATG (P-rATG) help the immune system recover sooner and decrease the chances of transplant-related side effects.
- Conditions
- Acute Myeloid Leukemia (AML), Acute Lymphoid Leukemia (ALL), Myelodysplastic Syndromes (MDS)
- Trial name
- NCT04872595
- Testing
- Personalized rATG (P-rATG), Hyper fractionated total body irradiation, Thiotepa
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Lymphoblastic Leukemia
Everolimus With Multiagent Re-Induction Chemotherapy in Pediatric Patients With ALL
Laboratory and other studies suggest that, the study drug, Everolimus (RAD001), may prevent tumor cell growth and also may increase the efficacy of other chemotherapy drugs.
- Trial name
- CRAD001NUS175T (NCT01523977)
- Testing
- Everolimus, Prednisone, Vincristine
- Where
- 8 sites in United States
- Volunteers
- 22 people
- Sponsor
- Dana-Farber Cancer Institute
Leukemia, Lymphoma
Arsenic Trioxide in Treating Young Patients With Refractory Leukemia or Lymphoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: This phase I trial is studying the side effects and best dose of arsenic trioxide in treating…
- Trial name
- NCT00020111
- Testing
- arsenic trioxide
- Where
- 52 sites in United States, Australia and 1 more
- Sponsor
- National Cancer Institute (NCI)
Acute Lymphoblastic Leukemia
Pediatric-Inspired Chemotherapy Plus Tyrosine Kinase Inhibitor in Adult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
This study will combine a standard, pediatric-inspired, chemotherapy regimen with the tyrosine kinase inhibitors (TKIs) Dasatinib and Ponatinib to treat adults with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
- Trial name
- NCT04845035
- Testing
- Dasatinib, Ponatinib, Berlin-Frankfurt-Münster Chemotherapy
- Where
- United States
- Sponsor
- University of Michigan Rogel Cancer Center
Sarcoma Metastatic
Pilot Study of TumorGlow for Intraoperative Molecular Imaging of Sarcoma Metastases to the Lungs in Pediatric Patients
Subjects will undergo infusion of 5 mg/kg indocyanine green, ICG ("TumorGlow") intravenously up to 5-days prior to surgery. Then, during the surgical procedure the next day, the subjects will undergo standard-of-care surgery.
- Trial name
- TumorGlow (NCT07658768)
- Testing
- ICG INFUSION 5MG/KG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Granulocyte Colony-Stimulating Factor, Chemotherapy-induced Neutropenia
Starting Granulocyte Colony-Stimulating Factor at 1 Day vs 3 Days Following Chemotherapy in Pediatric Cancer Patients
Chemotherapy places patients at an increased risk of infection. A medication called granulocyte colony-stimulating factor is given as a daily injection in order to help decrease the risk of infection.
- Conditions
- Granulocyte Colony-Stimulating Factor, Chemotherapy-induced Neutropenia, Chemotherapy-Induced Febrile Neutropenia, Pediatric Cancer
- Trial name
- NCT03823950
- Testing
- Granulocyte Colony-Stimulating Factor
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Mississippi Medical Center
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