Clinical trials: Pediatric Congenital Heart Surgery
Congenital Heart Defect
Erythropoietin and Pediatric Cardiac Surgery
Lack of bloodflow to the heart and brain when the heart is stopped during heart surgery can cause damage to those organs. We hypothesize that a single dose of erythropoietin prior to the heart bypass portion of surgery may…
- Trial name
- EPO (NCT00451698)
- Testing
- acyanotic erythropoietin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Medical College of Wisconsin
Low Cardiac Output Syndrome
Levosimendan Administration in Neonates With Transposition of the Great Arteries
Calcium sensitizer drugs such as Levosimendan may exert anti-ischemic effect in addition to positive inotropic and anti-stunning effects mediated by the opening of ATP-sensitive potassium (KATP) channels.
- Trial name
- NCT01120106
- Testing
- levosimendan
- Where
- Italy
- Volunteers
- 63 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Weaning Mechanical Ventilation, Pediatric Cardiac Surgery
Weaning From Mechanical Ventilation After Pediatric Cardiac Surgery
Weaning from mechanical ventilation post congenital cardiac surgery is often challenging. It is well known that not all patients can be early extubated, although most are suitable for early postoperative weaning and extubating…
- Trial name
- NCT07066748
- Testing
- group P:pressure support ventilation mode, group A:automatic tube compensation (ATC).
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Alexandria University
Hypoplastic Left Heart Syndrome, Heart Defects, Congenital
Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart Surgery
This study aims to evaluate the safety and feasibility of coronary infusion of autologous placental cord blood mononuclear cells during the Norwood heart operation in newborn hypoplastic left heart syndrome (HLHS) patients.
- Conditions
- Hypoplastic Left Heart Syndrome, Heart Defects, Congenital, Pediatric Disorder
- Trial name
- NCT03431480
- Testing
- Autologous Human Placental Cord Blood Mononuclear Cells
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Murdoch Childrens Research Institute
Congenital Heart Disease in Children, Cardiopulmonary Bypass
The Role of Dexmedetomidine As Myocardial Protection In Pediatric Cyanotic Congenital Heart Disease Undergoing Open Cardiac Surgery Using Cardiopulmonary Bypass Machine: A Preliminary Study
Congenital Heart Diseases (CHD) are one of the most common congenital anomalies. Worldwide, 8 to 9 out of 1000 of children are born with a CHD, of which 25 percent of are cyanotic CHD.
- Trial name
- NCT05300802
- Testing
- Dexmedetomidine Hcl 100 Mcg/mL Inj
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Congenital Heart Disease, Cardiomyopathy
Evaluation of the Prevalence and Clinical Manifestation of SARS-CoV-2 Infection in a Population of Adult and Pediatric Patients With Congenital Heart Disease
The goal of this observational study, drug-free, cross-sectional, single-center is to describe the incidence and characteristics of the clinical course and any short- and medium-term complications of patients with congenital…
- Conditions
- Congenital Heart Disease, Cardiomyopathy, Pulmonary Arterial Hypertension, SARS CoV-2 Infection
- Trial name
- NCT06784687
- Where
- Italy
- Volunteers
- 2,376 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Congenital Heart Defect
Use of ROTEM® in Pediatric Cardiac Surgical Patients
Cardiac surgery requiring use of a heart-lung machine, also known as cardiopulmonary bypass (CPB) can induce abnormalities in blood coagulation (clotting) that lead to excessive blood loss during and after operation.
- Trial name
- PedsROTEM (NCT01212289)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Weill Medical College of Cornell University
Hypoplastic Left Heart, Surgery
NIRS in Neonatal Cardiac Surgery
Due to the small size of infants and the use of bypass machines, physicians have difficulty assessing whether the infant's brain and body is getting enough oxygen during heart surgery.
- Trial name
- NCT00166101
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Congenital Heart Diseases
Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery
1. Explore the efficacy of Ulinastatin use in improving post-operative pulmonary insufficiency and safety in pediatric patients undergoing scheduled CPB open heart surgery to treat Complex Congenital Heart Disease 2.
- Trial name
- NCT02527811
- Testing
- Ulinastatin
- Where
- 5 sites in China
- Volunteers
- 450 people
- Sponsor
- Techpool Bio-Pharma Co., Ltd.
Cyanotic Heart Disease, Cardiopulmonary Bypass
Effect of Methylprednisolone on Systemic Inflammatory Response During Pediatric Congenital Open-Heart Surgery
The goal of this study is to evaluate the effects of steroids on the early postoperative inflammatory response in patients undergoing elective pediatric congenital cardiac surgery, requiring cardiopulmonary bypass (CPB).
- Trial name
- NCT05927233
- Testing
- Methylprednisolone, Saline
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Aga Khan University
Pediatric Heart Failure, Congenital Heart Disease (CHD)
MedlyPeds Feasibility Study
SickKids and UHN have developed MedlyPeds which is a smart phone application designed to remotely monitor patients with heart disease.
- Conditions
- Pediatric Heart Failure, Congenital Heart Disease (CHD), Acquired Heart Disease, Pulmonary Hypertension
- Trial name
- NCT07556185
- Testing
- MedlyPeds App
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Congenital Heart Disease
Cardiac Biomarker in Pediatric Heart Disease
The purpose of this study is to investigate cardiac biomarker during perioperative management in pediatric cardiac surgery.
- Trial name
- NCT01834976
- Where
- Japan
- Volunteers
- 74 people
- Sponsor
- Okayama University
Congenital Heart Disease
Bilateral Two Levels Serratus Anterior Plane Block in Pediatric Cardiac Surgery With Median Sternotomy
The serratus anterior plane block (SAPB) is an anterolateral thoracic wall block that was described in 2013 by Blanco et al. who presented it as an alternative to other regional anesthetic techniques.
- Trial name
- NCT06221150
- Testing
- Bilateral two level serratus anterior block
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Congenital Heart Disease (CHD), Postoperative Sleep
Starry-Sky Projection and Maternal Voice for Sleep After Pediatric Cardiac Surgery
The goal of this clinical trial is to determine whether a starry-sky projection affects sleep during the early period after cardiac surgery in young children.
- Trial name
- NCT07854145
- Testing
- Starry-Sky Projection, Conventional Lighting, Maternal Voice
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Post-cardiac Surgery, Hyperlactatemia
Lactate Acidosis in Postoperative Hearts
This is a single-center, observational study. Investigators aim to characterize the metabolism of lactate in children over the first forty-eight hours following cardiac surgery. Blood samples will be obtained up to 12 timepoints.
- Trial name
- NCT03025659
- Testing
- Pyruvate levels
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Florida
ERAS, Pediatric ALL
Pediatric Enhanced Recovery After Cardiac Surgery
Identify our institution's current perioperative management strategies for pediatric cardiac surgery patients. Identify predictive factors for receiving perioperative care following P-ERACS strategies.
- Conditions
- ERAS, Pediatric ALL, Congenital Heart Disease
- Trial name
- PERCS (NCT05665712)
- Testing
- enhanced recovery
- Where
- Canada
- Volunteers
- 483 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Central Line-associated Bloodstream Infection (CLABSI), Central Venous Catheter Associated Bloodstream Infection
Central Venous Catheter Insertion Site and Colonization in Pediatric Cardiac Surgery
Randomized controlled trial comparing femoral vs internal jugular insertion site of central venous catheters (CVC) in newborns and infants undergoing cardiac surgery.
- Conditions
- Central Line-associated Bloodstream Infection (CLABSI), Central Venous Catheter Associated Bloodstream Infection, Heart; Surgery, Heart, Functional Disturbance as Result, Congenital Heart Disease
- Trial name
- PRECiSE (NCT03282292)
- Testing
- Internal jugular vein CVC insertion
- Where
- Italy
- Sponsor
- IRCCS Policlinico S. Donato
Chylothorax
Chylothorax Following Heart Surgery
The purpose of this study is to determine at risk populations for certain congenital heart defects or certain operative procedures and to define the associated morbidity secondary to chylothorax - prolonged chest tube drainage…
- Trial name
- NCT00215098
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Children's Healthcare of Atlanta
Congenital Heart Disease, Congenital Heart Defect
Nitric Oxide Effect on Brain and Kidney in Pediatric Patients Undergoing Cardiopulmonary Bypass
The goals of this study are: 1. To evaluate the neuroprotective effect of nitric oxide by measuring glial fibrillary acid protein (GFAP) before and after surgery.
- Conditions
- Congenital Heart Disease, Congenital Heart Defect, Congenital Heart Malformations
- Trial name
- NCT05101746
- Testing
- Nitric Oxide (NO) 20 part per million (ppm), Standard of care cardiopulmonary bypass
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
CHD - Congenital Heart Disease
Bilateral Ultrasound Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block
Group (A): This group will receive fentanyl infusion at a dose of (0.5μg/kg/h) all through the whole operation plus ultrasound guided bilateral superficial parasternal intercostal Plane block which will be done by injecting…
- Trial name
- NCT06958120
- Testing
- superficial parasternal intercostal Plane block, Erecto spinea plane block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University